Colorectal cancer screening and subsequent incidence of colorectal cancer: re...Cancer Council NSW
Colorectal cancer screening and subsequent incidence of colorectal cancer: results from the 45 and Up Study
Annika Steffen, Marianne F Weber, David M Roder and Emily Banks
RESEARCH & TREATMENT NEWS: Highlights from the 2014 GI Cancer SymposiumFight Colorectal Cancer
Each January, the brightest minds in colorectal cancer research meet at the Gastrointestinal Cancer Symposium.
Fight Colorectal Cancer and The Colon Cancer Alliance are partnering to bring you the big news in colorectal cancer from the symposium. Dr. Allyson Ocean will be presenting.
Get insights about new types of treatments on the horizon, diagnostic tests available, research for upcoming drugs/biomarkers and the way colorectal cancer is treated. We’ll take a look back and a look forward. You’re not going to want to miss it.
Colorectal cancer screening and subsequent incidence of colorectal cancer: re...Cancer Council NSW
Colorectal cancer screening and subsequent incidence of colorectal cancer: results from the 45 and Up Study
Annika Steffen, Marianne F Weber, David M Roder and Emily Banks
RESEARCH & TREATMENT NEWS: Highlights from the 2014 GI Cancer SymposiumFight Colorectal Cancer
Each January, the brightest minds in colorectal cancer research meet at the Gastrointestinal Cancer Symposium.
Fight Colorectal Cancer and The Colon Cancer Alliance are partnering to bring you the big news in colorectal cancer from the symposium. Dr. Allyson Ocean will be presenting.
Get insights about new types of treatments on the horizon, diagnostic tests available, research for upcoming drugs/biomarkers and the way colorectal cancer is treated. We’ll take a look back and a look forward. You’re not going to want to miss it.
Feature story from the Garvan Institute of Medical Research's April 2013 issue of Breakthrough newsletter. More at https://www.garvan.org.au/news-events/newsletters
A prospective study of breast lump andclinicopathologicalanalysis in relation...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
People with Lynch syndrome have a higher risk of certain types of cancer, including endometrial, colorectal, and ovarian cancers. Heather Hampel, MS, CGC, Associate Director of the Division of Genetics and Genetic Counseling at City of Hope, will discuss genetic testing, hereditary cancer risk, prevention, and the latest updates for Lynch syndrome care.
An Interactive Discussion On Key Issues Affecting Young Adult Colorectal Cancer Patients and Their Caregivers
Powered By Our Survivor Community and Their Families
The impact of National Bowel Cancer Screening Program in AustraliaCancer Institute NSW
The full rollout of the National Bowel Cancer Screening Program (NBCSP), offering free biennial screening using immunochemical Fecal Occult Blood Test (iFOBT) for 50-74 years is targeted for 2020. In 2013-14, the overall participation rate among Australians who were invited to participate was 36%.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Feature story from the Garvan Institute of Medical Research's April 2013 issue of Breakthrough newsletter. More at https://www.garvan.org.au/news-events/newsletters
A prospective study of breast lump andclinicopathologicalanalysis in relation...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
People with Lynch syndrome have a higher risk of certain types of cancer, including endometrial, colorectal, and ovarian cancers. Heather Hampel, MS, CGC, Associate Director of the Division of Genetics and Genetic Counseling at City of Hope, will discuss genetic testing, hereditary cancer risk, prevention, and the latest updates for Lynch syndrome care.
An Interactive Discussion On Key Issues Affecting Young Adult Colorectal Cancer Patients and Their Caregivers
Powered By Our Survivor Community and Their Families
The impact of National Bowel Cancer Screening Program in AustraliaCancer Institute NSW
The full rollout of the National Bowel Cancer Screening Program (NBCSP), offering free biennial screening using immunochemical Fecal Occult Blood Test (iFOBT) for 50-74 years is targeted for 2020. In 2013-14, the overall participation rate among Australians who were invited to participate was 36%.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. for fatal interval cancer, 0.38 (95% CI, 0.22 to 0.65). Each 1.0% increase in the adenoma detection
rate was associated with a 3.0% decrease in the risk of cancer (hazard ratio, 0.97; 95% CI, 0.96 to
0.98).
CONCLUSIONS—The adenoma detection rate was inversely associated with the risks of interval
colorectal cancer, advanced-stage interval cancer, and fatal interval cancer. (Funded by the Kaiser
Permanente Community Benefit program and the National Cancer Institute.)
COLONOSCOPY IS A COMMONLY USED PRImary or follow-up screening test to detect colorectal cancer,1-3 the
second leading cause of death from cancer in the United States.4,5 Colonoscopy can reduce
the risk of death from colorectal cancer through detection of tumors at an earlier, more
treatable stage and through removal of precancerous adenomas.3,6 Conversely, failure to
detect adenomas during colonoscopy may increase the subsequent risk of cancer.
The adenoma detection rate, the proportion of screening colonoscopies performed by a
physician that detect at least one histologically confirmed colorectal adenoma or
adenocarcinoma, has been recommended as a quality benchmark by specialty societies7 and
has been recently proposed by the Centers for Medicare and Medicaid Services as a
reportable quality measure. Currently, professional societies recommend adenoma detection
rates of 15% or higher for female patients and 25% or higher for male patients as indicators
of adequate colonoscopy quality, although data are lacking to validate these thresholds.7
Adenoma detection rates vary widely among providers in both academic and community
settings8-20; however, the adenoma detection rate has not been well validated with respect to
its use in predicting the risk of important outcomes such as the development of colorectal
cancer after colonoscopy (hereafter referred to as interval cancer), advanced-stage interval
cancer, and fatal interval cancer. A study of 42 interval cancers identified over a period of 5
years showed an association between the colonoscopy-related adenoma detection rate
(<20% vs. ≥20%) and the risk of interval cancer.21
We evaluated the relationship between the adenoma detection rates in a large group of
endoscopists in a community-based setting and their patients’ risks of interval colorectal
cancer, advanced-stage interval cancer, and fatal interval cancer.
METHODS
STUDY POPULATION AND DATA SOURCES
The patients in the study were members of Kaiser Permanente Northern California, an
integrated health services organization that serves approximately 3.3 million people annually
at 17 medical centers. Demographic characteristics of the members closely approximate
those of the region’s diverse population (when compared with the regional demographic
characteristics estimated by the decennial census). The patients were enrolled in Medicare,
Medicaid, or a commercial insurance plan.22,23 We obtained data from electronic records on
the patients’ sex, age, race or ethnic group, family history of colorectal cancer, and Charlson
comorbidity index score (calculated for the year before the index colonoscopy). The
Charlson index predicts the influence of coexisting diseases on mortality; higher scores
indicate the presence of more (or more severe) coexisting conditions.24
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3. Patients were included in the study if they had undergone a colonoscopy between January 1,
1998, and December 31, 2010; were 50 years of age or older at the time of the colonoscopic
examination; and had at least 6 months of subsequent follow-up. The gastroenterologists
who performed the colonoscopies had to have completed 300 or more total colonoscopic
examinations and 75 or more screening examinations during the study period.
Patients were followed from the date of the colonoscopy to the first of the following events:
completion of 10 years of follow-up, diagnosis of a colorectal adenocarcinoma,
discontinuation of membership in Kaiser Permanente Northern California, or the end of the
follow-up period (December 31, 2010).
STUDY OVERSIGHT
The study was approved by the institutional review board of Kaiser Permanente Northern
California, which waived the requirement for informed consent. The listed authors had sole
responsibility for the study design, data collection, decision to submit the manuscript for
publication, and drafting of the manuscript. This study was conducted within the National
Cancer Institute (NCI) Cancer Research Network and as part of the NCI-funded Population-
based Research Optimizing Screening through Personalized Regimens (PROSPR)
consortium. The PROSPR consortium conducts multisite, coordinated, transdisciplinary
research to evaluate and improve cancer-screening processes.
COLONOSCOPIC EXAMINATIONS
Colonoscopies were identified from electronic records with the use of Current Procedural
Terminology codes, and adenomas detected at colonoscopy were identified with the use of
Systematized Nomenclature of Medicine codes.25 We used an algorithm that incorporated
data from electronic consultation records, clinical diagnostic codes from the International
Classification of Diseases, 9th revision, and laboratory, pathological, and radiologic tests to
categorize the indication for colonoscopy as screening, surveillance, or diagnosis. A
screening examination was defined as a colonoscopy for which there was no surveillance or
diagnostic indication. A surveillance examination was defined as a colonoscopy for which
there was no diagnostic indication and which was performed in a patient who had undergone
a colonoscopy within the previous 10 years or a sigmoidoscopy within the previous 5 years
or who had a history of polyps or colorectal cancer. A diagnostic indication was assigned if
the patient had one or more of the following findings before the colonoscopy: a positive test
for hemoglobin in stool within the past year; a gastrointestinal condition, such as abdominal
pain, iron-deficiency anemia, gastrointestinal bleeding, unexplained weight loss, a change in
bowel habits, an abnormal finding on abdominal imaging, a polyp detected by means of
flexible sigmoidos-copy, or diverticulitis, within the past 6 months; or a diagnosis of
inflammatory bowel disease within the past 10 years. Validation studies confirmed high
levels of sensitivity and accuracy for capture of colonoscopic examinations, indications for
colonoscopy, detection of cancers, and detection of adenomas.26
CANCER OUTCOMES
An interval cancer was defined as a colorectal cancer diagnosed between 6 months and 10
years after colonoscopy; cancers diagnosed within 6 months after colonoscopy were
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4. considered to be “detected” by the index examinations. Early interval cancers were those
diagnosed between 6 and 35 months after the colonoscopy; delayed cancers were those
diagnosed 3 or more years after the colonoscopy. The risk of interval cancer among patients
who underwent more than one colonos-copy was assigned to the physician who performed
the most recent colonoscopy.
Data on the diagnosis and stage of colorectal adenocarcinoma were obtained from the Kaiser
Permanente Northern California and California cancer registries, which are part of the
Surveillance, Epidemiology, and End Results (SEER) registry. Advanced-stage cancers
were defined as stage III (regional disease with spread to the regional lymph nodes only) or
stage IV (distant metastasis) according to the American Joint Committee on Cancer staging
system; for patients who did not undergo such staging, advanced-stage cancers were defined
as code 3 (disease in the regional lymph nodes), code 4 (regional disease with direct
extension and spread to the regional lymph nodes), or code 7 (distant metastasis) according
to the SEER Program Coding and Staging Manual 2013.27 Proximal cancers were those in
the cecum, ascending colon, hepatic flexure, and transverse colon; distal cancers were those
in the splenic flexure, descending colon, sigmoid colon, and rectum. The underlying causes
of death were obtained from cancer-registry and state mortality files.
STATISTICAL ANALYSIS
We examined whether physicians’ adenoma detection rates, categorized either in quintiles or
as a continuous variable, predicted patients’ risk of interval colorectal cancer. We used
multilevel Cox proportional-hazards regression, adjusting for patient sex and age, Charlson
comorbidity index score, and indication for colonoscopy; the race or ethnic group of the
patients did not substantially alter physicians’ adenoma detection rates and was not included
in the final model. We accounted for within-physician clustering and within-patient
correlation using marginal modeling, with a robust sandwich estimate of the covariance
matrix.28 Thus, for each physician, we used a standardized exposure (i.e., the adenoma
detection rate for screening examinations) to predict their patients’ outcomes for all
colonoscopies, irrespective of indications, after balancing for potential differences in their
patient populations. We tested for non-proportionality of covariates using time–covariate
interaction terms in the main model. There was heterogeneity in the effect over time for the
age of the patient (≤85 years vs. >85 years) and the indication for diagnostic examination
but not for the adenoma detection rate; inclusion of time–covariate interaction terms had no
effect on hazard-ratio estimates. Thus, we included only main-effect terms in our final
model.
The change in the potential number of interval cancers, from the lowest to the highest
quintile of adenoma detection rates, was analogous to the number needed to treat and was
calculated as 1 divided by the risk difference between quintiles 1 and 5. The risk difference
was estimated with the use of the following equation: risk difference = incidence − (hazard
ratio × incidence), where hazard ratio is the adjusted hazard ratio for quintile 5 relative to
quintile 1, and incidence is the unadjusted incidence per 10 years of follow-up after
colonoscopy in the lowest-performing quintile.
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5. Analyses were performed with the use of SAS software, version 9.3 (SAS Institute), and
Stata software, version 10.1 (StataCorp).
RESULTS
COLONOSCOPIES AND PHYSICIAN CHARACTERISTICS
We identified 331,164 eligible colonoscopic examinations during the study period;
exclusion of 12,765 colonoscopies by endoscopists who had performed fewer than 300 total
examinations, 2028 by providers who had performed fewer than 75 screening examinations,
1462 that were not performed at Kaiser Permanente facilities, and 37 performed in patients
with no follow-up time yielded 314,872 examinations, 8730 colorectal cancers, and 136
gastroenterologists for the calculation of adenoma detection rates. Exclusion of 8018
examinations in which a cancer was detected within 6 months after colonoscopy and an
additional 41,882 examinations with less than 6 months of follow-up data resulted in
264,972 colonoscopies among 223,842 patients, with 712 interval colorectal
adenocarcinomas (8.2% of all colorectal cancers) and 927,523 person-years of follow-up for
the analyses of interval cancer (Table 1 and Fig. 1, and Table S1 in the Supplementary
Appendix, available with the full text of this article at NEJM.org). The median interval
between the index examination and the diagnosis of an interval cancer was 39 months.
Characteristics of the physicians are shown in Table 1, and in Table S1 in the
Supplementary Appendix. The average number of colonoscopies performed by an individual
physician was 2150 (range, 355 to 6005); adenoma detection rates ranged from 7.4 to 52.5%
(9.7 to 60.5% for male patients and 3.9 to 45.9% for female patients). There was a strong
correlation between the adenoma detection rates based on screening examinations alone and
those based only on diagnostic examinations (r = 0.75, P<0.001) or only on surveillance
examinations (r = 0.72, P<0.001).
RISK OF INTERVAL COLORECTAL CANCER
The unadjusted risks of interval colorectal cancer according to quintiles of adenoma
detection rates, from lowest to highest, were 9.8, 8.6, 8.0, 7.0, and 4.8 cases per 10,000
person-years of follow-up, respectively. For patients of physicians with adenoma detection
rates in the highest quintile, as compared with patients of physicians with rates in the lowest
quintile, the risk of receiving a diagnosis of an interval cancer was 0.52 (95% confidence
interval [CI], 0.39 to 0.69), after adjustment for covariates (Table 2 and Fig. 2A). The risk of
interval cancer decreased approximately linearly with increasing adenoma detection rates,
without evidence of a threshold effect within the observed range of rates. With the adenoma
detection rate modeled as a continuous variable, each 1.0% increase in the rate predicted a
3.0% decrease in the risk of interval cancer (hazard ratio, 0.97; 95% CI, 0.96 to 0.98).
The results were similar in an analysis restricted to examinations involving persons with at
least 2 years of follow-up data (hazard ratio for an interval cancer, 0.97; 95% CI, 0.96 to
0.99; P<0.001) and separate analyses of screening colonoscopies (hazard ratio, 0.97; 95%
CI, 0.95 to 1.00; P = 0.05), diagnostic colonoscopies (hazard ratio, 0.97; 95% CI, 0.96 to
0.98; P<0.001), and surveillance colonoscopies (hazard ratio, 0.98; 95% CI, 0.97 to 0.99; P
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6. = 0.02). The unadjusted risks according to the most recent indication for colonoscopy were
5.0 cases of interval cancer per 10,000 person-years of follow-up for screening, 8.9 cases per
10,000 person-years for surveillance, and 8.0 cases per 10,000 person-years for diagnostic
examinations. The adjusted hazard ratio of 0.52 suggests that physicians who increase their
adenoma detection rate from less than 19% (the lowest quintile) to 34 to 53% (the highest
quintile) might prevent 1 additional interval cancer over the next 10 years for every 213
colonos-copies performed.
The association between the adenoma detection rate and the risk of interval cancer was
observed both among women (hazard ratio with quintile 5 vs. quintile 1, 0.43; 95% CI, 0.28
to 0.66) and among men (hazard ratio, 0.60; 95% CI, 0.42 to 0.88). There was no significant
interaction according to sex (P = 0.23) (Table S2 in the Supplementary Appendix).
There was an inverse association between the adenoma detection rate and the subsequent
risks of cancer in the proximal colon (hazard ratio with quintile 5 vs. quintile 1, 0.49; 95%
CI, 0.35 to 0.69), cancer in the distal colon (hazard ratio, 0.55; 95% CI, 0.39 to 0.79), early
cancer (hazard ratio, 0.40; 95% CI, 0.23 to 0.68), and delayed cancer (hazard ratio, 0.61;
95% CI, 0.39 to 0.96) (Table S2 in the Supplementary Appendix).
RISK OF ADVANCED-STAGE AND FATAL INTERVAL CANCERS
For patients of physicians with rates in the highest quintile of adenoma detection rates, as
compared with patients of physicians with rates in the lowest quintile, the risk of receiving a
diagnosis of advanced-stage interval colorectal cancer was reduced by 57% (hazard ratio,
0.43; 95% CI, 0.29 to 0.64) (Fig. 2B) and the risk of a fatal interval colorectal cancer was
reduced by 62% (hazard ratio, 0.38; 95% CI, 0.22 to 0.65) (Fig. 2C). Each 1% increase in
the adenoma detection rate was associated with a 5% decrease in the risk of a fatal interval
colorectal cancer (hazard ratio, 0.95; 95% CI, 0.94 to 0.97) within the observed range of
adenoma detection rates.
DISCUSSION
A physician’s adenoma detection rate, derived from screening examinations, is
recommended as a measure of the quality of colonoscopic examination, but the relationship
of the adenoma detection rate to the subsequent risks of colorectal cancer and death has been
unclear. Our study, which involved 136 gastroenterologists, more than 250,000
colonoscopies, and 712 cases of interval cancer diagnosed during a 10-year follow-up
period, showed a strong inverse association between the adenoma detection rate and the risk
of interval cancer in a dose-dependent fashion, within the observed range of adenoma
detection rates. Higher detection rates also predicted decreased risks of advanced-stage
disease, fatal interval cancer, both early and delayed interval cancers, and cancers in both the
proximal and distal colon. In separate analyses according to the indication for colonoscopy
(i.e., screening, surveillance, or diagnosis), higher adenoma detection rates also predicted
decreased risks of interval cancers.
The current study adds to our knowledge of how variation in the performance of
colonoscopy may influence its effectiveness with respect to cancer detection and prevention.
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7. A prior study of 42 interval cancers in a Polish screening program also evaluated the
relationship between the adenoma detection rate for colonoscopy and the risk of interval
cancer; that study showed that adenoma detection rates of less than 20% and rates of 20% or
higher differed in predicting the risk of interval cancer.21 Although the study represented an
important advance, it was limited by a relatively small number of cancers, with no data on
deaths, a maximum follow-up of 5 years, and a low percentage of physicians with an
adenoma detection rate of 20% or higher (14%, vs. >80% for physicians in the current
study).21 Two additional studies have evaluated the relationship between the rate of
colonoscopic polypectomy (without pathological classification of polyps) and the risk of
interval cancers over a 3-year period: one study showed an inverse association29; the other
study showed an inverse association only for cancer in the proximal colon.30 The
polypectomy rate alone, however, is difficult to use as a quality metric because of the
potential subjectivity of assigning polyp status in the absence of histo-logic findings.30
Finally, a recent study showed an inverse relationship between the adenoma detection rate
with flexible sigmoidoscopy and the risk of an interval cancer in the distal colon.31
The association between the adenoma detection rate and the risk of interval cancer is
presumed to be due to the enhanced detection of precancerous adenomas. However, other
factors such as the completeness of polyp removal may be involved.32 If physicians with
lower adenoma detection rates are also less likely to completely resect polyps, the increase
in the subsequent risk of cancer among their patients may be due in part to incomplete
resection rather than decreased detection alone. Higher adenoma detection rates may also
lead to more frequent surveillance. However, increased detection of asymptomatic cancers
(and, therefore, total interval cancers) might be expected in patients undergoing enhanced
surveillance. In contrast, we found fewer interval cancers in patients of physicians with
higher adenoma detection rates.
The current analyses also add to our knowledge about the timing of interval cancers: two
thirds of such cancers in our study were diagnosed more than 3 years after the index
colonos-copy, and we would expect this proportion to be even larger if all the patients had
undergone 10 years of follow-up. Previous studies have focused primarily on cancers
occurring within 3 to 5 years after the colonoscopic examination; rapidly progressing
adenomas or cancers that were present but not detected at the time of colonoscopy would
presumably account for these interval cancers.15,21,29,30,33-41 The number of cancers
detected in this study is similar to or lower than the numbers observed in other studies
(which often evaluated cancers over a shorter period).29,30 Interval cancers accounted for
only 8.2% of all colorectal cancers detected in our study cohort, and the absolute risk of an
interval cancer was relatively low (9.8 interval cancers per 10,000 person-years of follow-up
in quintile 1 of adenoma detection rates and 4.8 interval cancers per 10,000 person-years of
follow-up in quintile 5). A preliminary modeling study has suggested that these differences
in detection may influence the effectiveness of colonoscopic screening programs.42
Possible limitations of our study include an inability to adjust for other risk factors (e.g.,
bowel preparation and the extent of the colonoscopic examination) and an inability to
compare procedure-related complications among quintiles of adenoma detection rates. A
prior study based on a manual (not electronic) record review of data from Kaiser
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8. Permanente Northern California showed perforation rates of 1.1 per 1000 colonoscopies that
included biopsy or polypectomy and 0.6 per 1000 colonoscopies that did not include biopsy
or polypectomy. There were also 4.8 occurrences of postprocedure bleeding per 1000
colonoscopies that included biopsy or polypectomy.43
In conclusion, in a large community-based U.S. population across multiple medical centers,
physicians’ adenoma detection rates were inversely related to the risk of interval colorectal
cancer, including advanced-stage cancer and fatal interval colorectal cancer, among patients
with up to 10 years of follow-up. This association was approximately linear across quintiles
of adenoma detection rates in our population and was observed for male and female patients,
cancers in the proximal and distal colon, and early and delayed interval cancers. These
findings support the validity of the adenoma detection rate as a quality measure of
physicians’ performance of colonoscopy in community practice.44 Studies to determine
whether improving the adenoma detection rate leads to improved outcomes are warranted.20
Supplementary Material
Refer to Web version on PubMed Central for supplementary material.
Acknowledgments
Supported by grants from the Kaiser Permanente Community Benefit program and the National Cancer Institute
(U54 CA163262 [PROSPR] and U24 CA171524).
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11. Figure 1. Colonoscopic Examinations Performed by 136 Gastroenterologists
ADR denotes adenoma detection rate, CRC colorectal cancer, and KPNC Kaiser Permanente
Northern California.
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12. Figure 2. Hazard Ratios for Colorectal Cancer, According to Quintile of Adenoma Detection
Rates
Data were adjusted for sex, age, Charlson comorbidity index score, and indication for
colonoscopy, with clustering according to physician. Vertical lines indicate 95% confidence
intervals. HR denotes hazard ratio.
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Table 1
Characteristics of the Patients and Physicians.
Characteristic
All Colonoscopies
(N = 314,872)
Interval Colorectal Cancer
(N = 712)*
Patients
Sex — no. (%)
Female 164,711 (52.3) 344 (48.3)
Male 150,161 (47.7) 368 (51.7)
Race or ethnic group — no. (%)†
Non-Hispanic white 205,827 (65.4) 541 (76.0)
Hispanic 28,209 (9.0) 55 (7.7)
Black 20,608 (6.5) 46 (6.5)
Asian or Pacific Islander 35,531 (11.3) 41 (5.8)
Native American 1,365 (0.4) 2 (0.3)
Mixed or other 10,293 (3.3) 24 (3.4)
Unknown 13,039 (4.1) 3 (0.4)
Age — yr
Median 64 69
Interquartile range 57–72 63–77
Charlson comorbidity index score‡
Median 0 0
Interquartile range 0–1 0–1
Indication for colonoscopy — no. (%)§
Screening 57,588 (18.3) 90 (12.6)
Surveillance 76,418 (24.3) 232 (32.6)
Diagnosis 180,866 (57.4) 390 (54.8)
Location of interval colorectal cancer — no. (%)
Distal colon 267 (37.5)
Proximal colon 427 (60.0)
Unknown 18 (2.5)
Follow-up time between last colonoscopy and data censoring — mo¶
Median 35 39
Interquartile range 19–59 21–64
Physicians
Total — no. (%) 136 (100)
Year of graduation from medical school
Median 1989
Interquartile range 1980–1997
Adenoma detection rate quintile — no. (%)∥
Quintile 1: 16.56% (7.35–19.05%) 27 (19.9)
Quintile 2: 21.50% (19.06–23.85%) 27 (19.9)
Quintile 3: 25.70% (23.86–28.40%) 28 (20.6)
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Characteristic
All Colonoscopies
(N = 314,872)
Interval Colorectal Cancer
(N = 712)*
Quintile 4: 30.96% (28.41–33.50%) 27 (19.9)
Quintile 5: 38.86% (33.51–52.51%) 27 (19.9)
*
Interval cancers were defined as colorectal adenocarcinomas diagnosed between 6 months and 10 years after the index colonoscopy.
†
Information about race or ethnic group was derived from numerous sources, including medical records (physician report), patient self-report on
questionnaires, and cancer registries.
‡
Scores on the Charlson comorbidity index, a validated method of classifying prognosis according to coexisting conditions in longitudinal studies,
range from 0 to 33, with higher scores indicating a greater burden of coexisting conditions.
§
For patients with interval cancers, the indication for colonoscopy was the same as the indication for the colonoscopy that preceded the diagnosis
of the interval cancer.
¶
Follow-up time is shown for the 264,972 colonoscopic examinations included in Cox analyses. Patients were followed from the date of the
colonoscopy to the first of the following events: completion of 10 years of follow-up, diagnosis of a colorectal adenocarcinoma, discontinuation of
membership in Kaiser Permanente Northern California, or the end of follow-up (December 31, 2010).
∥
Quintiles are expressed as medians and ranges.
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Table 2
Adenoma Detection Rate and Risk of an Interval Colorectal Cancer among All Patients.
Adenoma Detection Rate
Interval
Cancer
Hazard Ratio
(95% CI) *
Unadjusted
Risk
no. of
cases
no. of cases/
10,000
person-yr
Continuous rate 712 0.97 (0.96–0.98) 7.7
Rate quintile
Quintile 1: 7.35–19.05% 186 1.00 (reference) 9.8
Quintile 2: 19.06–23.85% 144 0.93 (0.70–1.23) 8.6
Quintile 3: 23.86–28.40% 139 0.85 (0.68–1.06) 8.0
Quintile 4: 28.41–33.50% 167 0.70 (0.54–0.91) 7.0
Quintile 5: 33.51–52.51% 76 0.52 (0.39–0.69) 4.8
*
Hazard ratios were adjusted for age, Charlson comorbidity score, sex (in the model including both men and women), and indication for
colonoscopy, with clustering according to physician.
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