Trust is critical to the process of science. Two decades ago the Internet and World Wide Web fostered a new age in computational science with the emergence of accessible and high performance computing, storage, software, and networking. More recent paradigms, including virtual organizations, federated identity, big data, and global-scale operations continue to evolve the way computing for science is performed. Advancing technologies, the need to coordinate across organizations and nations, and an evolving threat landscape are sources of ongoing challenges in maintaining the trustworthy nature of computational infrastructure and the science it supports. To address these challenges, a number of projects have focused on improving the cybersecurity and trustworthiness of scientific computing. Recent examples include the Center for Trustworthy Scientific Cyberinfrastructure funded by NSF, the Software Assurance Marketplace funded by DHS, and the Extreme Scale Identity Management for Science project funded by DOE. This presentation will give a 20 year retrospective together with a vision for the future of cybersecurity for computational science. It will describe the state of trust and cybersecurity for scientific computing, its evolution over the past twenty years, challenges it is facing today, how the exemplar projects are addressing those challenges, and a vision of cybersecurity for research and higher education in general augmenting each other in the future.