Joyce Meyer discusses 12 of the most difficult things she has dealt with in ministry, including loneliness, the silent foundation-laying years, learning to handle rejection and betrayal, learning to say no, staying fresh, being consistently confident, enjoying the ministry, waiting on God's timing, having boldness to be your unique self, dealing with people, attacks against her health, and learning how to be in ministry with her husband. The document provides biblical references and personal examples for each difficulty.