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TSX-V: IGX
OTCQX: IGXT
WE MAKE APPROVED DRUGS BETTER
Investor Presentation
July 2017
Innovative Drug Delivery Solutions
1
2
To the extent any statements made in this presentation contain information that is not historical, these statements are forward-
looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the
Securities Exchange Act of 1934, as amended. We have based these forward-looking statements on our current expectations and
projections about future events. Our actual results could differ materially from those discussed in, or implied by, these forward-
looking statements.
Forward-looking statements are identified by words such as "believe," "anticipate," "expect," "intend," "plan," "will," "may" and
other similar expressions. In addition, any statements that refer to expectations, projections or other characterizations of future
events or circumstances are forward-looking statements. Forward-looking statements include, but are not necessarily limited to,
risks and uncertainties, including the difficulty of predicting U.S. Food and Drug Administration and Canadian Therapeutic
Products Directorate approvals, acceptance and demand for new pharmaceutical products, the impact of competitive products
and pricing, new product development and launch, reliance on key strategic alliances, availability of raw materials and finished
products, the regulatory environment, tax rate assumptions, the outcome of legal proceedings, fluctuations in operating results
and other risks detailed from time to time in the Company's filings with the Securities and Exchange Commission and the
Ontario Securities Commission. IntelGenx undertakes no obligation to update or revise any forward-looking statement.
2
Forward-Looking Statements
2
2
3
ā€¢ IntelGenx Corp.	Founded
ā€¢ TSX-V	(IGX)1
ā€¢ OTCQX	(IGXT)1
ā€¢ Market	Capitalization	
ā€¢ Shares	Issued
ā€¢ Shares	Fully	Diluted
ā€¢ Insider	Beneficial	Ownership
ā€¢ Cash/Equivalent	
(As	of	March	31,	2017)
2003
CAD$1.25
US$0.97
CAD$82M
65.5M
70.8M
18.7%
CAD$5.3M*
Analyst Coverage
Firm Analyst
H.C. Wainwright Swayampakula Ramakanth
Singular Research Greg Eisen
Company Snapshot
* As at June 30, 2017
* Does not include proceeds from July 2017 convertible debenture offering
3
Strengthened Management Team
Over 20 Employees, including 7 with Ph.D.ā€™s
Andre Godin, CPA, CA
Executive VP, CFO
ā€¢ 25+ years biotech/pharma industry
experience
ā€¢ Member of the Canadian Chartered
Professional Accountants and the
Canadian Institute of Chartered
Accountants
Nadine Paiement, M. Sc.
VP, Research & Development
ā€¢ Co-inventor of IntelGenx Trilayer
Technology
ā€¢ 15 years experience in product
development and technology transfer
Stephen Kilmer
Investor Relations
ā€¢ 20+ years experience in healthcare IR
and PR
ā€¢ President of Kilmer Lucas, a health-
care only investor relations and capital
markets advisory company
Horst G. Zerbe, Ph. D.
Chairman, President & CEO
ā€¢ Co-Founder of Listerine breath strips
ā€¢ 30+ years drug delivery / pharma
experience
ā€¢ Holds over 40 patents in drug
delivery and numerous scientific
publications
4
Dana Matzen, Ph.D.
VP, Business & Corporate
Development
ā€¢ 15 years experience in
pharmaceutical product licensing
ā€¢ Prev. Director, BD at Paladin
ā€¢ Completed 13 transaction,
7 new product launches
John Durham, B. Sc.
VP, Operations
ā€¢ 20+ years experience in
pharmaceutical manufacturing, quality
management, product development
ā€¢ Held executive positions with several
Canadian and US companies
4
We Make Approved Drugs Better
IntelGenx Drug Delivery Technology Platforms
Rapidly disintegrating films improving
drug performance and easing administration
without the need for water
Films
VersaFilmā„¢
Tablets
Controlled-release tablets for oral absorption
over an extended time period
AdVersaā„¢
We Make Approved Drugs Better
5
5
VersaFilmTM Oral Films
Oral Films Provide Significant Market Opportunities
for Improving Drug Delivery
2
ā€¢ IntelGenx CEO co-developer of the Listerine breath strips
ā€¢ Oral films ideal for elderly, children, patients who have
difficulty swallowing traditional tablets
ā€¢ Quicker action to relieve symptoms
VersaFilmā„¢ Oral Films
6
6
7
Advantages of Oral Thin Film Delivery
We are focused on areas where oral films
are particularly well-suited:
Develop and commercialize products that provide therapeutic advantages to patients
leveraging oral films, such as:
ā€¢ Reduced side effects
ā€¢ Improved bio-availability
ā€¢ Response time versus existing drugs
ā€¢ Abuse resistant
ā€¢ Convenience
ā€¢ Lifecycle management
ā€¢ Repurpose existing drugs for new indications using oral films
ā€¢ ā€œFirst-to-fileā€ generic drugs where high technology barriers to
entry exist in reproducing branded films
78
Clearly Defined BD Strategy
Balancing Risks and Opportunities for an Optimized Portfolio
Overall
Risk
Time to MarketSlow Fast
Low
High
Drug Repurposing
Patient Benefits
Lifecycle Mgmt
FTF Generics
IntelGenx Future Focus
Deal Value
Low
Medium
High
8
We Offer Full Service
to Foster the Growth of our Partners
We Offer Full Service
9
9
10
ā€¢ IntelGenx grants partners exclusive rights to market and sell its products in exchange for
upfront and milestone payments, together with a share of the partnerā€™s net profits or a
royalty on net product sales
ā€¢ IntelGenx retains manufacturing rights for its products
ā€¢ Payments are received as the contracted services are performed or when certain
milestones are achieved:
ā€¢ FDA submission
ā€¢ FDA approval
ā€¢ Commercial launch
ā€¢ Annual net sales target, etc.
ā€¢ Partners pay for part or all of the R&D expenses associated with developing a new
product and to obtain regulatory approval
Low Risk Development Model
10
11
State-of-the-Art Oral Film Facility Established
For Development & Manufacturing
ā€¢ 17,000 sq ft facility in Montreal -
construction completed in Q1 2016
ā€¢ High capacity manufacturing and packaging
equipment
ā€¢ Lower costs, controls quality
and de-risks investment
for new products
GROSS MARGINS of 40% PLUS
11
For Migraines
Leverages VersaFilmā„¢ Technology
VersaFilm
TM
Rizaport
ā€¢ European Marketing Approval ā€“ November 2015
ā€¢ Co-development partnership with RedHill Biopharma
āˆ’ Definitive agreement signed July 2016 with Grupo Juste for Spain
& additional territories
āˆ’ Definitive agreement signed Dec 2016 with Pharmatronic for
South Korea
āˆ’ Actively pursuing several opportunities to open new markets
ā€¢ Patent granted in April 2016 protecting Rizaport
ā€¢ Re-submission of 505(b)(2) NDA planned for Q4 2017
ā€¢ PDUFA date expected in early 2018
12
12
For Erectile Dysfunction
VersaFilm
TM
Tadalaļ¬l
ā€¢ A high value, pleasantly flavored, and convenient
VersaFilmā„¢ dosage form of 2.5, 5, 10 and 20 mg
tadalafil that can be administered without water
ā€¢ Pilot phase 1 clinical trial for safety and
pharmacokinetics have been successively
completed, confirming bioequivalence to CialisĀ®
(Eli Lilly)
ā€¢ 2 patents protecting Tadalafil VersaFilm pending
VersaFilm
TM
Tadalaļ¬l
13
13
Fr Erectile Dysfunction
ā€¢ Tadalafil market in the US estimated at $1.7B
ā€¢ Nov 2017 Lillyā€™s tadalafil composition patent
to expire, but orange book dosing patent still in
force until April 2020
ā€¢ IntelGenxā€™ exclusive license to Lillyā€™s tadalafil
ED dosing patent ā€˜166 will allow entry of
Tadalafil VersaFilmā„¢ into the ED US market
upon FDA approval, potentially before the
market entry of CialisĀ® generic competitors
ā€¢ 505(b)(2) USA NDA submission in Q3 2017
ā€¢ Expected US FDA approval H1/2018
$1,703$1,429
$175
$11
$48
$18
US ED Market by Sales ($M)
Cialis
Viagra
Levitra
Staxyn
Stendra
Edex
VersaFilm
TM
Tadalaļ¬l Significant Market Opportunity
14
14
For Schizophrenia & Bipolar
1 Disorder
15
ā€¢ Fast-acting loxapine oral dosage
ā€¢ For treatment of acute agitation and anxiety
in non-institutionalized patients with
schizophrenia & bipolar 1 disorder
ā€¢ Reduces risk of pulmonary problems
and potential risk of violence and injury to
patients and others
ā€¢ US patent & PCT applications submitted
ā€¢ Formulation optimization stage ā€“ results
expected H2 2017
VersaFilm
TM
Loxapine
VersaFilm
TM
Loxapine
15
For Mild Cognitive Impairment
VersaFilm
TM
Montelukast
16
VersaFilm
TM
Montelukast
ā€¢ IntelGenx is repurposing Montelukast
for the treatment of MCI by leveraging
its VersaFilmā„¢ technology
ā€¢ The drug is known and approved for a
different indication (asthma) and has an
excellent safety profile
ā€¢ Strong preclinical evidence
Global Sales for AD by Patients Category
(Global Data, 2013)
16
2
17
Clinical Data
0.0
100.0
200.0
300.0
400.0
500.0
600.0
0.00 5.00 10.00 15.00 20.00 25.00 30.00
Montelukastconcentration(ng/mL)
Time (hrs)
Montelukast Avg Plasma Profile
Test buccal film 10mg
Ref tablet 10mg
VersaFilm
TM
Montelukast
ā€¢ Phase 1 clinical study in human successfully completed
ā€¢ Significantly increased bioavailability after administration of VersaFilmā„¢ compared to
commercial tablet
ā€¢ Drug crosses blood/brain barrier when given as film
ā€¢ Phase II-a study (proof of concept) to commence Q3/2017
ā€¢ First efficacy data in humans available Q4/2017
ā€¢ Several pharma companies have expressed strong interest
Before
MMSE 13:
moderate to severe
dementia
MMSE 22:
mild dementia
After 2 Months of
Montelukast
17
Mucoadhesive Tablet
For Pain Management
ā€¢ AdVersaĀ® mucoadhesive tablet adheres to the oral
mucosa and releases the drug onto the site of application
at a controlled rate
ā€¢ Repurposing of synthetic THC dronabinol for use in pain
ā€¢ Protected by several issued and pending patents
ā€¢ Competitive advantages vs. MarinolĀ® capsules (Abbvie)
MarinolĀ® (dronabinol) capsule Dronabinol AdVersaĀ®
Conventional oral dosage form AdVerstaĀ® mucoadhesive tablet
High rate of metabolization Limited first-pass metabolism
Limited bioavailability Improved bioavailability
Undesired psycho activity
Reduced gastro-intestinal exposure
and side-effects
Limited shelf life Enhanced product stability
AdVersa
TM
DronabinolDronabinol
Mucoadhesive Tablet
For Pain ManagementAdVersa
TM
DronabinolDronabinol
18
18
19
ā€¢ High dose version of Wellbutrin XLĀ®
ā€¢ Only approved, once-daily, bupropion HCl 450mg dose in a
single tablet
ā€¢ Launched commercially October 2013 in partnership with
Edgemont Pharmaceuticals
ā€¢ Sold US revenue to SWK Holdings for US$6M
ā€¢ Development cost $2.5M, total revenue $15M = 6-fold ROI
ā€¢ Non-dilutive source of funding, will be used to advance film
projects
Successful Monetization of First
In-House Development
19
20
ā€¢ Licensing and development agreements entered for four generic
products
ā€¢ IntelGenx granted Chemo exclusive worldwide license to
commercialize two generic tablets and U.S. license for two other
generic oral films
ā€¢ IntelGenx to receive upfront, milestone, R&D revenues and share of
profits ā€“ total value of 7 digits
ā€¢ Combined total market of four products is over $7B
ā€¢ Chemo making a strategic move into novel drug delivery products
with IntelGenx as its partner
ā€¢ Partnership could result in numerous future product agreements
About Chemo Group:
ā€¢ Founded in 1978
ā€¢ 5,000 employees
ā€¢ Head office in Spain
ā€¢ Revenues of $1.2B annually
ā€¢ Markets over 300 products
ā€¢ Operating in over 40 countries
ā€¢ 20 state-of-the-art facilities
ā€¢ 9 specialized R&D centers
Strategic Partnership with Chemo Group
20
Robust Product Pipeline
Addressing Significant Market Opportunities
21
Migraine ā€“ RizaportĀ®
(Rizatriptan)
Available
ex-ES & SKR
Erectile Dysfunction
(Tadalafil) Available
Schizophrenia
(Loxapine) Available
Neurodegenerative Brain Diseases
(Montelukast) Available
Opioid Dependence - gSuboxoneĀ®
(Buprenorphine/ Naloxone)
Partnered
Undisclosed
Partnered
Undisclosed
Partnered
Undisclosed
Partnered
Major Depressive Disorder - Forfivo
XLĀ®
(Bupropion)
Available
ex-US
Hypertension
(undisclosed)
Partnered
Pain
(undisclosed)
Partnered
Pain
(Dronabinol)
Available
ex-US/ CAN
VersaFilmTMTablets
21
22
The IntelGenx Advantage
1. History
ā€¢ Dr. Zerbe a pioneer with over 30 plus years in oral films
2. Formulation Team
ā€¢ Strong in applying biopharmaceutical aspects to formulation development
ā€¢ Top quality scientists: highly creative, focused on problem solving & innovative approaches
ā€¢ Experienced in developing films for oral (GI), sublingual & buccal absorption
3. Clearly Defined Corporate Strategy And Business Model
ā€¢ Focus on drug repurposing, lifecycle management, patient benefits, and FTF
ā€¢ Provider of comprehensive pharmaceutical services to industry partners
4. Competitive Manufacturing Capabilities
ā€¢ First in Canada
ā€¢ New state-of-the-art manufacturing facility
ā€¢ Offer one-stop-shopping to our partners with lean operations keeping costs down
ā€¢ Customized manufacturing equipment
22
Financial Results
23
23
Financial Performance: Revenue
$M
1.4
0.8
5.2 5.1
0
1
2
3
4
5
6
First Quarter 2017 First Quarter 2016 2016 Full Year 2015 Full Year
Revenue
REVENUE ($M)
23
24
24
Net Comprehensive Income & Adjusted EBITDA ($M)
$M
Financial Performance: Income & EBITDA
25
-0.5
-0.7
-1.5
0.8
-0.1
-0.6
-0.3
1.7
-2
-1.5
-1
-0.5
0
0.5
1
1.5
2
First Quarter 2017 First Quarter 2016 2016 Full Year 2015 Full Year
Net Income Adjusted EBITDA
25
Conclusion
26
26
27
Solid Platform for Growth
Significant Market Potential
ā€¢ New manufacturing facility will offer many competitive advantages
ā€¢ Strengthened management team to accelerate execution of business plan
ā€¢ Implemented product sourcing strategy to identify high-value product opportunities
ā€¢ Building strategic partnerships with relevant partners in the pharmaceutical industry
Solid Platform for Growth
27
28
Thank	You!
www.IntelGenx.com
Contact	Info:
Stephen	Kilmer																																					AndrƩ	Godin																	
Investor	Relations																																	Executive	VP	&	CFO
+1-514-331-7440	ext.	232																		+1-514-331-7440	ext.	203
Stephen@intelgenx.com Andre@intelgenx.com
IntelGenx Corporate	Offices
6420	Abrams
Saint-Laurent	(Quebec)
H4S	1Y2	Canada
www.intelgenx.com

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Intelgenx presentation july 2017

  • 1. 0 TSX-V: IGX OTCQX: IGXT WE MAKE APPROVED DRUGS BETTER Investor Presentation July 2017 Innovative Drug Delivery Solutions
  • 2. 1 2 To the extent any statements made in this presentation contain information that is not historical, these statements are forward- looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. We have based these forward-looking statements on our current expectations and projections about future events. Our actual results could differ materially from those discussed in, or implied by, these forward- looking statements. Forward-looking statements are identified by words such as "believe," "anticipate," "expect," "intend," "plan," "will," "may" and other similar expressions. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances are forward-looking statements. Forward-looking statements include, but are not necessarily limited to, risks and uncertainties, including the difficulty of predicting U.S. Food and Drug Administration and Canadian Therapeutic Products Directorate approvals, acceptance and demand for new pharmaceutical products, the impact of competitive products and pricing, new product development and launch, reliance on key strategic alliances, availability of raw materials and finished products, the regulatory environment, tax rate assumptions, the outcome of legal proceedings, fluctuations in operating results and other risks detailed from time to time in the Company's filings with the Securities and Exchange Commission and the Ontario Securities Commission. IntelGenx undertakes no obligation to update or revise any forward-looking statement. 2 Forward-Looking Statements
  • 3. 2 2 3 ā€¢ IntelGenx Corp. Founded ā€¢ TSX-V (IGX)1 ā€¢ OTCQX (IGXT)1 ā€¢ Market Capitalization ā€¢ Shares Issued ā€¢ Shares Fully Diluted ā€¢ Insider Beneficial Ownership ā€¢ Cash/Equivalent (As of March 31, 2017) 2003 CAD$1.25 US$0.97 CAD$82M 65.5M 70.8M 18.7% CAD$5.3M* Analyst Coverage Firm Analyst H.C. Wainwright Swayampakula Ramakanth Singular Research Greg Eisen Company Snapshot * As at June 30, 2017 * Does not include proceeds from July 2017 convertible debenture offering
  • 4. 3 Strengthened Management Team Over 20 Employees, including 7 with Ph.D.ā€™s Andre Godin, CPA, CA Executive VP, CFO ā€¢ 25+ years biotech/pharma industry experience ā€¢ Member of the Canadian Chartered Professional Accountants and the Canadian Institute of Chartered Accountants Nadine Paiement, M. Sc. VP, Research & Development ā€¢ Co-inventor of IntelGenx Trilayer Technology ā€¢ 15 years experience in product development and technology transfer Stephen Kilmer Investor Relations ā€¢ 20+ years experience in healthcare IR and PR ā€¢ President of Kilmer Lucas, a health- care only investor relations and capital markets advisory company Horst G. Zerbe, Ph. D. Chairman, President & CEO ā€¢ Co-Founder of Listerine breath strips ā€¢ 30+ years drug delivery / pharma experience ā€¢ Holds over 40 patents in drug delivery and numerous scientific publications 4 Dana Matzen, Ph.D. VP, Business & Corporate Development ā€¢ 15 years experience in pharmaceutical product licensing ā€¢ Prev. Director, BD at Paladin ā€¢ Completed 13 transaction, 7 new product launches John Durham, B. Sc. VP, Operations ā€¢ 20+ years experience in pharmaceutical manufacturing, quality management, product development ā€¢ Held executive positions with several Canadian and US companies
  • 5. 4 We Make Approved Drugs Better IntelGenx Drug Delivery Technology Platforms Rapidly disintegrating films improving drug performance and easing administration without the need for water Films VersaFilmā„¢ Tablets Controlled-release tablets for oral absorption over an extended time period AdVersaā„¢ We Make Approved Drugs Better 5
  • 6. 5 VersaFilmTM Oral Films Oral Films Provide Significant Market Opportunities for Improving Drug Delivery 2 ā€¢ IntelGenx CEO co-developer of the Listerine breath strips ā€¢ Oral films ideal for elderly, children, patients who have difficulty swallowing traditional tablets ā€¢ Quicker action to relieve symptoms VersaFilmā„¢ Oral Films 6
  • 7. 6 7 Advantages of Oral Thin Film Delivery We are focused on areas where oral films are particularly well-suited: Develop and commercialize products that provide therapeutic advantages to patients leveraging oral films, such as: ā€¢ Reduced side effects ā€¢ Improved bio-availability ā€¢ Response time versus existing drugs ā€¢ Abuse resistant ā€¢ Convenience ā€¢ Lifecycle management ā€¢ Repurpose existing drugs for new indications using oral films ā€¢ ā€œFirst-to-fileā€ generic drugs where high technology barriers to entry exist in reproducing branded films
  • 8. 78 Clearly Defined BD Strategy Balancing Risks and Opportunities for an Optimized Portfolio Overall Risk Time to MarketSlow Fast Low High Drug Repurposing Patient Benefits Lifecycle Mgmt FTF Generics IntelGenx Future Focus Deal Value Low Medium High
  • 9. 8 We Offer Full Service to Foster the Growth of our Partners We Offer Full Service 9
  • 10. 9 10 ā€¢ IntelGenx grants partners exclusive rights to market and sell its products in exchange for upfront and milestone payments, together with a share of the partnerā€™s net profits or a royalty on net product sales ā€¢ IntelGenx retains manufacturing rights for its products ā€¢ Payments are received as the contracted services are performed or when certain milestones are achieved: ā€¢ FDA submission ā€¢ FDA approval ā€¢ Commercial launch ā€¢ Annual net sales target, etc. ā€¢ Partners pay for part or all of the R&D expenses associated with developing a new product and to obtain regulatory approval Low Risk Development Model
  • 11. 10 11 State-of-the-Art Oral Film Facility Established For Development & Manufacturing ā€¢ 17,000 sq ft facility in Montreal - construction completed in Q1 2016 ā€¢ High capacity manufacturing and packaging equipment ā€¢ Lower costs, controls quality and de-risks investment for new products GROSS MARGINS of 40% PLUS
  • 12. 11 For Migraines Leverages VersaFilmā„¢ Technology VersaFilm TM Rizaport ā€¢ European Marketing Approval ā€“ November 2015 ā€¢ Co-development partnership with RedHill Biopharma āˆ’ Definitive agreement signed July 2016 with Grupo Juste for Spain & additional territories āˆ’ Definitive agreement signed Dec 2016 with Pharmatronic for South Korea āˆ’ Actively pursuing several opportunities to open new markets ā€¢ Patent granted in April 2016 protecting Rizaport ā€¢ Re-submission of 505(b)(2) NDA planned for Q4 2017 ā€¢ PDUFA date expected in early 2018 12
  • 13. 12 For Erectile Dysfunction VersaFilm TM Tadalaļ¬l ā€¢ A high value, pleasantly flavored, and convenient VersaFilmā„¢ dosage form of 2.5, 5, 10 and 20 mg tadalafil that can be administered without water ā€¢ Pilot phase 1 clinical trial for safety and pharmacokinetics have been successively completed, confirming bioequivalence to CialisĀ® (Eli Lilly) ā€¢ 2 patents protecting Tadalafil VersaFilm pending VersaFilm TM Tadalaļ¬l 13
  • 14. 13 Fr Erectile Dysfunction ā€¢ Tadalafil market in the US estimated at $1.7B ā€¢ Nov 2017 Lillyā€™s tadalafil composition patent to expire, but orange book dosing patent still in force until April 2020 ā€¢ IntelGenxā€™ exclusive license to Lillyā€™s tadalafil ED dosing patent ā€˜166 will allow entry of Tadalafil VersaFilmā„¢ into the ED US market upon FDA approval, potentially before the market entry of CialisĀ® generic competitors ā€¢ 505(b)(2) USA NDA submission in Q3 2017 ā€¢ Expected US FDA approval H1/2018 $1,703$1,429 $175 $11 $48 $18 US ED Market by Sales ($M) Cialis Viagra Levitra Staxyn Stendra Edex VersaFilm TM Tadalaļ¬l Significant Market Opportunity 14
  • 15. 14 For Schizophrenia & Bipolar 1 Disorder 15 ā€¢ Fast-acting loxapine oral dosage ā€¢ For treatment of acute agitation and anxiety in non-institutionalized patients with schizophrenia & bipolar 1 disorder ā€¢ Reduces risk of pulmonary problems and potential risk of violence and injury to patients and others ā€¢ US patent & PCT applications submitted ā€¢ Formulation optimization stage ā€“ results expected H2 2017 VersaFilm TM Loxapine VersaFilm TM Loxapine
  • 16. 15 For Mild Cognitive Impairment VersaFilm TM Montelukast 16 VersaFilm TM Montelukast ā€¢ IntelGenx is repurposing Montelukast for the treatment of MCI by leveraging its VersaFilmā„¢ technology ā€¢ The drug is known and approved for a different indication (asthma) and has an excellent safety profile ā€¢ Strong preclinical evidence Global Sales for AD by Patients Category (Global Data, 2013)
  • 17. 16 2 17 Clinical Data 0.0 100.0 200.0 300.0 400.0 500.0 600.0 0.00 5.00 10.00 15.00 20.00 25.00 30.00 Montelukastconcentration(ng/mL) Time (hrs) Montelukast Avg Plasma Profile Test buccal film 10mg Ref tablet 10mg VersaFilm TM Montelukast ā€¢ Phase 1 clinical study in human successfully completed ā€¢ Significantly increased bioavailability after administration of VersaFilmā„¢ compared to commercial tablet ā€¢ Drug crosses blood/brain barrier when given as film ā€¢ Phase II-a study (proof of concept) to commence Q3/2017 ā€¢ First efficacy data in humans available Q4/2017 ā€¢ Several pharma companies have expressed strong interest Before MMSE 13: moderate to severe dementia MMSE 22: mild dementia After 2 Months of Montelukast
  • 18. 17 Mucoadhesive Tablet For Pain Management ā€¢ AdVersaĀ® mucoadhesive tablet adheres to the oral mucosa and releases the drug onto the site of application at a controlled rate ā€¢ Repurposing of synthetic THC dronabinol for use in pain ā€¢ Protected by several issued and pending patents ā€¢ Competitive advantages vs. MarinolĀ® capsules (Abbvie) MarinolĀ® (dronabinol) capsule Dronabinol AdVersaĀ® Conventional oral dosage form AdVerstaĀ® mucoadhesive tablet High rate of metabolization Limited first-pass metabolism Limited bioavailability Improved bioavailability Undesired psycho activity Reduced gastro-intestinal exposure and side-effects Limited shelf life Enhanced product stability AdVersa TM DronabinolDronabinol Mucoadhesive Tablet For Pain ManagementAdVersa TM DronabinolDronabinol 18
  • 19. 18 19 ā€¢ High dose version of Wellbutrin XLĀ® ā€¢ Only approved, once-daily, bupropion HCl 450mg dose in a single tablet ā€¢ Launched commercially October 2013 in partnership with Edgemont Pharmaceuticals ā€¢ Sold US revenue to SWK Holdings for US$6M ā€¢ Development cost $2.5M, total revenue $15M = 6-fold ROI ā€¢ Non-dilutive source of funding, will be used to advance film projects Successful Monetization of First In-House Development
  • 20. 19 20 ā€¢ Licensing and development agreements entered for four generic products ā€¢ IntelGenx granted Chemo exclusive worldwide license to commercialize two generic tablets and U.S. license for two other generic oral films ā€¢ IntelGenx to receive upfront, milestone, R&D revenues and share of profits ā€“ total value of 7 digits ā€¢ Combined total market of four products is over $7B ā€¢ Chemo making a strategic move into novel drug delivery products with IntelGenx as its partner ā€¢ Partnership could result in numerous future product agreements About Chemo Group: ā€¢ Founded in 1978 ā€¢ 5,000 employees ā€¢ Head office in Spain ā€¢ Revenues of $1.2B annually ā€¢ Markets over 300 products ā€¢ Operating in over 40 countries ā€¢ 20 state-of-the-art facilities ā€¢ 9 specialized R&D centers Strategic Partnership with Chemo Group
  • 21. 20 Robust Product Pipeline Addressing Significant Market Opportunities 21 Migraine ā€“ RizaportĀ® (Rizatriptan) Available ex-ES & SKR Erectile Dysfunction (Tadalafil) Available Schizophrenia (Loxapine) Available Neurodegenerative Brain Diseases (Montelukast) Available Opioid Dependence - gSuboxoneĀ® (Buprenorphine/ Naloxone) Partnered Undisclosed Partnered Undisclosed Partnered Undisclosed Partnered Major Depressive Disorder - Forfivo XLĀ® (Bupropion) Available ex-US Hypertension (undisclosed) Partnered Pain (undisclosed) Partnered Pain (Dronabinol) Available ex-US/ CAN VersaFilmTMTablets
  • 22. 21 22 The IntelGenx Advantage 1. History ā€¢ Dr. Zerbe a pioneer with over 30 plus years in oral films 2. Formulation Team ā€¢ Strong in applying biopharmaceutical aspects to formulation development ā€¢ Top quality scientists: highly creative, focused on problem solving & innovative approaches ā€¢ Experienced in developing films for oral (GI), sublingual & buccal absorption 3. Clearly Defined Corporate Strategy And Business Model ā€¢ Focus on drug repurposing, lifecycle management, patient benefits, and FTF ā€¢ Provider of comprehensive pharmaceutical services to industry partners 4. Competitive Manufacturing Capabilities ā€¢ First in Canada ā€¢ New state-of-the-art manufacturing facility ā€¢ Offer one-stop-shopping to our partners with lean operations keeping costs down ā€¢ Customized manufacturing equipment
  • 24. 23 Financial Performance: Revenue $M 1.4 0.8 5.2 5.1 0 1 2 3 4 5 6 First Quarter 2017 First Quarter 2016 2016 Full Year 2015 Full Year Revenue REVENUE ($M) 23 24
  • 25. 24 Net Comprehensive Income & Adjusted EBITDA ($M) $M Financial Performance: Income & EBITDA 25 -0.5 -0.7 -1.5 0.8 -0.1 -0.6 -0.3 1.7 -2 -1.5 -1 -0.5 0 0.5 1 1.5 2 First Quarter 2017 First Quarter 2016 2016 Full Year 2015 Full Year Net Income Adjusted EBITDA
  • 27. 26 27 Solid Platform for Growth Significant Market Potential ā€¢ New manufacturing facility will offer many competitive advantages ā€¢ Strengthened management team to accelerate execution of business plan ā€¢ Implemented product sourcing strategy to identify high-value product opportunities ā€¢ Building strategic partnerships with relevant partners in the pharmaceutical industry Solid Platform for Growth