2012 ircm annual_report

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DISCOVERING

2011-2012 ANNUAL REPORT

2 | 2011-2012 IRCM ANNUAL REPORT |3

The IRCM:
a biomedical
research
institute
located in
the heart of
Montréal


DISCOVERING T R E AT I N G
36 researchers – IRCM research professors 16,000 yearly visits at the clinic
182 scientific publications 31 health professionals
$22.9 million in research funding 21 physicians specialized in
hypertension
cholesterol
obesity and diabetes


I N N O V ating CONTRIBUTING
8 core facilities 5 new declarations of invention
3 research platforms 7 new patent filings (or applications)
5 specialized services


Cancer
Cholesterol
Diabetes
Hypertension
Cardiovascular diseases
Degenerative diseases

TRAINING Infectious diseases
Neuroethics
Clinical research
113 Master’s and PhD students
Nervous system
52 postdoctoral fellows
Systems biology
58 scholarship holders
HIV/AIDS
467 teaching hours
Medicinal chemistry
Embryonic development

10 | 2011-2012 IRCM ANNUAL REPORT MISSION / THE IRCM AT A GLANCE | 11

To understand the causes of diseases / To find diagnostic tools and means of prevention
and treatment / To train a new generation of high-calibre scientists / To contribute to
Quebec’s socioeconomic development by facilitating the commercial development of new
discoveries

MISSION
/ THE IRCM AT A GLANCE Founded in 1967 Supported by the Fonds de recherche du Québec
– Santé (frqs)
Independent non-profit institution
Member of the Université de Montréal’s ruis
Affiliated with the Université de Montréal (Réseau universitaire intégré de santé)

Associated with McGill University 425 researchers, students and employees

IRCM Clinic affiliated with the Centre hospitalier A budget of 42.3 million dollars
de l’Université de Montréal (CHUM)

Funded by Quebec ministry of Economic
Development, Innovation and Export Trade

12 | 2011-2012 IRCM ANNUAL REPORT | 13

Translational research at the IRCM:
precursor to Quebec’s model

As early as 1952, the IRCM was born from the
idea of bringing together basic and clinical
researchers under the same roof. Translational
research thus began with the fields of
hypertension, atherosclerosis, immune
disorders and Parkinson’s disease.

After all these years, this model continues to
be extremely relevant. The following are two
examples of translational research conducted
at the IRCM in 2011-2012.

14 | 2011-2012 IRCM ANNUAL REPORT Translational research at the IRCM: precursor to Quebec’s model | 15

REPLACING STATINS “We discovered that the PCSK9 enzyme leads IMPROVING THE CLINICAL MANAGEMENT OF THE “Although our society’s ever-growing problems
to the deterioration of receptors, located on the TYPE-2 DIABETES EPIDEMIC: A PROJECT AT THE of obesity and sedentary lifestyles are among
Since 1994, statins have been the treatment liver’s surface, that collect bad cholesterol (LDL) HEART OF PERSONALIZED HEALTHCARE the main risk factors for type-2 diabetes, they
of choice to lower cholesterol levels in the particles circulating in the blood and internalize far from justify the occurrence of the disease or
blood. Nearly 30 million people are prescribed them in the liver, where they are then disintegrated. Two IRCM teams are currently conducting a the associated cardio-metabolic risk. Resistance
statins today because they suffer from Consequently, PCSK9 leads to an accumulation study that, when completed, could have an impact to insulin, a hormone secreted by the pancreas,
familial hypercholesterolemia or have had a of LDL in the blood and contributes to the growth on the management of the type-2 diabetes displayed by peripheral tissues such as muscles,
cardiovascular incident such as a stroke. Others of plaque that eventually blocks arteries. Following epidemic. By using proteomics and computational the liver or the adipose tissue, is required for the
receive the drug because, in addition to having numerous observations, we found PCSK9 to be an biology, we will be able to use additional criteria development of the disease. However, the underlying
high levels of cholesterol, they are predisposed ideal therapeutic target for the development of a to predict the risk of developing type-2 diabetes, molecular mechanisms to this insulin resistance
to cardiovascular diseases due to various risk new generation of products more effective than the in addition to current criteria such as obesity and remain poorly understood. A better knowledge of
factors, including a sedentary lifestyle, smoking currently-available medication. We recently received family history. Hence, we could segment patient these mechanisms will allow us not only to better
or high blood pressure. However, many among a substantial investment from AmorChen that could groups so they could receive the appropriate understand the trigger and the progression of the
them have become intolerant to the drug, to the allow us to develop a novel cholesterol-lowering treatment in due course, according to their risk disease, but also to define therapeutic targets and
point of having to interrupt treatment. drug. This drug will block PCSK9, which will in turn of developing complications. develop tools for diagnosis and prediction.”
significantly lower levels of cholesterol in the blood.”
“This intolerance to statins is a catastrophe for “Recent genomic studies have shown that a series RÉMI RABASA-LHORET, MD, PhD
people suffering from familial hypercholesterolemia. NABIL G. SEIDAH, C.M., O.Q., PhD, MSRC Director, Metabolic Diseases research unit
of genes are “susceptible” to insulin resistance. We
Director, Biochemical Neuroendocrinology research unit Director, Obesity, Metabolism and Diabetes clinic
New therapeutic approaches are crucial for those developed a process to map protein interaction Director, Research platform on obesity, metabolism and
Full IRCM Research Professor
who are intolerant, but also for the large number of Canada Research Chairholder in Precursor Proteolysis networks in human cells. We then applied this diabetes
patients for whom the current treatment does not process to the characterization of networks involving Holder of the J.A. DeSève Chair of Excellence
allow them to reach the recommended cholesterol proteins that are coded with the insulin-resistant
levels. Clinical trials are currently underway at susceptibility genes. We are looking for specific
the IRCM in order to evaluate a new therapeutic signatures, named proteomic “imprints”, for each
approach, which, once completed, could replace phenotype. These imprints could then be used to
statins and thus provide individuals with a better diagnose or predict the onset of various phenotypes
treatment option. These clinical trials were made related to type-2 diabetes.”
possible thanks to the discovery of PCSK9 by our
basic researcher colleague, Nabil G. Seidah.” BENOIT COULOMBE, PhD
Director, Gene Transcription and Proteomics research unit
ROBERT DUFOUR, MD, M.Sc., CSPQ Director, Proteomics discovery platform
Director, Nutrition, Metabolism and Atherosclerosis clinic Director, National platform for human interactome mapping

16 | 2011-2012 IRCM ANNUAL REPORT TABLE OF CONTENTS | 17

Message from the Chairwoman of the Board / 18 IRCM Foundation / 100
Message from the President and Scientific Message from the President / 104
Director / 22 Message from the Director / 106
Planning the future / 26
SUPPORTING
dISCOVERING / 108
Benefit activities
/ 30
Research divisions Volunteering
TrEATING
/ 111
IRCM Foundation’s Board of Directors / 112
/ 52 Give for Life campaign Board / 113
IRCM Clinic

InnovATING GIVING
/ 116
/ 62
TABLE OF CONTENTS Core facilities and technology platforms
The impact of your donations / 118
Partners and donors / 120

ContribuTING Research Funds and Chairs / 130

/ 70
Technology transfer

TRAINING
/ 74
Tomorrow’s researchers

ParticipATING
/ 84
Science for all
Research funding / 90
Administration / 92
IRCM Board of Directors / 93
IRCM Management / 95
Organizational charts / 96
Financial statements / 98


MESSAGE FROM
THE CHAIRWOMAN
OF THE BOARD

20 | 2011-2012 IRCM ANNUAL REPORT MESSAGE FROM THE CHAIRWOMAN OF THE BOARD | 21

MESSAGE FROM THE CHAIRWOMAN OF THE BOARD A new signature engineer. I also welcome the arrival of Brian Z. I am undertaking my second year as Chair of the
Gelfand, Vice President of Institutional relations Board with confidence and enthusiasm, and hope
I proudly accepted to chair the IRCM’s Board of The Board’s Communications Committee expressed and market operations at the Montréal Exchange, that the IRCM’s excellent reputation, and that of its
Directors. I knew that I was undertaking a demanding a wish to increase the IRCM’s visibility by working who undertakes his first term on the Board in 2012- researchers, continues to spread.
mandate. I also knew that the groundwork had been on a signature project to define the IRCM in a few 2013. These news directors join our prestigious
well laid by my predecessor, Gérard A. Limoges, and words. Following a consultation exercise conducted in team of Board members (see page 93 of this annual
that I would be surrounded by competent individuals collaboration with Dr. Tarik Möröy, his management report).
who hold dear the Institut’s success. Working team and the Institut’s communications department,
with people I admire, including the President and the Communications Committee submitted a
Scientific Director, Dr. Tarik Möröy, the researchers proposal that was approved by the Board. Appointment
Louise Lambert-Lagacé, C.M., C.Q., Dt. P.
and the IRCM’s community, seemed an outstanding
proposal to me. Hence, the acronym “IRCM” becomes the designation The Board approved the appointment of Thérèse
of use, and the verb “Discovering” the official Leroux as Chair of the IRCM’s ethics committee
corporate signature. Discovering is the term that best for research on human subjects. A prominent lawyer,
A very busy year describes, in one word, what is done at the IRCM, Thérèse Leroux is a professor in the Faculty of Law
because every day, researchers make discoveries in at the Université de Montréal, and a main researcher
In the first months following my appointment, I various fields. The public will also be able to better at the university’s Centre de recherche en droit
visited Avenue des Pins on several occasions to recognize what happens at the Institut without public.
familiarize myself with my new role and the people having to decipher the letters of its acronym. This
I would have the pleasure of working with. A signature also invites people to discover the IRCM.
relationship of trust was established, and methods The word “Discovering” will henceforth appear in Acknowledgements
of operation were implemented so that we could all the IRCM’s different communications tools.
effectively manage our new tasks. I would like to thank members of the Board of
Directors for their hard work and support throughout
The Board worked on several projects, and more Board recruitments my first year at the helm of the IRCM.
particularly on the IRCM’s funding by the Quebec
ministry of Economic Development, Innovation and Influential members from the Montréal community, I wish to congratulate Dr. Tarik Möröy for the
Export Trade and the Fonds de recherche du Québec sitting on the IRCM’s Board of Directors, are remarkable work he accomplishes every year, and for
– Santé. This project had a favourable outcome. dedicated to the development, success and future his invaluable and open collaboration. I also thank
of our institution. This year, I had the pleasure of everyone at the Institut for their warm welcome.
recruiting and welcoming Monique Jérôme-Forget,
Special Advisor at Osler, Hoskin & Harcourt and Finally, I would like to acknowledge the departure
Korn/Ferry International; Michel Lespérance, of Camille Limoges, and sincerely thank him, on
corporate director; and Hélène Robitaille, civil behalf of the entire Board, for his outstanding
contributions since 2008 as a Board member.


MESSAGE
FROM THE
PrESIDENT
AND SCIENTIFIC
DIRECTOR

24 | 2011-2012 IRCM ANNUAL REPORT MESSAGE FROM THE PRESIDENT AND SCIENTIFIC DIRECTOR | 25

MESSAGE FROM THE PRESIDENT AND SCIENTIFIC Recruitment of researchers the Cardiovascular and Metabolic Diseases research Give for Life fundraising campaign
DIRECTOR division. Dr. Berthiaume was previously a researcher
I had the honour of welcoming, this year, Benjamin at the Hôtel-Dieu’s CHUM research centre. As The IRCM Foundation’s major fundraising campaign
It is my pleasure to once again present you with a Haibe-Kains as Assistant IRCM Research for Dr. Larochelle, he will continue his work on was publicly launched in fall 2011. Since then, many
report of this year’s activities at the IRCM, the first Professor and Director of the Bioinformatics and hypertension as IRCM Emeritus Professor, and will significant donations have been confirmed. I would
year of my second term of office. Firstly, I would Computational Genomics research unit, which keep consulting with his patients at the clinic. therefore like to thank everyone who contributed to
like to cordially thank the Chairwoman of the is part of the Systems Biology and Medicinal this important campaign. Without their continual
Board of Directors, Louise Lambert-Lagacé, for her Chemistry research division. He also supervises the Finally, it is with great enthusiasm that I announced support and their unwavering commitment, we could
commitment and her unwavering support. new Bioinformatics core facility. Dr. Haibe-Kains the return of Mathieu Ferron, who completed his not continue to recruit and set up elite researchers
holds a PhD in bioinformatics from the Université doctoral studies at the IRCM. He will be Assistant from around the world or offer cutting-edge training
Libre de Bruxelles in Belgium and, before his arrival IRCM Research Professor and Director of the new to our students.
Sustainable funding at the IRCM, was a postdoctoral fellow at the Dana- Integrative and Molecular Physiology research unit.
Farber Cancer Institute at Harvard in Boston. His laboratory will be part of the Cardiovascular
The IRCM’s funding is a key issue. Three years ago, and Metabolic Diseases research division. His arrival Congratulations
the Fonds de recherche du Québec – Santé announced I was also very pleased to announce the hiring of is scheduled for May 2013. He currently works
a complete reform of its funding program for its Cheolho Cheong as Assistant IRCM Research as a research associate in Dr. Gérard Karsenty’s I would like to sincerely congratulate all the
affiliated centres. Despite the IRCM’s excellent Professor. He is Director of the Cellular Physiology laboratory at Columbia University in New York. researchers who won prestigious awards this year,
performance, this FRQS reform significantly reduced and Immunology research unit, and has joined the here or abroad. These honours reflect upon the
the Institut’s annual funding. This placed the IRCM Immunity and Viral Infections research division. Institut’s entire community.
in a position that could become precarious in the Dr. Cheong obtained a PhD in genetics from the Appointment
long term. In collaboration with members of the Seoul National University in South Korea. He was Our researchers once again obtained excellent
Board of Directors, we undertook discussions with previously a research associate in the Laboratory of Towards the end of 2011, I suggested to the Board results in different funding agency competitions, at
the Quebec ministry of Economic Development, Cellular Physiology and Immunology at Rockefeller of Directors that Dr. Michel Chrétien, who directed a time when obtaining research grants has become
Innovation and Export Trade so that the IRCM’s University in New York. the Institut from 1984 to 1994, should be appointed increasingly difficult.
operating budget could henceforth be completely IRCM Emeritus Professor. In accordance with the
covered by the ministry. This project was a lengthy In addition, in response to the desire expressed by Dr. Board’s decision, Dr. Chrétien was reinstalled at the
one, but came to a positive conclusion in the summer Pierre Larochelle to reduce his professional activities, IRCM in January 2012. He can now continue his Acknowledgements
of 2012. I would therefore like to sincerely thank the position of Executive Director of the clinic and close collaboration with Dr. Nabil G. Seidah and his
everyone who worked on this crucial matter for the clinical research became available. I therefore had team in the field of cardiovascular diseases. I wish to warmly thank the researchers, students,
future of the IRCM, and more particularly, Louise the pleasure of announcing the appointment of employees, and Board members of the IRCM and
Lambert-Lagacé, Chair of the Board, and Monique Dr. Yves Berthiaume to this position. Renowned the Foundation for their commitment and dedication,
Jérôme-Forget, Board member, for their invaluable pulmonologist, Dr. Berthiaume will also set up a and for their contribution to our institution’s success.
assistance, and, of course, the ministry for its specialized research clinic in cystic fibrosis at the
support. IRCM, and will conduct his research projects in the
new Cellular and Molecular Lung Biology research
unit. He is Full IRCM Research Professor, and joined
Tarik Möröy, PhD


PLANNING THE FUTURE

We are continuing to implement the recommendations made in the
IRCM’s 2010-2015 strategic plan.

Regular communication with members of the Scientific Advisory Board
(SAB) occurred throughout the year. Their first scientific and institutional
evaluation visit of the IRCM took place in June 2012, and a report is
under preparation. The SAB members said to have been delighted by
their visit and impressed with the high calibre of the Institut’s researchers,
as well as by the cutting-edge technological facilities.

Committee members: Roderick R. McInnes, interim Chair (Lady Davis Research
Institute, Canada); John Aitchison (Institute for Systems Biology, USA); Peter Bruns
(Howard Hughes Medical Institute, USA); Gordon Fishell (New York University, USA);
Paul Frenette (Albert Einstein College of Medicine, USA); Walter Rosenthal (Max-
Delbrück Center for Molecular Medicine, Germany); Alfred Singer (National Cancer
Institute, USA).


Clinical research boost Evaluation of our engineering services and
physical plant
We continued our discussions with CHUM in order
to establish extensive collaborations in clinical and An external firm was commissioned to evaluate
translational research between our two institutions. our engineering services and physical plant.
A joint CHUM-IRCM committee was created, and This evaluation is now complete and a report is
this committee made several recommendations currently being studied by the IRCM’s management
that are currently being assessed. committee.

Consolidation of our alliance with the Prioritizing the training of graduate students
Université de Montréal
A new graduate studies option in molecular and
We held many meetings with the Université de cellular medicine was established at the IRCM as
Montréal and discussed financial support and the part of the Université de Montréal’s programmes de
potential revision of our affiliation contract, among biologie moléculaire (molecular biology programs).
other topics. These discussions were fruitful and the We should welcome the first students in July 2013.
university will continue supporting the IRCM, namely You can learn more about this new program on
through programs led by the Canada Research page 76 of this annual report.
Chairs and Canada Foundation for Innovation, and
through compensation for student training carried
out at the Institut.

Recruitment of researchers

We established a 2012-2014 recruitment plan
outlining available positions for new research
professors, which was reviewed by members of
the Scientific Management and Management
committees to ensure the scientific development of
all five research divisions.

30 | 2011-2012 IRCM ANNUAL REPORT DISCOVERING | 31

OUR PRIORITIES
Conquering cancer / Living with a healthy heart / Fighting infectious diseases /

DISCOVERING Understanding embryonic development and the nervous system / Exploring the
complexity of biological systems / Participating in ethical debates

5 research divisions
36 research units
182 scientific publications, including 167 peer-reviewed journals
254 researchers and clinicians*

* * including postdoctoral fellows and students (as of August 31, 2012)


2011-2012

7 teams • 2 Canada Research Chairs • 15 publications by the division’s researchers • 1 scholarship holder from the
Fonds de recherche du Québec – Santé: Katrina Podsypanina • 2 recipients of the Leaders Opportunity Fund from
the Canada Foundation for Innovation: Katrina Podsypanina and William Y. Tsang, for a total funding ot $829,680
(including the contribution from the government of Quebec) • 1 grant from the Cancer Research Society: Tarik

CONQUERING CANCER
Möröy ($120,000) • 1 grant from the Quebec Breast Cancer Foundation: Jean-François Côté (principal investigator)
and Jean-Philippe Gratton (co-applicant) ($450,000) • 1 researcher active in the community: Jean-François Côté
chaired the Canadian Cancer Society’s Gala des Grands Chefs de Bromont

Cancer research division

The IRCM actively participates in efforts to cure cancer – the leading cause

DID YOU KNOW…
of death in Quebec. Cancer research is complex, as more than 100 different
types of cancer exist, affecting various organs and systems.
...according to Osteoporosis Canada, as many as two million Canadians suffer from osteoporosis. In
Researchers in this field benefit from the extensive knowledge, gained over addition, approximately 25,000 hip fractures occur in Canada every year, and 80 per cent of these
20 years of intense basic and applied research, on the mechanisms and fractures are related to osteoporosis.
causes of the malignant transformation of cells. Despite new therapeutic
options that allow us to cure a high proportion of cancer, the battle is far
from over.

At the IRCM, current studies focus on malignant transformation and
tumour growth, metastasis, and the genetic bases for predisposition to
cancer. Research is also conducted on osteopetrosis, a genetic disease
characterized by the absence of bone resorption.


NEW RISK FACTOR FOR DEVELOPING
OSTEOPOROSIS

“My research team and I identified a new gene
that modulates bone mass and could become

Cancer research division a risk factor for developing osteoporosis. We
identified this gene as a novel modulator of
bone mineral density in mice and humans.
More importantly, we showed that the human
Osteoporosis is a “silent” genetic disease characterized by low bone mineral density and deterioration of gene could represent a new susceptibility
bone tissue, which leads to increased bone fragility and risk of fracture. In all cases, the disease is caused factor for osteoporosis. Hence, this discovery
by an imbalance between the formation and resorption of bone tissue. will help identify individuals with a greater
predisposition to the disease who could
benefit from preventive measures.”
JEAN VACHER, D.Sc.
Research unit directors Full IRCM Research Professor
Director, Cellular Interactions and Development
research unit
Jean-François Côté, PhD Katrina Podsypanina, MD, PhD
Director, Cytoskeletal Organization and Cell Migration Director, Breast Cancer Biology
Associate IRCM Research Professor Assistant IRCM Research Professor
Jean-Philippe Gratton, PhD Marie Trudel, PhD
Director, Endothelial Cell Biology Director, Cancer research division
Associate IRCM Research Professor Director, Molecular Genetics and Development
Canada Research Chair in Endothelial Cell Functional Full IRCM Research Professor
Signalling
William Y. Tsang, PhD
Tarik Möröy, PhD Director, Cell Division and Centrosome Biology
Director, Hematopoiesis and Cancer Assistant IRCM Research Professor
Jean Vacher, D.Sc.
Canada Research Chair in Hematopoiesis and Immune Cell
Director, Cellular Interactions and Development
Differentiation


2011-2012

8 teams • 1 Canada Research Chair • 1 IRCM Research Chair • 78 publications by the division’s researchers • 2
scholarship holders from the Fonds de recherche du Québec – Santé: Rémi Rabasa-Lhoret and Jennifer Estall • 1

LIVING WITH
New Investigator Award from the Canadian Institutes of Health Research: Jennifer Estall • 6 researchers honoured:
Nabil G. Seidah received the 2011 Wilder-Penfield Prix du Québec in biomedical research; May Faraj, visiting scientist,
received the 2011 Trophée Femmes arabes in the health category; Michel Chrétien, IRCM Emeritus Professor, was
promoted to Officer of the National Order of the Legion of Honour (France); Rémi Rabasa-Lhoret received an award for

A HEALTHY
teaching excellence in health sciences from the Université de Montréal; Timothy L. Reudelhuber received the Pierre-
Bois Excellence Award from the IRCM Foundation; and Claude Lazure was Acting Scientific Director of the Fonds de
recherche du Québec – Santé from January to July 2012 • 3 grants from the Canadian Diabetes Association: Jennifer
Estall, May Faraj, Rémi Rabasa-Lhoret • 1 « bridge » grant from the Canadian Institutes of Health Research: May Faraj

HEART
($100,000) • 1 funding from AmorChem: Nabil G. Seidah ($250,000)

Cardiovascular and Metabolic Diseases research division

Cardiovascular diseases remain among the leading causes of death in the

DID YOU KNOW…
western world. At the IRCM, researchers in this division work on the biology
of cardiovascular and metabolic diseases. Collectively, their projects lead
to a better understanding of these diseases’ risk factors, including genetic …according to the Heart and Stroke Foundation, high blood pressure affects one in five Canadians,
factors, hypertension, dyslipidemia, endothelial cell dysfunctions and and is the number one risk factor for strokes. High blood pressure is often referred to as the “silent
metabolic disorders. killer” as patients usually do not show any symptoms before complications occur.

Research is conducted by both basic and clinical researchers, thereby
increasing collaborations and, in turn, reaffirming the clinical relevance of
their work.


WHAT FACTORS ARE RESPONSIBLE
FOR HIGH BLOOD PRESSURE?

Cardiovascular and Metabolic “We are studying a hormonal system
that acts on blood pressure and are
Diseases research division trying to understand the mechanisms
responsible for the activity of this
system in the body’s various tissues.
More precisely, we are interested
Blood pressure is the pressure exerted upon the walls of arteries (blood vessels) when blood circulates in the renin-angiotensin system
through the body. Normal blood pressure is defined by a measurement of 120 (systolic pressure) over 80 and the molecular determinants of
(diastolic pressure). A person with hypertension (high blood pressure) will consistently show measurements renin’s activity. As a protein that plays
of 140 over 90. Beyond these blood pressure values, the risk of complications progressively increases. We a significant role in regulating blood
know these complications: cerebrovascular disease, heart disease, and chronic kidney disease, to name a pressure, renin is a prime target for
few. But, what are the factors responsible for hypertension? the treatment of hypertension. A
better understanding of all these
activities combined will certainly
Research unit directors provide us with the answers we are
searching for.”
Christian F. Deschepper, MD Timothy L. Reudelhuber, PhD
Director, Cardiovascular and Metabolic Diseases research Director, Molecular Biochemistry of Hypertension
division Full IRCM Research Professor TIMOTHY L. REUDELHUBER, PhD
Director, Experimental Cardiovascular Biology Director, Molecular Biochemistry of
M. Ram Sairam, PhD Hypertension research unit
Director, Molecular Endocrinology Full IRCM Research Professor
Jennifer Estall, PhD Full IRCM Research Professor
Director, Molecular Mechanisms of Diabetes
Nabil G. Seidah, C.M., O.Q., PhD, MSRC
Assistant IRCM Research Professor
Director, Biochemical Neuroendocrinology
Pierre Larochelle, MD, PhD, FRCPC, FACP, FAHA Full IRCM Research Professor
Director, Cardiovascular Pharmacology Canada Research Chair in Precursor Proteolysis
Claude Lazure, PhD
Director, Neuropeptide Structure and Metabolism
Rémi Rabasa-Lhoret, MD, PhD
Director, Metabolic Diseases
J.A. DeSève Chair of Excellence


2011-2012

FIGHTING
INFECTIOUS
6 teams • 4 Canada Research Chairs • 1 IRCM Research Chair • 17 publications by the
division’s researchers • 2 operating grants from the Canadian Institutes of Health Research:
Paul Jolicoeur, André Veillette ($968,320) • 1 grant from the Cancer Research Society: Javier

DISEASES
M. Di Noia ($120,000) • 1 researcher promoted to associate professor-researcher at the
Université de Montréal: Javier M. Di Noia

Immunity and Viral Infections research division

Allergic reactions, respiratory tract diseases and autoimmune diseases are
growing problems in our society. The resurgence of infectious diseases
thought to have been eradicated and the emergence of new viruses require
DID YOU KNOW…
...with over 25 million deaths over the past three decades, HIV is causing one
major research efforts in the field of immune system diseases.
of the world’s deadliest infectious diseases. According to the World Health
Organization, approximately 34 million people were living with HIV/AIDS in
This research division groups together scientists interested, on one hand, by 2010.
the development of immune cells and the regulation of their functions, and
on the other hand, by viral infections, especially those involving viruses that
infect immune cells.

Collectively, the researchers’ studies lead to a better understanding of
immune cell regulation in normal immune responses and during diseases
such as autoimmune diseases, viral infections and immunodeficiency.


WHY DEVELOP A MOUSE MODEL OF AIDS?

“One of my team’s main research projects
is the understanding of the HIV-1 virus. To
Immunity and Viral achieve this, our laboratory is interested
in developing mice models of AIDS. For

Infections research division example, to create one of these models, we
used a promoter of the CD4 human gene
(a receptor of HIV-1) to express the HIV-1
genome in transgenic mice, in the same cells
Paul Jolicoeur has earned degrees in medicine and endocrinology from the Université Laval. He joined that are normally infected in individuals with
the IRCM in 1976. At the time, cloning technologies were not yet discovered and the AIDS virus was not HIV-1. These mice developed many similar
yet known. Since then, Dr. Jolicoeur has become a major player in the field of HIV/AIDS by creating phenotypes to those observed in patients with
an animal model of the disease in mice. His work represents a significant and vital contribution to the AIDS, such as the loss and activation of CD4
international scientific community for the study of this disease. t-cells, thymic atrophy, immunodeficiency,
weight loss, abnormal growth, premature
death and a kidney disease typical of AIDS.
Research unit directors Such models are useful not only to understand
the disease, but also to eventually develop a
Éric A. Cohen, PhD Paul Jolicoeur, MD, PhD vaccine against HIV-1.”
Director, Immunity and Viral Infections research division Director, Molecular Biology
Director, Human Retrovirology Full IRCM Research Professor PAUL JOLICOEUR, MD, PhD
Canada Research Chair in Human Retrovirology Canada Research Chair in Studies of Pathogenesis of Director, Molecular Biology research unit
Retrovirus-Induced Diseases Full IRCM Research Professor
Javier Marcelo Di Noia, PhD Canada Research Chair in Studies of Pathogenesis of
Director, Mechanisms of Genetic Diversity Woong-Kyung Suh, PhD Retrovirus-Induced Diseases
Associate IRCM Research Professor Director, Immune Regulation
Canada Research Chair in Genetic Diversity Assistant IRCM Research Professor
Hua Gu, PhD André Veillette, MD, MSRC
Director, Molecular Immunology Director, Molecular Oncology
Full IRCM Research Professor Full IRCM Research Professor
André-Aisenstadt Chair of Excellence in Immunology Canada Research Chair in Immune System Signalling

UNDERSTANDING

THE NERVOUS 2011-2012

SYSTEM / 7 teams • 1 Canada Research Chair • 23 publications by the division’s researchers

PARTICIPATING
• 2 honoured researchers: Frédéric Charron received the 2012 Young Investigator
Award from the Canadian Association for Neuroscience; Éric Racine was elected a
member of the Dana Alliance for Brain Initiatives (DABI) • 1 operating grant from

IN ETHICAL
the Canadian Institutes of Health Research: Frédéric Charron ($796,365) • 1 grant
from the Foundation Fighting Blindness: Michel Cayouette ($295,743) • 1 Canada
Research Chair renewal: Marie Kmita • 1 researcher promoted to associate
professor-researcher at the Université de Montréal: Éric Racine

DEBATES Neurobiology and Development research division

Embryonic development is carefully controlled by cellular and molecular mechanisms that
ensure the proper functioning of organs in adults. The disruption of these mechanisms often
causes diseases, such as cancer, Parkinson’s or Alzheimer’s diseases.
DID YOU KNOW…
... the generation of baby boomers, those born between 1946 and 1956,
Researchers in this division study the basic mechanisms of development and provide started turning 65 in 2011. It is also known that the prevalence of
new considerations for the treatment of neurodegenerative diseases, blindness, muscular neurodegenerative diseases increases with age. We can therefore expect
dystrophies and hormone deficiencies. a growing portion of the population to be affected by these pathologies
(INSPQ, 2010).
In addition, research at the IRCM is conducted in the emerging field of neuroethics. Work
in this area is designed to improve our knowledge of the ethical challenges that arise from
neurosciences in terms of health care, public information and prevention in neurology,
psychiatry and neurosurgery.


IS IT POSSIBLE TO RECONNECT DAMAGED
AXONS?

“The nervous system is not the only system
Neurobiology and Development formed during human embryonic development.
Blood vessels are also organized into a very

research division complex network, which led to the idea that
certain molecules could be reused by both
the nervous system and the vascular system.
We recently discovered that a key molecule
The brain is made up of billions of neurons organized into a complex network. The inaccurate connection of the vascular system (VEGF) can attract
of these neurons has severe consequences on the nervous system’s sensory, motor and cognitive functions. nervous system axons to their targets. More
To properly form neural circuits, developing axons (long extensions that form the nerves) need molecules specifically, we identified Flk-1 as the receptor
to guide them towards their target. responsible for this effect, making it a prime
target for the development of therapies
to re-grow axons following lesions of the
Research unit directors central nervous system or neurodegenerative
diseases.”
Michel Cayouette, PhD Artur Kania, PhD
FRÉDÉRIC CHARRON, PhD
Director, Neurobiology and Development research division Director, Neural Circuit Development
Director, Molecular Biology of Neural Development
Director, Cellular Neurobiology Associate IRCM Research Professor
research unit
Associate IRCM Research Professor
Marie Kmita, PhD Associate IRCM Research Professor
Frédéric Charron, PhD Director, Genetics and Development
Director, Molecular Biology of Neural Development Associate IRCM Research Professor
Associate IRCM Research Professor Canada Research Chair in Molecular Embryology and
Genetics
Jacques Drouin, D.Sc., MSRC
Director, Molecular Genetics Éric Racine, PhD
Full IRCM Research Professor Director, Neuroethics
David R. Hipfner, PhD
Director, Epithelial Cell Biology


EXPLORING THE 2011-2012

COMPLEXITY 8 teams • 34 publications by the division’s researchers • 1 honoured researcher: Yvan

OF BIOLOGICAL
Guindon received the 2012 Alfred Bader Award from the Canadian Society for Chemistry
and was appointed Knight of the Ordre national du Québec • 1 scholarship holder from
the Fonds de recherche du Québec – Santé: François Robert • 1 grant from the National

SYSTEMS
Institutes of Health: Peter W. Schiller ($1,000,000) • 1 grant from the Cancer Research
Society: Jacques Archambault ($120,000)

Systems Biology and Medicinal Chemistry research division

Systems biology is a rapidly expanding area of research. It examines the immense
complexity of biological systems in order to gain a better understanding of the way
cells function. The IRCM has seized the opportunity to play a leading role in the DID YOU KNOW…
revolution of this emerging discipline. …genomics is the study of a living being’s complete genetic information
(DNA). Researchers in this field are working towards mapping human genes
The research units working in this division address questions that are central to by using sequencing methods, which will help them understand why, among
understanding normal cell functions and their deregulation in diseases, such as other questions, certain people become sick when others remain healthy.
cancer and viral infections.

The medicinal chemistry component of this division focuses on chemical biology, an
area of interdisciplinary research at the crossroads between chemistry and biology.
This is where expertise in synthesizing organic molecules is applied to solving
problems in cell and molecular biology.


A STEP CLOSER TO UNDERSTANDING THE
FUNCTION OF GENES

“By using modern functional genomics tools, our
Systems Biology and Medicinal research team confirmed the first hypothesis
that transcription operates in a uniform way

Chemistry research division across virtually all genes. As misregulation of
transcription often underlies genetic diseases
and cancer, this breakthrough provides critical
insights that could one day lead to new
By examining a small number of genes, certain pioneering studies that have been long-accepted in the treatments.”
field of molecular biology had shown that phosphorylation of RNA polymerase II – one of the most
important regulation mechanisms for cells – always occurred in the same prescribed pattern during FRANÇOIS ROBERT, PhD
transcription. However, recent genome-wide analyses challenged this idea by suggesting that this process Director, Systems Biology and Medicinal Chemistry
research division
was not uniform across different genes. The latter model is very controversial, because it is unclear how, Director, Chromatin and Genomic Expression research unit
or why, transcription could work in such radically different ways from one gene to the next. Associate IRCM Research Professor

Research unit directors

Jacques Archambault, PhD Éric Lécuyer, PhD
Director, Molecular Virology Director, RNA Biology
Full IRCM Research Professor Assistant IRCM Research Professor
Benoit Coulombe, PhD Marlene Oeffinger, PhD
Director, Gene Transcription and Proteomics Director, Ribonucleoprotein Biochemistry
Full IRCM Research Professor Assistant IRCM Research Professor
Yvan Guindon, C.M., PhD, MSRC François Robert, PhD
Director, Bioorganic Chemistry Director, Systems Biology and Medicinal Chemistry research
Full IRCM Research Professor division
Director, Chromatin and Genomic Expression
Benjamin Haibe-Kains, PhD
Director, bioinformatics and computational genomics
Assistant IRCM Research Professor Peter W. Schiller, O.Q., PhD, MSRC
Director, Chemical Biology and Peptide Research

52 | 2011-2012 IRCM ANNUAL REPORT TREATING | 53

IRCM CLINIC
A multidisciplinary team
Doctors, nutritionists, kinesiologists, nurses
T R E AT I N G
hypertension – cholestErol – DIABETES AND OBESITY
3 specialized research clinics
Hypertension clinic
Nutrition, metabolism and atherosclerosis clinic
Obesity, metabolism and diabetes clinic


ACCELERATING
The IRCM Clinic boasts three
specialized research clinics in the
fields of hypertension, cholesterol,

CLINICAL
and diabetes. Clinical research
protocols are regularly conducted,
thus contributing to the

RESEARCH
development of new diagnostic
methods, the identification of new
biochemical or genetic markers
for cardiovascular diseases, and
the evaluation of new therapeutic The IRCM’s Outpatient Clinic handles over 16,000 patient visits per year. The
approaches. This research IRCM offers its clinical researchers the unique opportunity to follow their patients’
progress on site thanks to its external consultation services. The Institut’s
bridges the gap between basic infrastructure and distinctive conceptual model allows for clinical and translational
laboratory research and its clinical research, within the framework of an institution devoted to basic research.
application in humans. The Institut’s clinic and clinical research are funded directly by the IRCM, and
also receive funding from private sources, such as the pharmaceutical industry,
government agencies and the Canadian Institutes of Health Research. The IRCM
Clinic is affiliated with the Centre hospitalier de l’Université de Montréal.

56 | 2011-2012 IRCM ANNUAL REPORT TReating | 57

The Nutrition, Metabolism and Atherosclerosis Clinic’s research activity The Hypertension clinic assesses and treats patients referred for their high
deals with the characterization and treatment of hyperlipidemia, that is to say blood pressure. The research protocols study new diagnostic methods and
the increase of cholesterol or other fats in the blood. Experts are studying the treatments for hypertension. Studies are also conducted to better understand
nutritional, genetic, biochemical, pharmacological, and molecular components the role of the autonomic nervous system in hypertension and its effects on
of these diseases to better understand what causes them and provide the vascular function.
appropriate treatment.

Nutrition, metabolism and atherosclerosis clinic Hypertension clinic

DID YOU KNOW… DID YOU KNOW…
... the liver produces the majority (80 per cent) of the cholesterol used by …according to the Société québécoise d’hypertension artérielle, one in
the body for various functions. The other 20 per cent comes from the food five adults in Canada suffers from hypertension. The risk of developing
we eat, particularly animal products. hypertension increases with age, in such a way that approximately 50 per
cent of men or women aged over 60 have high blood pressure.


Permanent staff – medical personnel

The Obesity, Metabolism and Diabetes clinic allows experts to follow the
Directors Nurses Kinesiologists
progress of patients suffering from obesity and various metabolic disorders, Robert Dufour Martine Gauthier, head nurse Philippe Briand
and, more particularly, patients with type-1 and type-2 diabetes. Patients benefit Pierre Larochelle Lucienne Bourque Corinne Suppere
from the support of a multidisciplinary team. Numerous research projects are Rémi Rabasa-Lhoret Maryse Dallaire
Joanie Houle Project coordinator
ongoing, including the development of an artificial external pancreas and the Nutritionists
Hélène Larchevêque Virginie Messier
identification of new relationships between hypercholesterolemia and the risk Chantal Blais
Jennifer Levasseur
Sonia Fortin
of developing type-2 diabetes. Annabelle Mathieu Technicians
Cherylene Pinaroc Annie Tardif
Diane Mignault

Obesity, metabolism and diabetes clinic

DID YOU KNOW…
…according to Diabetes Québec, an estimated 760,000 people in Quebec
have diabetes, 200,000 of whom are unaware that they have the disease.
The World Health Organization predicts that the number of people with
diabetes will double by 2025, making diabetes the new epidemic.

Hélène Larchevêque, Lucienne Bourque, Joanie Houle, Martine Gauthier


What is the
nutritionist’s role
DID YOU KNOW…
…as early as the 19th century, a French
at the IRCM Clinic?
gastronome, Brillat-Savarin, set the table
Nutritionists at the IRCM evaluate patients’ eating habits, develop treatment
for the notion that food has a significant
influence on the human body’s function- plans adapted to the needs of each person and supervise their effectiveness.
ing. In fact, we owe him this famous quote: They also advise patients to help them prevent disease, as well as maintain
“Tell me what you eat, and I will tell you or restore their health.
what you are.”
“For example, the Éducoeur study that we conducted at the IRCM showed that
Today, the increasing variety of food
at our disposal complicates the healthy people at risk of developing cardiovascular diseases could, with a nutritional
choices consumers should be making. In program tailored to their needs, improve many of the risk factors such as
addition, for adults and children alike, blood pressure, cholesterol, blood sugar and weight. With an evaluation,
chronic diseases are on the rise because of practical advice, accompanied visits to the grocery store and tastings of
inadequate lifestyles. lesser-known ingredients, we were able to motivate these individuals with
better eating habits and help them correct these risk factors.”

CHANTAL BLAIS, Dt.P., BSc
Head of the nutrition department, IRCM Clinic

62 | 2011-2012 IRCM ANNUAL REPORT INNOVATING | 63

Core facilities and technology platforms
8 core facilities
Animal facilities and animal experimentation | Bioinformatics | Chemical biology | Flow cytometry |
Histology | Microscopy and imaging | Molecular biology and functional genomics |
Transgenesis and microinjection

I N N O VAT I N G 3 ultra-specialized research platforms
National platform for human interactome mapping
8 core facilities Proteomics discovery platform
3 research platforms
Research platform on obesity, metabolism and diabetes (PROMD)

Electrophysiology | Molecular modelling | Nuclear magnetic resonance | Protein sequencer |
Specialized equipment

50 people serving research


STRENGTHENING
This year, the IRCM set up a
Bioinformatics core facility. Supervised
by Dr. Benjamin Haibe-Kains, this

OUR
2011-2012
new facility aims at providing support
to scientists, from the IRCM and the

TECHNOLOGICAL
scientific community, in the analysis
of biological and clinical data, and
particularly next-generation genomic

ADVANTAGE
data. With the development of
new technologies generating large
amounts of biological data, including
next-generation sequencing, the To facilitate innovation, the IRCM ensures that it provides its researchers with the
complexity of many studies now lies best technologies. The IRCM’s core facilities thereby allow researchers to remain
at the forefront of modern science, achieve important scientific breakthroughs, and
in the computational analysis of such offer cutting-edge training to tomorrow’s scientists.
data. This analysis, which has become
Over the years, its core facilities and technology platforms have proven to be
impossible to complete “manually”, extremely useful and effective. Certain discoveries may not have been possible
now requires the development of without these state-of-the-art resources.

algorithms and support from personnel
specialized in bioinformatics.


“Flow cytometry is a specialized technique
that has existed for several years and is
currently used by many IRCM researchers.
Over the years, after numerous technical
modifications, the level of sophistication
has greatly increased and now allows for
more effective sorting and more complex
approaches. For example, in my laboratory,
we are interested in intracellular organelles,
much smaller than cells. We incorporated
a fluorescent protein specifically in the
organelles we are studying, namely the
endocrine secretion granules (pituitary or
pancreatic) or the endosomes. We therefore
needed to optimize the cytometer’s
parameters in order for the device to “see”
FLOW CYTOMETRY CORE FACILITY
and sort extremely small particles while
preserving their structural integrity. This
work was complex and required much
effort. Today, as a result, we have a brand
new method at our disposal that was made DID YOU KNOW…
possible thanks to the expertise of the ...flow cytometry is a technique that can analyse individual cells, which offers, among other things, a quick
IRCM’s flow cytometry team.” method for researchers to confirm the transfer of a gene using fluorescent markers.

CLAUDE LAZURE, Phd The technique consists of streaming cells very quickly, one cell behind the other, through a laser beam. The
Director, Neuropeptide Structure and Metabolism
research unit device used, the cytometer, can analyze cells individually according to numerous parameters, at the speed
Full IRCM Research Professor of several thousand particles per second. The light, reemitted by diffraction and fluorescence, enables
the classification and sorting of cells in accordance with several criteria. A computer then calculates the
statistical data associated with the measured parameters.

68 | 2011-2012 IRCM ANNUAL REPORT INNOVATING | 69

Research services

Executive Director: Louis-Gilles Durand | Assistant Director: Judith Cotton-Montpetit

Core facilities

Animal experimentation and animal facilities Director: Ion-Ovidiu Jumanca
Animal facilities Head: Julie D’amours
Animal physiology Head: Manon Laprise
Bioinformatics Head: Rashad El-Badrawi | Expert advisor: Benjamin Haibe-Kains
Chemical biology Contact person: David Gagnon | Expert advisor: Jacques Archambault
Flow Cytometry Head: Éric Massicotte | Contact person: André Veillette
Histology Head: Dominique Lauzier
Microscopy and imaging Head: Dominic Filion
MICROSCOPY AND IMAGING CORE FACILITY Molecular biology and functional genomics Head: Odile Neyret | Expert advisor: François Robert
Transgenesis and microinjection Director: Qinzhang Zhu | Supervisor: André Veillette

DID YOU KNOW… Technology platforms

...a jellyfish contributed to the explosion of fluorescence in microscopy. The Green Proteomics discovery platform Director: Benoit Coulombe
Fluorescent Protein (GFP), a molecule discovered in 1962 and now commonly used in Mass spectrometry and proteomics Head: Denis Faubert
microscopy, has existed for over 160 million years in a bioluminescent jellyfish called Research platform on obesity,
Aequorea Victoria. Researchers at the IRCM use fluorescent microscopy, a technique metabolism and diabetes (PROMD) Director: Rémi Rabasa-Lhoret | Contact person: Diane Mignault
that uses the light emitted by fluorescent molecules to form an image of various National platform for human interactome mapping Director: Benoit Coulombe
samples, such as live or fixed cells and tissues. They can thus obtain digital data
that would otherwise require many hours of manual data manipulation, including the Other specialized services
quantity of cells, the relative fluorescent intensity, surface measures and speed of
movement. Electrophysiology Contact persons: Artur Kania, Michel Paquet
Molecular modelling Contact persons: Peter W. Schiller, Brian Wilkes
Nuclear magnetic resonance Contact persons: Yvan Guindon, Michel Prévost
Protein sequencer Contact person: Claude Lazure
Specialized equipment Head: Richard Cimon

70 | 2011-2012 IRCM ANNUAL REPORT CONTRIBUting | 71

Technology Transfer

The IRCM’s mission states that the Institut must contribute
to Quebec’s socioeconomic development by facilitating

CONTRIBUTING the commercial development of new discoveries. To carry
out this mission, the IRCM’s Technology Transfer Office
collaborates with Univalor, a limited partnership whose goal
78% of IRCM researchers shared their discoveries is to accelerate the transfer to industry of research results.
5 declarations of invention in 2011-2012
7 files (applications) for patents in 2011-2012 In 2011-2012, the Office’s efforts led to the implementation
$2 million in revenue over the past six years of two research collaborations and to the signature of two
contracts with biotechnology companies and pharmaceutical
33 patents in the past 26 years
partners, both locally and internationally. The Technology
Transfer Office also participated in funding applications for
the commercial development of new promising technologies.

Director: Stéphane Létourneau, LLB, M.Litt.
Technology Transfer Officer: Dominique Bergeron, PhD

72 | 2011-2012 IRCM ANNUAL REPORT CONTRIBUTING | 73

“The discovery of PCSK9-
inhibiting molecules would offer a
beneficial alternative to treatments
currently used to reduce the level
2011-2012 of bad cholesterol in the blood
and, consequently, the risks of
cardiovascular disease.”
DOMINIQUE BERGERON, PhD
Technology Transfer Officer

© Gouvernement du Québec (Les Prix du Québec)
This year’s Dr. Seidah’s work aroused great

highlight: small interest from the limited partnership
AmorChem and obtained, with

PCSK9-inhibitor support from Univalor, substantial
investment for the development of

molecules an innovative drug to control the
level of LDL-cholesterol in the blood
by targeting PCSK9. Dr. Seidah’s
project, conducted in collaboration
with NuChem Therapeutics Inc., is the
first to be supported by the seed fund
established by AmorChem.

Dr. Nabil G. Seidah, pioneer in the field of proprotein convertases (PC), including
PCSK9 (the 9th member of the PC family), has been working for many years on
developing therapeutic applications for this promising target.

74 | 2011-2012 IRCM ANNUAL REPORT TRAINING | 75

TRAINING Tomorrow’s researchers

Training tomorrow’s researchers is a key element in the IRCM’s mission
statement. Each year, more than 150 Master’s and doctoral students,
and approximately 50 postdoctoral fellows pursue their studies at the
IRCM. In addition, about 40 undergraduate students complete research
internships. These students, generally registered at the Université de

TRAINING
Montréal or McGill University, come from all over the world, making the
IRCM a very cosmopolitan institute whose diversity reflects that of the
city of Montréal.
113 Master’s and PhD students
The Institut also contributes to raising young people’s awareness of the
benefits of choosing a research career in biomedical sciences. Therefore,
58 scholarship holders high school, CEGEP and university students regularly visit the IRCM’s
467 teaching hours laboratories and meet its researchers.

Academic Affairs department
Executive Director: Timothy L. Reudelhuber, PhD | Associate Director, scientific activities: Jean-
François Côté, PhD | Associate Director, student affairs: Jean-Philippe Gratton, PhD | Advisor:
Johanne Langevin | Agent: Virginie Leduc | Coordinator, graduate studies program in molecular
and cellular medicine: Danielle Méthot, PhD | Chief, documentation centre: Nicole Campeau
(until June 2012) | Head, documentation centre: Tabasum Abdul-Rasul (since June 2012)

* 376.5 hours at the Université de Montréal (29 of our researchers)
90.5 hours at McGill University (14 of our researchers)


2011-2012

GRADUATE STUDIES
IN TRANSLATIONAL
RESEARCH
In 2011-2012, the IRCM created a new training program for graduate students. As early as July
2013, students will have the opportunity of pursuing their graduate studies in molecular biology by
registering in the new molecular and cellular medicine option at the Université de Montréal. Based
on a rotation system, the program will offer students accelerated training, allowing them to quickly
move from their Master’s to their doctoral degree.


“The molecular and cellular
medicine option offers unique AN INNOVATIVE APPROACH
training in Montréal in translational
research. Its goal is to bridge the This option will actively prepare students for their chosen doctoral
gap between the basic research project through intensive internships in the IRCM’s laboratories,
conducted in laboratories and where the research topics are mainly focused on human diseases.
the needs of the clinical practice. Students in this new program will also benefit from practical
It focuses on the use of state- experience in translational medicine by being exposed to the
of-the-art technologies in the research laboratory, the clinical environment and concepts of
study of human diseases in order personalized medicine, while also acquiring a strong knowledge
to develop new diagnostic and of the ethical issues involved.
therapeutic approaches that will
be readily available to patients.”

DANIELLE MÉTHOT, PhD • One-year intensive Master’s degree
Program coordinator
• Possibility of fast-tracking to a doctoral program
• No writing of a Master’s thesis
• Spaces limited to the best applicants
• Multidisciplinary training in molecular biology
• Use of various core facilities
• Research internships and clinic visits


Frederick Banting
Master’s student in the Metabolic Diseases research unit,
directed by Dr. Rémi Rabasa-Lhoret, Katherine Chabot
received a 2012 Frederick Banting and Charles Best
Canada Graduate Scholarship from the Canadian Institutes

and Charles Best
of Health Research. Katherine Chabot is also the recipient
of the IRCM Foundation’s 2012 Métro Master’s scholarship.

“While I was completing my bachelor’s degree in
nutrition at the Université de Montréal, I attended
a conference given by Dr. Rémi Rabasa-Lhoret
that truly impressed me, which eventually Canada Graduate
Scholarship
convinced me to pursue my graduate studies at
the IRCM. My research project is about obese
individuals without metabolic complications.
I enjoy the direct contact with patients, but
have always been curious to know more about
what causes their condition. At the Institut, I
finally have the unique opportunity to acquire
a deeper knowledge of the subject. I continue DID YOU KNOW…
to see patients at the clinic, and am learning so …the Frederick Banting and Charles Best Canada Graduate
much in the basic research laboratory. Thanks Scholarships from the Canadian Institutes of Health Research
to its supportive environment, the IRCM makes support the best Master’s and doctoral students in Canada.
me want to surpass myself. I am proud to have These scholarships are dedicated to Sir Frederick Banting and
received these scholarships, which contribute to Dr. Charles Best in honour of their discovery of insulin, which,
my laboratory’s reputation, and that of the IRCM.” in turn, made them leaders in other areas of health research.
KATHERINE CHABOT
Research project – Evaluation of the relationship between For more information on scholarship holders, refer to the IRCM’s academic report. In
the activity of AMPK, inflammation and adipose tissue 2011-2012, 48 nominal scholarships and 13 internal scholarships were granted to
fibrosis, and the development of systemic insulin resistance the IRCM’s graduate students and postdoctoral fellows.
in obese humans, before and after bariatric surgery


IRCM Research Day

A true forum for scientific exchanges, this event
allows the IRCM’s students and postdoctoral
fellows to showcase the quality of their research 2011-2012
projects and their communication skills. Once again
this year, this day was a great success. Thanks
to the generosity of several partners, the Institut
granted 15 awards for the best posters and oral
presentations.

Students and postdoctoral fellows
IRCM Student Association
The IRCM Student Association brings together the 72 doctoral students
Institut’s students and postdoctoral fellows. It also 41 Master’s students
58 scholarship holders
fosters their relationships with other members of the
internal community and represents them in dealings
with governing bodies. The Association acts as a Completed fellowships and awarded degrees
liaison between students and postdoctoral fellows
and scientific management to facilitate interaction 13 postdoctoral fellowships
and cooperation, thereby positively contributing to 10 doctorate degrees (PhD)
07 Master’s degrees
the IRCM’s development. Moreover, the Association
84 undergraduate internships
maintains ties with other student bodies at the
Université de Montréal and McGill University.
Alumni association
Total members: 1,218 (as of August 31, 2012)
New members in 2011-2012: 30
Postdoctoral fellows: 13
Doctoral students: 10
Master’s students: 7

IRCM Research Day | Tyler Sloan McGill University Award / Division of Experimental Medicine


2011-2012

SCIENCE
PARTICIPATING
FOR ALL
International conferences

Cafés scientifiques

Appearances by IRCM experts on radio and television shows

Social networks

Public exhibition

86 | 2011-2012 IRCM ANNUAL REPORT PARTICIPATING | 87

INTERNATIONAL CONFERENCES CAFÉS SCIENTIFIQUES

Each year, the IRCM’s researchers organize The Institut held its third season of cafés
symposiums in order to share the knowledge scientifiques in 2011-2012. The three organized 2011-2012
acquired in their respective fields with their events were held at the IRCM for the first time. The
international colleagues in the scientific community. experts shared the results of their research projects
This year, two events held outside the Institut were with the public, as well as new developments in their
organized by our researchers. field of expertise.

Mont-Tremblant Type-2 diabetes and a healthy heart (Le diabète My blood pressure and I (Ma pression et moi) Type-1 diabetes: towards a needle-free future
de type 2 et la santé du cœur)
12th International Conference on Limb
Development and Regeneration
Organized by Jacques Drouin and Marie Kmita
Over 100 participants

Bécancour

Signalisation Québec 2012
Organized by Jean-François Côté, Jean-Philippe Gratton and
André Veillette
Nearly 120 participants

The IRCM also hosts national and international
symposiums. This year, it welcomed for the second I suffer from type-2 diabetes: Why is it important to control blood pressure? How is diabetes research progressing?
What are the risks of developing a heart disease? What are the consequences of a hypertension diagnosis? What are the potential future treatments?
time the MonBug bioinformatics symposium
What research advances are being made in this field? What are the negative effects of salt on blood pressure? How can they improve the lives of people with type-1 diabetes?
organized by the Montreal Bioinformatics Users How can I change my lifestyle to reduce the risks? Which physical activities are best suited for someone? What is an artificial external pancreas and how does it work?
Group. More than 120 participants, mainly from
Quebec, but also from Ottawa and Toronto, attended Experts: Rémi Rabasa-Lhoret, Sonia Fortin, Philippe Briand Experts: Pierre Larochelle, Ghislaine Roederer, Chantal Experts: Rémi Rabasa-Lhoret, Jennifer Estall, Laurent
the event. / Host: Véronique Perrault Blais / Host: Véronique Perrault / Host: Louise Lambert-Lagacé
Legault *

* Laurent Legault is a paediatric endocrinologist at the Montreal Children’s Hospital


PUBLIC AFFAIRS PROGRAMMES EXTERNAL MEDIA EVENT

Researchers, physicians and other professionals This year, the IRCM also hosted a national media
from the Institut and the IRCM Clinic are often event as it welcomed the Bank of Canada for its
approached by various media searching for experts launch of the new $100 polymer bank note. As
for an article or program. Their participation as this bank note celebrates Canadian innovation in
experts contributes to increasing the IRCM’s medical research, the Bank of Canada associated
visibility and informing the general public of hot itself with research institutions in each province, and
topics related to health and health research. chose the IRCM for its Quebec launch.

SOCIAL NETWORKS

The IRCM is present on Facebook:

facebook.com/IRCM.Montreal

It also has a YouTube channel where it showcases
videos of its cafés scientifiques as well as videos
produced for the IRCM Foundation.

youtube.com/IRCM100

PUBLIC EXHIBITION

Through its research platform on obesity,
metabolism and diabetes (PROMD), the IRCM
hosted a booth at the 2012 Salon Ma Santé held
at Complexe Desjardins. The hundreds of visitors
had the opportunity to learn more about what takes
place at the Institut, especially in terms of research
projects on diabetes.

Tarik Möröy and Phuong Anh Ho Huu, Senior Representative of the Quebec Regional Office, Bank of Canada

90 | 2011-2012 IRCM ANNUAL REPORT RESEARCH FUNDING | 91

(April 1, 2011 to March 31, 2012) Sciences and Humanities Research Council of
Canada – Terry Fox Research Institute – United
Government agencies and departments provide States Army Medical Research Acquisition Activity
essential funding for the Institut’s research
activities. In most cases, funds are granted TOTAL: $13,838,596
based on the recommendations of peer-review
committees. Researchers, as well as the students
and postdoctoral fellows on their team, benefit from Pharmaceutical industry
this funding.
AstraZeneca Canada – Boehringer Ingelheim
Following is a list of the IRCM’s major funding (Canada) Ltd – Bristol-Myers Squibb Canada
partners for 2011-2012: – Eli Lilly Canada Inc. – Immunotec Inc. – Isis
Pharmaceutical – Merck – Novartis Pharma Canada
Inc. – Novo Nordisk – Pfizer Canada Inc. – Sanofi-
Peer-reviewed granting agencies aventis Canada Inc.

Association française contre les myopathies – TOTAL: $558,185
RESEARCH FUNDING Canada Foundation for Innovation – Canada
Research Chairs – Canadian Blood Services –
Canadian Cancer Society – Canadian Diabetes
Association – Canadian Foundation for AIDS Peer-reviewed granting agencies: 88.7%
Research – Canadian Institutes of Health Research Donations from the IRCM Foundation: 6.1%
– Cancer Research Society – Cornell University – Pharmaceutical industry: 2.4%
Cystic Fibrosis Canada – Diabetes Québec – Fonds Other sources: 2.8%
de recherche du Québec - Santé – Foundation $22.9 million: 100%
Fighting Blindness – Génome Québec – Heart
and Stroke Foundation of Canada – Muscular
Distrophy Association – National Institutes of
Health – Natural Sciences and Engineering
Research Council of Canada – Neurodevelopment
Network – Parkinson Society Canada – Polycystic
Kidney Disease Foundation of Canada – Quebec
Breast Cancer Foundation – Québec Consortium
for Drug Discovery – Quebec ministry of Economic
Development, Innovation and Export Trade – Social

92 | 2011-2012 IRCM ANNUAL REPORT ADMINISTRATION | 93

IRCM BOARD OF DIRECTORS Members
Guy Breton
The IRCM relies on the council and volunteer Rector, Université de Montréal
support of its Board members for help in achieving Raymond Chrétien
its mission. Partner and Strategic Advisor
Fasken Martineau DuMoulin LLP
Between the 2011 general assembly to the one Hélène Desmarais
Chairwoman of the Board of Directors, HEC Montréal
held in 2012, five regular Board meetings took
Monique Jérôme-Forget
place. The Board members’ attendance rate was of
Special Advisor, Osler, Hoskin & Harcourt and Korn/Ferry
80 per cent. International
Paule Leduc
During this period, the number of seats on the Corporate Director
Board increased to 18 as three new members Michel Lespérance
joined: Monique Jérôme-Forget, Michel Lespérance Corporate Director
and Hélène Robitaille. Christine Le Jeune
CMA, FCA

ADMINISTRATION Members of the IRCM Board of Directors
Camille Limoges
Corporate Director
Alain Mayrand
Corporate Director
President of the IRCM Foundation
(Members appointed from June 2011 to June
Hélène Robitaille
2012) Corporate Director
Pierre Shooner
Chair Corporate Director
Louise Lambert-Lagacé
Yvon Turcot
President
Strategic Communications Consultant
La clinique de nutrition Louise Lambert-Lagacé et associées
Corporate Director
Michael L. Turcotte
Vice-Chair Chairman of the Board of Directors, Hydro-Québec
W. Robert Laurier
Corporate Director
Corporate Director

Secretary
President and Scientific Director
Tarik Möröy Stéphane Létourneau
Executive Director, Corporate and Legal Affairs, IRCM

94 | 2011-2012 IRCM ANNUAL REPORT ADMINISTRATION | 95

Treasurer Audit Committee IRCM MANAGEMENT Scientific Management Committee
Louis-Gilles Durand W. Robert Laurier, Chair
Executive Director, Administration and research services, IRCM Christine Le Jeune
As President and Scientific Director, Tarik (Appointed for 2011-2012)
Pierre Shooner
Observer Möröy oversees both the IRCM’s administrative
Martin Doyon and scientific operations. In this respect, he The Scientific Management Committee includes all
The IRCM’s directors are individuals not only
Ministry of Economic Development, Innovation and Export receives support from other scientists who share five research division directors. This committee’s
committed to the Institut, but to society in general.
Trade administrative responsibilities for the research primarily role is to advise the President and Scientific
In this regard, they are often honoured by various
units they each manage. Dr. Möröy chairs the Director on the recruitment of new research unit
prestigious organizations for their contributions to
Management Committee and the Scientific directors, the Institut’s strategic planning, and the
Board Committees the community.
Management Committee, and also supervises his mandate and relevance of various core facilities.
This year, Gérard A. Limoges, outgoing Chairman of own research unit at the IRCM.
Executive Committee Committee members
the Board, received the Prix-Bénévolat 2011 from Michel Cayouette
Louise Lambert-Lagacé, Chair
W. Robert Laurier, Vice-Chair
Montréal’s Chartered Accountants in recognition of Éric A. Cohen
his exceptional accomplishments and commitment Management Committee Benoit Coulombe (until November 2011)
Alain Mayrand
Tarik Möröy to the IRCM from 1999 to 2011. This honour was Christian F. Deschepper
Michael L. Turcotte granted along with a $3,000 donation to the IRCM. (Appointed for 2011-2012) Tarik Möröy
François Robert (since November 2011)
Marie Trudel
Communications Committee The Management Committee is responsible for
Monique Jérôme-Forget supporting the President and Scientific Director
in his administrative and management functions.
Christine Le Jeune
Yvon Turcot, Chair To accomplish the IRCM’s fundamental missions
of excellence in research and training the next
Governance Committee generation of scientists, this committee coordinates
W. Robert Laurier the departments and personnel supervised by
Christine Le Jeune Executive Directors.
Michel Lespérance
Camille Limoges
Michael L. Turcotte, Chair Committee members
Louis-Gilles Durand
Pierre Larochelle
Human Resources Committee
Stéphane Létourneau
Raymond Chrétien
Tarik Möröy
Timothy L. Reudelhuber
Paule Leduc
Alain Mayrand, Chair

96 | 2011-2012 IRCM ANNUAL REPORT ADMINISTRATION / ORGANIZATIONAL CHARTS | 97

Administrative Organization Scientific Organization
March 2012 March 2012

Board of Directors
Board of Directors

President and Scientific Director
President and Scientific Director Advisor Tarik Möröy
Tarik Möröy Marielle Gascon-Barré

Research division Director Research division Director Research division Director
Systems Biology and Research division Director Research division Director Cardiovascular and Neurobiology and
Executive Director Executive Director Executive Director Executive Director Medicinal Chemistry Cancer Immunity and Viral Infections Metabolic Diseases Development
Academic Affairs Administration and Research Services Corporate and Legal Affairs Clinic and Clinical Research François Robert Marie Trudel Éric A. Cohen Christian F. Deschepper Michel Cayouette
Timothy L. Reudelhuber Louis-Gilles Durand Stéphane Létourneau Pierre Larochelle

Chemical Biology and Molecular Biochemistry of
Endothelial Cell Biology Molecular Biology Epithelial Cell Biology
Associate Director Director Director Associate Director Peptide Reseach Hypertension
Scientific Activities Finances Human Resources Jean-Philippe Gratton Paul Jolicoeur David R. Hipfner
Robert Dufour Peter W. Schiller Timothy L. Reudelhuber
Jean-François Côté Benoit Papineau Jacqueline Turgeon

Biochemical Molecular Biology of
RNA Biology Breast Cancer Biology Molecular Immunology
Associate Director Director Information Director Head Nurse Neuroendocrinology Neural Development
Student Affairs System Technology Technology Transfer Éric Lécuyer Katrina Podsypanina Hua Gu
Martine Gauthier Nabil G. Seidah Frédéric Charron
Jean-Philippe Gratton Richard Tanguay Stéphane Létourneau

Molecular Genetics and Mechanisms of Genetic Experimental Neural Circuit
Assistant Director Director Animal Facilities Bioorganic Chemistry
Academic Staff Development Diversity Cardiovascular Biology Development
Research Services and Animal Experimentation Yvan Guindon
Timothy L. Reudelhuber
Judith Cotton-Montpetit Ion-Ovidiu Jumanca Marie Trudel Javier Marcelo Di Noia Christian F. Deschepper Artur Kania

Director Director Chromatin and Genomic Hematopoiesis and Molecular Oncology Molecular Endocrinology Genetics and
Chief
Documentation Center
Engineering Services Communications Expression Cancer André Veillette M. Ram Sairam Development
and Physical Plant Lucette Thériault Marie Kmita
Nicole Campeau
Michel Gaudreau
François Robert Tarik Möröy

Gene Transcription and Cellular Interactions and Immune Regulation Metabolic Diseases Molecular Genetics-
Director
Proteomics Development Woong-Kyung Suh Rémi Rabasa-Lhoret Jacques Drouin
Foundation
Hélène Véronneau Benoit Coulombe Jean Vacher

Assistant Director
Engineering Services Cytoskeletal Organization Human Retrovirology Molecular Mechanisms Cellular Neurobiology
Molecular Virology
Marcel Leclerc and Cell Migration Éric A. Cohen of Diabetes Michel Cayouette
Jacques Archambault
Jean-François Côté Jennifer Estall

Coordinator
Security
Michel Charest Ribonucleoprotein Cell Division and Cardiovascular Neuroethics
Biochemistry Centrosome Biology Pharmacology Éric Racine
Marlene Oeffinger William Y. Tsang Pierre Larochelle

Neuropeptide Structure
Bioinformatics and
and Metabolism
Computational Genomics
Claude Lazure
Benjamin Haibe-Kains

These researchers are members of the IRCM’s Scientific Committee
Also members : Jean Davignon, Robert Dufour, Louis-Gilles Durand, Zaher S. Hanna, Maxime Lamarre-Cliche, Annik Prat

98 | 2011-2012 IRCM ANNUAL REPORT ADMINISTRATION / FINANCIAL STATEMENTS | 99

FINANCIAL STATEMENTS
Summarized statement of financial position / March 31, 2012, with comparative information for 2011
Summarized statement of operations / March 31, 2012, with comparative information for 2011

2012 2011
2012 2011 2012 2011 2012 2011
Restricted Funds Restricted Funds Restricted Funds
Operating Research Capital Asset Operating Research Capital Asset Operating Fund Research Fund Capital Asset Fund
Fund Fund Fund Total Fund Fund Fund Total
Revenues:
Assets Peer review grant program $ - $ - $ 20,302,334 $ 16,020,980 $ - $ -
Grants - interest and management fees portion - - - - 1,621,426 1,754,701
Current assets: Other grants - - 1,115,332 1,216,443 - -
Cash and cash equivalents $ 2,269,253 $ 3,124,988 $ - $ 5,394,241 $ 2,278,847 $ 3,020,426 $ - $ 5,299,273 Restricted donations - - 33,017 98,603 - -
Grants receivable and other receivables 432,546 4,660,823 - 5,093,369 224,439 2,718,103 - 2,942,542 Grant from ministère du Développement
Donations receivable from the Foundation - 194,934 - 194,934 - - - - économique, de l'Innovation et de l'Exportation 14,753,951 14,631,534 - - - -
Current portion of grants receivable - 19,280,156 19,280,156 - - 3,403,706 3,403,706 Grant from Fonds de la recherche en santé du Québec 2,655,175 2,923,514 - - - -
Grant from Fonds de la recherche en santé du Québec -
Prepaid expenses 138,755 20,233 - 158,988 205,758 34,546 - 240,304
(1) Soutien à la recherche 107,033 96,423 - - - -
Interfund advances - 187,092 - - - 266,644 - -
Grant from federal councils for indirect costs 1,158,275 1,111,464 - - - -
Advances receivable from the Foundation 6,522 138,440 - 144,962 29,555 169,068 - 198,623
Donations from Fondation de l'Institut de recherches cliniques
2,847,076 8,326,510 19,280,156 30,266,650 2,738,599 6,208,787 3,403,706 12,084,448
de Montréal - - 1,400,494 1,461,389 - -
Contribution from Université de Montréal 650,000 650,000 - - - -
Investments 335,313 - - 335,313 277,137 500,000 - 777,137
Other revenues 132,428 149,350 - - - -
Investment in a subsidiary - 143,664 - 143,664 - 136,213 - 136,213
Investment income 29,015 4,677 25,265 23,750 - -
Grants receivable - 12,988,858 12,988,858 - 29,808,354 29,808,354
Change in fair value of investments (12,109) 27,449 - - - -
Capital assets - 47,371,112 47,371,112 - 47,144,096 47,144,096
$ 19,473,768 $ 19,594,411 $ 22,876,442 $ 18,821,165 $ 1,621,426 $ 1,754,701
$ 3,182,389 8,470,174 $ 79,640,126 $ 91,105,597 - $ 3,015,736 $ 6,845,000 $ 80,356,156 $ 89,950,248

Expenses:
Research Fund expenses for the year $ - $ - $ 15,363,143 $ 15,682,413 $ - $ -
Liabilities Operating Fund expenses for the year 18,235,640 18,704,270 - - - -
Donation transfer to the Foundation - - 120,345 - - -
Current liabilities: Depreciation of capital assets - - - - 5,388,775 4,904,130
Accounts payable and accrued liabilities $ 486,902 $ 1,372,080 $ 455,460 $ 2,314,442 $ 447,764 $ 2,331,142 $ 470,475 $ 3,249,381 Interest on notes payable - - 913 7,925 1,625,744 1,770,313
Accrued remuneration and salaries payable 2,115,393 422,072 - 2,537,465 1,909,933 493,114 - 2,403,047 Share in the loss of the subsidiary - - 185,718 167,532 - -
Deferred grants 307,938 - - 307,938 307,938 - - 307,938
Current portion of notes payable - - 18,824,696 18,824,696 - - 3,100,688 3,100,688 $ 18,235,640 $ 18,704,270 $ 15,670,119 $ 15,857,870 $ 7,014,519 $ 6,674,443
(1)
Interfund advances 187,092 - - - 266,644 - - -
3,097,325 1,794,152 19,280,156 23,984,541 2,932,279 2,824,256 3,571,163 9,061,054
Excess (deficiency) of revenues over expenses $ 1,238,128 $ 890,141 $ 7,206,323 $ 2,963,295 $ (5,393,093) $ (4,919,742)
Notes payable 12,988,858 12,988,858 29,808,354 29,808,354

Fund Balances (Deficiencies)

Invested in capital assets - - 47,371,112 47,371,112 - - 46,978,194 46,978,194 Summarized Statement of Changes in Fund Balances
Summarized statement of changes in fund balances
Externally restricted - 8,333,571 8,333,571 - 7,316,209 7,316,209
Deficiency on internally restricted balances - (1,657,549) (1,657,549) - (3,295,465) (3,295,465) Year ended March 31, 2012, with comparative information for 2011
Unrestricted net assets (deficiency) 85,064 - - 85,064 83,457 - (1,555) 81,902
85,064 6,676,022 47,371,112 54,132,198 83,457 4,020,744 46,976,639 51,080,840
2012 2011 2012 2011 2012 2011
$ 3,182,389 8,470,174 $ 79,640,126 $ 91,105,597 $ 3,015,736 $ 6,845,000 $ 80,356,156 $ 89,950,248 Restricted Funds
Operating Fund Research Fund Capital Asset Fund
(1)
For presentation purposes, the interfund advances were eliminated from the total column.
Fund balances, beginning of year $ 83,457 $ 1,534 $ 4,020,744 $ 8,888,895 $ 46,976,639 $ 43,256,716

Excess (deficiency) of revenues over expenses 1,238,128 890,141 7,206,323 2,963,295 (5,393,093) (4,919,742)

Interfund transfers (1,236,521) (808,218) (4,551,045) (7,831,446) 5,787,566 8,639,665

Fund balances, end of year $ 85,064 $ 83,457 $ 6,676,022 $ 4,020,744 $ 47,371,112 $ 46,976,639


IRCM FOUNDATION


SUPPORTING
1 major fundraising campaign / $9,759,855 in commitments and donations
3 annual benefit activities / $354,047 collected
1 annual direct mail campaign / $81,432 collected

VOLUNTEERING
15 Board members
16 fundraising campaign Board members MESSAGES
43 honorary chairpersons, patrons, volunteers and organizers for the benefit activities
FROM MANAGEMENT

GIVING
$1,400,494 donated to the IRCM
$12.6 million in capitalized funds
6 Research Chairs
24 personalized funds
14 scholarships and awards


MESSAGE FROM THE PRESIDENT Major fundraising campaign

For the 2011-2012 fiscal year, the IRCM Foundation The public launch of our major fundraising
gave $1,400,494 to the Institut. Aside from the campaign was a great success. With our volunteers
scientific projects and training activities to which this on the Campaign Board, we continued our efforts to
sum is allocated, a significant portion of the donation solicit the business and philanthropic communities.
will be used to complete the ongoing recruitment of Outstanding donations were confirmed. I would
researchers in the five research divisions. like to thank everyone who has supported us thus
far. I also thank all the volunteers for the time they
dedicated to our various meetings.
Recruitment of new members
In closing, I would like to acknowledge the
One of the Board’s priorities is to interest the excellent work accomplished by the Director of
business community in supporting our objectives, the Foundation, Hélène Véronneau. I wish to thank
which include the IRCM’s first-rate biomedical and the Institut’s staff members who work with us on
clinical research. In this respect, we formed a special various projects. Of course, I also thank the IRCM’s
committee to recruit new members to our Board of President and Scientific Director, Tarik Möröy, for
Directors, thereby ensuring a wider reach for our his active participation in the Foundation’s activities
Foundation and its needs. This committee, chaired and in the major fundraising campaign.
by André J.P. Couillard, submitted three nominations
this year. Finally, I sincerely thank my colleagues on the Board
of Directors for their support and collaboration.
It is therefore with pleasure that the Board welcomed
Alain Brunet, Senior Vice-President of Insurance at
National Bank Financial Group and President of

National Bank Insurance, and Emmanuel Triassi,
CEO of Groupe TEQ. Mr. Triassi also co-chairs our Alain Mayrand
Give for Life major fundraising campaign’s Board. As
for Marie-Hélène Nolet, Assistant Vice President
of Corporate Relations and Partnerships at the
Business Development Bank of Canada, she began
her first term on the Board for the year 2012-2013.

Sophie Brochu et Emmanuel Triassi / Grande campagne de financement


MESSAGE FROM THE DIRECTOR Benefit activities

This year, the IRCM Foundation once again donated Our benefit activities continue to be successful and
nearly 1.5 million dollars to the Institut. This we obtained very good results once more this year.
donation was made possible thanks to our different In 2012, we celebrated the 10th anniversary of our
fundraising activities. bilan de santé – golf tournament. We collected a
record amount of $100,000. I wish to thank all the
volunteers who worked with us to make this event a
Give for Life major fundraising campaign success.

It’s official; we publicly launched our Give for
Life major fundraising campaign. The event took Acknowledgements
place on October 20, 2011. Several members of
Montréal’s business and scientific communities were I would also like to acknowledge the outstanding
in attendance. This fundraising campaign is essential collaboration of my IRCM colleagues, more
for IRCM researchers to continue their work and specifically those in the departments of finance,
clinical studies. It is also very important if we want communications, academic affairs, and corporate and
to continue innovating and improving treatments legal affairs.
against the deadliest diseases including cancer,
cardiovascular diseases, and diabetes. Finally, I thank the President of the Foundation,
Alain Mayrand, and all the Board members, as well
From a 15-million dollar objective, nearly 10 million as the Institut’s President and Scientific Director,
dollars have already been raised. We still have much Tarik Möröy, for their trust.
work to do, but by combining our efforts, we remain
confident that we will achieve our goal. I would
like to acknowledge the exceptional participation
of patients from the IRCM Clinic, who answered
our call in large numbers for the major fundraising
campaign. Their support is greatly appreciated. Hélène Véronneau

I wish to thank our volunteers who have worked
tirelessly since the beginning of this campaign, which
took place in three stages. We have now reached
the last stage. I would also like to thank everyone
who has supported us so far. Your generosity and
commitment are truly valued.

108 | 2011-2012 IRCM ANNUAL REPORT IRCM FOUNDATION / supporting | 109

Together, the Give for Life major fundraising 2012 bilan de santé – golf tournament
campaign, the benefit activities and the direct
mail campaign directly help the IRCM set up new $100,000
research units and grant scholarships to tomorrow’s 152 golfers
researchers. 76 health checks

Honorary chair: Stéphane Gauthier, President and CEO
Give for Life major fundraising campaign of Transelec/Common Inc.

10 partners
$9,759,855 in commitments and donations

Co-chairs: Sophie Brochu and Emmanuel Triassi
2012 IRCM Challenge – Run for Life
12 exceptional donors (donation of over $500,000)
200 runners
Over 1,000 donors
19 partners

SUPPORTING 2011 annual dinner
One Master’s scholarship awarded to a deserving
student
$162,450
380 guests
2011-2012 direct mail campaign
Honorary chair: Edmée Métivier and Patrice Bernard,
$81,432
Business Development Bank of Canada
906 donors
Host: Normand Brathwaite
285 Friends
Musical guest: Rémi Bolduc jazz ensemble
15 Builders
Recipient of the Merit Award: Gérard A. Limoges
9 Great Builders
1 main partner / 10 major partners / 9 important
partners


The $500,000 donation from
the National Bank served to
create the National Bank
Recruitment Program for
new researchers in cancer.
This donation helped recruit
Dr. Katrina Podsypanina,
Director of the Breast
Cancer Biology research
unit.

“At National Bank, we have
always been concerned with
the ravages of cancer in our
society. We are therefore
VOLUNTEERING
proud to support the next
generation of research in
this field at the IRCM.”

Louis Vachon
President and CEO
National Bank

112 | 2011-2012 IRCM ANNUAL REPORT IRCM FOUNDATION / voluntEering | 113

To a foundation, the commitment of volunteers Jacques Gauthier Audit Committee Reford MacDougall
is crucial. The IRCM Foundation is therefore Corporate Director Special Advisor to the President – Montreal Economic
Louise Lambert-Lagacé André J. P. Couillard Institute
privileged to be able to rely on people who value its Chairwoman of the IRCM Board of Directors Alain Mayrand
Jean-Pierre Desrosiers, interim Chair (since January 2012)
mission and the IRCM’s success. These individuals President, La clinique de nutrition Louise Lambert-Lagacé et Edmée Métivier, Chair (until December 2011) Corporate Director and President of the IRCM Foundation
are members of the Board of Directors, members associées Joseph J. Paulin L. Jacques Ménard
of the major fundraising campaign’s Board, or Reford MacDougall Chairman of the Board of Directors – BMO
Special Advisor to the President Yvon Turcot
honorary patrons and volunteers who contribute to
Montreal Economic Institute Communications Consultant and Corporate Director
the organization of our benefit activities. Edmée Métivier (until December 2011) Give for Life Campaign Board Michael L. Turcotte
Executive Vice President – Financing and Consulting Chairman of the Board of Directors – Hydro-Québec
IRCM FOUNDATION BOARD OF DIRECTORS Business Development Bank of Canada Members of the major fundraising campaign’s Louis Vachon
Tarik Möröy President and CEO – National Bank
President and Scientific Director – IRCM Board were once again very involved this year. They René Vézina
(Members appointed from June 2011 to June J.-Robert Ouimet supported the Foundation in numerous donation Columnist and Senior Reporter – journal Les Affaires
2012) Chairman of the Board of Directors and CEO and partnership requests and obtained excellent
Holding O.C.B. Inc.; Cordon Bleu International Ltd; & Ouimet results. 2011 annual dinner
In 2011-2012, five regular Board meetings were Tomasso Inc.
Joseph J. Paulin
held. Co-chairs Honorary co-chairs
President – Preston Phipps
Sophie Brochu Edmée Métivier and Patrice Bernard
Emmanuel Triassi
President President and CEO – Groupe TEQ President and CEO – Gaz Métro
Alain Mayrand Emmanuel Triassi Honorary patrons
Corporate Director Director President and CEO – Groupe TEQ Nathalie Bernier
Hélène Véronneau Serge A. Boileau
Members Jean-Pierre Desrosiers
Members Marinella Ermacora
Serge A. Boileau Secretary Nathalie Bernier
Stéphane Létourneau Associate Director – KPMG Michel Gaudreau
President – Commission des services électriques de Montréal Jacques Gauthier
Normand Brathwaite Executive Director Françoise Bertrand
Corporate and Legal Affairs – IRCM President and Executive Director – Fédération des chambres Pierre Larochelle
Host Rémi Rabasa-Lhoret
Alain Brunet de commerce du Québec
Treasurer Jean-Guy Desjardins Emmanuel Triassi
Senior Vice-President, Insurance – National Bank Financial Yvon Turcot
Group Louis-Gilles Durand Desjardins-Moreau Foundation
President – National Bank Insurance Executive Director Claude A. Garcia
André J. P. Couillard Administration and Research services – IRCM Corporate Director
Vice-president – Executive Search Jacques Gauthier
Optimum Talent Corporate Director
Jean-Pierre Desrosiers Norman E. Hébert
Partner – Fasken Martineau Dumoulin LLP President and CEO – Groupe Park Avenue Inc.
Marinella Ermacora W. Robert Laurier
Senior Vice President – Business Solutions Corporate Director
Fujitsu Canada Inc.


2011 bilan de santé – golf tournament

Honorary chair
Stéphane Gauthier

Organizing committee
Serge A. Boileau, co-chair
Louise Boucher
Nathalie Brisson
Robert Dufour
Jacques Gauthier, co-chair
François Lebrun
Marcel Leclerc
Lucette Thériault
Hélène Véronneau

Bilan de santé committee 2012 IRCM Challenge – Run for Life
Diane Bergevin-Lachapelle
Marie Bernard
Chantal Blais Steves Morin, organizer and race founder
Bianca Couvrette Joël Bonin
Robert Dufour Rémi Bonin
Martine Gauthier Louise Boucher
Ana Maria Penalva Anne-Sophie Brazeau
Chantal Delisle
Claire Duval
Sonia Fortin
Hélène Lambin
Julie Langelier
Lucette Thériault
Hélène Véronneau
Joanne Véronneau
Ying Zhang

116 | 2011-2012 IRCM ANNUAL REPORT IRCM FOUNDATION / GIVING | 117

Many businesses, foundations, and individuals support the IRCM each
year, either through its benefit activities, its direct mail campaign or
by creating personalized funds. Other donors choose to support the
Foundation by donating shares or making bequests.
GIVING
Sincere thanks
to all our donors.


THE IMPACT OF YOUR DONATIONS
Thanks to your support, the Foundation can, in turn, support the IRCM

$1,400,494 donated to the IRCM in 2011-2012

11 nominal scholarships were awarded
to Master’s and doctoral students, and postdoctoral fellows:

Angelo-Pizzagalli postdoctoral scholarship (Rushikesh Sheth)
Jean-Coutu postdoctoral scholarship (Marine Lacomme)
Industrial Alliance doctoral scholarship (Damien Grapton)
Michel-F.-Bélanger doctoral scholarship (Adèle Coriati)
Jacques-Gauthier doctoral scholarship (WooJin Kim)
Gérard-Limoges doctoral scholarship (Joanne Leung)
Joseph-Paulin doctoral scholarship (Huaijian Guo)
Métro Master’s scholarship (Katherine Chabot)
IRCM – Norman Hébert Family Master’s scholarship (Karen Cholmondeley)
IRCM – Run for Life Master’s scholarship (Félix Legendre)
IRCM Master’s scholarship (Olivia Zhang)

3 in-house excellence awards were granted to a researcher, an employee, and a student

André-Barbeau Excellence Award (Pierre Fabre)
Pierre-Bois Excellence Award (Timothy L. Reudelhuber)
Vincent-Castellucci Excellence Award (Chantal Blais)

Tarik Möröy, Joanne Leung, Gérard A. Limoges


OUR PARTNERS AND DONORS Over $1,000,000 $10,000 to $24,999 Donors – In-house fundraising campaign, Laniel – Julie Lapointe – Mathieu Lapointe – Manon Laprise
Marcelle and Jean Coutu Foundation CIBC L’IRCM la vie. J’y crois, je participe – Louise Laramée – François Larivière – Lise Laroche – Pierre
Éric A. Cohen Larochelle – Tommy Larouche – W. Robert Laurier – Mélanie
2011-2012 distribution of Robert Dufour Laurin – Christine Le Jeune – Marcel Leclerc – Éric Lécuyer
donations $500,000 to $999,999 – Paule Leduc – Gino Lefebvre – Stéphanie Lemay – Félix-
Claude A. Garcia
Desjardins-Moreau Foundation
$1,472,247 (total donations) Estelle and Jacques Genest 257 donors (46 anonymous) Antoine Lessard-Ouellet – Stéphane Létourneau – Danielle
Gaétane Beauchemin Estate
Italian Chamber of Commerce in Jaime Agudelo – Richard Alain – Robert Alain – Jeannine Lévesque – Martin Lévesque – Camille Limoges – Gérard A.
Gosselin Family Foundation
Canada Amyot – Geneviève Archambault – Association des étudiants et Limoges – Bastien Llamas – Gaétan Lussier – Martine Maheu
Major fundraising campaign IRCM internal community
stagiaires postdoctoraux de l’IRCM – Émélie Aucoin – Aurélio – Andrew P. Makrigiannis – Carole Marcotte – Gérard Marcoux
Pierre Larochelle
$1,068,216 72.6% Marie and Guy Lamarre
Tarik Möröy Balsalobre – Gaétan Baril – Alain Roger Bataille – Catherine – Cleiton Martins de Souza – Ginette Massé – Éric Massicotte
National Bank
Benefit activities Monique and Robert Parizeau Beauregard – Dorothée Bégin – Mohammed Bencheqroum – Alain Mayrand – Michael A. Meighen – Johanne Mercier –
Power Corporation of Canada
$305,681 20.8% Paul A. Fournier Foundation – Ines Lilia Benzaghou – Iréna Berezowska – Dominique Chantal Mercure – Philippe Mochirian – Yves Morin – Tarik
Joseph J. Paulin Bergeron – Lise Bernier – Monique Bernier – René Bibeau Möröy – Gina Muccigrosso – Benoit Papineau – Mario Paquet
Direct mail campaign $100,000 to $499,999 Guylaine Saucier – Julie Binette – Chantal Blais – Serge A. Boileau – Pierre – Robert Parizeau – Manishha Patel – Lise Patenaude – Ariane
$78,349 5.3% BMO Financial Group Bois – François Bordeleau – Annie Bouchard – Lucie Boulet Pelletier – Stéphane Perras – Jessica My Tram Pham – Sylvie
Bequest Cogeco Inc.
$5,000 to $9,999 – Frédéric Bourque – Daniel Bouthillier – Isabelle Brisson – Picard – Christian Poitras – Annik Prat – Amanda Prioletta
$20,000 1.4% Gaz Métro Nicole Campeau – Michel Cayouette – Michel Chamberland – Jessica Prioletta – Mike Prioletta – Éric Racine – Vasanth
Anonymous (2)
Hydro-Québec – Michel Charest – Frédéric Charron – Marcel A. Chartrand – Ramamurthy – Émilie Raymond – Inmoo Rhee – Rina Riberdy
Jacques Archambault
Jeanne-Mance Foundation Radu Chiriac – France Chrétien Desmarais – Michel Chrétien – Jonathan Richard – François Robert – Michel Robillard –
Serge A. Boileau
Mirella and Lino Saputo Foundation – Raymond Chrétien – Richard Cimon – Éric A. Cohen – Marc Ghislaine Roederer – Nicole Rougeau – Raymond Roy – Odile
Benoit Coulombe
Quebecor Cool – Jean-François Côté – Richard Côté –Judith Cotton- Royer – Alexis Sabourin – Guy Saint-Pierre – Ram M. Sairam
Jacques De Champlain
Give for Life major RBC Foundation Montpetit – André J.P. Couillard – Dominique Davidson – Jean – Guylaine Saucier – Giuseppe Schiavone – Peter W. Schiller
Christian F. Deschepper
Samcon Davignon – Jacques de Champlain – Sébastien Decelles – – Carole Schmidt – Nabil G. Seidah – Hélène Sénéchal – Jijun
fundraising campaign donors Jacques Gauthier
SAQ Chantal Delisle – Christian F. Deschepper – Hélène Desmarais Shang – Pierre Shooner – Sardar Sindhu – Sodexo – Lise St-
Paul Jolicoeur
Scotia Bank – Javier Di Noia – Dimitrios Jimmy Dikeakos – Céline Domecq – Germain – Julie St-Jean – Lyne St-Pierre – Catherine Strifas
The major fundraising campaign Louise Lambert-Lagacé
TD Bank Group Jacques Drouin – Simon Drouin – Patrick Du Souich – Caroline – Woong-Kyung Suh – Jean-René Sylvestre – Gaétan Thibault
Paule Leduc
was publicly launched on Stéphane Létourneau Dubé – Robert Dufour – Pierre Dupont – Louis-Gilles Durand – Carole Tremblay – Jocelyn Tremblay – Michel Tremblay
October 20, 2011. To date, $25,000 to $99,999 Camille Limoges – Jean-Marie Ekoé – Denis Faubert – Claudia Fiorentino – – Marie Trudel – Yvon Turcot – Jean Vacher – Annie Vallée –
we have raised $9,759,855. Anonymous (1) Gaétan Lussier Fondation Desjardins-Moreau – Clara Forestier – Diane Forget Hélène Véronneau – Luc Vinet – Grazyna Weltrowska – Ewa
Aon Consulting Alain Mayrand – Jocelyne Fouquette – Nadine Fradet – L. G. Serge Gadbois B. Wesolowska – Zeina Yared – Shaohua Zhang – Ming-Chao
The Foundation thanks all Hélène Desmarais – Marc Gagnon – Sergio Galeno – Claude A. Garcia – Michel Zhong – Qinzhang Zhu
Michael A. Meighen
donors who contributed to this Louis-Gilles Durand Gaudreau – Dany Gauthier – Jacques Gauthier – Yves Gauthier
Roscoe Postle Associates Inc.
campaign. Groupe Park Avenue Guy Saint-Pierre – Estelle et Jacques Genest – Alexandra Gervais – Francisco
Groupe TEQ M. Ram Sairam Gomes – Raphaël Gottardo – Lysanne R. Goyer – Jean-Philippe
Industrial Alliance Cécile and Pierre Shooner Gratton – Michel Greenshield – Pierre Guiot-Guillain – Anne
Gérard A. Limoges Peter W. Schiller Haché – Josée Hamelin – Dagmar Hipfner – Alice Tania
Luigi Liberatore Foundation Richard Tanguay Hobeika – Jean Huet – Natacha Jackson – Claude Jacques
Métro Inc. Michael L. Turcotte – Hélène Jacques – Pierre-Étienne Jacques – Christine
Petra Ltd Jacqueline Turgeon Jolicoeur – Louise Joly – Claudia Jones – Artur Kania – KCI
Placements Borsa Inc. Hélène Véronneau Ketchum – Samer Jacques Khaouam – Marie Kmita – Dayana
André Toupin Krawchuk – Christine L’Abbé – Benoît Laganière – Olivier
Lagueux – Maxime Lamarre-Cliche – Louise Lambert-Lagacé
Less than $5,000 – Josette-René Landry – Johanne Langevin – Dominique
Over 1,000 donors


AN OUTSTANDING
COMMITMENT BY MARIE AND GUY LAMARRE
“We have known the IRCM for several years and regularly support the
Foundation’s fundraising activities. When we were asked to support
the Give for Life fundraising campaign, we did not hesitate because we
believe in the research conducted by this excellent institution.”
MARIE AND GUY LAMARRE

Marie and Guy Lamarre, Jean-Philippe Gratton, IRCM researcher, Jacques Gauthier, Hélène Véronneau


Friends, Builders and Great Corporate benefactors Denise and Guy St-Germain Signotech Inc. Builders Andrée Bédard
Builders Foundation SNC-Lavalin Inc. $500 to $999 Jean-Louis Bégin
Desjardins Sodexo Michel Behamdouni
Anonymous (2)
Great Builders Dubo Électrique Ltd SSQ Financial Group Louis-P. Bélanger
The IRCM and its Foundation Serge Archambault
Electroméga Ltd Systèmes urbains Inc. Charles Belzil
thank all their donors, whether over $25,000 Environnement Routier NRJ Inc. Telecon
Roberto Berloni
Hugh Bennett
Business Development Bank of Line Brisson
they are businesses, founda- Ernst & Young The Jean Coutu Group (PJC) Inc. Henri Berbari
Canada Kay and Raymond Chrétien
Franklin Empire Inc. Unibéton Denis Bernier
tions or individuals. Donors Fujitsu Consulting (Canada) Inc. Université de Montréal
Philippe Dalphond
Constant Bernier
become Friends, Builders or Louis J. Duhamel
Gaz Métro Versalab Inc. Françoise Bertrand
Great Builders, according to Builders Estelle and Jacques Genest
GDI Services d’entretien Distinction Guy Bertrand
the amount of their contribu- $10,000 to $24,999 Goudreau Gage Dubuc
Monique Jérome-Forget
Jean-Serge Bienvenu
A. Pizzagalli Family Foundation Michel Lafortune
tion. Donors can join the IRCM Government of Quebec Individual benefactors Robert Boileau
HVAC Inc. W. Robert Laurier
Groupe LHA Inc. Andrée Boily
Foundation’s circle of benefac- KPMG Groupe MMO Inc.
Pierre Léonard
Fernand Boily
tors by donating to the direct Merck Frosst / Schering Camille Limoges
Groupe TNT Merceron Jacqueline Boisjoli
Great Builders Gaétan Lussier
mail campaign, participating in Pharmaceuticals G-teck Louise Boisvert Furholter
National Bank of Canada Infrastructel Experts-Conseils over $1,000 Anne and Michel Mandron
Johanne Bonneau
benefit activities, or making a Clemens Mayr
Norton Rose Canada Ipex Electrical Inc. Anonymous (1 ) Richard Boucher
donation in the memory of a Power Corporation of Canada Kenniff & Racine Inc. Mihai Balaban Alain Mayrand
Pierre Boulay
loved one. Following is a list of PricewaterhouseCoopers Marthe Bélanger Irene O’Brien
Lafleur portes de garage Daniel Bourbonnais
the individuals, businesses and Transelec / Common Inc. Janine Bombardier Gilbert Ouellette
Lécuyer et Fils Ltd L. Jean Bourgault
René Coupal Pierre Robitaille
foundations who made a do- Les services Financiers Labelle Inc. Jacques Bourgeois
Friends Letko, Brosseau & Associates Louis Deumié Hélène Bourgeois Phisel
nation between September 1,
$1,000 to $9,999 Location Sauvageau Inc. Pierre Dozois Friends Sylvie Bourque
2011 and August 31, 2012: Louise Hogues Inc. Jacques Duquette Estelle Bourret
AGIR Consultants Inc.
$100 to $499
Métal Pole-Lite Inc. Marinella Ermacora Martin Boutet
Air-Ins Inc. Anonymous (49)
Migertin Inc. Guy Frenette Claudette Boyte
Aon Parizeau Inc. Yvan Ally
Montréal Chartered Accountants Claude A. Garcia Claude Brosseau
Atrium Innovations Inc. Rodney Anderson
Mp2b Jacques Gauthier Gilbert Brosseau
Axor Experts-Conseils Inc. Maria Andrade Costa
NOJ Démolition 9245-4561 Pierre Guindon André Brunet
Bell Mobility Alain André
Pageau Morel et associés inc. Diane Jacques Gérard Caisse
Boehringer Ingelheim (Canada) Ltd Jacques Archambault
Pfizer Canada Inc. Richard Labbé Serge A. Cantin
BPR Bâtiment Inc. Ali Asghar Sabour
Pharmascience Inc. Bernard Lamarre Hubert Canuel
Canmarc Reit Management Inc. Jean Auger
Philips Lumec Louise Lambert-Lagacé Alain Carey
Centre Hospitalier de l’Université de Christian Baron
Pomerleau Inc. Sylvain Le Saux Marie-Lucette Casseus
Montréal André Bastien
Preston Phipps Inc. Brian Mulroney Vincent Castellucci
CMS Entrepreneurs Généraux Inc. Claude Bayard
RBC Foundation André J. Roy Jacques Chamberland
Confab Laboratories Inc. André Beaulieu
RBC Royal Bank Marika F. Teakle François Charbonneau
Construction N R C Inc. Monique Beaulieu Gagnon
Régulvar Inc. Gilles Charette
CTRL Informatique Ltd Gilles N. Beauregard
Robert Hydraulique Richard Charruau
Deloitte & Touche Foundation Canada Marie Beauregard Ducharme
S.M. Group International Inc. Jean Charton
/ La Fondation Samson Bélair Claude Beausoleil
Schneider Canada Michel Chartrand
Luc Beausoleil


Gilles Chatel Kien Quoc Duong Jean Robert Jean-Marie Rita Lepage Danielle Richer Monique Vermette
Jean-Marie Chauret Louis-Gilles Durand Michèle Jodoin and Robert Keaton Jacques Letendre Huguette Rioux Hélène Véronneau
Rossana Cininni Colletti Christiane Élie Rosee Jomphe Stéphane Létourneau Martine Rivard Louis Véronneau
Paul Cobetto Robert Estall Albert Kassab Jo-Anne L’Heureux-Giguère Michel Robert Thérèse Vien Clermont
Raphael Cohen Jean R. Fabi Otto Kuchel Juan Jesus Lopez Louise Robert-Gascon Régis Vigneau
Bernard Comtois Bernard Faribault Maurice Labelle Kamal Maari Guy Robillard Jean Vincent
Gérard P. Cordebas Émile Filion Loyal Lachapelle Normande M. Mailloux Casgrain Marc Rochefort Juanita Westmoreland-Traore
Andrée Cossette Poitevin Michael Fish and Gisèle Hamelin Raymond Lacourse Bernard Mainville Rolande Rompré Leduc André Wilkin
José Costa Normand Fortin Michel Lamarre Marie Louis Mallouk Léo Rosshandler David Wimhurst
Jean-François Côté André Fournier Bernard Lambert Jean-Claude Mareuil Richard Rousseau
Langevin Côté André Gagnon Marcel Lamothe Gilles Marin Richard Rowland
André J.P. Couillard Robert Galardo Louise Landry Paul-André Massé Yves Roy
Pierre Couvrette Nessim Garzon René Laneville Aline Mayer Gerd Rutkowski
Chantal Croze Marielle Gascon Pierre Lapointe Hortensia Mircescu Jules Saint-Michel
Claire D’Ange Morel Michel Gaudreau Denise Laramée Marielle Miron Leduc M. Ram Sairam
Roger Daoust Fernand Gaudreault Denis Lareau Victoria Elias Moghrabi Élie Saleh
Huguette Day Lanois Normand Gaulin Yvon Larin Pierre Monahan Esperia Salvatore Seringnese
François De Champlain Gilles J. Gauthier François Larivière François Moquin Salim Sayegh
Claude De Launière Solange Gauthier Antonio Larouche Jean-Pierre Morin Peter W. Schiller
Andrée Delisle Gaston Germain Jacques Larouche Serge Morin Denis R. Séguin
Edgard Delvin Albert Giguère Lisette Laurent and Claude Boyer Françoise Morin Dumont Richard Serri
Gilles Demers Monique Giguère Paul Lavallée Sylvie Nadeau Amina Shaarawi
Roland Demers Jeannine Gingras Durand Suzanne Lavallée-Hammer Guy Nadon Claude-Armand Sheppard
Alain Derome Pierre H. Girard Gilles-Albert Lavigne Roxana Nemes Bratis Pierrette Sinclair
Louise Desaulniers Michel Giroux Pierre Lavigne Paul Nguyen François Spain
Pierre-Yves Desbiens Jacques Godbout Thérèse Lavigne Petitclerc Paul Noiseux Martin St-Georges
Estelle Deschamps Genest Denis Goyette Claude Lavoie Élaine Ouellet Fernand Sylvestre
Jacques Deschênes Jean-Philippe Gratton France Lavoie Bernard Paquet Marc Gérard Termote
Monique Deserres Juliette Gratton St-Cyr Gérard Lebeau Jacques Paré Robert Tessier
Guy Desjardins John Gray Pierre Lebeau Monique Parent and Gérald Dufour Monique Thisdale Baribeau
Louise Desjardins Joubert Jacques Gresset François Lebrun Michel Pasquin Muryelle Thouin
Lison and Robert Désourdy Claudette Guay-Cloutier Simon Lebrun Jocelyne Pelland Philip Tousignant
Serge Desrochers Serge Guérette Richard Lecavalier Jude Péloquin Daniel Tremblay
Renée Di Gregorio Castonguay Marcelle Hamel Monique Leclair Francine Pépin Gilles Tremblay
Jacques Di Muro Pierre Harvey Hélène Leclerc Jean-Yves Pépin André Trempe
Solange Doucet Daniel Hébert Paule Leduc Marie-Danie Pierre Yves Trépanier
Odette Drouin Rolande Henrichon Pierre Leduc Michael Pilley Lise Trudeau Barbeau
Joanne Dubé Julie Héroux Philippe Lefebvre Raynald Pineault Sophie Truesdell-Ménard
Michel Dubuc Isabelle Hervet Richard Léger Andrée Pizzagalli Micheline Turcot
Jean Dufour Normand Huard Raymond Lemay Serge Racette Yvon Turcot
Michel Dufour René Hubert René Lemire Gilbert Racine Louise Vadnais
Robert Dufour Véronique Jallabert Monique Le Page and Richard Suzanne Ranger Ferdinando Vallone
Pierrette Dufresne Jabbour Bernard Jasmin Bernèche Marc Régnier Calogera Vella


LOYAL DONORS

“Being patients at the IRCM Clinic, we can testify to the great expertise
of its team and the quality of care we receive there. For several years,
we have said yes to the Foundation’s annual direct mail campaign. We are
proud to support the IRCM. The funds raised by these campaigns provide
scholarships to students with remarkable results. We were therefore
delighted to be invited this year, on behalf of all patients at the IRCM
Clinic, to award a Master’s scholarship.”
Selim AND Victoria Moghrabi / IRCM Foundation’s Circle of Friends

Tarik Möröy, Victoria Moghrabi, Olivia Zhang, Selim Moghrabi


The IRCM Foundation’s research funds and chairs The annual report is a review
of the year’s highlights and
summarizes the main scientific
André-Aisenstadt Research Chair in Immunology* and academic activities for the
period of September 1, 2011 to
Angelo-Pizzagalli Postdoctoral Scholarship Fund * August 31, 2012. The report also
Bell-Bombardier Chair in Cardiovascular Diseases * includes a summary of the IRCM
BMO Fund for Priority Research Foundation’s activities for the
same period. The financial figures
Canadian Pacific Research Chair in pain *
cover the period of April 1, 2011
Cogeco Fund for Cancer Research to March 31, 2012.
Diana and Sam Scalia Fund for Research on Cardiovascular and Metabolic
Diseases For more information on
the IRCM’s and the IRCM
Gaz Métro Fund for Priority Research Foundation’s activities, you can
Georges Lachapelle Fund * refer to the academic report and
Gosselin Family Foundation Fund the Institut’s website (ircm.qc.ca).
Hydro-Québec Fund for Priority Research
IRCM In-House Fund for Excellence *
J.A. DeSève Research Chair of Excellence * PRODUCTION
IRCM – Communications department
Jacques Genest – Royal Bank Chair *
Jean Coutu Postdoctoral Scholarship Fund * COORDINATION
Lucette Thériault
Jean-Guy Desjardins Fund for Priority Research *
John Low-Beer Chair * RESEARCH, WRITING, TRANSLATION
Lucette Thériault, Julie Langelier
Lucille, Rollande and Gaétane Côté Fund
Marcel and Béatrice Piché Fund * ART DIRECTION, GRAPHIC DESIGN
Hélène Lambin
Marie and Guy Lamarre Fund for Priority Research
Marie and Willie Chrétien Fund * PHOTOGRAPHY
Hélène Lambin, Getty Images, Fotolia,
Michel-F.-Bélanger Cancer Research Chair * Christian Guay and others
Mirella and Lino Saputo Fund for Clinical Research
Illustrations cafés scientifiques
National Bank Fund for Cancer Research Yves Dumont
Power Corporation Fund for Priority Research
EDITORIAL COMMITTEE
Quebecor Fund for Neurology Research Judith Cotton-Montpetit, David R. Hipfner,
RBC Royal Bank Fund for Research on Infectious Diseases Hélène Lambin, Julie Langelier, Johanne
Langevin, Stéphane Létourneau, Lucette
Rosario and Annette Genest Fund * Thériault, Hélène Véronneau
Sainte-Thérèse de l’Enfant-Jésus Fund in memory of Mable and Lucien Toupin
December 2012
SAQ pour Fund for Priority Research ISBN- : 978-2-924029-03-9
Scotia Bank Fund for Diabetes Research LEGAL DEPOSIT – BIBLIOTHÈQUE ET
ARCHIVES NATIONALES DU QUÉBEC, 2012

We thank everyone who contributed to the
production of this annual report.
*Capitalized funds

IRCM – Institut de recherches cliniques de Montréal
110 avenue des Pins Ouest
Montréal (QuEbec) H2W 1R7
514-987-5500
info@ircm.qc.ca • ircm.qc.ca
Facebook.com/ircm.montreal

2012 ircm annual_report

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