The sermon by Brian Birdow emphasizes God's command for fathers as outlined in Ephesians 6:1-4, highlighting the importance of nurturing children without provoking them to anger. It discusses how fathers can unintentionally harm their children through negative behavior and the necessity of loving discipline. The sermon also draws parallels between godly fathering and God's own example as the ultimate father, encouraging faithful living and trust in God for spiritual prosperity.