The document provides instructions for setting up and running a MiSeq sequencer to sequence GeneRead DNAseq Gene Panel Libraries. It describes checking the software versions of various components, creating a sample sheet with sample and index information, following reagent kit preparation instructions, using the MiSeq Control Software wizard to start a run by loading the flowcell, cartridge, and buffer, and notes that FASTQ files will be generated including demultiplexed sequence data following automated data analysis after the run is complete.