Aadaab-e-Murshid e-kamil

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The document discusses the history and development of artificial intelligence over the past several decades. It outlines major advances in machine learning and deep learning techniques that have enabled AI systems to perform complex tasks like image recognition and natural language processing. Recent progress in AI has sparked debate about its societal impacts and how to ensure its safe and responsible development.

Rapid urbanization and population growth are largely responsible for very high increasing rate of solid waste in the urban areas, its proper management and recycling is major problems of Municipal Corporation. The analytical analysis revealed that the leachate show high concentration of heavy metals viz., Pb, Zn, Fe, Mn and Cu. However, their high concentration in municipal solid waste leachate may cause contaminants for environmental pollution. Therefore, present investigation deals with analyze the heavy metals concentration in municipal solid waste leachate.

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kHUTBAT-E-MAOLANA ANSARICCL Pharmaceuticals

Evaluation of topical bioavailability of clotrimazole using dermato pharmaco ...

IJSIT Editor

In this single-dose-one arm, open label two way parallel design, pharmacokinetic study of two marketed formulations of Clotrimazole using 12 healthy Indian male subjects the pharmacokinetic parameters of two marketed Clotrimazole topical formulations were compared . Marketed Clotrimazole topical formulations (A & B) were applied on the pre-marked forearms of the subjects as per the dosing schedule. Treatment sample B was used as a reference sample. Subjects received treatment A & treatment B on both the arms simultaneously, following open label two way parallel design. Skin Stratum Corneum samples were collected in sterile glass test tubes during the study period. The samples were collected predose and at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, & 6.0 hours post-dose application. The Stratum Corneum samples were analysed for Clotrimazole concentrations only. Pharmacokinetic parameters of Clotrimazole were calculated as Cmax, tmax, AUC (0-t) and AUC (0-∞) Clotrimazole was estimated in Stratum Corneum using a validated Spectroscopic method. If the point estimate of the geometric mean ratio and the confidence intervals for the entire log transformed pharmacokinetic parameters [Cmax, AUC (0-t) and AUC (0-∞)] were entirely included in the range of 80-125%, then the treatments were claimed to be bio-equivalent.

Introduction: The tunneled hemodialysis catheters(THCs) are preferred for the patients who are expected to poor survival and the attempts to arteriovenous fistulas (AVF) are failure. In our study,in hemodialysis patients who are implemented tunneled catheter it is evaluated the mean duration for the catheters , their complications and the factors which affect the period of the catheters. Methods: At the Antalya Research and Education Center Hemodialysis Unit it is retrospectively evaluated the data of 297 hemodialysis patients who are implemented tunneled catheter during 5 years . Results: The mean duration time of the tunneled catheters has been 224.9+162.9 days. The duration time of right internal jugular vein(RIJV) is considerably higher than left internal jugular vein(LIJV) and subclavian veins (235.8+96.6 days). In diabetic hemodialysis patients, the duration time of the catheter is rather lower than the other end stage renal disease reasons(184.4±72.1 days). Conclusions: THCs must be considered as an alternative but not a permanent vascular access in hemodialysis patients. Because of relatively short duration times than AVF, high infection risks and thrombosis , it must be used only in patients who have problems with the creating permanent vascular access or patients with expected low survival time. Moreover, it must be taken into consideration the duration time of the catheter is low in diabetic hemodialysis patients. According to our results, catheter duration time was longer in RIJV than in other insertion sites and RIJV must be preferred as first place to placement of THCs.

Protective effects of commelina benghalensis linn (root) extract on ethanol i...

IJSIT Editor

The present study was undertaken to investigate the protective effect and possible mechanism of alcoholic (AlE) and aqueous extract (AqE) from Commelina benghalensis root (CB) on EtOH-induced hepatic injury in Wistar rat. Hepatotoxic parameters studied in vivo include serum transaminases (AST, and ALT), ALP, bilirubin, protein, lipid profile (Cholesterol, triglyceride, VLDL and HDL) and level of antioxidants together with histopathological examination. Liv 52® was used as a reference hepatoprotective agent (5ml/kg-1b.w.). AlE and AqE (200 mg/kg-1b.w.) on oral administration decreased the level of AST, ALP, ALT, bilirubin, cholesterol, triglyceride, VLDL, MDA and increased the level of protein, HDL and antioxidants (SOD, GSH and CAT) in rats being treated with ethanol (EtOH). Pentobarbitone -induced sleeping time study was carried out to verify the effect on microsomal enzymes Histopathological observations confirmed the beneficial roles of MF against EtOH-induced liver injury in rats. Possible mechanism may involve their antioxidant activity

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COMPARSION OF ANTIOXIDANT POTENTIAL OF DIMOCARPUS LONGAN LOUR. EXTRACTS AND ...

IJSIT Editor

The present study was carried out to evaluate antioxidant activity of Dimocarpus longan stems extracts and also to investigate the main phytoconstituents in the bio-active extract. N-hexane, dichloromethane, ethyl acetate and methanol 80% extract were tested for free radical scavenging activity on model reaction with stable 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The results showed that ethyl acetate was the most active one as antioxidant agent and phytochemical analysis of that extract revealed the presence of triterpenes, flavonoids, tannins and carbohydrates. The results may help to discover new chemical classes of natural antioxidant substances that could serve as selective agents for infectious diseases.

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