The document evaluates the performance of the Galileo Echo automated blood bank instrument for pre-transfusion testing at Willis-Knighton Health System, which consists of one main hospital and three satellite facilities. Various tests were performed in parallel on the Galileo Echo and using existing manual methods, including ABO/Rh typing, weak D testing, and antibody screening and identification. The results showed high concordance rates between the Galileo Echo and manual methods, ranging from 95.0% to 100%. The implementation of the Galileo Echo allowed for standardization of pre-transfusion testing across the health system and the potential for more antibody identifications to be performed in-house.