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MINDFULNESS, AFFECT LABELING
& AMYGDALA ACTIVITY
Ariana Cunningham MS4
Mindfulness
= process whereby one is aware and
receptive to present moment experiences
(mental state achieved by focusing awareness on the
present moment; calmly acknowledging and
accepting one's feelings, thoughts, and bodily
sensations, used as a therapeutic technique)
Affect Labeling “I’m angry”
= putting feelings into words, either of an
external stimulus or one’s own
(instead of trying to push an emotion away, the idea is
to actually draw closer to it by feeling it, identifying it,
and putting a label on it. Can be done verbally, with
pen and paper...etc)
Reappraisal “find the silver lining”
= technique by which we reframe the
meaning of an event, thereby changing its
emotional significance and impact (used in
CBT) (Gross 1998)
*of note this is an intentional attempt to regulate one’s
emotion, whereas affect labeling is incidental
Areas of Interest in the Brain
Amygdala = emotional distress
Prefrontal cortex = higher functioning
● Right Ventrolateral prefrontal cortex (RVLPFC) =
associated with symbolic processing of emotional
information (Hariri et all 2000, Lieberman 2005)
● Medial Prefrontal cortex (MPFC) = has dense projections
to amygdala, activated during self-relevant task such as
monitering ones own emotional state (Quirk et al 2003,
Talor et al 2003, Ghashghaei 2002)
Background
studies have shown that mindful
traits/meditation practices reduce negative
affect, stress, mood disturbance, and dz spec
health sx
○ Can this be quantified?
○ What is the mechanism?
○ How can this be applied?
Creswell, J. D., Way, B. M., Eisenberger, N. I., &
Lieberman, M. D. (2007). Neural correlates of
dispositional mindfulness during affect labeling.
Psychosomatic medicine, 69(6), 560-565. (Cited 824)
DESIGN
● n = 27 (UCLA graduates) indicated trait level of
mindfulness then completed affect labeling task
while undergoing fMRI
● variable = matching facial expressions to affect words
● control = matching faces to gender appropriate names
● connectivity analyses conducted to test for relationship
between PFC and amygdala
Creswell, J. D., Way, B. M., Eisenberger, N. I., &
Lieberman, M. D. (2007). Neural correlates of
dispositional mindfulness during affect labeling.
Psychosomatic medicine, 69(6), 560-565.
Creswell, J. D., Way, B. M., Eisenberger, N. I., &
Lieberman, M. D. (2007). Neural correlates of
dispositional mindfulness during affect labeling.
Psychosomatic medicine, 69(6), 560-565.
RESULTS
First neural evidence for association of
mindfulness, affect labeling, and improved
neural affect regulation
● disposition mindfulness is associated with greater
widespread PFC activation and reduced b/l amygdala
activity (no correlation to ethnicity or reaction time)
Creswell, J. D., Way, B. M., Eisenberger, N. I., &
Lieberman, M. D. (2007). Neural correlates of
dispositional mindfulness during affect labeling.
Psychosomatic medicine, 69(6), 560-565.
Participants with high
mindfulness showed a
negative association
between between
prefrontal cortex and
R.amygdala responses
DESIGN
● n=30, completed various
tasks with concurrent fMRI
● control = gender label,
gender match & shape
match
● variable = affect label &
affect match & observe
condition (negative emotion
faces presented and
subjects instructed to
observe without processing
instructions)
Lieberman, Matthew D., et al. "Putting feelings into
words." Psychological Science 18.5 (2007): 421-428.
(Cited 879)
DESIGN
● fMRI imaging data analyzed for entire brain and with
more specific region of interest (ROI) on the amygdala.
● observe condition used to ID areas in the amygdala
sensitive to passive viewing of emotionally evocative
stimuli
● activity in the identified clusters were then computed for
each matching and labeling condition and compared to
control (shape matching condition)
Lieberman, Matthew D., et al. "Putting feelings into
words." Psychological Science 18.5 (2007): 421-428.
(Cited 879)
RESULTS
● ROI identified single cluster in L. amygdala sensitive to
passive viewing of single emotionally evocative image
● no sex differences in amygdala activity
● affect labeling diminishes emotional reactivity along a
pathway from RVLPFC to MPFC
● affect labeling => inc activity in a single brain region RVLPFC
(this was the only region in the entire brain more active during
affect labeling as compared to gender labeling)
● RVLPFC and MPFC both had inverse correlation with
amygdala activity
Lieberman, Matthew D., et al. "Putting feelings into
words." Psychological Science 18.5 (2007): 421-428.
Lieberman, Matthew D., et al. "Putting feelings into
words." Psychological Science 18.5 (2007): 421-428.
Lieberman, Matthew D., et al. "Putting feelings into
words." Psychological Science 18.5 (2007): 421-428.
Lieberman, Matthew D., et al. "Putting feelings into
words." Psychological Science 18.5 (2007): 421-428.
affect labeling showed
significantly less
amygdala activity than
affect matching
(linguistic processing is
more effective than non
linguistic processing in
regards to activating
RVLPFC)
Burklund, L. J., Creswell, J. D., Irwin, M. R., &
Lieberman, M. D. (2014). The common and distinct
neural bases of affect labeling and reappraisal in
healthy adults. Frontiers in Psychology, 5. (Cited 74)
● n = 39, aged 55-85 y/o, 8 wk mindfulness-based
stress reduction program
● fMRI with more personally relevent affect labeling
and appraisal, aka modified so that participants
labeled their own emotional responses (instead of
external stimuli)
Burklund, L. J., Creswell, J. D., Irwin, M. R., &
Lieberman, M. D. (2014). The common and distinct
neural bases of affect labeling and reappraisal in
healthy adults. Frontiers in Psychology, 5.
(A) Reappraisal
(B) Label
(C) Observe
(D) Shape Match
conditions.
Burklund, L. J., Creswell, J. D., Irwin, M. R., &
Lieberman, M. D. (2014). The common and distinct
neural bases of affect labeling and reappraisal in
healthy adults. Frontiers in Psychology, 5.
Similar mechanism, different degrees of effect:
● Affect labeling activated PFC to a greater extent
than reappraisal, though amygdala/limbic activity
did not show significant differences
● Reappraisal is more effective than labeling in
reducing self-reported feelings of unpleasantness
This connection = mechanism by which language
alters basic mechanisms of limbic control
aka incidental emotion regulation
Big Picture
Affect labeling ⇒ ↑RVLPFC ⇒ ↑MPFC ⇒ ↓amygdala → ↓ emotional distress
Identifying an emotion in a patient and
guiding them to label (verbalize) it can have
therapeutic benefit by decreasing patients
limbic system activity (aka anxiety, fear,
anger etc)
(talk therapy, various spiritual coping mechanisms)
Therapeutic
Increase your chance of survival
● immediate/short lived fear = analgesic
● chronic fear = magnify pain sensation
(Eckman 2007)
● patients with chronic pain who engaged in tasks that caused
increases in VLPFC activity were associated with improved
pain symptoms (Lieberman 2004)
● Affect labeling decreased diminished skin conductance
responses (compared to affect matching) (Crockett et al
2006)
Affect labeling to decrease Pain

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Affect labeling

  • 1. MINDFULNESS, AFFECT LABELING & AMYGDALA ACTIVITY Ariana Cunningham MS4
  • 2. Mindfulness = process whereby one is aware and receptive to present moment experiences (mental state achieved by focusing awareness on the present moment; calmly acknowledging and accepting one's feelings, thoughts, and bodily sensations, used as a therapeutic technique)
  • 3. Affect Labeling “I’m angry” = putting feelings into words, either of an external stimulus or one’s own (instead of trying to push an emotion away, the idea is to actually draw closer to it by feeling it, identifying it, and putting a label on it. Can be done verbally, with pen and paper...etc)
  • 4. Reappraisal “find the silver lining” = technique by which we reframe the meaning of an event, thereby changing its emotional significance and impact (used in CBT) (Gross 1998) *of note this is an intentional attempt to regulate one’s emotion, whereas affect labeling is incidental
  • 5. Areas of Interest in the Brain Amygdala = emotional distress Prefrontal cortex = higher functioning ● Right Ventrolateral prefrontal cortex (RVLPFC) = associated with symbolic processing of emotional information (Hariri et all 2000, Lieberman 2005) ● Medial Prefrontal cortex (MPFC) = has dense projections to amygdala, activated during self-relevant task such as monitering ones own emotional state (Quirk et al 2003, Talor et al 2003, Ghashghaei 2002)
  • 6. Background studies have shown that mindful traits/meditation practices reduce negative affect, stress, mood disturbance, and dz spec health sx ○ Can this be quantified? ○ What is the mechanism? ○ How can this be applied?
  • 7. Creswell, J. D., Way, B. M., Eisenberger, N. I., & Lieberman, M. D. (2007). Neural correlates of dispositional mindfulness during affect labeling. Psychosomatic medicine, 69(6), 560-565. (Cited 824) DESIGN ● n = 27 (UCLA graduates) indicated trait level of mindfulness then completed affect labeling task while undergoing fMRI ● variable = matching facial expressions to affect words ● control = matching faces to gender appropriate names ● connectivity analyses conducted to test for relationship between PFC and amygdala
  • 8. Creswell, J. D., Way, B. M., Eisenberger, N. I., & Lieberman, M. D. (2007). Neural correlates of dispositional mindfulness during affect labeling. Psychosomatic medicine, 69(6), 560-565.
  • 9. Creswell, J. D., Way, B. M., Eisenberger, N. I., & Lieberman, M. D. (2007). Neural correlates of dispositional mindfulness during affect labeling. Psychosomatic medicine, 69(6), 560-565. RESULTS First neural evidence for association of mindfulness, affect labeling, and improved neural affect regulation ● disposition mindfulness is associated with greater widespread PFC activation and reduced b/l amygdala activity (no correlation to ethnicity or reaction time)
  • 10. Creswell, J. D., Way, B. M., Eisenberger, N. I., & Lieberman, M. D. (2007). Neural correlates of dispositional mindfulness during affect labeling. Psychosomatic medicine, 69(6), 560-565. Participants with high mindfulness showed a negative association between between prefrontal cortex and R.amygdala responses
  • 11. DESIGN ● n=30, completed various tasks with concurrent fMRI ● control = gender label, gender match & shape match ● variable = affect label & affect match & observe condition (negative emotion faces presented and subjects instructed to observe without processing instructions) Lieberman, Matthew D., et al. "Putting feelings into words." Psychological Science 18.5 (2007): 421-428. (Cited 879)
  • 12. DESIGN ● fMRI imaging data analyzed for entire brain and with more specific region of interest (ROI) on the amygdala. ● observe condition used to ID areas in the amygdala sensitive to passive viewing of emotionally evocative stimuli ● activity in the identified clusters were then computed for each matching and labeling condition and compared to control (shape matching condition) Lieberman, Matthew D., et al. "Putting feelings into words." Psychological Science 18.5 (2007): 421-428. (Cited 879)
  • 13. RESULTS ● ROI identified single cluster in L. amygdala sensitive to passive viewing of single emotionally evocative image ● no sex differences in amygdala activity ● affect labeling diminishes emotional reactivity along a pathway from RVLPFC to MPFC ● affect labeling => inc activity in a single brain region RVLPFC (this was the only region in the entire brain more active during affect labeling as compared to gender labeling) ● RVLPFC and MPFC both had inverse correlation with amygdala activity Lieberman, Matthew D., et al. "Putting feelings into words." Psychological Science 18.5 (2007): 421-428.
  • 14. Lieberman, Matthew D., et al. "Putting feelings into words." Psychological Science 18.5 (2007): 421-428.
  • 15. Lieberman, Matthew D., et al. "Putting feelings into words." Psychological Science 18.5 (2007): 421-428.
  • 16. Lieberman, Matthew D., et al. "Putting feelings into words." Psychological Science 18.5 (2007): 421-428. affect labeling showed significantly less amygdala activity than affect matching (linguistic processing is more effective than non linguistic processing in regards to activating RVLPFC)
  • 17. Burklund, L. J., Creswell, J. D., Irwin, M. R., & Lieberman, M. D. (2014). The common and distinct neural bases of affect labeling and reappraisal in healthy adults. Frontiers in Psychology, 5. (Cited 74) ● n = 39, aged 55-85 y/o, 8 wk mindfulness-based stress reduction program ● fMRI with more personally relevent affect labeling and appraisal, aka modified so that participants labeled their own emotional responses (instead of external stimuli)
  • 18. Burklund, L. J., Creswell, J. D., Irwin, M. R., & Lieberman, M. D. (2014). The common and distinct neural bases of affect labeling and reappraisal in healthy adults. Frontiers in Psychology, 5. (A) Reappraisal (B) Label (C) Observe (D) Shape Match conditions.
  • 19. Burklund, L. J., Creswell, J. D., Irwin, M. R., & Lieberman, M. D. (2014). The common and distinct neural bases of affect labeling and reappraisal in healthy adults. Frontiers in Psychology, 5. Similar mechanism, different degrees of effect: ● Affect labeling activated PFC to a greater extent than reappraisal, though amygdala/limbic activity did not show significant differences ● Reappraisal is more effective than labeling in reducing self-reported feelings of unpleasantness
  • 20. This connection = mechanism by which language alters basic mechanisms of limbic control aka incidental emotion regulation Big Picture Affect labeling ⇒ ↑RVLPFC ⇒ ↑MPFC ⇒ ↓amygdala → ↓ emotional distress
  • 21. Identifying an emotion in a patient and guiding them to label (verbalize) it can have therapeutic benefit by decreasing patients limbic system activity (aka anxiety, fear, anger etc) (talk therapy, various spiritual coping mechanisms) Therapeutic
  • 22. Increase your chance of survival
  • 23. ● immediate/short lived fear = analgesic ● chronic fear = magnify pain sensation (Eckman 2007) ● patients with chronic pain who engaged in tasks that caused increases in VLPFC activity were associated with improved pain symptoms (Lieberman 2004) ● Affect labeling decreased diminished skin conductance responses (compared to affect matching) (Crockett et al 2006) Affect labeling to decrease Pain