Trasformare la Medicina è davvero possibile - 24 aprile 2016Lorenzo Capello
OLTRE I LIMITI DELLA MEDICINA CONVENZIONALE E TRADIZIONALE, L’UOMO.Il corpo parla e la Medicina si trasforma - 24 aprile 2016 - Open day teorico-pratico interattivo presso Casa Novarini, via Monte Ortigara 7, San Giovanni Lupatoto
Presentazione di strumenti utili per la scuola e lo studio. Dalle applicazioni per imparare una lingua nuova ai motori di ricerca semantici. Le App di Google, le piattaforme di condivisione file, i social per il lavoro, le opportunità per sperimentare cose nuove
Trasformare la Medicina è davvero possibile - 24 aprile 2016Lorenzo Capello
OLTRE I LIMITI DELLA MEDICINA CONVENZIONALE E TRADIZIONALE, L’UOMO.Il corpo parla e la Medicina si trasforma - 24 aprile 2016 - Open day teorico-pratico interattivo presso Casa Novarini, via Monte Ortigara 7, San Giovanni Lupatoto
Presentazione di strumenti utili per la scuola e lo studio. Dalle applicazioni per imparare una lingua nuova ai motori di ricerca semantici. Le App di Google, le piattaforme di condivisione file, i social per il lavoro, le opportunità per sperimentare cose nuove
This study analyzed 45 observational studies including over 272,000 patients to determine the association between red blood cell transfusion and morbidity and mortality in high-risk hospitalized patients. The analysis found that in 42 of the 45 studies, the risks of red blood cell transfusion outweighed the benefits, with transfusion associated with increased risk of death, infections, multi-organ dysfunction syndrome, and acute respiratory distress syndrome. A meta-analysis found that transfusion was associated with 70% higher odds of death and 80% higher odds of developing an infectious complication. The study suggests current transfusion practices may need reevaluation given the risks appear to outweigh the benefits in most patients.
The document discusses the results of a study on the effects of a new drug on memory and cognitive function in older adults. The double-blind study involved 100 participants aged 65-80 who were given either the drug or a placebo daily for 6 months. Researchers found that those who received the drug performed significantly better on memory and problem-solving tests at the end of the study compared to those who received the placebo.
This study analyzed 45 observational studies including over 272,000 patients to determine the association between red blood cell transfusion and morbidity and mortality in high-risk hospitalized patients. The analysis found that in 42 of the 45 studies, the risks of red blood cell transfusion outweighed the benefits, with transfusion associated with increased risk of death, infections, multi-organ dysfunction syndrome, and acute respiratory distress syndrome. A meta-analysis found that transfusion was associated with 70% higher odds of death and 80% higher odds of developing an infectious complication. The study suggests current transfusion practices may need reevaluation given the risks appear to outweigh the benefits in most patients.
The document discusses the results of a study on the effects of a new drug on memory and cognitive function in older adults. The double-blind study involved 100 participants aged 65-80 who were given either the drug or a placebo daily for 6 months. Researchers found that those who received the drug performed significantly better on memory and problem-solving tests at the end of the study compared to those who received the placebo.
2. Dopo una serie di immersioni (5 volte a 40 metri)
2 dei 5 atleti presentavano un incremento
significativo della concentrazione di eritropoietina
Balestra C, Germonpre´ P, Poortmans JR, Marroni A.
Serum erythropoietin levels in healthy humans after a
short period of normobaric and hyperbaric oxygen
breathing: the ‘normobaric oxygen paradox’. J Appl
Physiol 2006; 100: 512–8
3. Non si tratta di un meccanismo di ipossia
assoluta, ma di ipossia relativa
Balestra C, Germonpre´ P, Poortmans JR, Marroni A.
Serum erythropoietin levels in healthy humans after a
short period of normobaric and hyperbaric oxygen
breathing: the ‘normobaric oxygen paradox’. J Appl
Physiol 2006; 100: 512–8
4. Il fenomeno si manifesta anche con
l’ipossia normobarica intermittente,
attualmente molto utilizzata nello sport
Balestra C, Germonpre´ P, Poortmans JR, Marroni A.
Serum erythropoietin levels in healthy humans after a
short period of normobaric and hyperbaric oxygen
breathing: the ‘normobaric oxygen paradox’. J Appl
Physiol 2006; 100: 512–8
7. Non ci sono
variazioni
tra i 16 soggetti
trattati con ossigeno
normobarico ed
iperbarico per Ht e
Hb
Balestra C, Germonpre´ P, Poortmans JR, Marroni A. Serum erythropoietin
levels in healthy humans after a short period of normobaric and hyperbaric
oxygen breathing: the ‘normobaric oxyge paradox’. J Appl Physiol 2006; 100:
512–8
8. Si è evidenziato un
incremento significativo di
Epo dopo aver respirato
100% ossigeno
normobarico per due ore
Balestra C, Germonpre´ P, Poortmans JR, Marroni A. Serum erythropoietin levels in
healthy humans after a short period of normobaric and hyperbaric oxygen breathing:
the ‘normobaric oxygen paradox’. J Appl Physiol 2006; 100: 512–8
9. L’incremento si è
determinato in un
periodo compreso
tra le 4 e le 8 ore
Balestra C, Germonpre´ P, Poortmans JR, Marroni A. Serum erythropoietin
levels in healthy humans after a short period of normobaric and hyperbaric
oxygen breathing: the ‘normobaric oxygen paradox’. J Appl Physiol 2006; 100:
512–8
10. Balestra C, Germonpre´ P,
Poortmans JR, Marroni A.
Serum erythropoietin levels
in healthy humans after a
short period of normobaric
and hyperbaric oxygen
breathing: the ‘normobaric
oxygen paradox’. J Appl
Physiol 2006; 100: 512–8
11. La respirazione di ossigeno iperbarico
non determina incremento di Epo ed,
anzi, lo deprime
Balestra C, Germonpre´ P, Poortmans JR, Marroni A. Serum
erythropoietin levels in healthy humans after a short period of
normobaric and hyperbaric oxygen breathing: the ‘normobaric
oxygen paradox’. J Appl Physiol 2006; 100: 512–8
12. Balestra C, Germonpre´ P, Poortmans JR, Marroni A. Serum
erythropoietin levels in healthy humans after a short period of
normobaric and hyperbaric oxygen breathing: the ‘normobaric
oxygen paradox’. J Appl Physiol 2006; 100: 512–8
13. Balestra C, Germonpre´ P, Poortmans JR, Marroni A. Serum
erythropoietin levels in healthy humans after a short period of
normobaric and hyperbaric oxygen breathing: the ‘normobaric
oxygen paradox’. J Appl Physiol 2006; 100: 512–8
14. Balestra C, Germonpre´ P, Poortmans JR, Marroni A. Serum
erythropoietin levels in healthy humans after a short period of
normobaric and hyperbaric oxygen breathing: the ‘normobaric
oxygen paradox’. J Appl Physiol 2006; 100: 512–8
15. De Bels D, Corazza F, Germonpré P, Balestra C. The normobaric
oxygen paradox: a novel way to administer oxygen as an adjuvant
treatment for cancer? Med Hypotheses 2011;76:467-70
16. De Bels D, Corazza F, Germonpré P, Balestra C. The normobaric
oxygen paradox: a novel way to administer oxygen as an adjuvant
treatment for cancer? Med Hypotheses 2011;76:467-70
17. Hypoxia Bone metastatic
cells
HIF1a nuclear
translocation
TGFb1
HIF1a stabilization
HGF
COX2 induction
Gene target HIF1a activation
expression
Met/HGF
COX2
HIF1a
VEGF
CXCR4
Maroni P, Matteucci E, Luzzati A, Perrucchini G, Bendinelli P,
Desiderio MA. Nuclear co-localization and functional interaction of
COX-2 and HIF-1α characterize bone metastasis of human breast
carcinoma. Breast Cancer Res Treat. 2011;129:433-50.
18. Lu X, Kang Y
Hypoxia and hypoxia-inducible factors: master regulators
of metastasis
Clin Cancer Res 2010;16:5928-35
L’ipossia e i fattori che la regolano sono cruciali per
l’attecchimento delle metastasi, in particolare nell’osso.
L’ambiente del tumore primitivo non è generalmente
descritto come iperossico.
19. Non ci sono differenze
significative tra i 2 gruppi
per [Epo], c’è solo
differenza significativa
sull’incremento nel
tempo
Ciccarella Y, Balestra C, Valsamis J, Van der Linden P. Increase in
endogenous erythropoietin synthesis through the normobaric
oxygen paradox in cardiac surgery patients. Br J Anesthesiol
2011;106:752-3
20. Normobaric oxygen paradox
Non c’è incremento per una sola esposizione
Fattori confondenti
-ritmo circadiano individuale dell’Epo (occorrono
alcuni giorni)
-attività del glutatione (non c’è incremento in
anziani e soggetti non fisicamente attivi per
concentrazioni troppo basse di glutatione)
-dose di ossigeno
Balestra C, Germonpré P. Increasing EPO using the normobaric
oxygen paradox: a “not so simple” task. Acta Physiol 2011;211:287-
8
21. Normobaric oxygen paradox
La concentrazione minima di ossigeno
necessaria per il “paradosso” è circa del 40%;
aumentando la concentrazione dell’ossigeno
fino al 100% i risultati sono variabili
Balestra C, Germonpré P. Increasing EPO using the normobaric
oxygen paradox: a “not so simple” task. Acta Physiol
2011;211:287-8
22. Normobaric oxygen paradox
Non si conosce la dose ottimale
Non si conosce la frequenza ottimale
Balestra C, Germonpré P. Increasing EPO using the normobaric
oxygen paradox: a “not so simple” task. Acta Physiol
2011;211:287-8