Aigner intelgenx

•

0 likes•380 views

ItelGenx

Healthcare

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner
Rejuvenation of the Aged Brain
An Example of Drug Delivery in Drug Repurposing
Ludwig Aigner
IntelGenx, Grand Opening, Saint-Laurent, May 10th 2016

YESTERDAY
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 2

TODAY
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 3

TOMORROW
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 4

5
Age: Risk Factor Number 1
Teresa Niccoli , Linda Partridge, Ageing as a Risk Factor for Disease, Current Biology, Volume 22, Issue 17, 2012, R741 - R752
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 6

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 7
Massive Increase in the Prevalence of AD

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 8

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 9

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 10

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 11
GeneticNon-Genetic

Alt
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 12
Alzheimer Pathology

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 13
Are We Targeting the Right Thing ?
Rodrigue et al., Neuropsychol Rev. 2009

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 14
1001 Reasons for Neuronal Cell Death ???

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 15
Neurodegeneration
eg Schapira et al. 2011
Neuroinflammation
eg Hirsch et al. 2009
Blood Brain Barrier
eg Zlokovic et al. 2008
Neurogenesis
eg Regensburger et al. 2014
Neurotransmission
eg Calabresi et al. 2007
Our Targets:
Pleiotropic Signaling
Demyelination
Axonal Damage
eg Franklin et al. 2008

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 16
AGING and REJUVENATION

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 17
Neurodegeneration
eg Schapira et al. 2011
Neuroinflammation
eg Hirsch et al. 2009
Blood Brain Barrier
eg Zlokovic et al. 2008
Neurogenesis
eg Regensburger et al. 2014
Neurotransmission
eg Calabresi et al. 2007
Demyelination
Axonal Damage
eg Franklin et al. 2008
The Aged Brain is a „Diseased“ Brain

Regeneration
Disease Risk
Disease Risk
Live = Aging
Growth Plasticity Degeneration Disease
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 18

Growth Plasticity Degeneration
Aging and Rejuvenation
„Regenerative Pharmacology“
Disease
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 19

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 20
Can We Turn Back the Clock ?

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 21
Muscle Research, Aging, and Regenerative Medicine ?

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 22

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 23
inflammation
neurogenesis
cognitiion
Modulating the Systemic Milieu: a Valid Approach

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 24
Eotaxin Reduces Neurogenesis
Eotaxin Worsens Cognition
Old Blood Contributes to Brain Aging
EOTAXIN

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 25
Eotaxin Leukotrienes
Allergy / Asthma Brain Aging
Aging / Degeneration

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 26
Leukotrienes Impact on Brain Aging
Leukotrienes
Neurodegeneration
eg Schapira et al. 2011
Neuroinflammation
eg Hirsch et al. 2009
Blood Brain Barrier
eg Zlokovic et al. 2008
Neurogenesis
eg Regensburger et al. 2014
Neurotransmission
eg Calabresi et al. 2007
Demyelination
Axonal Damage
eg Franklin et al. 2008
Montelukast

Proof of Principle:
Inhibition of Leukotriene Receptors Improves Cognition in Aged Rats
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 27

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 28

symptoms pathology therapy
motoric dopaminergic cell loss dopamine replacement
60%
Parkinson´s Disease Dementia / Lewy Body Dementia
symptoms pathology therapy
motoric dopaminergic cell loss dopamine replacement
dementia ??? rivastigmine
Neurogenesis
Blood Brain Barrier
Neuroinflammation
Neurodegeneration
Neurotransmission
eg Schapira et al. 2011
eg Hirsch et al. 2009
eg Zlokovic et al. 2008
eg Regensburger et al. 2014
eg Calabresi et al. 2007
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 29

**
Learning Memory
*
Montelukast Improves Cognitive Functions in PD / LBD Animals
© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 30

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 31

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 32
1 1 2 2 1 1 2 3 3 4 3 2 2 4 4 2 3 3 6 7 6 11 7
14
7 13 15 12 15 19 17 23 25
50 48
99
126
239
317
414
0
50
100
150
200
250
300
350
400
450
1973
1975
1976
1977
1978
1979
1980
1982
1983
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
NumberofPublications
Annual Counts of Publications “Drug Repurposing”

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 33
“All De- and Regenerations are Similar”

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 34
REPAIR
REPLACE
RESTORE
REGENERATE
REJUVENATE
Regenerative Medicine
All Organs
Different Diseases

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 35
MMSE 13:
moderate to severe dementia
Montelukast as an Anti-Dementia Therapeutic
Before After 2 Months of Montelukast
MMSE 22:
mild dementia

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 36
Discover
y
Preclini
c
Phase
I
Phase
II
Phase
III
Approval
BIOTECH
Academia Big Pharma

© Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 37
Let‘s make a better Montelukast

Similar to Aigner intelgenx

Therapeutic Plasma Exchange (TPE), frequently referred to as plasmapheresis. is an automated procedure which separates whole blood into plasma and blood cells. The plasma is discarded and replaced with physiologic fluids and returned to the patient along with the blood cells. Theoretically, any disease in which a humoral phase is implicated in the pathogenesis may be at least partially mitigated by removal of the patient’s plasma and replacement with physiologic solutions

A Paradigm Shift in the Utilization of Therapeutic Plasmapheresis in Clinical...

semualkaira

A review on treatment of alzheimer disease

Priti Pal

Pharmacovigilance in ophthalmology

Agnes Mbatu, MD, BCMAS

Alzheimer's, Parkinson's, ALS, MS,

morwenna2

Test File

meducationdotnet

Annovis Bio (NYSE American: ANVS) is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing Phase 2a study in AD patients and plans to commence a second Phase 2a study in PD patients. Learn more at ANVSinfo.com.

Annovis Bio (ANVS) Presentation - May 7, 2020

RedChip Companies, Inc.

Biomarcadores en epilepsia

Hospital General Universitario Gregorio Marañón

Reaxys Medicinal Chemistry

Reaxys

INDUCED PLURIPOTENT STEM CELL AND GENOME ENGINEERING

harrisonjoshua

Devinsky preventing sudep jama neruo 2018

NicoleJohnson262

2014 09-25 MipTec Europe's Drug Discovery event

Alain van Gool

AdVax is a company that is well positioned, developing a new suite of diagnostics, therapeutics, healthcare management tools, vaccines, and monoclonal antibodies in the emerging multi-billion dollar arena of oral-systemic biology. Newly discovered links between two unique oral bacterial pathogens and chronic debilitating systemic illnesses are the basis for AdVax’s groundbreaking solutions for multiple systemic diseases—including Alzheimer’s disease and cardiovascular diseases.

AdVax Complete Overview

drdansindelar

Chronic Neuroinflammation in Alzheimer’s Disease New Perspectives Animal Mode...

Niloo Karunaweera

AdVax - Oral Systemic Biology

drdansindelar

Bioelectronic medicines

KalyaniOvhal

AstraZeneca, Lund, May 7 2014

MentLife

Proteins

Carlos Lopez Diaz

The proteins are so much important, are versatile molecules because can realize diverses functions and we can use it like: enzymes: can catalysis chemical reactions Hormones: the proteins can work with the plataletes to help to the blood coagulation Transport of substances Immunological factor: the antibodies produced with leukocyte And the most important characteristic, they are molecular target so, we can use it to medical treatment, therapies to the cancer and another diseases . Also we can use the proteins presence and characteristic behavior for diagnosis of many sicknesses 1.Poor protein control key to Alzheimer's progression New research investigating the pattern of protein build-up in Alzheimer's brains may open the door to a deeper understanding. Previous research has identified that certain areas of the brain are more sensitive to the aggregation of proteins. The disease often begins in the entorhinal region (at the base of the brain) and spreads out to all of the neocortex (the largest part of the cerebral cortex) How did it? They analyzed approximately 500 samples of healthy brain taken from the Allen Brain Atlas In the healthy tissue, they observed a distinctive joint of genes important in the control of beta amyloid and tau protein. They contrasted with Alzheimer`s brains and discovered a identical pattern in advance of the sickness throughout the brain. 2. 2 Zika Virus Proteins Linked to Microcephaly ID'd First study to examine Zika infection in human neural stem cells from second-trimester fetuses, researchers say. USC researchers have tracked down two Zika proteins potentially responsible for thousands of microcephaly cases; taking one small step toward preventing Zika-infected mothers from birthing babies with abnormally small heads. Babies with microcephaly have abnormally small heads and brains. The Zika virus include 10 proteins, however only NS4B and NS4A are the responsible, in accordance with the study published in the journal Cell Stem Cell. These malicious proteins, researchers discovered, have two shared life goals: to handicap fetal brain formation and to mobilize their malevolent forces.

ALZHEYMER'S DISEASE, ZIKA VIRUS AND PROTEINS

Carlos Lopez Diaz

Maria Luisa Verteramo

Annovis Bio (ANVS) Presentation - April 9, 2020

RedChip Companies, Inc.

Similar to Aigner intelgenx (20)

A Paradigm Shift in the Utilization of Therapeutic Plasmapheresis in Clinical...

A review on treatment of alzheimer disease

Pharmacovigilance in ophthalmology

Alzheimer's, Parkinson's, ALS, MS,

Test File

Annovis Bio (ANVS) Presentation - May 7, 2020

Biomarcadores en epilepsia

Reaxys Medicinal Chemistry

INDUCED PLURIPOTENT STEM CELL AND GENOME ENGINEERING

Devinsky preventing sudep jama neruo 2018

2014 09-25 MipTec Europe's Drug Discovery event

AdVax Complete Overview

Chronic Neuroinflammation in Alzheimer’s Disease New Perspectives Animal Mode...

AdVax - Oral Systemic Biology

Bioelectronic medicines

AstraZeneca, Lund, May 7 2014

Proteins

ALZHEYMER'S DISEASE, ZIKA VIRUS AND PROTEINS

Maria Luisa Verteramo

Annovis Bio (ANVS) Presentation - April 9, 2020

Recently uploaded

VIP ℂall Girls Hyderabad 8250077686 WhatsApp: Me All Time Serviℂe Available D...

Model Neeha Mumbai

Abortion pills in Kuwait city !🌆+919101817206) Where to get cytotec pills in salmiyah, WhatsApp '''(+919101817206)''' Explore Discreet and Safe Abortion Pill Options in Dubai, Empowering Women With Confidential and Medically Supervised Choices For Reproductive Health" Abortion Pills In Dubai, Abu Dhabi/Alain/Sharjah/RAK City Satwa-Mifepristone and Misoprostol Available in Dubai/Abu Dhabi - i Pills in Dubai and Cost Of Cytotec in WhatsApp (+919101817206) Abortion Pills in Dubai/Abu Dubai/ Abu Dhabi. Are you stranded with unwanted pregnancy in Dubai, Abu Dhabi , the United Arab Emirates (U.A.E), Qatar, Oman, Saudi Arabia or Kuwait? you can now contact us now on Whatsapp 9101817206 buy safe abortion pills In Dubai, Abu Dhabi, Sharjah, Al Ain, Ajman, RAK City, Ras Al Khaimah and Fujairah to terminate an unwanted pregnancy in Dubai and the United Arab Emirates. Get your Discreet 100% Safe (+919101817206)*Effective Abortion Pills For Sale in Dubai, Abu Dhabi, KUWAIT, QATAR, BAHRAIN, DOHA, SALMIYA, Sharjah, Ajman, Alain, Fujairah, Ras Al Khaimah, Umm Al Quwain, UAE. BUY Mifepristone and Misoprostol (Cytotec), Mtp Kit In UAE. Abortion pills available in UAE (United Arab Emirates), Saudi Arabia, Kuwait, Oman, Bahrain and Qatar. Contact us today. +919101817206 -The UAE’s leading abortion care service in Dubai. Abortion Treatment. Medical Abortion. Surgical Abortion. Find A Clinic like Dr Maria Abortion clinic in Dubai We have Abortion Pills / Cytotec Tablets Available in Dubai, Abu Dhabi, KUWAIT, QATAR, BAHRAIN, DOHA, SALMIYA, Sharjah, Ajman, Alain, Fujairah, Ras Al Khaimah, Umm Al Quwain, UAE., buy cytotec in Dubai abortion Pills Cytotec also available Oman Qatar Doha Saudi Arabia Bahrain We sell original abortion medicine which includes: Cytotec 200mcg (Misoprostol), Mifepristone, Mifegest-kit, Misoclear, Emergency contraceptive pills, Morning after sex pills, ipills, pills to prevent pregnancy 72 hours after sex. All our pills are manufactured by reputable medical manufacturing companies like PFIZER. Medical abortion is easy and effective for everyone to perform in their own privacy. There are very few complications that may arise from medical abortion if one follows the right guidelines as instructed by the obstetrician. Abortion Pills in Dubai Can Now Be Offered at Dr Maria Abortion clinic in Dubai, F.D.A. Mifepristone and Misoprostol, the first of two drugs in medication abortions, previously had to be dispensed only by clinics, doctors or a few mail-order pharmacies like Dr Maria Abortion clinic in Dubai . Now, We can provide it. For the first time, retail pharmacies, like Dr Maria Abortion clinic in Dubai, will be Able to offer abortion pills in Dubai under a regulatory change made Tuesday by the Food and Drug Administration. The action could significantly expand access to abortion through medication. Cytotec Abortion Pills are Available In Dubai / UAE, you will be very happy to do abortion in Dubai we are providing cytotec 200mg abortion pi

Cytotec 200mcg tab in Riyadh (+919101817206// Get Abortion Pills in Saudi Arabia

jaanualu31

Mike Lowe’s cancer fight lowe strong shirt

rahman018755

Young & Hot ℂall Girls Kolkata 8250077686 WhatsApp Number Best Rates of Kolka...

Model Neeha Mumbai

Famous Indian Vedic Astrologer | Best Astrological Solutions UK

darmandersingh4580

Selamat datang di Apotek Amanah Shop Dokter Kandungan Jual Obat Aborsi Asli Resep Halodoc / Alodokter Rekomendasi Cytotec 200 mcg Untuk Obat Aborsi Ampuh dan Terbaik – Beli Obat Penggugur Kandungan di apotik tanpa resep dokter wa.me/628561234742 Cara Gugurkan Kandungan Awal dengan Obat Cytotec Pfizer Misoprostol 200 mcg [ 24 Jam Tuntas ] – Jual Cytotec Asli Obat MENGGUGURKAN kandungan Kuat dengan cepat selesai dalam 24 jam secara alami – Cara Menggugurkan Kandungan Usia Janin 1, 2, 3, 4 Bulan Sampai 5, 6, 7 , Bulan Dengan Cepat Dalam Hitungan jam Secara Alami Obat Aborsi Asli [ Cytotec dan Gastrul ] Obat Penggugur Kandungan AMPUH untuk Usia Janin 1-7 Bulan Dengan Cepat Dalam Hitungan jam Secara Alami Jual Obat Aborsi Asli Bisa COD / Bayar Di Tempat wa.me/628561234742 Cara Aborsi dengan Obat Cytotec 200 mg Misoprostol Pfizer salah satu Obat Penggugur Kandungan Di Apotik Paling Ampuh yang tidak dijual secara umum, Cara Menggugurkan Kandungan [ Gugurkan Kehamilan Kuat 1-8 Bulan dengan Cepat Dalam Hitungan Jam secara Alami ] dari janin muda hingga tua usia 1 Bulan, 2 Bulan, 3 Bulan, 4 Bulan, 5 Bulan, 6 Bulan, 7 Bulan, sangat mudah diatasi dengan pil aborsi cytotec asli ampuh 100% Berhasil TUNTAS. Cara menggugurkan kandungan dengan cepat selesai dalam 24 jam secara alami usia Kehamilan 1 2 3 4 5 6 7 Bulan. Pertanyaan Tentang Obat Aborsi Cytotec 200 mg untuk Anda yang cari penjual cytotec di apotek Indonesia seperti K24, Kimia Farma, Apotik Online, Century Apotik, Apotik roxy, Farmasi, dll. itu harus dengan resep dokter, Hanya Di website kami yang tidak perlu pakai resep dokter karena kami jual secara online. Pertanyaan Tentang Obat Penggugur Kandungan Cytotec 200 mcg: Asli dan Palsu, Daftar Harga, Testimoni Nyata, Fungsi Obat Aborsi, Dosis Tinggi, Aturan Pakai, dan Efek Samping, Dengan Senang Hati Kami Akan Membantu Masalah Anda Sampai Tuntas. INFO KONSULTASI: wa.me/628561234742 Jual Obat Aborsi Asli dan Obat Penggugur Kandungan Bisa COD / Bayar Ditempat Pengobatan yang tepat untuk mengakhiri kehamilan lemah dan kuat, Pil Cytotec 200mcg adalah salah satu produk populer di indonesia sebagai Obat Penggugur Kandungan Yang Aman Untuk Ibu Menyusui yang tepat dan teruji secara klinis. PESAN / BELI CALL / WHATSAPP 08561234742 Testimoni Obat Aborsi Cytotec Misoprostol 200 mcg Asli Nyata Inilah Bukti Keberhasilan Pasien Kami REAL [ ASLI Nyata ] Tanpa Rekayasa, Testimoni Obat Penggugur Kandungan Asli Satu Obat Aborsi Yang Aman Untuk Ibu Menyusui Yaitu Dengan Cytotec Original kemasan Botol Dan Tablet Dosis Misoprostol 200 mcg untuk Menggugurkan Kehamilan usia 1, 2, 3, 4, 5 , 6, 7, bulan dengan cepat selesai dalam waktu 24 jam.

Cara menggugurkan kandungan paling ampuh 08561234742

Jual obat penggugur 08561234742 Cara menggugurkan kandungan 08561234742

Today’s healthcare leaders are seeking technology solutions to optimize efficiencies and improve patient care. However, without effective change management and strategies in place, healthcare leaders struggle to strategically improve patient flow, space, to strategically improve patient flow, space, and schedule management, and implement daily huddles. The role of technology in supporting operational efficiency and change management initiatives is inevitable. During this webinar, attendees will learn how to optimize Ambulatory Operational Efficiencies and Change Management. Attendees will also learn about the importance of visual management boards in enhancing clinic performance and insights into effective change management approaches.

Unlock the Secrets to Optimizing Ambulatory Operations Efficiency and Change ...

Health Catalyst

Catheterization of the bladder involves introducing a latex or plastic tube through the urethra and into the bladder. The catheter provides a continuous flow of urine in patients unable to control micturition or those with obstructions. It also provides a means of assessing urine output in hemodynamically unstable patients. Because bladder catheterization carries the risk of UTI, blockage, and trauma to the urethra, it is preferable to rely on other measures for either specimen collection or management of incontinence. Types of Catheterization. Intermittent and indwelling retention catheterizations are the two forms of catheter insertion INTERMITTENT CATHETERIZATION introduce a straight single-use catheter long enough to drain the bladder (5 to 10 minutes When the bladder is empty, you immediately withdraw the catheter. COMPLICATION- increases risk of trauma and infection. INDICATION- It is common for people with spinal cord injury or other neurological problems such as multiple sclerosis to perform self– intermittent catheterization up to every 4 hours daily for months or years. UTI rate is lower than for patients with long-term indwelling catheters. INDWELLING CATHETERIZATION- remains in place for a longer period, until a patient is able to void voluntarily or continuous accurate urine measurements are no longer needed The straight single-use catheter has a single lumen with a small opening about 1.3 cm ( 1 2 inch) from the tip. . Urine drains from the tip, through the lumen, and to a receptacle. An indwelling Foley catheter has a small inflatable balloon that encircles the catheter just above the tip. When inflated the balloon rests against the bladder outlet to anchor the catheter in place. The indwelling retention catheter often has two or three lumens within the body of the catheter . One lumen drains urine through the catheter to a collecting tube. A second lumen carries sterile water to and from the balloon when it is inflated or deflated. A third (optional) lumen is sometimes used to instill fluids or medications into the bladder. It is easy to determine the number of lumens by the number of drainage and injection ports at the end of the catheter A second type of intermittent catheter has a curved tip A Coudé catheter is used on male patients who may have enlarged prostates that partly obstruct the urethra. It is less traumatic during insertion because it is stiffer and easier to control than the straight-tip catheter Plastic catheters are suitable only for intermittent use because of their inflexibility Latex catheters are recommended for use up to 3 weeks. Be aware of allergies. Pure silicon or Teflon catheters are best suited for long-term use (2 to 3 months) because of less encrustation at the urethral meatus Balloon sizes range from 3 mL (pediatric) to large postoperative volumes (75 mL). In adults the 5-mL and 30-mL sizes are the most common: The 5-mL size allows for optimal drainage, whereas the 30-mL size is used after pros

Catheterization Procedure by Anushri Srivastav.pptx

AnushriSrivastav

Tortora PRINCIPLES OF ANATOMY AND PHYSIOLOGY - Tortora - 14th Ed.pdf

Dr. Afreen Nasir

Anthony Edwards We Want Dallas T-shirtsAnthony Edwards We Want Dallas T-shirts

rahman018755

Etiology for RRT and Code Blue Workshop.

Brian Locke

Leadership Style - Code and Rapid Response Workshop

Brian Locke

Session-3-Promoting-Breastfeeding-During-Pregnancy.ppt

Medidas Medical Center INC

Oppenheimer & Co. Inc, co-Head of Healthcare Investment Banking, Michael Margolis, provides H1 Healthcare Financing, Funding and M&A Overview. Table of Contents 1. Broader Market Overview 2. Biotech M&A Market Overview 3. Private Biotech Financing Market Update 4. Key Advice For Healthcare Companies Current State of Play; Healthcare has Underperformed the Broader Market Over the Last Twelve Months; Signal-to-Noise is Getting Worse; Healthcare IPO Activity has Decreased Significantly Since 20–21 Pandemic Levels; Biotech Financing Activity Has Remained Robust in 2024; Biotech M&A Market Remains Incredibly Active; Biotech M&A Market Remains Incredibly Active; Big Pharma Upcoming Patent Expirations; Since November 2023 Oncology has accounted for over half of all M&A; Oncology, Autoimmune / I&I, and CV & Metabolic Remain the Top Areas in M&A; Small Molecule Beats Out All Other Modalities in M&A Despite IRA Concerns; Value of Big Pharma Acquisitions by Therapeutic Area in Q1 2024; Private Financing Market Update; 2024 Private Placement Activity On Track to Approach, If Not Exceed, 2020 Levels; Oncology, Particularly Solid Tumor, Continues to Attract VC Investors; Despite the IRA, Small Molecules Continue to Attract VC Dollars; Preclinical-Stage Companies Make Up Almost Half of Private Placements in 2023; Valuations by Development Stage – 2023; Typical Biotech Investors Remained Active in Q1 2024; 23 $100M+ Deals were Raised in Q1 2024; Biotech Fundraising Momentum Continued into 2024; Key Advice For Israeli Healthcare Companies; Although Israel has Strong Presence on US Public Markets, There is Room to Grow; Telling Your Story Effectively; Interacting with Investors to Build Long-term Credibility; Seven Simple Rules for Pitch Decks;

Healthcare Market Overview, May 2024: Funding, Financing and M&A, from Oppenh...

Levi Shapiro

WORLD HEALTH ORGANIZATION WE CHAMPION HEALTH AND A BETTER FUTURE FOR ALL’ INTRODUCTION- WHO leads and champions global efforts to give everyone, everywhere, an equal chance to live a healthy life. HISTORY- founded in 1948, 7 April HEADQUARTERS- Geneva OFFICES- 6 semi autonomus regional and 150 fields offices DIRECTOR- Dr. Tedros Adhanam Ghebeyesus OBJECTIVES- Direction, co-ordination agencies Collaboration with local bodies Help the government in health services Proper technological assistance To attain highest possible level of health Prioritize and support health Formulate health policies Disease inspection and analysis Health education GOAL: To ensure that a billion more people have universal health coverage, to protect a billion more people from health emergencies and provide a further billion people with better health and well being ORGANIZATION: executive board, secretariat, world health assembly FUNCTION: FOR UNIVERSAL HEALTH Focus on PHCare Sustainable financing and protection Access to health products and medicines Training of health workforce and advice on labor policies Support people participation in National health policies Increasing monitoring, data and information FOR HEALTH EMERGENCIES Identification, mitigation and risk management Prevention and support of development of tools Detect and respond to acute health emergencies Support delivery of essential health services FOR HEALTH AND WELL BEING Address social determinants Promote intersectoral approach for health Prioritize health in all policies and healthy settings THROUGH WORK, ADDRESS Prevention of non- communicable disease Mental health promotion Climate change Antimicrobial resistance Elimination and eradication of communicable disease UNITED NATION FUND FOR POPULATION ACTIVITYINTRODUCTION- SEXUAL AND REPRODUCTIVE HEALTH AGENCY MISSION- To deliver a world where every pregnancy is wanted, every childbirth is safe, and every young person’s potential is fullfilled AIM- to improve reproductive and maternal health worldwide ESTABLISHED YEAR- 1969 (1974 in INDIA) HEADQUARTER- NEW YORK DIRECTOR- Dr. Natalia Kanem (2017) FUNCTION Develop national healthcare Increasing the access to birthcontrol Leading campaigns against child marriage Prevention of violence against gender Prevention of female genital mutiliation Treatment and prevention of STD and RTI MCH care HIV prevention and treatment IEC on sexuality and treatment of infertility and Abortion FOCUS area: Reproductive health Gender equality Population and development strategies Girl education Political participation for women FGM Child marriage UNITED NATION DEVELOPMENT PROGRAMME 1965 ESTABLISHED- 22 November. 1965 HEADQUARTER- New York HEAD- Achim steiner STRUCTURE- 170 member countries and territories INTRODUCTION- Advocates for change and connect countries to knowledge, experience and resources to help people bulid a better life for themselves Encourages Human right protection, women empowerment in all its programme

INTERNATIONAL HEALTH AGENCIES BY ANUSHRI SRIVASTAV.pptx

AnushriSrivastav

Leading large scale change: a life at the interface between theory and practice

HelenBevan4

Top^Clinic ^%[+27785538335__Safe*Abortion Pills For Sale In Soweto

doctorjoe1984

Making change happen: learning from "positive deviancts"

HelenBevan4

Jual Obat Aborsi Cytotec di Makassar WA 085226114443 Apotek Online 24 Jam WA ( 085226114443 ) Obat Cytotec Makassar, Jual Obat Cytotec Makassar, Penjual Obat Cytotec Makassar, Alamat Penjual Obat Cytotec Makassar, Toko Online Jual Obat Cytotec Makassar, Apotek Jual Obat Cytotec Makassar, Klinik Jual Obat Cytotec Makassar, Jual Obat Cytotec Wilayah Makassar, Jual Obat Cytotec Daerah Makassar, Jual Obat Cytotec Asli Di Makassar, Obat Aborsi Makassar, Obat Aborsi Cytotec Makassar, Jual Obat Aborsi Makassar, Jual Obat Aborsi Cytotec Makassar, Penjual Obat Aborsi Makassar, Alamat Penjual Obat Aborsi Makassar, Toko Online Jual Obat Aborsi Makassar, Apotek Jual Obat Aborsi Makassar, Klinik Jual Obat Aborsi Makassar, Jual Obat Aborsi Wilayah Makassar, Jual Obat Aborsi Daerah Makassar, Jual Obat Aborsi Asli Di Makassar, Obat Penggugur Kandungan Makassar, Jual Obat Penggugur Kandungan Makassar, Penjual Obat Penggugur Kandungan Makassar, Alamat Penjual Obat Penggugur Kandungan Makassar, Toko Online Jual Obat Penggugur Kandungan Makassar, Apotek Jual Obat Penggugur Kandungan Makassar, Klinik Jual Obat Penggugur Kandungan Makassar, Jual Obat Penggugur Kandungan Wilayah Makassar, Jual Obat Penggugur Kandungan Daerah Makassar, Jual Obat Penggugur Kandungan Asli Di Makassar. Jual Obat Aborsi Penggugur Kandungan Cytotec Asli Terpercaya (Whatsapp) 085226114443 Selamat Datang Di APOTEK resmi Penjualan obat aborsi Misoprostrol Cytotec, dan Mifepristone Asli di Makassar. Kami Adalah Apotek Penjual Obat Aborsi Cytotec Yang Sangat Terpercaya Untuk Membantu Masalah Penggugur Kandungan Dengan Produk Unggulan Kami Yaitu Obat Misoprostrol Cytotec 200mcg dan 400mcg, dan Mifepristone. TENTANG CYTOTEC MISOPROSTOL Cytotec Misoprostol cara yang digunakan untuk menggugurkan kandungan ketika tes mengungkapkan bahwa janin abnormal. Obat Misoprostol Cytotec sangat dianjurkan bila kesehatan ibu beresiko. Cytotec misoprostol dan Mifeprestone Miferex dan mifegen lebih manjur dari obat telat bulan tradisional kami menjual Cytotec yang sering disebut dengan nama obat aborsi, yang kami jual adalah Misoprotol Cytotec dari Pfizer Australia, Misoprostol Cytotec adalah obat paling ampuh untuk menggugurkan kandungan anda dengan cepat. MISOPROSTOL CYTOTEC Obat ini lebih dikenal dengan nama merek seperti Misotrol Cytotec, dan Cyprostol. Tujuan dari obat sekunder ini adalah untuk mengosongkan rahim sepenuhnya dengan merangsang kontraksi. Studi menunjukkan bahwa di sekitar 99% kasus, menggunakan misoprostol saja berhasil mengakhiri kehamilan. Namun prosedur yang ditentukan dan dilakukan melalui layanan aborsi yang aman dan legal dengan pengawasan dokter adalah prosedur yang menggunakan dua obat terbaik yaitu Misoprostol Cytotec 200mcg dan Mifepristone. BAGAIMANA CARA KERJA OBAT ABORSI CYTOTEC MISOPROSTOL CYTOTEC – Sering dijuluki sebagai pil aborsi, dan juga diidentifikasi sebagai RU 486, obat ini adalah salah satu dari dua obat yang digunakan di klinik aborsi. Obat ini bekerja

Obat Aborsi Makassar WA 085226114443 Jual Obat Aborsi Cytotec Asli Di Makassar

clarintahafafa

Mangalore * HiFi ℂall Girls Reshm@ Phone No 8250077686 Elite ℂall Serviℂe Ava...

Model Neeha Mumbai

Recently uploaded (20)

VIP ℂall Girls Hyderabad 8250077686 WhatsApp: Me All Time Serviℂe Available D...

Cytotec 200mcg tab in Riyadh (+919101817206// Get Abortion Pills in Saudi Arabia

Mike Lowe’s cancer fight lowe strong shirt

Young & Hot ℂall Girls Kolkata 8250077686 WhatsApp Number Best Rates of Kolka...

Famous Indian Vedic Astrologer | Best Astrological Solutions UK

Cara menggugurkan kandungan paling ampuh 08561234742

Unlock the Secrets to Optimizing Ambulatory Operations Efficiency and Change ...

Catheterization Procedure by Anushri Srivastav.pptx

Tortora PRINCIPLES OF ANATOMY AND PHYSIOLOGY - Tortora - 14th Ed.pdf

Anthony Edwards We Want Dallas T-shirtsAnthony Edwards We Want Dallas T-shirts

Etiology for RRT and Code Blue Workshop.

Leadership Style - Code and Rapid Response Workshop

Session-3-Promoting-Breastfeeding-During-Pregnancy.ppt

Healthcare Market Overview, May 2024: Funding, Financing and M&A, from Oppenh...

INTERNATIONAL HEALTH AGENCIES BY ANUSHRI SRIVASTAV.pptx

Leading large scale change: a life at the interface between theory and practice

Top^Clinic ^%[+27785538335__Safe*Abortion Pills For Sale In Soweto

Making change happen: learning from "positive deviancts"

Obat Aborsi Makassar WA 085226114443 Jual Obat Aborsi Cytotec Asli Di Makassar

Mangalore * HiFi ℂall Girls Reshm@ Phone No 8250077686 Elite ℂall Serviℂe Ava...

Aigner intelgenx

1. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner Rejuvenation of the Aged Brain An Example of Drug Delivery in Drug Repurposing Ludwig Aigner IntelGenx, Grand Opening, Saint-Laurent, May 10th 2016

2. YESTERDAY © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 2

5. 5 Age: Risk Factor Number 1 Teresa Niccoli , Linda Partridge, Ageing as a Risk Factor for Disease, Current Biology, Volume 22, Issue 17, 2012, R741 - R752 © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner

7. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 7 Massive Increase in the Prevalence of AD

11. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 11 GeneticNon-Genetic

12. Alt © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 12 Alzheimer Pathology

13. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 13 Are We Targeting the Right Thing ? Rodrigue et al., Neuropsychol Rev. 2009

14. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 14 1001 Reasons for Neuronal Cell Death ???

15. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 15 Neurodegeneration eg Schapira et al. 2011 Neuroinflammation eg Hirsch et al. 2009 Blood Brain Barrier eg Zlokovic et al. 2008 Neurogenesis eg Regensburger et al. 2014 Neurotransmission eg Calabresi et al. 2007 Our Targets: Pleiotropic Signaling Demyelination Axonal Damage eg Franklin et al. 2008

16. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 16 AGING and REJUVENATION

17. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 17 Neurodegeneration eg Schapira et al. 2011 Neuroinflammation eg Hirsch et al. 2009 Blood Brain Barrier eg Zlokovic et al. 2008 Neurogenesis eg Regensburger et al. 2014 Neurotransmission eg Calabresi et al. 2007 Demyelination Axonal Damage eg Franklin et al. 2008 The Aged Brain is a „Diseased“ Brain

18. Regeneration Disease Risk Disease Risk Live = Aging Growth Plasticity Degeneration Disease © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 18

19. Growth Plasticity Degeneration Aging and Rejuvenation „Regenerative Pharmacology“ Disease © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 19

20. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 20 Can We Turn Back the Clock ?

21. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 21 Muscle Research, Aging, and Regenerative Medicine ?

23. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 23 inflammation neurogenesis cognitiion Modulating the Systemic Milieu: a Valid Approach

24. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 24 Eotaxin Reduces Neurogenesis Eotaxin Worsens Cognition Old Blood Contributes to Brain Aging EOTAXIN

25. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 25 Eotaxin Leukotrienes Allergy / Asthma Brain Aging Aging / Degeneration

26. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 26 Leukotrienes Impact on Brain Aging Leukotrienes Neurodegeneration eg Schapira et al. 2011 Neuroinflammation eg Hirsch et al. 2009 Blood Brain Barrier eg Zlokovic et al. 2008 Neurogenesis eg Regensburger et al. 2014 Neurotransmission eg Calabresi et al. 2007 Demyelination Axonal Damage eg Franklin et al. 2008 Montelukast

27. Proof of Principle: Inhibition of Leukotriene Receptors Improves Cognition in Aged Rats © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 27

29. symptoms pathology therapy motoric dopaminergic cell loss dopamine replacement 60% Parkinson´s Disease Dementia / Lewy Body Dementia symptoms pathology therapy motoric dopaminergic cell loss dopamine replacement dementia ??? rivastigmine Neurogenesis Blood Brain Barrier Neuroinflammation Neurodegeneration Neurotransmission eg Schapira et al. 2011 eg Hirsch et al. 2009 eg Zlokovic et al. 2008 eg Regensburger et al. 2014 eg Calabresi et al. 2007 © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 29

30. ** Learning Memory * Montelukast Improves Cognitive Functions in PD / LBD Animals © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 30

32. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 32 1 1 2 2 1 1 2 3 3 4 3 2 2 4 4 2 3 3 6 7 6 11 7 14 7 13 15 12 15 19 17 23 25 50 48 99 126 239 317 414 0 50 100 150 200 250 300 350 400 450 1973 1975 1976 1977 1978 1979 1980 1982 1983 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 NumberofPublications Annual Counts of Publications “Drug Repurposing”

33. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 33 “All De- and Regenerations are Similar”

34. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 34 REPAIR REPLACE RESTORE REGENERATE REJUVENATE Regenerative Medicine All Organs Different Diseases

35. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 35 MMSE 13: moderate to severe dementia Montelukast as an Anti-Dementia Therapeutic Before After 2 Months of Montelukast MMSE 22: mild dementia

36. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 36 Discover y Preclini c Phase I Phase II Phase III Approval BIOTECH Academia Big Pharma

37. © Paracelsus Medizinische Privatuniversität | Institute of Molecular Regenerative Medicine | Ludwig Aigner 37 Let‘s make a better Montelukast

Aigner intelgenx

Recommended

Recommended

More Related Content

Similar to Aigner intelgenx

Similar to Aigner intelgenx (20)

More from ItelGenx

More from ItelGenx (20)

Recently uploaded

Recently uploaded (20)

Aigner intelgenx