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Alanise Glycerol.pptx
- 1. How Alanise, Glycerol and lactate are converted to glucose? What is significance of Gluconeogenesis? Presented By:- MADIHA RUBAB Roll # 41
- 2. Conversion Of Alanine To Glucose:- Alanine like other Amino Acids, derived from hydrolysis of tissue proteins & source of glucose during fast.
- 3. Alanine Alanine aminotransferase ALT Pyruvate Pyruvate carboxykinase Oxaloacetate PEP Carboxykinase Phosphoenol pyruvate Enolase Phosphoglycerate Phosphoglycerate Mutase Phosphoglycerate Phosphoglycerate kinase Bisphosphoglycerate Glyceraladehyde phosphate Dehyclrogence Glyceraldehyde Phosphate Glucose Glucose Phosphatase Glucose Phosphate Phosphaglucose isomerase Fructose 6 phosphate Fructose 1,6 bisphosphatose Fructose 1,6 bisphosphate
- 4. Conversion of Lactate to Glucose: Lactate is released by exercising skeletal Muscles & from the cells lacking Mitochondria leg RBC’S This lactate is taken up by liver, and reconverted to glucose from where it is released back into circulation (called as Cori’s Cycle)
- 5. Lactate Lactate Dehydrogenase Pyruvate Pyruvatecarboxylase Oxaloactate PEP carboxy kinase Phophoenolpysuvate Enolase Phophoglycerate Phophogly cerate Mutase Phosphoglycerate Phosphogly cerate kinase Bisphosphoglycerate Glyceraldehyde Phosphate Delydrogenose Glucose Glucose 6 Phosphatase Glucose 6 Phosphate Phosphaglucose isomerase Fructose 6 phosphate Fructose 1,6 bisphosphatose Fructose 1,6 bisphosphate Glyceraldehyde 3 phosphate DHAP
- 6. Conversion of Glycerol to Glucose: Glycerol is released from Adipose Tissue during hydrolysis of______ it is transported to liver, in blood where it is phosphorylated is then oxidized to DHAP, an intermediate of glycolysis (phosphorylation does not occur in adipose tissue because they lack the required enzymes)
- 7. Glycerol Glycerol kinase Glycerol 3 phosphate Glycerol phosphate delyorogenose Dilydroxyacetone phosphate Triose phosphate isonerase Glyceraldehyole 3 phasphate Aldolase Fructose 1,6Bisphosphate Fructose 1,6bisphosphatase Fructose 6 phosphate Phosphogluciseisomerase Glucose Glucose 6 Phosphatase Glucose 6 Phosphate D- glucose Fructose 6 phosphate Fructose 1,6 bisphosphatose Fructose 1,6 bisphosphate
- 8. Significance of Glucineogeresis: Some tissues such as brain, RBC’S, kidney, lens, cornea of eyes & exercising Muscles require a continuous supply of glucose as Metabolic fuel. Glycogen can meet energy needs for only 10-18 has in the absence of dietary intake of glucose. So during a prolonged fast when glycogen stores are deplated glucose is formed from non-carbohydrate precersors such as lactate, glycerol, etc.
- 9. Certain Metabolites produced in tissues accumulate in the blood such as lactate, glycerol, pyruvate which are effectively derived from blood by gluconeogenesis (which utilize them as precursor