here in this slide a case of abdominal pain or colitis has been studied. Questions and answrs of case is given in these slides.

1. AbdominalPain
or
Colitis
Submitted By :
Abu Bakr Ansari
Pharm. D 5th Year
Roll No. 1601096001
Enroll No. 1600100627
Submitted To :
Dr. Mohd Ajmal Sir
Assistant Professor
Integral University, Lucknow
Faculty of Pharmacy

2. Case Study
Mr G is newly diagnosed with mild ulcerative
colitis. His abdominal X-ray suggests
predominantly disease of the rectum and
sigmoid colon. His past medical history
includes joint stiffness due to rheumatoid
arthritis. He presents at the pharmacy with a
prescription for sulphasalazine tablets and
Predfoam® one at night.

3. Questions ?
1. What advice would you give Mr G about the
administration of Predfoam® enemas?
2. What are the side effects associated with the use of
topical
steroids?
Mr G expresses concerns to the primary care doctor about
the
possibility of sulphasalazine impairing fertility as he and
his wife
hope to start a family. The primary care doctor decides to
switch Mr G to mesalazine tablets, 800mg taken three
times a day.
3. Mesalazine 400mg tablets are available in several
different
brands. Does it matter which brand is supplied?

4. Answers
1. Rectal therapy is appropriate for mild left-sided
disease. Enemas are best administered just before
bedtime when the supine position allows longer retention
times. Predfoam® comes in an aerosol can and the drug
is delivered by attaching some plastic rectal tubes to the
canister. A new tube is used for each dose. Patients with
rheumatoid arthritis may have difficulty in using enemas
and this may affect adherence and treatment
success.The aerosol canister is flammable and care
should be taken.
2. Prednisolone sodium metasulphobenzoate
(Predfoam®) is poorly absorbed and the systemic side
effects are minimal.

5. 3. Once initiated, patients should remain on the same
brand of
mesalazine as different brands have different release
profiles.
Relapse of disease can occur if patients are inadvertently
switched to another brand. Prescribers are encouraged to
prescribe by brand and not by generic name.
4. Mesalazine does not cause problems with fertility, only
sulfasalazine is associated with infertility and this only
affects
men. Sulfasalazine affects sperm but is reversible on
stopping
treatment.

6. THANK YOU