This document provides an overview of health, safety, security and environment (HSSE) implementation during the construction, commissioning and start-up phases of the Pearl GTL project. It discusses several key aspects of HSSE including developing a safety culture, implementing an HSSE management system, establishing an HSSE organization and roles, and identifying critical HSSE processes. The document is intended to share lessons learned from Pearl GTL to help other projects improve their HSSE performance during project transitions from construction to operations.