Efficacy and safety of traditional Chinese medicine kidney-nourishing formula...LucyPi1
Abstract Objective: Finding an effective therapy against Alzheimer’s disease (AD) has been associate increasingly pressing issue and traditional Chinese medicine (TCM) is widespread in the prevention and treatment of AD in China. The aim of this study was to judge the efficaciousness and safety of TCM kidney-nourishing (the changes of pathological state of kidney deficiency by means of TCM treatment and so on) formula (TKNF) for AD in comparison with donepezil. Methods: The retrieval period of seven databases was from the establishment of each database to April 2019. Two authors independently identified randomized controlled trials (RCTs), fetched data and assessed bias risk. Comprehensive analysis process was conducted with review manager for eligible and appropriate RCTs. Results: A complete of 981 AD patients from 13 studies were enclosed. Meta-analysis of RCTs showed that there was no significant difference in the improvement of Alzheimer's disease assessment scale-cognitive subscale score between 2 groups in short term, but the effect of long-term treatment may exceed donepezil; there was a significant difference in the improvement of activities of daily living score between 2 groups; there was a significant difference in TCM curative efficacy between 2 groups with long-term treatment. There was no significant difference in the incidence of adverse events between 2 groups. The quality of the evidence was high or moderate. Conclusion: Compared with donepezil, TKNF was an effective drug for AD patients and the clinical application of TKNF was safe. TKNF's long-term benefits need more evidence to verify.
This document summarizes a randomized controlled trial that investigated whether stable patients with infective endocarditis could be safely treated with oral antibiotics rather than continued intravenous antibiotics. The trial involved 400 patients across multiple centers in Denmark who had infective endocarditis of the left heart caused by common bacterial species. Patients received either continued intravenous antibiotics according to guidelines or a partial oral antibiotic treatment regimen. The primary outcome was to show non-inferiority of oral treatment. Results showed that oral antibiotic treatment was found to be non-inferior to continued intravenous treatment for stable patients.
A SEEMINGLY BENIGN DRUG IN THE SPOTLIGHT: AN EDUCATIONAL INTERVENTION TO REDU...Khushboo Gandhi
INTRODUCTION
Overutilization of Proton pump inhibitors (PPI) in hospitalized patients is a well-recognized problem. In our previous study at St. Luke’s Hospital, we found that the lack of published guidelines for PPI use in non-critically ill patients results in overutilization of PPI in hospitalized patients. We conducted an educational intervention program to address this problem.
DISCUSSION
Overutilization of PPI in non-critically ill hospitalized patients is a known problem in medical practice. Use of PPI has been implicated in number of adverse consequences including but not limited to Clostridium difficile infection, pneumonia, and osteoporosis. In recent studies, PPI was found to be associated with increased in-hospital mortality, increased risk of cardiovascular events, dementia and chronic renal failure (CRF). We studied the magnitude of the problem in our hospital and employed an educational intervention program, which resulted in a significant reduction of inappropriate use of PPI in the hospital.
There were several limitations to our study. This was a retrospective study where we noted a lack of proper documentation for outpatient use of PPI. We also were unable to precisely determine for how long the patients were taking PPI as outpatients. Our intervention included only medical residents (a total of 41), so we excluded data from NPs, hospitalists or PCPs after intervention. As a result, we are unable to determine the effect of the educational intervention on their practice.
CONCLUSION
PPIs have long been considered as relatively harmless drugs. In recent years, it has been implicated in several adverse effects that increases patient morbidity and mortality along with increased healthcare expenditure. Our data shows that proper education and ongoing surveillance, especially during admission and discharge can significantly reduce overutilization of PPI.
Estimate of the Patients Commitment Concerning Medical Follow-Up with Angina ...AnuragSingh1049
Angina pectoris above referred to as coronary course malady, is caused by the buildup of whittle core the arteries saunter source oxygen-rich blood for the heart. Break in, a mid of broad, cholesterol, and calcium deposits, rear entertain in the arteries over a long time. They are the standard causes of dying in both ripe and evolvement countries, relation for far one third of circa deaths worldwide. All grow pre-eminent groups may die stranger a heart attack. But older kith and kin are in all directions liable to die than younger people.
Elucidative investigate is bump off outside in Al-Sadr Medical City, from January, 7th to May, 6th 2018, in act to review patients' appeal everywhere curative backup adjacent to angina pectoris in Al- Najaf Borough, and to get it out the association between the demographic evidence , clinical information, dance and mercantile statuses, and the patients' pertinence thither Remedial follow-up. A Non-Probability (Purposive Sample) of (50) respecting regard to patients’ angina pectoris, those who visited Al-Sadr therapeutic Megalopolis, the data were composed skim flip the perseverance of the developed questionnaire after the soldiers are estimated, and by means of interview technique. The validity of the questionnaire is propensity look over (9) experts. The data analyzed through the relation of the expository and inferred statistical analysis procedures.
The alertness of the real anatomize specific depart the diversified imputation for the patient’s attention concerning medicinal follow-up with angina pectoris is moderate.
The assay accomplish focus everywhere is a conspicuous reach of the patient's centered of the woe and medicine, and the social and economic low-down, on the patients' commitment to iatrical follow-up with angina pectoris.
The Critique pertinent that benefit Sine qua non be working (e.g., domicile visits, visits outpatient’s of the medical center) may suspended patients to cope with their medical follow-up program. Forced to be the recommendations have in the offing help in the pedagogical resolve wont for patients hence as to improve their commitment. In helper healthiness, oriented pile media betterment should be employed to mass folk familiarity and knowledge of angina pectoris and the importance of the patient’s commitment to medical follow-up. Beyond hegemony of jugs policies which deliver with the monitoring and information the turn the heat on united with the patients' commitment to medical follow-up.
This study evaluated the effectiveness of a classroom intervention aimed at increasing students' knowledge of head safety and positive attitudes towards bicycle helmet use. 74 students ages 11-15 participated. They completed pre-and post-tests on safety knowledge and questionnaires on helmet use attitudes. Before the intervention, most students only wore helmets when forced by parents and few saw them as safety devices. After viewing presentations on head injuries, more students reported being likely to wear helmets. The study concluded the intervention successfully increased safety knowledge and positive helmet attitudes as intended.
Journal club - Disease progression in hemodynamically stable patients present...Farooq Khan
Critical appraisal of:
Glickman SW et al. Disease Progression in Hemodynamically Stable Patients Presenting to the Emergency Department With Sepsis. Acad Emerg Med. 2010 17:383-90
Interactive quiz on early goal-directed therapy, surviving sepsis guidelines and EBM topic of prognosis studies.
An audit was conducted of ward nurses' knowledge of sepsis definitions and management guidelines. A questionnaire was administered to 73 ward nurses which assessed their understanding of the signs and symptoms of sepsis, as well as case studies depicting potential sepsis patients. The results showed that some nurses had a poor understanding of the standard definitions of sepsis, severe sepsis/septic shock and recommended initial management. In response, targeted educational initiatives were implemented to improve nurses' knowledge of sepsis definitions and management guidelines put forth by the Surviving Sepsis Campaign. The study concluded that focused education for ward nurses is needed if the goal of reducing sepsis mortality by 25% is to be achieved.
Efficacy and safety of traditional Chinese medicine kidney-nourishing formula...LucyPi1
Abstract Objective: Finding an effective therapy against Alzheimer’s disease (AD) has been associate increasingly pressing issue and traditional Chinese medicine (TCM) is widespread in the prevention and treatment of AD in China. The aim of this study was to judge the efficaciousness and safety of TCM kidney-nourishing (the changes of pathological state of kidney deficiency by means of TCM treatment and so on) formula (TKNF) for AD in comparison with donepezil. Methods: The retrieval period of seven databases was from the establishment of each database to April 2019. Two authors independently identified randomized controlled trials (RCTs), fetched data and assessed bias risk. Comprehensive analysis process was conducted with review manager for eligible and appropriate RCTs. Results: A complete of 981 AD patients from 13 studies were enclosed. Meta-analysis of RCTs showed that there was no significant difference in the improvement of Alzheimer's disease assessment scale-cognitive subscale score between 2 groups in short term, but the effect of long-term treatment may exceed donepezil; there was a significant difference in the improvement of activities of daily living score between 2 groups; there was a significant difference in TCM curative efficacy between 2 groups with long-term treatment. There was no significant difference in the incidence of adverse events between 2 groups. The quality of the evidence was high or moderate. Conclusion: Compared with donepezil, TKNF was an effective drug for AD patients and the clinical application of TKNF was safe. TKNF's long-term benefits need more evidence to verify.
This document summarizes a randomized controlled trial that investigated whether stable patients with infective endocarditis could be safely treated with oral antibiotics rather than continued intravenous antibiotics. The trial involved 400 patients across multiple centers in Denmark who had infective endocarditis of the left heart caused by common bacterial species. Patients received either continued intravenous antibiotics according to guidelines or a partial oral antibiotic treatment regimen. The primary outcome was to show non-inferiority of oral treatment. Results showed that oral antibiotic treatment was found to be non-inferior to continued intravenous treatment for stable patients.
A SEEMINGLY BENIGN DRUG IN THE SPOTLIGHT: AN EDUCATIONAL INTERVENTION TO REDU...Khushboo Gandhi
INTRODUCTION
Overutilization of Proton pump inhibitors (PPI) in hospitalized patients is a well-recognized problem. In our previous study at St. Luke’s Hospital, we found that the lack of published guidelines for PPI use in non-critically ill patients results in overutilization of PPI in hospitalized patients. We conducted an educational intervention program to address this problem.
DISCUSSION
Overutilization of PPI in non-critically ill hospitalized patients is a known problem in medical practice. Use of PPI has been implicated in number of adverse consequences including but not limited to Clostridium difficile infection, pneumonia, and osteoporosis. In recent studies, PPI was found to be associated with increased in-hospital mortality, increased risk of cardiovascular events, dementia and chronic renal failure (CRF). We studied the magnitude of the problem in our hospital and employed an educational intervention program, which resulted in a significant reduction of inappropriate use of PPI in the hospital.
There were several limitations to our study. This was a retrospective study where we noted a lack of proper documentation for outpatient use of PPI. We also were unable to precisely determine for how long the patients were taking PPI as outpatients. Our intervention included only medical residents (a total of 41), so we excluded data from NPs, hospitalists or PCPs after intervention. As a result, we are unable to determine the effect of the educational intervention on their practice.
CONCLUSION
PPIs have long been considered as relatively harmless drugs. In recent years, it has been implicated in several adverse effects that increases patient morbidity and mortality along with increased healthcare expenditure. Our data shows that proper education and ongoing surveillance, especially during admission and discharge can significantly reduce overutilization of PPI.
Estimate of the Patients Commitment Concerning Medical Follow-Up with Angina ...AnuragSingh1049
Angina pectoris above referred to as coronary course malady, is caused by the buildup of whittle core the arteries saunter source oxygen-rich blood for the heart. Break in, a mid of broad, cholesterol, and calcium deposits, rear entertain in the arteries over a long time. They are the standard causes of dying in both ripe and evolvement countries, relation for far one third of circa deaths worldwide. All grow pre-eminent groups may die stranger a heart attack. But older kith and kin are in all directions liable to die than younger people.
Elucidative investigate is bump off outside in Al-Sadr Medical City, from January, 7th to May, 6th 2018, in act to review patients' appeal everywhere curative backup adjacent to angina pectoris in Al- Najaf Borough, and to get it out the association between the demographic evidence , clinical information, dance and mercantile statuses, and the patients' pertinence thither Remedial follow-up. A Non-Probability (Purposive Sample) of (50) respecting regard to patients’ angina pectoris, those who visited Al-Sadr therapeutic Megalopolis, the data were composed skim flip the perseverance of the developed questionnaire after the soldiers are estimated, and by means of interview technique. The validity of the questionnaire is propensity look over (9) experts. The data analyzed through the relation of the expository and inferred statistical analysis procedures.
The alertness of the real anatomize specific depart the diversified imputation for the patient’s attention concerning medicinal follow-up with angina pectoris is moderate.
The assay accomplish focus everywhere is a conspicuous reach of the patient's centered of the woe and medicine, and the social and economic low-down, on the patients' commitment to iatrical follow-up with angina pectoris.
The Critique pertinent that benefit Sine qua non be working (e.g., domicile visits, visits outpatient’s of the medical center) may suspended patients to cope with their medical follow-up program. Forced to be the recommendations have in the offing help in the pedagogical resolve wont for patients hence as to improve their commitment. In helper healthiness, oriented pile media betterment should be employed to mass folk familiarity and knowledge of angina pectoris and the importance of the patient’s commitment to medical follow-up. Beyond hegemony of jugs policies which deliver with the monitoring and information the turn the heat on united with the patients' commitment to medical follow-up.
This study evaluated the effectiveness of a classroom intervention aimed at increasing students' knowledge of head safety and positive attitudes towards bicycle helmet use. 74 students ages 11-15 participated. They completed pre-and post-tests on safety knowledge and questionnaires on helmet use attitudes. Before the intervention, most students only wore helmets when forced by parents and few saw them as safety devices. After viewing presentations on head injuries, more students reported being likely to wear helmets. The study concluded the intervention successfully increased safety knowledge and positive helmet attitudes as intended.
Journal club - Disease progression in hemodynamically stable patients present...Farooq Khan
Critical appraisal of:
Glickman SW et al. Disease Progression in Hemodynamically Stable Patients Presenting to the Emergency Department With Sepsis. Acad Emerg Med. 2010 17:383-90
Interactive quiz on early goal-directed therapy, surviving sepsis guidelines and EBM topic of prognosis studies.
An audit was conducted of ward nurses' knowledge of sepsis definitions and management guidelines. A questionnaire was administered to 73 ward nurses which assessed their understanding of the signs and symptoms of sepsis, as well as case studies depicting potential sepsis patients. The results showed that some nurses had a poor understanding of the standard definitions of sepsis, severe sepsis/septic shock and recommended initial management. In response, targeted educational initiatives were implemented to improve nurses' knowledge of sepsis definitions and management guidelines put forth by the Surviving Sepsis Campaign. The study concluded that focused education for ward nurses is needed if the goal of reducing sepsis mortality by 25% is to be achieved.
Organ support during critical illness requires considering many factors: 1) when to start support and how much is needed, 2) safety, costs and technology considerations, 3) appropriate monitoring, and 4) determining when to discontinue support. Essential measures like checklists, early goal-directed therapy, and focusing on basic supportive interventions can help optimize outcomes for critically ill patients.
EBM is the practice of integrating individual clinical expertise with the best available clinical evidence from systematic research to maximize the quality and quantity of life for individual patients.
New Perspectives on Alzheimer’s Disease and NutritionNutricia
This document summarizes a roundtable discussion on the role of nutrition in Alzheimer's disease (AD). The discussion focused on how being overweight or obese in midlife may increase the risk of developing AD decades later, though evidence is conflicting. After midlife, higher body weight and BMI are associated with lower dementia risk. Weight loss and underweight in late life are linked to higher dementia risk. The natural trajectory of BMI over the lifespan differs between those who do and do not develop dementia. Changes in BMI and weight loss may also be associated with clinical progression of AD. Further research is needed to better understand these complex relationships between nutritional status and AD risk and progression.
Physician burnout is a significant problem, with nearly half of physicians experiencing at least one symptom of burnout. Primary care physicians, especially those in family medicine, internal medicine, and emergency medicine, have the highest rates of burnout. However, physicians spend less than half (45%) of their time in direct patient care activities, with the rest spent on tasks like documentation, care coordination, and follow up for patients not present. New models are needed that leverage technology, protocols, and team-based care to automate tasks and delegate work to reduce burdens on physicians in order to address burnout and make primary care sustainable.
A talk by Pratik Pandharipande at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All of the conference content can be found here: https://scanfoam.org/ssai2017/
Developed in collaboration between scanFOAM, SSAI and SFAI.
What WikiCite can learn from biomedical citation networks--Wikicite2017--2017...jodischneider
This is a quick, high-level tour of some ideas from evidence-based medicine, citation-related ontologies for argumentation and evidence curation and biomedicine.
Efficacy of a medical food in mild Alzheimer’s disease: A randomized, control...Nutricia
1. This randomized, double-blind, controlled trial investigated the effects of a medical food supplement called Souvenaid on cognitive function in 225 patients with mild Alzheimer's disease over 12 weeks.
2. The study found a statistically significant improvement in delayed verbal recall, the primary outcome measure, in the group receiving Souvenaid compared to the control group at 12 weeks.
3. Secondary measures of cognitive function, behavior, functional abilities, and quality of life did not differ between the groups. The medical food was well-tolerated with high compliance among patients.
This summary provides the key information from the document in 3 sentences:
The document discusses a systematic review conducted to identify health state values for Huntington's disease (HD) reported in published literature. Only two papers were found that reported health state values for HD using the EQ-5D instrument. The review assessed the methods used to obtain health state values and investigated the content validity of the EQ-5D for measuring quality of life in people with HD.
The document provides an overview of the Canadian Consensus Document on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). It summarizes the development of the consensus document, which was spearheaded by the National ME/FM Action Network of Canada in response to the need for a clinical case definition and guidelines for diagnosis and treatment of ME/CFS. An expert panel of 11 clinicians and researchers with experience treating over 20,000 ME/CFS patients was selected to develop the consensus document. The panel held a funded workshop to reach consensus on a clinical case definition, diagnostic guidelines, and treatment guidelines for medical practitioners dealing with ME/CFS patients.
Fluid balance is a determining factor of mortality in patients with sepsis and septic shock. A prospective study of 42 critically ill patients with severe sepsis or septic shock found that those who did not survive (nonsurvivors) had higher accumulated positive fluid balances at 48, 72, and 96 hours compared to survivors. The risk of mortality was significantly higher for patients with over 2.5L of accumulated fluid balance at 72 hours. While initial fluid resuscitation is important, the results suggest that excessive positive fluid balances later in treatment are associated with worse outcomes for patients with severe sepsis or septic shock.
PCORI utilizes a topic pathway approach to select and prioritize comparative effectiveness research topics nominated by multiple stakeholders. This project analyzed submitted topics, mapped them to US health burdens, and conducted evidence reviews. Topics were analyzed based on primary diseases/conditions, populations, and interventions. Mapping identified which nominated topics addressed the top 10 causes of death and calculated disease prevalence, DALYs, and economic costs. Results from this analysis will help PCORI identify and prioritize new topics for funding announcements by providing evidence on existing research gaps.
This study evaluated the relationship between Emergency Severity Index (ESI) triage scores, pain medication selection, and timeliness of pain medication administration. The records of 1,966 emergency department patients who received opioid pain medication were analyzed. While there were no significant differences in time to pain medication across ESI levels, patients given higher ESI scores (greater acuity) received stronger opioids more often than those with lower scores. The type of opioid administered differed significantly based on ESI level. However, ESI level was not related to timeliness of pain medication administration.
This study examined disseminated intravascular coagulation (DIC) scores on day 1 and day 3 in sepsis patients and their association with mortality. The incidence of overt DIC was 27.9% on day 1 and 30.1% on day 3. While day 1 and 3 DIC scores were not associated with mortality, the change in DIC score between days was significantly associated with mortality. Patients with pneumonia had lower DIC on day 1 but higher mortality than other sepsis patients. Day 3 DIC scores predicted mortality more accurately than day 1 scores, especially for non-pneumonia sepsis patients.
This document summarizes recent research on treatments for acute spinal cord injuries. It discusses approaches such as neuroprotection, regeneration, transplantation, and rehabilitation that have been areas of focus. For neuroprotection, it reviews studies on methylprednisolone and other anti-inflammatory strategies. For regeneration, it discusses inhibiting glial scar formation and replacing damaged cells through transplantation of Schwann cells, olfactory ensheathing cells, and neural stem cells. However, it notes that while animal studies show promise for many of these approaches, there remain limitations and no proven therapies currently exist for acute spinal cord injuries.
Comparative Studies of Diabetes in Adult Nigerians Lipid Profile and Antioxid...YogeshIJTSRD
The study sought to determine the extent to which the usage of social media in the marketing of agricultural products in South West Nigeria can enhance farmers turnover. It employed the survey research design to collect data with the help of a structured questionnaire to elicit information from respondents selected from six 6 south western states. Research data were analysed using structural equation modelling. The results showed that the use of social media WhatsApp and Facebook in marketing of agricultural products significantly enhances farmers turnover. The managerial implication is that use of Whatsapp and Facebook in the marketing of agricultural products for the enhancement of farmers’ turnover was found to have significant influence on the enhancement in farmers’ turnover from agricultural products. Policy makers in government should provide the enabling environment for the telecommunication companies to enhance their reach by installing their facilities across the length and breadth of the country so that the network coverage will be strong at all times so that the benefits of social media usage will not be constrained. Egejuru, Leonard O | Akubugwo, Emmanuel I | Ugorji, Beatrice N "Comparative Studies of Diabetes in Adult Nigerians: Lipid Profile and Antioxidants Vitamins (A and C)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45021.pdf Paper URL: https://www.ijtsrd.com/biological-science/biochemistry/45021/comparative-studies-of-diabetes-in-adult-nigerians-lipid-profile-and-antioxidants-vitamins-a-and-c/egejuru-leonard-o
This document summarizes a study that assessed the quality of life of 100 glaucoma patients using the WHOQOL-Bref questionnaire. The study found that glaucoma patients had significantly lower quality of life scores than healthy controls in the physical, mental, social, and environmental domains. Among socio-demographic factors, quality of life was lower in older patients and those with lower socioeconomic status. Several clinical factors, such as severity of glaucoma, were also associated with lower quality of life. The study concludes that glaucoma significantly impacts patients' quality of life and that socio-demographic and clinical factors should be considered in glaucoma management.
2006 presentation at The European Health Psychology Conference in Bath: Can We Bury the Idea That Psychotherapy Extends the survival of Cancer Patients?
A Study On Clinical Profile Of Sepsis Patients In Intensive Care Unit Of A Te...dbpublications
Background : Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection which is one of the most important cause of mortality & morbidity in critically ill patients. In this study clinical profiles of the sepsis patients admitted in ICU in this part of India have been evaluated. Methods & Materials: This prospective hospital based observational study was undertaken in the department of Emergency Medicine ICU of Gauhati Medical College & Hospital, over a period of one year from August 2014 to July 2015 after obtaining institutional ethical committee clearance.
RESULTS: Clinical profiles of 50sepsis patients, with male preponderance (56%) & mortality rate 36% were studied. Mean age was 48.36 years (SD ±17.16). fever & tachycardia were present in all patients. 30 patients (60%) required ventilatory support, 28 patients (56%) required inotropic support, 10 patients (20%) required dialysis. Gram negative bacteria were found to be the predominant pathogens associated with sepsis(73.4%) where most common organism responsible was Klebsiella (36.8%). Conclusion : assessment of clinical signs & initial serological & radiological investigations are of utmost importance to detect more critically ill patients as early as possible to intervene earlier for saving the life of the sepsis patients.
The study profiles renal failure patients undergoing hemodialysis at B.P. Koirala Institute of Health Sciences in Nepal. It found that the majority of patients were male (74%), Hindu (93%), and from very poor communities (80%). Many patients had little knowledge about their disease, with 30% unaware of what condition they had. The most common complication reported during dialysis was nausea and vomiting (20%), followed by hypotension (9%). The study aims to help improve management and prevention of renal failure in Nepal by providing insight into patients' socio-demographic characteristics and knowledge about their treatment.
Jesse Crump is a business and technology instructor seeking a management position. He has 8 years of customer service experience in roles with instruction and leadership responsibilities. Currently, he teaches at Stanly Community College and holds a Bachelor's in Business Management and Leadership, pursuing a Master of Science in Leadership. His experience includes roles in general contracting, flooring sales, tutoring, and customer service.
Pai Peng is an experienced manager and CPA candidate seeking to leverage her skills in team leadership, client relations, and financial analysis. She has a Master's in Accountancy and is eligible to work in the US without sponsorship. Her experience includes managing a translation studio, developing new clients, and assisting with financial reporting and consolidated statements as an accounting intern.
Organ support during critical illness requires considering many factors: 1) when to start support and how much is needed, 2) safety, costs and technology considerations, 3) appropriate monitoring, and 4) determining when to discontinue support. Essential measures like checklists, early goal-directed therapy, and focusing on basic supportive interventions can help optimize outcomes for critically ill patients.
EBM is the practice of integrating individual clinical expertise with the best available clinical evidence from systematic research to maximize the quality and quantity of life for individual patients.
New Perspectives on Alzheimer’s Disease and NutritionNutricia
This document summarizes a roundtable discussion on the role of nutrition in Alzheimer's disease (AD). The discussion focused on how being overweight or obese in midlife may increase the risk of developing AD decades later, though evidence is conflicting. After midlife, higher body weight and BMI are associated with lower dementia risk. Weight loss and underweight in late life are linked to higher dementia risk. The natural trajectory of BMI over the lifespan differs between those who do and do not develop dementia. Changes in BMI and weight loss may also be associated with clinical progression of AD. Further research is needed to better understand these complex relationships between nutritional status and AD risk and progression.
Physician burnout is a significant problem, with nearly half of physicians experiencing at least one symptom of burnout. Primary care physicians, especially those in family medicine, internal medicine, and emergency medicine, have the highest rates of burnout. However, physicians spend less than half (45%) of their time in direct patient care activities, with the rest spent on tasks like documentation, care coordination, and follow up for patients not present. New models are needed that leverage technology, protocols, and team-based care to automate tasks and delegate work to reduce burdens on physicians in order to address burnout and make primary care sustainable.
A talk by Pratik Pandharipande at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All of the conference content can be found here: https://scanfoam.org/ssai2017/
Developed in collaboration between scanFOAM, SSAI and SFAI.
What WikiCite can learn from biomedical citation networks--Wikicite2017--2017...jodischneider
This is a quick, high-level tour of some ideas from evidence-based medicine, citation-related ontologies for argumentation and evidence curation and biomedicine.
Efficacy of a medical food in mild Alzheimer’s disease: A randomized, control...Nutricia
1. This randomized, double-blind, controlled trial investigated the effects of a medical food supplement called Souvenaid on cognitive function in 225 patients with mild Alzheimer's disease over 12 weeks.
2. The study found a statistically significant improvement in delayed verbal recall, the primary outcome measure, in the group receiving Souvenaid compared to the control group at 12 weeks.
3. Secondary measures of cognitive function, behavior, functional abilities, and quality of life did not differ between the groups. The medical food was well-tolerated with high compliance among patients.
This summary provides the key information from the document in 3 sentences:
The document discusses a systematic review conducted to identify health state values for Huntington's disease (HD) reported in published literature. Only two papers were found that reported health state values for HD using the EQ-5D instrument. The review assessed the methods used to obtain health state values and investigated the content validity of the EQ-5D for measuring quality of life in people with HD.
The document provides an overview of the Canadian Consensus Document on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). It summarizes the development of the consensus document, which was spearheaded by the National ME/FM Action Network of Canada in response to the need for a clinical case definition and guidelines for diagnosis and treatment of ME/CFS. An expert panel of 11 clinicians and researchers with experience treating over 20,000 ME/CFS patients was selected to develop the consensus document. The panel held a funded workshop to reach consensus on a clinical case definition, diagnostic guidelines, and treatment guidelines for medical practitioners dealing with ME/CFS patients.
Fluid balance is a determining factor of mortality in patients with sepsis and septic shock. A prospective study of 42 critically ill patients with severe sepsis or septic shock found that those who did not survive (nonsurvivors) had higher accumulated positive fluid balances at 48, 72, and 96 hours compared to survivors. The risk of mortality was significantly higher for patients with over 2.5L of accumulated fluid balance at 72 hours. While initial fluid resuscitation is important, the results suggest that excessive positive fluid balances later in treatment are associated with worse outcomes for patients with severe sepsis or septic shock.
PCORI utilizes a topic pathway approach to select and prioritize comparative effectiveness research topics nominated by multiple stakeholders. This project analyzed submitted topics, mapped them to US health burdens, and conducted evidence reviews. Topics were analyzed based on primary diseases/conditions, populations, and interventions. Mapping identified which nominated topics addressed the top 10 causes of death and calculated disease prevalence, DALYs, and economic costs. Results from this analysis will help PCORI identify and prioritize new topics for funding announcements by providing evidence on existing research gaps.
This study evaluated the relationship between Emergency Severity Index (ESI) triage scores, pain medication selection, and timeliness of pain medication administration. The records of 1,966 emergency department patients who received opioid pain medication were analyzed. While there were no significant differences in time to pain medication across ESI levels, patients given higher ESI scores (greater acuity) received stronger opioids more often than those with lower scores. The type of opioid administered differed significantly based on ESI level. However, ESI level was not related to timeliness of pain medication administration.
This study examined disseminated intravascular coagulation (DIC) scores on day 1 and day 3 in sepsis patients and their association with mortality. The incidence of overt DIC was 27.9% on day 1 and 30.1% on day 3. While day 1 and 3 DIC scores were not associated with mortality, the change in DIC score between days was significantly associated with mortality. Patients with pneumonia had lower DIC on day 1 but higher mortality than other sepsis patients. Day 3 DIC scores predicted mortality more accurately than day 1 scores, especially for non-pneumonia sepsis patients.
This document summarizes recent research on treatments for acute spinal cord injuries. It discusses approaches such as neuroprotection, regeneration, transplantation, and rehabilitation that have been areas of focus. For neuroprotection, it reviews studies on methylprednisolone and other anti-inflammatory strategies. For regeneration, it discusses inhibiting glial scar formation and replacing damaged cells through transplantation of Schwann cells, olfactory ensheathing cells, and neural stem cells. However, it notes that while animal studies show promise for many of these approaches, there remain limitations and no proven therapies currently exist for acute spinal cord injuries.
Comparative Studies of Diabetes in Adult Nigerians Lipid Profile and Antioxid...YogeshIJTSRD
The study sought to determine the extent to which the usage of social media in the marketing of agricultural products in South West Nigeria can enhance farmers turnover. It employed the survey research design to collect data with the help of a structured questionnaire to elicit information from respondents selected from six 6 south western states. Research data were analysed using structural equation modelling. The results showed that the use of social media WhatsApp and Facebook in marketing of agricultural products significantly enhances farmers turnover. The managerial implication is that use of Whatsapp and Facebook in the marketing of agricultural products for the enhancement of farmers’ turnover was found to have significant influence on the enhancement in farmers’ turnover from agricultural products. Policy makers in government should provide the enabling environment for the telecommunication companies to enhance their reach by installing their facilities across the length and breadth of the country so that the network coverage will be strong at all times so that the benefits of social media usage will not be constrained. Egejuru, Leonard O | Akubugwo, Emmanuel I | Ugorji, Beatrice N "Comparative Studies of Diabetes in Adult Nigerians: Lipid Profile and Antioxidants Vitamins (A and C)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45021.pdf Paper URL: https://www.ijtsrd.com/biological-science/biochemistry/45021/comparative-studies-of-diabetes-in-adult-nigerians-lipid-profile-and-antioxidants-vitamins-a-and-c/egejuru-leonard-o
This document summarizes a study that assessed the quality of life of 100 glaucoma patients using the WHOQOL-Bref questionnaire. The study found that glaucoma patients had significantly lower quality of life scores than healthy controls in the physical, mental, social, and environmental domains. Among socio-demographic factors, quality of life was lower in older patients and those with lower socioeconomic status. Several clinical factors, such as severity of glaucoma, were also associated with lower quality of life. The study concludes that glaucoma significantly impacts patients' quality of life and that socio-demographic and clinical factors should be considered in glaucoma management.
2006 presentation at The European Health Psychology Conference in Bath: Can We Bury the Idea That Psychotherapy Extends the survival of Cancer Patients?
A Study On Clinical Profile Of Sepsis Patients In Intensive Care Unit Of A Te...dbpublications
Background : Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection which is one of the most important cause of mortality & morbidity in critically ill patients. In this study clinical profiles of the sepsis patients admitted in ICU in this part of India have been evaluated. Methods & Materials: This prospective hospital based observational study was undertaken in the department of Emergency Medicine ICU of Gauhati Medical College & Hospital, over a period of one year from August 2014 to July 2015 after obtaining institutional ethical committee clearance.
RESULTS: Clinical profiles of 50sepsis patients, with male preponderance (56%) & mortality rate 36% were studied. Mean age was 48.36 years (SD ±17.16). fever & tachycardia were present in all patients. 30 patients (60%) required ventilatory support, 28 patients (56%) required inotropic support, 10 patients (20%) required dialysis. Gram negative bacteria were found to be the predominant pathogens associated with sepsis(73.4%) where most common organism responsible was Klebsiella (36.8%). Conclusion : assessment of clinical signs & initial serological & radiological investigations are of utmost importance to detect more critically ill patients as early as possible to intervene earlier for saving the life of the sepsis patients.
The study profiles renal failure patients undergoing hemodialysis at B.P. Koirala Institute of Health Sciences in Nepal. It found that the majority of patients were male (74%), Hindu (93%), and from very poor communities (80%). Many patients had little knowledge about their disease, with 30% unaware of what condition they had. The most common complication reported during dialysis was nausea and vomiting (20%), followed by hypotension (9%). The study aims to help improve management and prevention of renal failure in Nepal by providing insight into patients' socio-demographic characteristics and knowledge about their treatment.
Jesse Crump is a business and technology instructor seeking a management position. He has 8 years of customer service experience in roles with instruction and leadership responsibilities. Currently, he teaches at Stanly Community College and holds a Bachelor's in Business Management and Leadership, pursuing a Master of Science in Leadership. His experience includes roles in general contracting, flooring sales, tutoring, and customer service.
Pai Peng is an experienced manager and CPA candidate seeking to leverage her skills in team leadership, client relations, and financial analysis. She has a Master's in Accountancy and is eligible to work in the US without sponsorship. Her experience includes managing a translation studio, developing new clients, and assisting with financial reporting and consolidated statements as an accounting intern.
Honglin Chen is a sophomore at Southern Methodist University majoring in finance and statistics with a 4.0 major GPA. He has experience as an event planner in China organizing parties for 6,000 people and as an intern at an insurance brokerage reading and editing forms. At SMU, he serves as vice president of public relations for the Chinese Student Union and is a campus ambassador for an online tuition payment platform.
This document contains Elva Nelly Garcia's contact information, objectives, employment history, computer skills, and reference. Garcia's objective is to pursue professional growth opportunities utilizing her skills. Her employment history includes customer service roles at Metro PCS, Tisun Beauty, and IBeauty 210 while in high school. She has computer skills including being bilingual, proficient in Microsoft Word and PowerPoint, and strong communication abilities. Haley, a former manager at Tisun Beauty, is listed as a reference that can be contacted.
Caroline Allen has over 10 years of experience in customer service, office operations, personnel management, and clinical work. She has a Bachelor's degree in Healthcare Administration and certificates in medical coding and massage therapy. Her skills include maintaining patient records, submitting insurance claims, administering a practice management software system, and providing clinical services such as physical therapy and massage therapy. She is currently seeking a position that utilizes her leadership, problem-solving, and strong administrative and customer service abilities.
Tiphanie Doucet is a French-American actress, singer, and dancer based in New York and Paris. She has performed in both musical theatre and film/television in roles such as Margaux in Uncle Tom vs Uncle Sam and Oceane in the French TV series Chante. Her training includes studies at the American Musical and Dramatic Academy as well as the Musician Institute. She is fluent in English and French with skills in dance, voice, and multiple instruments.
This document is a resume for Tin Tran. It summarizes his education, work experience, volunteer activities, languages, and interests. He is currently studying Radiation Therapy at Massachusetts College of Pharmacy and Health Science and expects to graduate in August 2018. He has worked as a pharmacy technician at CVS Pharmacy since 2014 where he assists customers, collects patient data, assembles and delivers medicines, and maintains inventory. In his free time, he has volunteered for numerous community organizations and plays intramural sports.
Patient-Reported Outcomes: Does Stigma Affect the Quality of Life of Patients...semualkaira
The degree to which stigma affects the
health-related quality of life (HRQoL) of patients with chronic
hepatitis B (CHB)-related diseases is not known. We evaluated the
HRQoL of patients with CHB-related disease and identified stigma
associated with HRQoL
Depression Involved in the Chemotherapy Induced Event-based Prospective Memor...IJEAB
The aim of this study was to investigate the relationships between depression and occurrence of chemotherapy induced prospective memory impairment in patients with breast cancer (BC).The 63 BC patients before and after chemotherapy were administered with the self-rating depression scale (SDS) and a battery of cognitive neuropsychological tests including event-based and time-based prospective memory (EBPM and TBPM, respectively) tasks. The changes in their prospective memory and cognitive neuropsychological characteristics before and after chemotherapy were compared. Compared with the scores before chemotherapy, the EBPM score exhibited a statistically significant difference after chemotherapy (t = 6.069, P < 0.01), while the TBPM score showed no significant difference (t = 1.087, P > 0.05). Further, compared with the patients without depression, the patients with depression exhibited a statistically significant difference in the EBPM score (t = -4.348, P < 0.01), while the TBPM scores did not show a statistically significant difference between the two groups (t = -1.260, P > 0.05). Post-chemotherapy, EBPM and overall cognitive functions in BC patients merged with depression were found to decline, while TBPM did not show a significant change, suggesting that the combination of chemotherapy and depression might be related with the occurrence of post-chemotherapy EBPM impairment.
The document summarizes a study that assessed the validity of using the PHQ-2 and PHQ-9 questionnaires to screen for and diagnose depression in a rural area of Chiapas, Mexico. The study found that:
1) Confirmatory factor analysis suggested the 1-factor structure of the PHQ-9 fit the data reasonably well.
2) The PHQ-9 showed good internal consistency and validity, with participants diagnosed with depression having lower quality of life scores.
3) Using the PHQ-9 as the standard, the optimal cutoff for the PHQ-2 to screen for depression was a score of 3, with a sensitivity of 80% and specificity of 86.8%.
The diagnosis of dementia due to Alzheimer’s diseaseDario Yac
The document presents revised criteria for diagnosing Alzheimer's disease (AD) dementia put forth by a workgroup convened by the National Institute on Aging and the Alzheimer's Association. The summary is:
1. The workgroup updated the 1984 NINCDS-ADRDA criteria for AD dementia to incorporate advances in understanding of AD pathology and clinical presentation, as well as biomarkers.
2. The revised criteria distinguish between all-cause dementia, probable AD dementia based on clinical criteria alone, and probable or possible AD dementia when biomarkers are also considered.
3. Probable AD dementia requires a gradual onset of cognitive decline in one of several domains including memory, language, visuospatial skills or executive function.
Depresi dan bunuh diri sebagai masalah kesehatan mental yang lazim untuk pasien hemodialisis. Tujuan: Para penulis meneliti faktor-faktor demografi dan psikologis yang terkait dengan depresi pada pasien hemodialisis dan dijelaskan hubungan antara depresi, kecemasan, kelelahan, kualitas kesehatan yang berhubungan hidup yang buruk, dan meningkatkan risiko bunuh diri.
Long-Term Outcome in Adults with Obsessive-Compulsive DisorderChristy Green
This study examined the long-term outcomes of 83 adults with obsessive-compulsive disorder (OCD) who were originally enrolled in placebo-controlled trials of serotonin reuptake inhibitors (SRIs) for OCD treatment between 10-20 years prior. The study found that only 20% of subjects had experienced remission of their OCD symptoms, while 49% still had clinically significant OCD symptoms. Initial response to SRI pharmacotherapy strongly predicted long-term outcome, with those who initially responded to SRIs more likely to experience remission over the long term. The study did not find an association between long-term outcome and OCD symptom dimensions.
This study assessed outcomes of physical therapy and surgery for 150 patients with neurogenic thoracic outlet syndrome (NTOS) using patient-reported measures. 40 patients (27%) had satisfactory improvement with a 6-week physical therapy trial, while 90 (60%) underwent surgery after physical therapy failed. Patients who underwent surgery had greater reductions in disability scores and better patient-rated outcomes compared to those who received only physical therapy. However, pre-treatment factors did not reliably predict who would benefit from each treatment. This study provides information on contemporary outcomes for physical therapy and surgery for NTOS.
Palliative care could help improve the quality of life for Parkinson’s diseas...Δρ. Γιώργος K. Κασάπης
A small study of individuals with Parkinson’s disease finds that adding palliative care to standard care may help raise their quality of life. Half the patients in a 210-person trial were assigned to visit physicians as usual, while the others also received palliative care — a team of a social worker, nurse, palliative medicine specialist, and chaplain visited the patient at home or via telemedicine to discuss symptoms and difficult emotions and offer support to caregivers. Patients in the combination care group had more improvement in their quality of life score (as measured by a survey that assesses physical and mental health).
These patients also scored higher on quality of life measures when their caregivers were surveyed in their stead.
Improving Comprehensive Carefor OEF and OIF Vetsby Aslie.docxbradburgess22840
Improving Comprehensive Care
for OEF and OIF Vets
by Aslie Burnett
FILE
T IME SUBMIT T ED 20- MAR- 2015 10:4 4 AM
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Improving Comprehensive Care for OEF and OIF Vets
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Karen H. Seal. "VA mental health services
utilization in Iraq and Af ghanistan veterans in
the f irst year of receiving new mental health
diagnoses", Journal of Traumatic Stress, 2010
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onlinelibrary.wiley.com
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patriotoutreach.org
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Ticknor, Bobbie and Tillinghast, Sherry. "Virtual
Reality and the Criminal Justice System: New
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Rehabilitation", Journal of Virtual Worlds
Research, 2011.
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digital.library.adelaide.edu.au
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Yelena Bogdanova. "Cognitive Sequelae of
Blast-Induced Traumatic Brain Injury: Recovery
and Rehabilitation", Neuropsychology Review,
02/17/2012
Publicat ion
Nanda, U., H. L. B. Gaydos, K. Hathorn, and N.
Watkins. "Art and Posttraumatic Stress: A
Review of the Empirical Literature on the
Therapeutic Implications of Artwork f or War
Veterans With Posttraumatic Stress Disorder",
Environment and Behavior, 201.
Evaluation of Level of Anxiety among the Patients of Hip OsteoarthritisBRNSSPublicationHubI
The study evaluated anxiety levels among 98 patients with hip osteoarthritis in Pakistan. Most patients were female (57.1%) and from rural areas (68.3%). When assessing anxiety, 44.8% of patients reported moderate anxiety and 25.5% reported severe anxiety. The study determined that patients with hip osteoarthritis generally experienced moderate anxiety levels due to factors like pain limiting physical activity and independence, concerns about disability progression, and impacts on socioeconomic status from reduced work ability.
Abstract—Prevalence of degenerative dementias and dementias associated with cerebrovascular disease is increasing with the time. Dementia is one of the most significant public health problems. Demographic data, medical history, general biochemical data and serum total homocysteine (tHcy) levels was used in this study to examine the differences between dementia and normal control groups. A cross-sectional study was conducted on 236 individuals who were above the age of 65 years. These participants went through the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), demographic characteristics, biochemical data and tHcy level. Each of the above mentioned factors was assessed. There were significant differences in the history of hypertension, diabetes mellitus, marital status, alcohol consumption (AC), BMI value, and triglyceride (TG) and serum tHcy levels. The logistic regression analysis showed significant differences in marital status, AC and tHcy. So it can be concluded that elevated serum tHcy, no AC and no partner are associated with the risk of dementia in elders of Southern Taiwan. It needs further researches to identify and reduce the risk of dementia.
Does Liuzijue Qigong affect anxiety in patients with chronic obstructive pulm...LucyPi1
Abstract Background: Anxiety is a common comorbidity associated with chronic obstructive pulmonary disease (COPD), but no well-recognized method can provide effective relief. Liuzijue Qigong (LQG) is a traditional Chinese fitness method, based on breath pronunciation. This study aimed to examine the efficacy of LQG to relieve anxiety in COPD patients and to explore the factors that influence anxiety, including whether LQG is effective during the coronavirus disease 2019 (COVID-19) outbreak. Methods: We conducted an open-label, randomized, controlled, clinical trial. A total of 60 patients with stable COPD were randomly assigned to two groups. Both groups were given routine medical treatment, and the patients in the pulmonary rehabilitation (PR) group were given an extra intervention in the form of LQG, performed for 30 minutes each day for 12 weeks. Data collection was performed at baseline and 12 weeks (during the COVID-19 epidemic). The primary outcomes were the self-rating anxiety scale (SAS) scores, and the secondary outcomes were relevant information during the epidemic and analyses of the related factors that influenced SAS scores during the COVID-19 outbreak. Results: Compared with baseline, patients in both groups demonstrated varying degrees of improvements in their SAS scores (all P < 0.01). An analysis of covariance, adjusted for baseline scores, indicated that the SAS scores improved more dramatically in the PR group than in the control group (F = 9.539, P = 0.004). During the outbreak, the SAS scores for sleep disorder were higher than all other factors, reaching 1.38 ± 0.67, and the scores for “I can breathe in and out easily” for the PR group were lower than the scores for the control group (Z = −2.108, P = 0.035). Significant differences were identified between the two groups for the categories “How much has the outbreak affected your life”, “Do you practice LQG during the epidemic” and “Do you practice other exercises during the epidemic” (all P < 0.05). Compared with current reports, LQG had a relatively high adherence rate (80.95%). A multiple linear regression analysis revealed multiple predictors for SAS scores during the outbreak: group (b = −3.907, t = −3.824, P < 0.001), COPD assessment test score (b = 0.309, t = 2.876, P = 0.006), SAS score at baseline (b = 0.189, t = 3.074, P = 0.004), and living in a village (b = 4.886, t = 2.085, P = 0.043). Conclusion: LQG could effectively reduce the risks of anxiety among COPD patients, even during the COVID-19 outbreak. For those COPD patients with high COPD assessment test and high baseline SAS scores or who live in villages, we should reinforce the management and intervention of psychological factors during the epidemic.
This study analyzed genetic sequences of HIV-1 subtype C tat and env genes from blood samples of 155 HIV-infected patients in India who underwent neuropsychological testing. Around 36% of patients showed neurocognitive impairment. Two signature residues were identified in tat exon 1 that were associated with impairment - arginine at codon 29 and proline at codon 68. Positive selection was seen at these codons in both impaired and normal groups. The signatures were also linked to lower CD4+ counts but remained associated with impairment after excluding those with low CD4+. No unique signatures were found in env. This supports a link between diversifying selection in subtype C tat and neurocognitive impairment in this population.
This case report describes a 35-year-old female patient who was diagnosed with schizophrenia. She presented with symptoms of sleep disturbances, loss of appetite, hallucinations, and hearing voices. Her symptoms had gradually worsened over the past 1.5 years. After examination, she was diagnosed with schizophrenia and admitted to the hospital for treatment. Her treatment included antipsychotic medications, antidepressants, family therapy, yoga, and cognitive behavioral therapy. With this comprehensive treatment, her symptoms minimized and she was eventually discharged from the hospital with ongoing monitoring. The case report aims to demonstrate the identification and treatment of schizophrenia symptoms.
The document summarizes 10 research breakthroughs from the last decade that support chiropractic care. Some of the key findings include:
1) Seeing a chiropractor as a first contact provider was associated with decreases in hospital admissions, days, surgeries, and pharmaceutical costs compared to conventional medicine.
2) One study found that upper cervical chiropractic care was associated with marked and sustained reductions in blood pressure similar to two-drug combination therapy.
3) A wellness program implemented by chiropractors improved various health metrics such as weight, blood pressure, and strength.
The document concludes that these and other studies provide evidence that chiropractic care can positively impact multiple dimensions
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tests for analysis of different pharmaceutical.pptx
ACS 2013_DC_Abstract_SONG LIU_et al.
1. ACS Clinical Congress, Washington DC, Oct. 2013. SONG LIU, et al.
Copyrights reserved by all authors. 1
Psychological factors correlated with health-related quality of life (HRQoL) and
should be taken into consideration in evaluation of clinical outcome in Chinese
patients with Crohn’s disease
Song Liu1, 2, &
, MD; Jianan Ren1, *
, MD, PhD, FACS; Zhiwu Hong1, &
, MD; Xiaoting Li3
,
BN; Min Yao4
, MD, MPH; Dongsheng Yan1
, MD; Huajian Ren1
, MD; Xiuwen Wu1
, MD,
PhD; Gefei Wang1
, MD, PhD; Guosheng Gu1
, MD, PhD; Qiuyuan Xia5
, MD; Gang Han6
,
MD; Jieshou Li1
, MD.
1
Department of Surgery, Jinling Hospital, Medical School of Nanjing University,
Nanjing, China
2
Center for the Study of Inflammatory Bowel Disease, GI Unit, Department of Medicine,
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
3
Department of Surgery, Jinling Hospital, Nursing College, Nanjing University of
Chinese Medicine, Nanjing, China
4
Department of Surgery, Limb Preservation and Wound Care Research, VA New
England Health Care Division, Providence, RI, USA
5
Department of Pathology, Jinling Hospital, Medical School of Nanjing University,
Nanjing, China
6
Department of General Surgery, Second Affiliated Hospital of Jilin University, General
Surgery Center of Jilin University, Changchun, China
2. ACS Clinical Congress, Washington DC, Oct. 2013. SONG LIU, et al.
Copyrights reserved by all authors. 2
*
Correspondence to: Dr. Jianan Ren, MD, PhD, FACS, 305 East Zhongshan RD,
Nanjing, 210002, China. (Tel) +86-25-80860108; (E-mail) JiananR@gmail.com
&
These authors contribute equally to this work.
Conflict of interest: all authors declare no conflict of interest
Source of grants and fundings: This work was supported by grants from National
Natural Science Foundation of China, No.81270478 (J.R.); Climbing Program in Natural
Science Foundation of Jiangsu Province for Distinguished Scholars No.BK2010017
(J.R.); High-Level Personnel Training Project, No. BRA2011232 (J.R.), and Chinese
Scholarship Council (award to S.L. for study at Massachusetts General Hospital, Harvard
Medical School).
3. ACS Clinical Congress, Washington DC, Oct. 2013. SONG LIU, et al.
Copyrights reserved by all authors. 3
Abstract
Background Health-related quality of life (HRQoL) is recommended as one of essential
parameters to evaluate treatment effect and clinical outcome in patients with Crohn’s
disease (CD). Recent studies reported that psychological factors might play a role in
HRQoL in CD patients. This study is dedicated to investigate the correlation of various
psychological factors with HRQoL and their potential impact on clinical outcome
evaluation in Chinese patients with CD.
Methods Forty active CD and 40 quiescent CD patients were prospectively enrolled.
Validated Inflammatory Bowel Disease Questionnaire (IBDQ), Neuroticism (N) and Lie
(L) subscale of the Eysenck Personality Inventory (EPI), Hospital Anxiety and
Depression Scale (HADS) and Buss-Perry Aggression (BPA) questionnaire were
completed by each participant.
Results Neuroticism, anxiety and depression were correlated well with IBDQ and its
subscales in both active and quiescent CD groups. In quiescent CD group, neuroticism
could predict IBDQ, IBDQ emotional function and IBDQ bowel function while anxiety
could predict IBDQ systemic symptom. In active CD group, IBDQ emotional function
could be predicted by both neuroticism and anxiety while other IBDQ and its subscales
could be predicted by neuroticism independently.
Conclusions Psychological factors, especially neuroticism and anxiety, significantly
correlate with HRQoL in both active and quiescent CD patients, and should be taken into
4. ACS Clinical Congress, Washington DC, Oct. 2013. SONG LIU, et al.
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account when using IBDQ to evaluate HRQoL and clinical outcome in CD patients.
Continued researches to identify predictors of HRQoL in CD are expected in the future to
enhance our capacity to design interventions to improve HRQoL and maximize health
outcomes.
Keywords:
Crohn’s disease; Inflammatory bowel disease; personality; psychological; healthy-related
quality of life; HRQoL
ClinicalTrial.gov Registration Number: NCT01887548