AChE
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The document reports results from assays testing compounds 15a, 15b, tacrine, 6-chlorotacrine, and donepezil against human BChE, human AChE, and bovine AChE. It provides IC50 values in nM for each compound and enzyme combination. It also reports reduction of fluorescence percentages from a thioflavin T competition assay for tacrine, 6-chlorotacrine, donepezil, 15a, and 15b. Structures are provided for compounds 15a and 15b, which are donepezil-tacrine hybrids.
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2
iss
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Mi
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j
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j
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i
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j,ijiji Corr)r,r(Cov ×σ×σ=
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T)r1(
1
PV
+
=
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T
T )y1(
)y1(
f
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+
=
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i1
r1
R −
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+
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i is the inflation rate
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gk
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×=
n
t
t t
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)RR( COV 2 - )RVAR( + )RVAR(
)RR( COV - )RVAR( = W
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gk
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fp
p
rr
S
σ
−
=
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p
fp
p
rr
T
β
−
=
Jensen’s measure, or alpha:
)]rr(r[r fMfpp −β+−=α
…/continued overleaf
∑
=
×=
n
t
t t
iceMarket
CFPV
D
1 Pr
)(
3
CONTINUED OVERLEAF...
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Period 1% 2% 3% 4% 5% 6% 7% 8% 9% 10% 11% 12% 13% 14% 15% 16% 17% 18% 19% 20%
1 0.990 0.980 0.971 0.962 0.952 0.943 0.935 0.926 0.917 0.909 0.901 0.893 0.885 0.877 0.870 0.862 0.855 0.847 0.840 0.833
2 0.980 0.961 0.943 0.925 0.907 0.890 0.873 0.857 0.842 0.826 0.812 0.797 0.783 0.769 0.756 0.743 0.731 0.718 0.706 0.694
3 0.971 0.942 0.915 0.889 0.864 0.840 0.816 0.794 0.772 0.751 0.731 0.712 0.693 0.675 0.658 0.641 0.624 0.609 0.593 0.579
4 0.961 0.924 0.888 0.855 0.823 0.792 0.763 0.735 0.708 0.683 0.659 0.636 0.613 0.592 0.572 0.552 0.534 0.516 0.499 0.482
5 0.951 0.906 0.863 0.822 0.784 0.747 0.713 0.681 0.650 0.621 0.593 0.567 0.543 0.519 0.497 0.476 0.456 0.437 0.419 0.402
6 0.942 0.888 0.837 0.790 0.746 0.705 0.666 0.630 0.596 0.564 0.535 0.507 0.480 0.456 0.432 0.410 0.390 0.370 0.352 0.335
7 0.933 0.871 0.813 0.760 0.711 0.665 0.623 0.583 0.547 0.513 0.482 0.452 0.425 0.400 0.376 0.354 0.333 0.314 0.296 0.279
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This document provides balance sheet, profit and loss account, and cash flow statements for State Bank of India from March 2005 to March 2010. It shows the bank's total assets grew from Rs. 459,882.8 crore in 2005 to Rs. 964,432.08 crore in 2009. Net profit increased from Rs. 4,304.52 crore to Rs. 9,121.23 crore over the same period. Key financial ratios like return on net worth and interest spread remained healthy, demonstrating the bank's strong and steadily growing financial position over the years.
Ενδέκατη Εβδομάδα Τιμώμενου Μέλους
The document appears to be statistics from an online game, listing players' usernames and their scores over multiple dates. It shows the changes in scores for each player from one date to the next. The player named "Tallos" had the largest increase in score of 22,730 points over the period recorded.
Gpz bearing catalogue
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AChE
- 1. 7273 ± 621 11.6 ± 1.6 8.12 ± 0.26 Donepezil 916 ± 19 8.32 ± 0.75 5.73 ± 0.44 6-Chlorotacrine 43.9 ± 17 205 ± 18 130 ± 10 Tacrine 72.7 ± 4.2 1.06 ± 0.05 0.82 ± 0.08 17b 88.7 ± 0.2 2.60 ± 0.23 1.86 ± 0.07 17a 7.25 ± 0.33 2.16 ± 0.21 0.82 ± 0.06 16b 8.06 ± 0.32 5.13 ± 0.52 2.28 ± 0.06 16a 66.3 ± 4.0 0.27 ± 0.03 0.09 ± 0.01 15b 136 ± 9 0.67 ± 0.06 0.57 ± 0.05 15a 12.4 ± 0.6 0.88 ± 0.04 0.29 ± 0.03 14b 12.4 ± 0.6 4.04 ± 0.06 1.74 ± 0.02 14a human BChE human AChE bovine AChE compound IC 50 (nM)
- 2. Structures of tacrine, donepezil, and the known donepezil−tacrine hybrids 3 and 4. Synthesis of the donepezil−tacrine hybrids 14−17a,b
- 3. 15a 15b
- 4. Thioflavin T Competition Assay Results with the Dihydrochlorides of the Donepezil−Tacrine Hybrids 15a and 15b, and the Hydrochlorides of Tacrine, 6-Chlorotacrine, and Donepezil 26.0 ± 3.5 Donepezil·HCl 12.4 ± 1.9 6-Chlorotacrine·HCl 12.6 ± 3.8 Tacrine·HCl 57.0 ± 2.0 15b ·2HCl 79.4 ± 3.5 15a ·2HCl Reduction of fluorescence (%) Compound
- 5. Compounds 15a and 15b superimposed 15a, donepezyl, tacrine 15b, donepezyl, tacrine
- 6. Stacking Epot, rms (backbone, heavy)