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A good
looking
pipeline
nacho caballero
slide
makeover 3
BEfore
after
Read the
accompanying
explanation
BEfore
P. acnes S. epidermidis
Core 88% 80%
Avg Size 2.5Mb 2.5Mb
GC 60% 32%
Average ORFs 2,626 2,436
# Sequenced Genomes 78 61
Comparative genome analyses
Conlan&et&al.,&Genome&Biology&2012,&Tomida&et&al.,&mBio&2013&
after 1
Conlan et al., Genome Biology 2012, Tomida et al., mBio 2013
Genomes highly conserved within a species
after 2
Conlan et al., Genome Biology 2012, Tomida et al., mBio 2013
Genomes highly conserved within a species
BEfore
after 1
after 2
Align reads !
to strain
sequences
Reassign !
ambiguous reads !
with Pathoscope
Reassign !
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