This document provides guidance on implementing comprehensive HIV/STI programmes with sex workers. It discusses the importance of community empowerment, addressing violence against sex workers, and establishing community-led services such as outreach, drop-in centers, and quality improvement initiatives. The document emphasizes working with sex worker communities and fostering sex worker leadership to develop effective and sustainable programmes. It also provides practical guidance and examples of interventions to integrate sex worker-led approaches into HIV/STI programming.