The Future of Allergy and Clinical Immunology Prof. G. Walter Canonica - Con...Juan Carlos Ivancevich
Prof.G.Walter Canonica
Allergy and Respiratory Diseases Clinic
DIMI-‐University of Genoa
Italy
Presidente Congreso SLaai 2015: Dr. Alfonso Cepeda Sarabia
The Future of Allergy and Clinical Immunology Prof. G. Walter Canonica - Con...Juan Carlos Ivancevich
Prof.G.Walter Canonica
Allergy and Respiratory Diseases Clinic
DIMI-‐University of Genoa
Italy
Presidente Congreso SLaai 2015: Dr. Alfonso Cepeda Sarabia
Immunotherapy in children SCIT or SLIT. Dra. Desirée Larenas WISC Dec2014 ...Juan Carlos Ivancevich
Symposium: Immunotherapy in Latin America - WISC 2014- Rio de Janeiro
Symposium 5: Latin American Society of Allergy and Immunology (SLAAI) Symposium: Immunotherapy in Latin America Sala 1 & 2 (Sul America)
Programa Congreso Para Todos
XVIII Congreso Latinoamericano de Alergia, Asma e Inmunología 2015.XVIII Congreso Latinoamericano de Alergia, Asma e Inmunología 2015
Presidente: Alfonso Mario Cepeda Sarabia
Comité Organizador Local: Edgardo Jares, Anahí Yañez, Estrella Asayag
Presidentes Sociedad Latinoamericana de Alergia, Asma e Inmunología, Slaai: 2013-2015: Alfonso Mario Cepeda Sarabia - 2015-2017: Juan Carlos Sisul Alvariza
Buenos Aires, marzo 14-16, 2015 - http://www.slaai2015.com
Hypersensitivity reactions to nonsteroidal anti-inflammatory drugsNatacha Santos
Reis-Ferreira A, Santos N, Botelho C, Castro E, Cernadas JR. Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: single versus multiple reactors. Allergy 2011;66(Suppl.94):51-52.
Immunotherapy in children SCIT or SLIT. Dra. Desirée Larenas WISC Dec2014 ...Juan Carlos Ivancevich
Symposium: Immunotherapy in Latin America - WISC 2014- Rio de Janeiro
Symposium 5: Latin American Society of Allergy and Immunology (SLAAI) Symposium: Immunotherapy in Latin America Sala 1 & 2 (Sul America)
Programa Congreso Para Todos
XVIII Congreso Latinoamericano de Alergia, Asma e Inmunología 2015.XVIII Congreso Latinoamericano de Alergia, Asma e Inmunología 2015
Presidente: Alfonso Mario Cepeda Sarabia
Comité Organizador Local: Edgardo Jares, Anahí Yañez, Estrella Asayag
Presidentes Sociedad Latinoamericana de Alergia, Asma e Inmunología, Slaai: 2013-2015: Alfonso Mario Cepeda Sarabia - 2015-2017: Juan Carlos Sisul Alvariza
Buenos Aires, marzo 14-16, 2015 - http://www.slaai2015.com
Hypersensitivity reactions to nonsteroidal anti-inflammatory drugsNatacha Santos
Reis-Ferreira A, Santos N, Botelho C, Castro E, Cernadas JR. Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: single versus multiple reactors. Allergy 2011;66(Suppl.94):51-52.
Asthma is the most frequent chronic illness in children and is a common noncommunicable disease (NCD) that affects both adults and children. Coughing, wheezing, chest tightness, and shortness of breath are among the symptoms. This presentation target therapies for Asthma including its clinical use, etc. For more information, please contact us: 9779030507.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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20171111 - Bucca - Esperienze nella terapia con omalizumab
1. Caterina Bucca
S.C. Pneumologia U ,
Città della Salute e della Scienza, Torino
Dipartimento di Scienze Mediche,
Università di Torino
2. International ERS/ATS Guidelines on Definition,
Evaluation and Treatment of Severe Asthma
Kian Fan Chung; Sally E Wenzel; Jan L Brozek; Andrew Bush; Mario Castro; Peter J Sterk ;
Ian M Adcock; Eric D Bateman; Elisabeth H Bel; Eugene R Bleecker; Louis‐Philippe Boulet;
Christopher Brightling; Pascal Chanez; Sven‐Erik Dahlen; Ratko Djukanovic; Urs Frey; Mina Gaga;
Peter Gibson; Qutayba Hamid; Nizar N Jajour; Thais Mauad; Ronald L Sorkness; W Gerald Teague.
SEVERE ASTHMA
Asthma that requires treatment with high dose inhaled
corticosteroids plus a second controller and/or systemic
corticosteroids to prevent it from becoming “uncontrolled” or
that remains “uncontrolled“ despite this therapy.
Severe asthma is a heterogeneous condition, consisting of multiple
phenotypes.
Studies are beginning to define phenotypic biomarkers, and phenotype
targeted biologic therapies are increasingly showing efficacy.
Eur Respir J. 2014 Feb;43(2):343-73
4. Identifying new biological treatments
to target molecular mechanisms of
severe asthma
MONOCLONAL ANTIBODIES (MOA)
IgE, TNFalpha, IL5, IL13, IL4R, IL-17
NOVEL MOLECULES
GATA-3-mRNA-specific DNAzyme
CXCR2 antagonist
PHARMACOLOGIC AGENTS
Roflumilast, Tiotropium, Macrolides
5. Studio TENOR*: IgE elevate nell’asma
moderata e grave
n=38 n=435 n=253 n=19 n=228 n=228 n=81 n=1529n=1690
137
108
84
146
224
82
280
238
88
0
50
100
150
200
250
300
Children Adolescents Adults
MeanIgElevels(IU/mL)
Mild
Moderate
Severe
Dolan CM et al. Ann Allergy Asthma Immunol. 2004;92:32-39.
*TENOR: The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens Study
6. Elevati livelli locali di IgE in
pazienti con asma fatale
302328
Fatal Asthma
(n=10)
Non-Pulmonary
Deaths
(n=9)
FceRIreceptorexpressionin
laminapropria(+cells/mm2)
Mild Intermittent
Asthma†
(n=16)
1200
1000
800
600
400
200
0
1085*
*P<0.05 vs other groups.
†Biopsy
Fregonese L, et al. Am J Respir Crit Care Med. 2004;169:A297.
12. Regime di rimborsabilita' e
prezzo di vendita della specialita'
medicinale «Xolair»
(omalizumab), autorizzata con
procedura centralizzata europea
dalla Commissione europea con la
decisione del 25 ottobre 2005 ed
inserita nel registro comunitario
dei medicinali con il numero:
EU/1/05/319/002-150 mg polvere e
solvente per soluzione iniettabile
uso so...
13. Indicazioni approvate per l’uso di omazulimab (Xolair), come
terapia aggiuntiva:
migliorare il controllo dell’asma in pazienti adulti e adolescenti
(a partire dai dodici anni di età) con le seguenti caratteristiche
➢ asma allergico grave e persistente
➢ positività ai test cutanei o al test di reattività in vitro per un
aeroallergene perenne
➢ funzionalità polmonare ridotta (FEV1 <80%)
➢ frequenti sintomi diurni e risvegli notturni
➢ numerosi e documentati episodi di riacutizzazione di asma
grave, nonostante assunzione giornaliera di corticosteroidi
inalatori ad alto dosaggio, + b2-agonista a lunga durata
d’azione per via inalatoria
➢ Il trattamento con omalizumab dovrebbe essere
considerato solo per i pazienti con asma di accertata di
natura IgE mediata
14. Benefits of omalizumab as add-on therapy in patients with
severe persistent asthma who are inadequately controlled
despite best available therapy
(GINA step 4 treatment): INNOVATE
0.48
0.24
omalizumab
omalizumab
placebo
placebo
Clinicallysignificant
Asthmaexacerbationsrate
Severeasthma
exacerbationsrate
0
0
0.2
0.4
0.6
0.8
1.0
0.2
0.4
0.6
0.68
0.91P=0.042
P=0.002
Humbert M et al; Allergy 2005; 60:309-316
419 pazienti con
asma grave
persistente, allergia
ad aero-allergene
perenne,
scarsamente
controllati
nonostante terapia
secondo linee guida
GINA , IgE 30-
700 IU/ml
FEV1 tra 40% e 80%
del teorico
omalizumab x 28 sett.
➢ Riduzione del 26%
delle esacerbazioni
dell’asma
clinicamente
significative e del
50% delle
esacerbazioni gravi
➢ Miglioramento
della qualità della
vita
15.
16. Riduzione degli
eosinofili nello
sputo indotto e
nella sottomucosa
bronchiale dopo 16
settimane di
terapia con
omalizumab
(Djukanovic R. Am J Respir
Crit Care Med 2004)
28. During treatment: significant increase in ACT, and decrease in AE in both groups,
already evident after 6 months. By contrast,
FENO and FEV1 and improved only in G1.
Omalizumab attenuates airway inflammation and remodeling, acting in the first few
months of therapy. This effect can be expected in patients with high FENO and
eosinophilia before treatment.
Bucca et al. ERS Congress 2016
29. Forty-five patients [mean age 44.9 years
(range 19e69), females 37/45 (82%), mean
duration of omalizumab treatment 60.7 ±
30.9 months (range 23-121) were included in
the analysis.
Efficacia mantenuta dopo 5 anni di
trattamento
40. Kaplan outlined 7 potential mechanisms that may contribute to
the efficacy of omalizumab in CSU:
1. Decreased free IgE and IgE receptors;
2. Reduced mast cell releasability;
3. Reversal of basopenia and improved basophil IgE receptor
function;
4. Reduced activity of IgE autoantibodies against IgE and IgE
receptors;
5. Reduced activity of intrinsically ‘abnormal’ IgE;
6. Reduced activity of IgE autoantibodies against and unknown
autoantigen;
7. Decreased role of coagulation involvement.
No single theory or combination of theories was found to fully
explain the pattern of response seen with omalizumab for CSU
patients .
44. Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published
evidenceJournal of Allergy and Clinical Immunology [0091-6749] Maurer, Marcus anno:2017
45.
46.
47.
48. Caterina Bucca
S.C. Pneumologia U ,
Città della Salute e della Scienza, Torino
Dipartimento di Scienze Mediche,
Università di Torino