This document discusses profiling Python code to optimize performance. It provides an overview of different types of profilers, including event-based, instrumentation-based, and statistical profilers. It then demonstrates how to use Intel VTune Amplifier to profile Python code with low overhead. Key steps include creating a project, running a basic hotspot analysis, and interpreting the results to identify optimization opportunities. Mixed Python/C++ profiling is also supported to optimize Python code calling native extensions.