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• Nobel Prize in Medicine 2006 awarded to Andrew Z. Fire and Craig C.
Mello for discovery of RNA interference - gene silencing by double-
stranded RNA
• RNA interference activated when double-stranded RNA activates
mechanism degrading mRNA, stopping production of protein of gene
corresponding to mRNA
• Gene is silenced, no protein of specified type is made




                                                          A. Fire     C. Mello

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Gene silencing

  • 1. • Nobel Prize in Medicine 2006 awarded to Andrew Z. Fire and Craig C. Mello for discovery of RNA interference - gene silencing by double- stranded RNA • RNA interference activated when double-stranded RNA activates mechanism degrading mRNA, stopping production of protein of gene corresponding to mRNA • Gene is silenced, no protein of specified type is made A. Fire C. Mello