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Laboratory LOINC Workshop – Chicago, IL!




                    LOINC!
         Introduction and Mapping Boot Camp!
              Daniel J. Vreeman, PT, DPT, MSc!
                   Assistant Research Professor, Indiana University School of Medicine!
                               Research Scientist, Regenstrief Institute, Inc!


                            Clem McDonald, MD!
   Director, Lister Hill National Center for Biomedical Communications – National Library of Medicine !




05.26.2011!                      dvreeman@regenstrief.org!                                       © 2011!
Acknowledgements!
LOINC Development Team!
Kathy Mercer, Jaci Phillips, Ian Pyle, David Baorto,
Fran Brahmi!
!



RELMA Development Team!
John Hook, Mark Fisher, Karen Ahmed, Anandhi
Sowmyan, James Dennis!
!



LOINC Committee!
Supporters: NLM, Regenstrief, CHITREC,
Metropolitan Chicago Healthcare Council,
Chicago Department of Public Health!
Overview!
1.  Origins of LOINC!
2.  LOINC 101!
3.  Using RELMA!
4.  Searching and Mapping to LOINC!
5.  Approaches to Mapping and
    Domain-speci"c Help!
6.  Other RELMA features!
7.  Your turn!
Origins of LOINC!
The lingua franca of clinical observation exchange!
Soda or Pop?!
                    what you see in the order list
                                                 !


Lab A!                                Lab B!
Test Name: Lyme Disease Serology!     Test Name: Lyme Disease Antibody!
Measures: B. burgdorferi Ab IgG!      Measures: B. burgdorferi Ab IgM!
Method: ELISA!                        Method: Immune blot!
Scale: quantitative!                  Scale: qualitative!
e.g.: Titer 1:40!                     e.g.: Positive!
!                                     !
LOINC Code = 5062-5!                  LOINC Code = 6321-4!
Logical
           Observation
           Identi"ers
           Names and
           Codes!
A universal code system that facilitates exchange,
        pooling, and processing of results!
If an observation is a question
and the observation value is
an answer…

  !LOINC provides codes for
   !questions

   !Other vocabularies provide
   !codes for the answers!
What is my patient’s
hemoglobin level?!
718-7:Hemoglobin:MCnc:Pt:Bld:Qn!
How fast does my
patient usually walk?!
41959-8:Walking speed:Vel:1W^mean:^Patient:Qn:Calculated
Indiana Network for Patient Care!
   HL7 v.2.X Message!
MSH|^~&|HOSPITAL_A|SAMPLE_HOSPITAL_A|||$YearMonthDay|||||||||||||||
PID|||$patientId$||$patientName$||||||||||||||||||||
     LocalCode^LocalName^CodeSystem^LOINCcode^LOINCname^CodeSystem
PV1|||||||$attendingDoctor$||$consultingDoctor$||||||||
OBR|1|||012^CBC/Auto Diff^HSPA^57021-8^CBC W Auto Diff^LN||$reqDate|||||||||
OBX|2|NM|123^WBC^HSP_A^26464-8^Leukocytes [#/volume] in Blood^LN||10.8|K/MM3|||||F|
OBX|3|NM|234^RBC^HSP_A^26453-1^Erythrocytes [#/volume] in Blood^LN||4.82|MIL/MM3|||||F|
OBX|4|NM|345^HGB^HSP_A^718-7^Hemoglobin [Mass/volume] in Blood^LN||15.7|GM/DL|||||F|
OBX|5|NM|456^HCT^HSP_A^20570-8^Hematocrit [Volume Fraction] of Blood^LN||45|%|||||||F|




          !"




                        Message Processor!                        !"



                                                     Institutional Repository!
Result with a Coded Value!

   Data type of
result (OBX-5) is a      This code is          This code is
 coded element!          from LOINC!         from SNOMED!


 OBX||CE|6609-2^Listeria ID^LN||36094007^L. monocytogenes^SCT




 Code identifying this
     observation !                 Code identifying the
(what are these results?        result (L. monocytogenes)!
   Listeria culture)!
Laboratory LOINC!
Clinical LOINC!
The LOINC Community!
Open. Nimble. Pragmatic.!
Open Development!
Worldwide distribution at no cost!
End-user content additions!
Welcome all comers!
Volunteers!
!
Regenstrief Institute!
Steward!
Developer of content!
Developer of tools!
Developer of community!
Distributor!
Voice!
!
LOINC Codes Over Time By Release!
70,000!
          LOINC Codes!
          Lab Codes!
60,000!
                                        Slope = 2200!
50,000!

                         Slope = 600!
40,000!


30,000!


20,000!


10,000!
                                   laboratory terms only!

     0!
loinc.org members!
12,000!



10,000!



 8,000!



 6,000!



 4,000!



 2,000!          11 new members per day!
               330 new members per month!
     0!
11,100+ users in 141 countries!
Downloads: ~1100/month!
6,900 views!
           !
  100 views!
  260 views!
International Adoption!
participation, translation, implementation!
LOINC Submitters!




Since 2009, 84 organizations from 14 countries!
LOINC Translators!




   18 organizations!
New and Updated!
Estonian!
French!
German!
Greek!
Italian!
Spanish!
In-progress!
Catalan!
Dutch!
French!
Russian!
!
Large Implementations!
SIGA Saúde project !
Canada Health Infoway!
ePSOS!
Assistance publique - Hôpitaux de Paris!
Hong Kong Hospital Authority!
Red Agrolab!
BiTAC!
  Lots more…success is often silent!
US Adoption!
A few key highlights!
US Federal Agencies!
       NLM!
        VA!
       DoD!
       IHS!
       NCI!
       CDC!
Other Key US Adoptions!
        HITSP!
        eLINCS!
       NAACCR!
        CDISC!
      NCQA/HEDIS!
         HL7!
        HIPAA!
         HIE’s!
EHR Incentive
   Program
a.k.a. “Meaningful Use”!
New Frontiers in
Content Modeling!
Standardized Assessments!
Purpose!
Assessments are widely used…!




…and not unlike other clinical observations!
!
LOINC could be a
           !!
  master question "le
           and

 uniform representation !
Panels/Forms Available as
   Separate Download!
Currently in LOINC!
US Government Forms!
   CARE, MDSv2, MDSv3, OASIS B1, OASIS C, RFC!
   US Surgeon General’s Family Health Portrait!
Brief Interview for Mental Status (BIMS)!
Confusion Assessment Method (CAM)!
Geriatric Depression Scale (GDS)!
HIV Signs and Symptoms Checklist!
Home Health Care Classi"cation!
howRU!
Living with HIV (LIV-HIV)!
Morse Fall Scale!
OMAHA!
PHQ (9 and 2)!
Quality Audit Marker (QAM)!
!
Translational Research Variables!
LOINC 101!
LOINC for newbs (not nOObs)!
The LOINC Distribution!
http://search.loinc.org!
Anatomy of a LOINC Term!
       5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!

         5193-8!                                          LOINC Code!

Hepatitis B virus surface Ab!                            Component
                                                                 !
          ACnc
             !                                   Property Measured!
           Pt
            !                                                    Timing!

           Ser
             !                                                   System!
           Qn!                                                    Scale!

           EIA!                                              Method!

                   There are six major LOINC axes
                                                !
NOT part of a LOINC Name!
Testing instrument!
Speci"c details about the specimen!
Priority (e.g. STAT)!
Where testing was done!
Who did the test!
Test interpretation!
Anything not part of naming the test!
Stu# carried in other parts of HL7 message!
Component!
    The substance or entity that is measured,
             evaluated, or observed!
Sodium!
Glucose!
Brucella sp. organism!
In$uenza A Virus antigen!
Cytomegalovirus antibody!
Lipids.total!
    5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
Component Structure                                      !


      Analyte Name^Challenge^Adjustments
                                       !

Formal analyte name!                                Calcium!
    Specify “subanalytes”!                  Coronavirus Ag!
    May have subclasses!                    Calcium.ionized!
  !                                                        !
Challenge!                   1H post 100 g Glucose PO!
    Two parts separated       <time delay>post<challenge type>!
    by “post”!                                               !
!                                                            !
Adjustments!                          Adjusted to pH 7.4!
Property!                      * the most di"cult LOINC axis!




The characteristic or attribute of the analyte that
      is measured, evaluated, or observed.!
Major Categories:!
 !mass!
 !substance!
 !catalytic activity!
 !arbitrary!
 !number!
     5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
Property!                       * the most di"cult LOINC axis!




Fully Named Properties!                                    mg/dL!
MCnc! mass concentration!                                 umol/L!
SCnc! substance concentration!                              mg/g!
MCnt! mass content !                                         U/L!
CCnc! catalytic concentration!
Prid!   presence or identity!
Imp!    impression!
Type! “kind of”!

    Property is related to units of measure!
     5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
Common Property Issues!
               Fraction versus Ratio!
Fraction = Part/Whole!
    !NFr: % Eosinophils / leukocytes!
    !SFr: % HGB which is A2!
!                                        photo via jurvetson!



Ratio = multiple analytes from same system!
     !MCrto: BUN/Creatinine in urine!
!
Relative Ratio = measures from di"erent system!
     !RelRto: actual to normal control!
!
Timing!
The interval of time over which the observation
          or measurement was made!

Pt!       point in time!
12H!      12 hour collection!
24H!      24 hour collection!

       Non-Pt timings are often !
       found with Ratio Property!
System!
The system (context) or specimen type upon which the
               observation was made.!

Ser!          serum!
Ser/Plas!     serum or plasma!
Bld!          whole blood !
Ur!           urine!
Flu!          body #uid!                                   photo via AlishaV!




Tiss!         tissue!
XXX!          speci$ed elsewhere !
     5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
System Structure!
                  System^Super System!

Super System!
Patient is the default!
Used to indicate!
   blood product unit!
   bone marrow donor!
   fetus!
                                                         photo via Xurble!




               818-5:A Ag:ACnc:Pt:RBC^BPU:Ord: !
 11670-7:Blood $ow.mean:Vel:Pt:Aortic arch^fetus:Qn:US.doppler
                                                             !
Scale!
Qn!     Quantitative!
!           continuous numeric!
!           optional operator!
Ord! Ordinal!
!           Ranked set (1+, 2+, 3+)!                      photo via puuikibeach !


Nom! Nominal!
!           unranked collection!
!           Taxonomy (e.g. bacteria)!
Nar! Narrative!
      5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
Method!
Only needed if interpretation a#ected!
  Di#erent normal ranges!
  Test sensitivity!
Listed at the generic level!
  Agglutination!
  Immunoassay!
  Probe with target ampli"cation!


    5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
LOINC Parts !




Uses !
translation, synonymy, building hierarchies,
creating display names, linking descriptions!
Hierarchies!
LOINC class !
Each LOINC axis!
Multi-axial!
    Component | System!
    Separate download!
    !
!
    !
RELMA®!
REgenstrief LOINC Mapping Assistant!
We’ll Cover!
RELMA “Boot Camp”!
Mapping tips/pitfalls!
Get started!
What’s it Good For?!
Browse LOINC!
Map your local terms to LOINC!
   !import/export!
   !translate local words to LOINC-speak!
   !manual/automated mapping!
Get RELMA!
http://search.loinc.org!
RELMA Highlights!
Hierarchies!
Search!
Enhanced details view!
Common test list!
Panels and forms!
Export, copy, paste!
Search Syntax!
Google-like!
AND, OR, -<word>, +<word>!
Limit by category (e.g. micro)!
Wildcards (? and *)!
!
    Assumes EXACT MATCH
!   unless you use wildcards!
More RELMA Features !
User Speci"ed Search Limits !
Selectable trees for:!
 Class!
 Multiaxial (component/system)!
 System (specimen)!
 Component!
 Method!
Installing RELMA!
Installation Steps!
Need Windows (or a VM on a Mac)!
Got disk space? 2Gb is recommended!
Start installer <drive>:RELMASetup!
Specify installation directory keep default!
Two database "les installed!
  RELMA.MDB – LOINC terms database!
  LMOF3.MDB – Local Master Observation File!
Two sample "les included !
Run it!!
File Locations!
Database and Ancillary Files!
Windows XP!
    !
  C:Documents and SettingsAll UsersDocumentsRELMA
Windows Vista and 7!
!C:UsersPublicDocumentsRELMA
!
Sample "les!
Windows XP!
   !
C:Documents and SettingsAll   UsersDocumentsRELMASamples

Windows Vista and 7!
!C:UsersPublicDocumentsRELMASamples
   !
Running RELMA!
Main Menu/Welcome Screen!



     File->Set Preferred Language!
Select Linguistic Variant(s)!
LOINC Terms with Spanish Linguistic Variant!




                                All Spanish!
                                           !
Simple Search!
Search Window!




enter search terms
                 !

                                      limit to common tests
                                                          !

                     limit to speci"c units
                                          !
Search Window!




          Help!
              !




    “common tests”
   relative frequency!
New RELMA Help"le!
Context Menu!




right click to bring up
    context menu   !
Setting User Preferences!
Set User Preferences!


               select User Preferences
                                     !
                 from the File Menu!




              ...or from Welcome Screen!
Set User Preference Dialog!
                     File locations: !
              (see prior slide for location)
                                           !




               startup screen preference!
User Map Screen Preferences!




             Include/exclude battery terms
                                         !

              add comments on mappings
                                     !
Importing Local Terms
into RELMA!
4 Ways to Build LMOF!
1.  Hand enter!              bad!
2.  Make your own table !    bad!
3.  Import text "le from    good!
    your test catalog!          !
4.  Import from real HL7    best!
    v2.x messages !
Make a Local Dataset!
Extract from Your Test Catalog!
 Battery code!
 Battery description or name!
 *Local code !
 *Test description or name!
   Include method if important!
 Units!
 Example Values!
 Laboratory Section!
Make a Delimited Text File!
Need separate "elds!
Use any delimiter!
Fields in any order!
Required "elds (minimum):!
  Local Code!
  Local Description!
  Units (highly recommended)!
Importing Local Terms!
1.  Start it up!
2.  Find local term "le!
C:Documents and SettingsAll UsersDocumentsRELMASamples

C:UsersPublicDocumentsRELMASamples


3.  Name your working set!
4.  Identify "eld delimiter in your "le!
5.  Match your "elds to LMOF
    attributes!
6.  Import!!
Example Tab-Delimited File!
Importing Local Files!

             select “Import Local Terms
                from Delimited File”!




                  or just click here!
Navigate to File Location!

               select File andstored in !
                 sample "les click Open
                   RELMA Directory  !
Open File in RELMA!

                               Give it a name!
                        (RELMA allows multiple sets in
                            one LMOF database)  !


select your delimiter
                    !


                                Import button!
Open File in RELMA!




     oh "ddlesticks!!!
                     !
Match Your Fields!


                assign LMOF attribute!
Match Your Fields!



                choose "eld name!
Now You’re Ready!!


minimum assignments
                  !




                               Do It!
                                    !
After import, RELMA will
search for words it does not
         recognize!
Alternate Import (best)!
Nothing closer to the truth than real data!
Big Pile of HL7 Messages!
!
RELMA parses into dataset!
    OBR ID!
    OBR description!
    OBX ID!
    OBX description!
    Sample results:!
        actual values, units, abnormal #ags,
        normal ranges!
        !
    !
Generate Local term "le from HL7 messages !

                       select Import Terms from
                                HL7 File!
Select File to Import!




                  select HL7 "le!
Specify HL7 File Name and Sample Size!




name the local term
 "le (working set)!                     select the number of
                                            sample values
                                                        !


                      select which codes to store!
HL7 Messages Data Statistics!
Your turn!
         !
 Import Local Terms
                  !
(or sample OBX "le)!
Cleaning Your Data!
A little time upfront saves more later!




                                          photo via Mu#et!
Prep Your Data for Mapping!
Improve mapping success!
  !Expand abbreviations!
  !Ignore “administrative” words!
  !Standardize idiosyncratic words!
  !Standardize time references!
RELMA can help!
RELMA Cleaning Tools!

                use this tool to edit
                  unknown terms   !
Review Unknown Local Terms!



         may re-scan "le for
          unknown terms   !
Replace Local Terms!




 Assign LMOF Attribute
  replacement options !
                     !
RELMA Cleaning Tools!
                use this tool to make
                 global substitutions
                                    !
Term Substitution!
save this global substitution
  for only this working set!
Clean Up!
        !
Take some time to
  clean up your
    sample "le!
Reviewing your
Local Terms!
Change Local Term File!


             Select the Working Set
                                  !
Manual Enter/Edit !

           View/Add/Edit Local Terms
                                   !
Edit Term Dialog!




                                        EditAddDelete Terms
                                                            !
                                             Export Terms!
                         Search Terms by Keyword!


Text alignment option!
                                              Print Preview List
                                                               !
New Terms added to LMOF!




click on “Edit Term” to see
        sample data!

                              new battery code!
Sample Results for Observation!




                    Sample Values from
                        Messages !
Search Local Term File!


Calcium!




                  Enter Keyword from any
                                  Return to Full List
                                                    !
                           Field!
Export Local Term File!




Delimiters supported:!
 Tab, comma, bar (|)
                   !
Searching and
Mapping to LOINC !
what RELMA was born to do!




                             Photo via Jeffrey Beall!
Hit It!
               !



Are you working on the
    right local "le?
                   !
Core Mapping Screen Features!




Customizable grid !   Export results grid!
Sort by columns!      Stores mappings!
View term details!
Mapping Screen !

          View or edit local term!



        Navigate through the local terms
                                       !



Quick select button list
                       !




               Custom Grid Con"guration!
Con"gure Grid!

                        Select elements to display!


                                          Reorder grid elements
                                                              !




                                      Visually resize elements
                                                             !
Reset Default Con"guration!
Quick choice buttons!




Viewing LOINC term detail!
View Local Term Details!




          Select level of
          detail to display!
Select detail display level!




Select level of detail to
         display!
Standard Mapping Screen!




Begin a search !
(or hit “enter”)
               !
Initial Mapping Results!




                   Fiddlesticks !#*$%!!
                       What now??? !



  Click to
show words
  used in
   search!
Initial Mapping Results!




Use term    Number of LOINC    Battery terms
checkbox!   terms containing    included in
                keyword !          search!
Revised Mapping Results!




                        Number of
                         matching
                       records found!
 Units restriction
selected by default!
Re-revised Mapping Results!




               Click any column
               header to re-sort
                               !



                          Number of
                           matching
Match units
                         records found!
unselected!
Standard Mapping Screen!




                   CANINE DISTEMPER VIRUS IF




Enter keywords here!


                             Clear all
                           input "elds !
Ad hoc term search!
Tabbed Access to Functions!




    Navigate to Functions
     from Mapping Page  !




          Switch between Grid and
                 Tree Views
                          !
Tree View!
Tree View!

  Can map to terms                 Cannot map to
  with LOINC Codes!                    terms
                                    representing
                                     LOINC parts
                                               !
Tree Navigation
    Buttons!
Assigning a LOINC Map!




                     Click “Map” Button!
                        (or doubleclick)
                                       !
 Highlight correct
       term !
Adding Mapping Comments!




Check with Frank in Chemistry




          If comments
        option is selected,
         prompt appears  !
Assigning a LOINC Map!




  LOINC Term
   Assigned!
View LOINC Term Details!


                                 View details for a
                                speci"c LOINC Term  !




 Right clicking on a LOINC
term brings up a Task Menu !
LOINC Term Details!

                                Can scroll down a single
                                    formatted page  !



                              Can scroll through
Change to expanded            returned subset of
   details view!                    terms  !
          Change text size!
LOINC Term Details: Panels!
View Panel Children!




Select View Panel Children
    from context menu  !
Panel Children!
Con"gure Export Options!




                    Output options
                                 !
                                         Include!
Save con"guration                    column headers
                                                  !
  and/or export!
Excel Export Format!
More on Search Syntax!
Tips and Tricks!




                    Photo via Jeffrey Beall!
Wildcards!
“*” replaces any number of characters!
  GLUC*!
  *COSE!
  GLU*SE!
“?” replaces a single character!
  GLUCOS?!
  ?LUCOSE!
  GLUC?SE!
Search Quali"ers !




            Detailed help available!


Includes Glucuronidase,
      Glucosidase,
Glucosylceramidase, etc.!
Search in a Field!
Field!       Example!
LOINC!       loinc:12628-4!
Component!   component:chemotherapy!
Property!    glucose property:CCnc!
Timing!      glucose timing:24H!
System!      glucose system:CSF!
Scale!       glucose scale:Nar!
Method!      mycobacterium method:EIA!
Class!       glucose class:UA!
Other Cool Tricks!
Use parentheses!
!(flu OR rhinovirus) -haemophilus
!
 component:(norepinephrine creatinine)
!
Fuzzy search (~)!
!Bergdorferi~
Limiting Your Searches!
Sometimes 60,000 terms is too many!
Setting Search Limits!
Reduces number of candidate terms!
Many, many options!
Hierarchy allows domain restrictions!
with great power comes
  great responsibility!
                          Photo via [cipher]!
Setting Search Limits!




click Hierarchy & Search Limits tab!
Search Constraints!
                                         Attribute trees
                                                       !




                            Local Unit Constraint:
                                                 !
                               Default is “ON”!




                              LOINC term status
                                              !
Prede"ned, general search
       constraints
                 !
Terms Consistent with Units!




               Only terms consistent
                with mmol/L appear !
Quick Access Toggles For
 Common Restrictions!


                 On/O# Toggles
                             !
Specimen Restriction!




              Specimen
              constraints
                        !
Terms Consistent with Specimen !


                           CSF




           enter default
             specimen!
Terms Consistent with Specimen !




Only CSF Terms are
     returned!
Setting Search Limits!




Methodless Terms     Override Methodless Terms
   Restriction!              Restriction!
Limit to Methodless Terms!
Limit to Methodless Terms!




only Methodless
 terms appear!
Methodless Only Unchecked!




         All terms returned!
Methodless Only Checked!



                     Only Methodless
                      terms returned!




 Di#er in one or
more components  !
Conditional Methodless!

                   More terms
                    returned!




No methodless
term; all shown!
Setting Search Limits!




         Limit to Lab Tests Only!
        (No Clinical LOINC Terms) !
Setting Search Limits!




           Empirically derived common tests
                                          !
               (99.8% of INPC volume)!



Next Release: Top 2000 from
humungous sample!
A brief aside…!
Developing convenience sets!




                               photo via x-ray delta one!
A Few Tests Give Most Results!
                                                100%!
Cumulative Laboratory Observation Volume (%)!




                                                 90%!

                                                 80%!

                                                 70%!

                                                 60%!

                                                 50%!

                                                 40%!

                                                 30%!

                                                 20%!

                                                 10%!

                                                  0%!
                                                        0!   500! 1000! 1500! 2000! 2500! 3000! 3500!                                               4000!
                                                              Number of Laboratory Observation Codes (N)!
                        Vreeman DJ, Finnell JT, Overhage JM. A Rationale for Parsimonious Laboratory Term Mapping by Frequency. AMIA Annu Symp Proc. 2007;:771-775.
                                                                                                                                                                  !
Setting Search Limits!




      include Trial, Deprecated or
     Discouraged LOINC codes with
            returned terms  !
LOINC Term Status!
Trial!
! as the concept and associated attributes may change.
  Concept is experimental in nature. Use with caution


Discouraged!
! mappings to this concept are discouraged although
  Concept is not recommended for current use. New

  existing mappings may continue to be valid in
! context.
Deprecated!
 Concept is retired and should not be used, but it is
 retained in LOINC for historical purposes.
Include Deprecated LOINC Terms!

Can’t map to a deprecated term!
Warning before mapping to discouraged term!




      Discouraged LOINC Terms appear as an
                inverted triangle!




     Deprecated LOINC Terms appear as strikethrough text
                   with a “Do Not” symbol!
LOINC Hierarchies – Class Tree!




          Three top-level
             branches !

                            Tree Navigation
                                Buttons!
Before Class Restriction!




              Most terms have class of “CHAL”
                                            !




Large number of candidate terms
                              !
Hierarchies!




       Restrict eligible tests
         to non-challenge
        chemistry tests only !
Following Class Restriction!




  Only Non-Challenge
Chemistry tests returned!
A Reminder About Search Limits!




                  Indicates that you’ve got
                   something set over here !
Component Hierarchy!

             “right click” for context menu
                with “view details” option!




      Show the LOINC Codes
       associated with these
           components   !
Details Screen: LOINC Part!
Show Associated LOINCs!
Hierarchy Wrap-up!
All trees operate the same way!
All grids operate the same way!
Tree is searchable !
Combine tree limits with others!
                      “Mulligan” button!
Search Hints and Tips!
Zero hit keywords are ignored!
    !(may need to rephrase)!
!
Common causes of Zero results!
    !Too many keywords!
    !Limits and keyword contradictions!
    !Local term weirdness!
!
Units are GREAT discriminators!
RELMA’s Auto Mapper!
Starting with our best guesses may save you time!
What Does It Do?!
Batch processes local term "le to get
N- closest candidate LOINCs!
!
Uses words and units from local terms!
!
Produces a ranked list for your review!
Recent Improvements!
Faster. Way faster.!
Better clean-up routine!
New specimen guesser!
Better local to LOINC word "nder!
Break ties with frequency data!
Does it Work?!
Lab terms (internal analysis)!
            !#1 ranking: 60-70ish%!
            !In Top 5: 70-80ish%!
!

Radiology terms!
           !#1 ranking: 80-90ish%!
            !In Top 5: 90ish%!
            !Using CPT-based restriction helped!
            !(but we couldn’t distribute it)!
    Vreeman DJ, McDonald CJ. A Comparison of Intelligent Mapper and Document Similarity Scores
    for Mapping Local Radiology Terms to LOINC. Proc AMIA Symp. 2006;809-813.!
    !
    Vreeman DJ and McDonald CJ. Automated Mapping of Local Radiology Terms to LOINC. Proc
    AMIA Symp. 2005;769-773.!
(Lab) Auto Mapper!


                                     launch it here!




a couple of options
                  !




      print report or work through
       the ranked list when done !
Intelligent Mapper - Mapping Screen!
Mapping Guidance and
Approaches to Special
Domains!
Top N, Reportable Conditions, Newborn Screening!
Not just an IT problem!
Get real.!
units, results, experts!
Don’t be a
 one hit
 wonder.!
Additional Pearls and
Guidance!
Clem McDonald, MD!
Director, Lister Hill National Center for Biomedical Communications – National Library of Medicine !
Other               RELMA ®

Features!
Oh yes, there’s more!!
Using Your Mapped Terms!
You’ve done the work. Now reap the glory.!




                                             photo via janeandd!
Con"gure Export Format!




Context Sensitive Export
     Con"guration!
LMOF Export Con"guration!


Select Export Format!



                        Select Fields to Export
                                              !

                            Save Con"guration and
                                    Export
                                         !
Printing Mapped Terms!




                            Click Print button to Preview
May highlight terms to be               output!
         printed!
Custom Export Con"guration!




    Select the Format you wish
             to Export
                     !




    Select the Fields you wish to
               Export !
Excel™ Export!
Export Terms Dialog!


Select Term Set
              !



                                          Select Delimiter
                                                         !




Check Fields you
 wish to export!
More RELMA Fun!
Parts, Panels, and Proposing New Terms!
LOINC Part Search!
Works just like the term search!
Handy for looking at descriptions!
Parts Search!
Parts Search!




   only parts that have
descriptions, references, etc
                            !
Panels, Forms, and Surveys!
Wanted to make it easy to "nd!
Special features for browsing!
Panels, Forms and Survey Review!
                           Review Panels, Forms and
                                   Surveys !




Review Panels, Forms and
        Surveys !
Government Forms!
Laboratory Panels!




         Double-click panel
           name to see
           components   !
Expanded Panel Detail!
Clinical Panels!




      Find where a term has
            been used !
LOINC Term Panel Usage!
Other Survey Instruments!
Proposing New LOINC Terms!
LOINC grows because you ask.!
Proposing a New Term!
Are you sure?!
Give us all you got!
RELMA is best!
Send them in groups!
What We Need!
•    Local test/observation name!
•    Local order (panel) name!
•    Description of the test !
•    Name of send out lab (if applicable)!
•    Name of healthcare organization that stimulated the request for
     this term (if you are submitting on behalf of someone else)!
•    Units of measure (for quantitative observations)!
•    Answer lists (for qualitative observations)!
•    Sample results, reports (if applicable)!
•    Package inserts, test kit documentation (if applicable)!
•    Vendor, instrument, and/or reagent kit used to perform this test (if
     applicable)!
•    Description of the project or activity that stimulated the request
     for this term, or any other documentation you have!
Propose new LOINC terms!




                    Select Propose a
                         LOINC !
Your Info!




Navigate through   Create new term,
 proposed terms!   save current term
                      or Exit form!



                   Suggested LOINC Name!
Use Existing Terms as Template!

        Click the Propose
           Term button !
                            Select your closest
                                   match!
Use Existing Terms as Template!




                     All required
                  components "lled in!
Review Proposed Terms!




                   Review your new
                        terms!
Review Proposed Terms!




                   Choose whether to
                    send or postpone!


                   All proposed terms
                       fully editable!
Submitting New Terms!
Still need to email us the "le!
      !submissions@loinc.org!
!
More Information!
      !http://loinc.org/submissions!
!
LOINC Submissions Policy!
      !http://loinc.org/submissions-policy!
!
      !!
http://loinc.org/submissions/new-terms!
photo via milos milosevic!

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Laboratory LOINC Workshop – Chicago, IL

  • 1. Laboratory LOINC Workshop – Chicago, IL! LOINC! Introduction and Mapping Boot Camp! Daniel J. Vreeman, PT, DPT, MSc! Assistant Research Professor, Indiana University School of Medicine! Research Scientist, Regenstrief Institute, Inc! Clem McDonald, MD! Director, Lister Hill National Center for Biomedical Communications – National Library of Medicine ! 05.26.2011! dvreeman@regenstrief.org! © 2011!
  • 2. Acknowledgements! LOINC Development Team! Kathy Mercer, Jaci Phillips, Ian Pyle, David Baorto, Fran Brahmi! ! RELMA Development Team! John Hook, Mark Fisher, Karen Ahmed, Anandhi Sowmyan, James Dennis! ! LOINC Committee! Supporters: NLM, Regenstrief, CHITREC, Metropolitan Chicago Healthcare Council, Chicago Department of Public Health!
  • 3. Overview! 1.  Origins of LOINC! 2.  LOINC 101! 3.  Using RELMA! 4.  Searching and Mapping to LOINC! 5.  Approaches to Mapping and Domain-speci"c Help! 6.  Other RELMA features! 7.  Your turn!
  • 4. Origins of LOINC! The lingua franca of clinical observation exchange!
  • 5.
  • 6.
  • 7.
  • 8. Soda or Pop?! what you see in the order list ! Lab A! Lab B! Test Name: Lyme Disease Serology! Test Name: Lyme Disease Antibody! Measures: B. burgdorferi Ab IgG! Measures: B. burgdorferi Ab IgM! Method: ELISA! Method: Immune blot! Scale: quantitative! Scale: qualitative! e.g.: Titer 1:40! e.g.: Positive! ! ! LOINC Code = 5062-5! LOINC Code = 6321-4!
  • 9. Logical Observation Identi"ers Names and Codes! A universal code system that facilitates exchange, pooling, and processing of results!
  • 10. If an observation is a question and the observation value is an answer… !LOINC provides codes for !questions !Other vocabularies provide !codes for the answers!
  • 11. What is my patient’s hemoglobin level?! 718-7:Hemoglobin:MCnc:Pt:Bld:Qn!
  • 12. How fast does my patient usually walk?! 41959-8:Walking speed:Vel:1W^mean:^Patient:Qn:Calculated
  • 13. Indiana Network for Patient Care! HL7 v.2.X Message! MSH|^~&|HOSPITAL_A|SAMPLE_HOSPITAL_A|||$YearMonthDay||||||||||||||| PID|||$patientId$||$patientName$|||||||||||||||||||| LocalCode^LocalName^CodeSystem^LOINCcode^LOINCname^CodeSystem PV1|||||||$attendingDoctor$||$consultingDoctor$|||||||| OBR|1|||012^CBC/Auto Diff^HSPA^57021-8^CBC W Auto Diff^LN||$reqDate||||||||| OBX|2|NM|123^WBC^HSP_A^26464-8^Leukocytes [#/volume] in Blood^LN||10.8|K/MM3|||||F| OBX|3|NM|234^RBC^HSP_A^26453-1^Erythrocytes [#/volume] in Blood^LN||4.82|MIL/MM3|||||F| OBX|4|NM|345^HGB^HSP_A^718-7^Hemoglobin [Mass/volume] in Blood^LN||15.7|GM/DL|||||F| OBX|5|NM|456^HCT^HSP_A^20570-8^Hematocrit [Volume Fraction] of Blood^LN||45|%|||||||F| !" Message Processor! !" Institutional Repository!
  • 14. Result with a Coded Value! Data type of result (OBX-5) is a This code is This code is coded element! from LOINC! from SNOMED! OBX||CE|6609-2^Listeria ID^LN||36094007^L. monocytogenes^SCT Code identifying this observation ! Code identifying the (what are these results? result (L. monocytogenes)! Listeria culture)!
  • 17. The LOINC Community! Open. Nimble. Pragmatic.!
  • 18. Open Development! Worldwide distribution at no cost! End-user content additions! Welcome all comers! Volunteers! !
  • 19. Regenstrief Institute! Steward! Developer of content! Developer of tools! Developer of community! Distributor! Voice! !
  • 20. LOINC Codes Over Time By Release! 70,000! LOINC Codes! Lab Codes! 60,000! Slope = 2200! 50,000! Slope = 600! 40,000! 30,000! 20,000! 10,000! laboratory terms only! 0!
  • 21.
  • 22. loinc.org members! 12,000! 10,000! 8,000! 6,000! 4,000! 2,000! 11 new members per day! 330 new members per month! 0!
  • 23. 11,100+ users in 141 countries!
  • 25. 6,900 views! ! 100 views! 260 views!
  • 27. LOINC Submitters! Since 2009, 84 organizations from 14 countries!
  • 28. LOINC Translators! 18 organizations!
  • 31. Large Implementations! SIGA Saúde project ! Canada Health Infoway! ePSOS! Assistance publique - Hôpitaux de Paris! Hong Kong Hospital Authority! Red Agrolab! BiTAC! Lots more…success is often silent!
  • 32. US Adoption! A few key highlights!
  • 33. US Federal Agencies! NLM! VA! DoD! IHS! NCI! CDC!
  • 34. Other Key US Adoptions! HITSP! eLINCS! NAACCR! CDISC! NCQA/HEDIS! HL7! HIPAA! HIE’s!
  • 35. EHR Incentive Program a.k.a. “Meaningful Use”!
  • 36.
  • 39. Purpose! Assessments are widely used…! …and not unlike other clinical observations! !
  • 40. LOINC could be a !! master question "le and uniform representation !
  • 41.
  • 42. Panels/Forms Available as Separate Download!
  • 43. Currently in LOINC! US Government Forms! CARE, MDSv2, MDSv3, OASIS B1, OASIS C, RFC! US Surgeon General’s Family Health Portrait! Brief Interview for Mental Status (BIMS)! Confusion Assessment Method (CAM)! Geriatric Depression Scale (GDS)! HIV Signs and Symptoms Checklist! Home Health Care Classi"cation! howRU! Living with HIV (LIV-HIV)! Morse Fall Scale! OMAHA! PHQ (9 and 2)! Quality Audit Marker (QAM)! !
  • 45.
  • 46.
  • 47. LOINC 101! LOINC for newbs (not nOObs)!
  • 50. Anatomy of a LOINC Term! 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA! 5193-8! LOINC Code! Hepatitis B virus surface Ab! Component ! ACnc ! Property Measured! Pt ! Timing! Ser ! System! Qn! Scale! EIA! Method! There are six major LOINC axes !
  • 51. NOT part of a LOINC Name! Testing instrument! Speci"c details about the specimen! Priority (e.g. STAT)! Where testing was done! Who did the test! Test interpretation! Anything not part of naming the test! Stu# carried in other parts of HL7 message!
  • 52. Component! The substance or entity that is measured, evaluated, or observed! Sodium! Glucose! Brucella sp. organism! In$uenza A Virus antigen! Cytomegalovirus antibody! Lipids.total! 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
  • 53. Component Structure ! Analyte Name^Challenge^Adjustments ! Formal analyte name! Calcium! Specify “subanalytes”! Coronavirus Ag! May have subclasses! Calcium.ionized! ! ! Challenge! 1H post 100 g Glucose PO! Two parts separated <time delay>post<challenge type>! by “post”! ! ! ! Adjustments! Adjusted to pH 7.4!
  • 54. Property! * the most di"cult LOINC axis! The characteristic or attribute of the analyte that is measured, evaluated, or observed.! Major Categories:! !mass! !substance! !catalytic activity! !arbitrary! !number! 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
  • 55. Property! * the most di"cult LOINC axis! Fully Named Properties! mg/dL! MCnc! mass concentration! umol/L! SCnc! substance concentration! mg/g! MCnt! mass content ! U/L! CCnc! catalytic concentration! Prid! presence or identity! Imp! impression! Type! “kind of”! Property is related to units of measure! 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
  • 56. Common Property Issues! Fraction versus Ratio! Fraction = Part/Whole! !NFr: % Eosinophils / leukocytes! !SFr: % HGB which is A2! ! photo via jurvetson! Ratio = multiple analytes from same system! !MCrto: BUN/Creatinine in urine! ! Relative Ratio = measures from di"erent system! !RelRto: actual to normal control! !
  • 57. Timing! The interval of time over which the observation or measurement was made! Pt! point in time! 12H! 12 hour collection! 24H! 24 hour collection! Non-Pt timings are often ! found with Ratio Property!
  • 58. System! The system (context) or specimen type upon which the observation was made.! Ser! serum! Ser/Plas! serum or plasma! Bld! whole blood ! Ur! urine! Flu! body #uid! photo via AlishaV! Tiss! tissue! XXX! speci$ed elsewhere ! 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
  • 59. System Structure! System^Super System! Super System! Patient is the default! Used to indicate! blood product unit! bone marrow donor! fetus! photo via Xurble! 818-5:A Ag:ACnc:Pt:RBC^BPU:Ord: ! 11670-7:Blood $ow.mean:Vel:Pt:Aortic arch^fetus:Qn:US.doppler !
  • 60. Scale! Qn! Quantitative! ! continuous numeric! ! optional operator! Ord! Ordinal! ! Ranked set (1+, 2+, 3+)! photo via puuikibeach ! Nom! Nominal! ! unranked collection! ! Taxonomy (e.g. bacteria)! Nar! Narrative! 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA!
  • 61. Method! Only needed if interpretation a#ected! Di#erent normal ranges! Test sensitivity! Listed at the generic level! Agglutination! Immunoassay! Probe with target ampli"cation! 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
  • 62. LOINC Parts ! Uses ! translation, synonymy, building hierarchies, creating display names, linking descriptions!
  • 63. Hierarchies! LOINC class ! Each LOINC axis! Multi-axial! Component | System! Separate download! ! ! !
  • 65. We’ll Cover! RELMA “Boot Camp”! Mapping tips/pitfalls! Get started!
  • 66. What’s it Good For?! Browse LOINC! Map your local terms to LOINC! !import/export! !translate local words to LOINC-speak! !manual/automated mapping!
  • 69. RELMA Highlights! Hierarchies! Search! Enhanced details view! Common test list! Panels and forms! Export, copy, paste!
  • 70. Search Syntax! Google-like! AND, OR, -<word>, +<word>! Limit by category (e.g. micro)! Wildcards (? and *)! ! Assumes EXACT MATCH ! unless you use wildcards!
  • 71. More RELMA Features ! User Speci"ed Search Limits ! Selectable trees for:! Class! Multiaxial (component/system)! System (specimen)! Component! Method!
  • 73. Installation Steps! Need Windows (or a VM on a Mac)! Got disk space? 2Gb is recommended! Start installer <drive>:RELMASetup! Specify installation directory keep default! Two database "les installed! RELMA.MDB – LOINC terms database! LMOF3.MDB – Local Master Observation File! Two sample "les included ! Run it!!
  • 74. File Locations! Database and Ancillary Files! Windows XP! ! C:Documents and SettingsAll UsersDocumentsRELMA Windows Vista and 7! !C:UsersPublicDocumentsRELMA ! Sample "les! Windows XP! ! C:Documents and SettingsAll UsersDocumentsRELMASamples Windows Vista and 7! !C:UsersPublicDocumentsRELMASamples !
  • 76.
  • 77. Main Menu/Welcome Screen! File->Set Preferred Language!
  • 79. LOINC Terms with Spanish Linguistic Variant! All Spanish! !
  • 81. Search Window! enter search terms ! limit to common tests ! limit to speci"c units !
  • 82. Search Window! Help! ! “common tests” relative frequency!
  • 84. Context Menu! right click to bring up context menu !
  • 86. Set User Preferences! select User Preferences ! from the File Menu! ...or from Welcome Screen!
  • 87. Set User Preference Dialog! File locations: ! (see prior slide for location) ! startup screen preference!
  • 88. User Map Screen Preferences! Include/exclude battery terms ! add comments on mappings !
  • 90. 4 Ways to Build LMOF! 1.  Hand enter! bad! 2.  Make your own table ! bad! 3.  Import text "le from good! your test catalog! ! 4.  Import from real HL7 best! v2.x messages !
  • 91. Make a Local Dataset! Extract from Your Test Catalog! Battery code! Battery description or name! *Local code ! *Test description or name! Include method if important! Units! Example Values! Laboratory Section!
  • 92. Make a Delimited Text File! Need separate "elds! Use any delimiter! Fields in any order! Required "elds (minimum):! Local Code! Local Description! Units (highly recommended)!
  • 93. Importing Local Terms! 1.  Start it up! 2.  Find local term "le! C:Documents and SettingsAll UsersDocumentsRELMASamples C:UsersPublicDocumentsRELMASamples 3.  Name your working set! 4.  Identify "eld delimiter in your "le! 5.  Match your "elds to LMOF attributes! 6.  Import!!
  • 95. Importing Local Files! select “Import Local Terms from Delimited File”! or just click here!
  • 96. Navigate to File Location! select File andstored in ! sample "les click Open RELMA Directory !
  • 97. Open File in RELMA! Give it a name! (RELMA allows multiple sets in one LMOF database) ! select your delimiter ! Import button!
  • 98. Open File in RELMA! oh "ddlesticks!!! !
  • 99. Match Your Fields! assign LMOF attribute!
  • 100. Match Your Fields! choose "eld name!
  • 101. Now You’re Ready!! minimum assignments ! Do It! !
  • 102. After import, RELMA will search for words it does not recognize!
  • 103. Alternate Import (best)! Nothing closer to the truth than real data!
  • 104. Big Pile of HL7 Messages! ! RELMA parses into dataset! OBR ID! OBR description! OBX ID! OBX description! Sample results:! actual values, units, abnormal #ags, normal ranges! ! !
  • 105. Generate Local term "le from HL7 messages ! select Import Terms from HL7 File!
  • 106. Select File to Import! select HL7 "le!
  • 107. Specify HL7 File Name and Sample Size! name the local term "le (working set)! select the number of sample values ! select which codes to store!
  • 108. HL7 Messages Data Statistics!
  • 109. Your turn! ! Import Local Terms ! (or sample OBX "le)!
  • 110. Cleaning Your Data! A little time upfront saves more later! photo via Mu#et!
  • 111. Prep Your Data for Mapping! Improve mapping success! !Expand abbreviations! !Ignore “administrative” words! !Standardize idiosyncratic words! !Standardize time references! RELMA can help!
  • 112. RELMA Cleaning Tools! use this tool to edit unknown terms !
  • 113. Review Unknown Local Terms! may re-scan "le for unknown terms !
  • 114. Replace Local Terms! Assign LMOF Attribute replacement options ! !
  • 115. RELMA Cleaning Tools! use this tool to make global substitutions !
  • 116. Term Substitution! save this global substitution for only this working set!
  • 117. Clean Up! ! Take some time to clean up your sample "le!
  • 119. Change Local Term File! Select the Working Set !
  • 120. Manual Enter/Edit ! View/Add/Edit Local Terms !
  • 121. Edit Term Dialog! EditAddDelete Terms ! Export Terms! Search Terms by Keyword! Text alignment option! Print Preview List !
  • 122. New Terms added to LMOF! click on “Edit Term” to see sample data! new battery code!
  • 123. Sample Results for Observation! Sample Values from Messages !
  • 124. Search Local Term File! Calcium! Enter Keyword from any Return to Full List ! Field!
  • 125. Export Local Term File! Delimiters supported:! Tab, comma, bar (|) !
  • 126. Searching and Mapping to LOINC ! what RELMA was born to do! Photo via Jeffrey Beall!
  • 127. Hit It! ! Are you working on the right local "le? !
  • 128. Core Mapping Screen Features! Customizable grid ! Export results grid! Sort by columns! Stores mappings! View term details!
  • 129. Mapping Screen ! View or edit local term! Navigate through the local terms ! Quick select button list ! Custom Grid Con"guration!
  • 130. Con"gure Grid! Select elements to display! Reorder grid elements ! Visually resize elements ! Reset Default Con"guration!
  • 131. Quick choice buttons! Viewing LOINC term detail!
  • 132. View Local Term Details! Select level of detail to display!
  • 133. Select detail display level! Select level of detail to display!
  • 134. Standard Mapping Screen! Begin a search ! (or hit “enter”) !
  • 135. Initial Mapping Results! Fiddlesticks !#*$%!! What now??? ! Click to show words used in search!
  • 136. Initial Mapping Results! Use term Number of LOINC Battery terms checkbox! terms containing included in keyword ! search!
  • 137. Revised Mapping Results! Number of matching records found! Units restriction selected by default!
  • 138. Re-revised Mapping Results! Click any column header to re-sort ! Number of matching Match units records found! unselected!
  • 139. Standard Mapping Screen! CANINE DISTEMPER VIRUS IF Enter keywords here! Clear all input "elds !
  • 140. Ad hoc term search!
  • 141. Tabbed Access to Functions! Navigate to Functions from Mapping Page ! Switch between Grid and Tree Views !
  • 143. Tree View! Can map to terms Cannot map to with LOINC Codes! terms representing LOINC parts ! Tree Navigation Buttons!
  • 144. Assigning a LOINC Map! Click “Map” Button! (or doubleclick) ! Highlight correct term !
  • 145. Adding Mapping Comments! Check with Frank in Chemistry If comments option is selected, prompt appears !
  • 146. Assigning a LOINC Map! LOINC Term Assigned!
  • 147. View LOINC Term Details! View details for a speci"c LOINC Term ! Right clicking on a LOINC term brings up a Task Menu !
  • 148. LOINC Term Details! Can scroll down a single formatted page ! Can scroll through Change to expanded returned subset of details view! terms ! Change text size!
  • 150. View Panel Children! Select View Panel Children from context menu !
  • 152. Con"gure Export Options! Output options ! Include! Save con"guration column headers ! and/or export!
  • 154. More on Search Syntax! Tips and Tricks! Photo via Jeffrey Beall!
  • 155. Wildcards! “*” replaces any number of characters! GLUC*! *COSE! GLU*SE! “?” replaces a single character! GLUCOS?! ?LUCOSE! GLUC?SE!
  • 156. Search Quali"ers ! Detailed help available! Includes Glucuronidase, Glucosidase, Glucosylceramidase, etc.!
  • 157. Search in a Field! Field! Example! LOINC! loinc:12628-4! Component! component:chemotherapy! Property! glucose property:CCnc! Timing! glucose timing:24H! System! glucose system:CSF! Scale! glucose scale:Nar! Method! mycobacterium method:EIA! Class! glucose class:UA!
  • 158. Other Cool Tricks! Use parentheses! !(flu OR rhinovirus) -haemophilus ! component:(norepinephrine creatinine) ! Fuzzy search (~)! !Bergdorferi~
  • 159. Limiting Your Searches! Sometimes 60,000 terms is too many!
  • 160. Setting Search Limits! Reduces number of candidate terms! Many, many options! Hierarchy allows domain restrictions!
  • 161. with great power comes great responsibility! Photo via [cipher]!
  • 162. Setting Search Limits! click Hierarchy & Search Limits tab!
  • 163. Search Constraints! Attribute trees ! Local Unit Constraint: ! Default is “ON”! LOINC term status ! Prede"ned, general search constraints !
  • 164. Terms Consistent with Units! Only terms consistent with mmol/L appear !
  • 165. Quick Access Toggles For Common Restrictions! On/O# Toggles !
  • 166. Specimen Restriction! Specimen constraints !
  • 167. Terms Consistent with Specimen ! CSF enter default specimen!
  • 168. Terms Consistent with Specimen ! Only CSF Terms are returned!
  • 169. Setting Search Limits! Methodless Terms Override Methodless Terms Restriction! Restriction!
  • 171. Limit to Methodless Terms! only Methodless terms appear!
  • 172. Methodless Only Unchecked! All terms returned!
  • 173. Methodless Only Checked! Only Methodless terms returned! Di#er in one or more components !
  • 174. Conditional Methodless! More terms returned! No methodless term; all shown!
  • 175. Setting Search Limits! Limit to Lab Tests Only! (No Clinical LOINC Terms) !
  • 176. Setting Search Limits! Empirically derived common tests ! (99.8% of INPC volume)! Next Release: Top 2000 from humungous sample!
  • 177. A brief aside…! Developing convenience sets! photo via x-ray delta one!
  • 178. A Few Tests Give Most Results! 100%! Cumulative Laboratory Observation Volume (%)! 90%! 80%! 70%! 60%! 50%! 40%! 30%! 20%! 10%! 0%! 0! 500! 1000! 1500! 2000! 2500! 3000! 3500! 4000! Number of Laboratory Observation Codes (N)! Vreeman DJ, Finnell JT, Overhage JM. A Rationale for Parsimonious Laboratory Term Mapping by Frequency. AMIA Annu Symp Proc. 2007;:771-775. !
  • 179.
  • 180. Setting Search Limits! include Trial, Deprecated or Discouraged LOINC codes with returned terms !
  • 181. LOINC Term Status! Trial! ! as the concept and associated attributes may change. Concept is experimental in nature. Use with caution Discouraged! ! mappings to this concept are discouraged although Concept is not recommended for current use. New existing mappings may continue to be valid in ! context. Deprecated! Concept is retired and should not be used, but it is retained in LOINC for historical purposes.
  • 182. Include Deprecated LOINC Terms! Can’t map to a deprecated term! Warning before mapping to discouraged term! Discouraged LOINC Terms appear as an inverted triangle! Deprecated LOINC Terms appear as strikethrough text with a “Do Not” symbol!
  • 183. LOINC Hierarchies – Class Tree! Three top-level branches ! Tree Navigation Buttons!
  • 184. Before Class Restriction! Most terms have class of “CHAL” ! Large number of candidate terms !
  • 185. Hierarchies! Restrict eligible tests to non-challenge chemistry tests only !
  • 186. Following Class Restriction! Only Non-Challenge Chemistry tests returned!
  • 187. A Reminder About Search Limits! Indicates that you’ve got something set over here !
  • 188. Component Hierarchy! “right click” for context menu with “view details” option! Show the LOINC Codes associated with these components !
  • 191. Hierarchy Wrap-up! All trees operate the same way! All grids operate the same way! Tree is searchable ! Combine tree limits with others! “Mulligan” button!
  • 192. Search Hints and Tips! Zero hit keywords are ignored! !(may need to rephrase)! ! Common causes of Zero results! !Too many keywords! !Limits and keyword contradictions! !Local term weirdness! ! Units are GREAT discriminators!
  • 193. RELMA’s Auto Mapper! Starting with our best guesses may save you time!
  • 194. What Does It Do?! Batch processes local term "le to get N- closest candidate LOINCs! ! Uses words and units from local terms! ! Produces a ranked list for your review!
  • 195. Recent Improvements! Faster. Way faster.! Better clean-up routine! New specimen guesser! Better local to LOINC word "nder! Break ties with frequency data!
  • 196. Does it Work?! Lab terms (internal analysis)! !#1 ranking: 60-70ish%! !In Top 5: 70-80ish%! ! Radiology terms! !#1 ranking: 80-90ish%! !In Top 5: 90ish%! !Using CPT-based restriction helped! !(but we couldn’t distribute it)! Vreeman DJ, McDonald CJ. A Comparison of Intelligent Mapper and Document Similarity Scores for Mapping Local Radiology Terms to LOINC. Proc AMIA Symp. 2006;809-813.! ! Vreeman DJ and McDonald CJ. Automated Mapping of Local Radiology Terms to LOINC. Proc AMIA Symp. 2005;769-773.!
  • 197. (Lab) Auto Mapper! launch it here! a couple of options ! print report or work through the ranked list when done !
  • 198. Intelligent Mapper - Mapping Screen!
  • 199. Mapping Guidance and Approaches to Special Domains! Top N, Reportable Conditions, Newborn Screening!
  • 200. Not just an IT problem!
  • 202. Don’t be a one hit wonder.!
  • 203. Additional Pearls and Guidance! Clem McDonald, MD! Director, Lister Hill National Center for Biomedical Communications – National Library of Medicine !
  • 204. Other RELMA ® Features! Oh yes, there’s more!!
  • 205. Using Your Mapped Terms! You’ve done the work. Now reap the glory.! photo via janeandd!
  • 206. Con"gure Export Format! Context Sensitive Export Con"guration!
  • 207. LMOF Export Con"guration! Select Export Format! Select Fields to Export ! Save Con"guration and Export !
  • 208. Printing Mapped Terms! Click Print button to Preview May highlight terms to be output! printed!
  • 209. Custom Export Con"guration! Select the Format you wish to Export ! Select the Fields you wish to Export !
  • 211. Export Terms Dialog! Select Term Set ! Select Delimiter ! Check Fields you wish to export!
  • 212. More RELMA Fun! Parts, Panels, and Proposing New Terms!
  • 213. LOINC Part Search! Works just like the term search! Handy for looking at descriptions!
  • 215. Parts Search! only parts that have descriptions, references, etc !
  • 216. Panels, Forms, and Surveys! Wanted to make it easy to "nd! Special features for browsing!
  • 217. Panels, Forms and Survey Review! Review Panels, Forms and Surveys ! Review Panels, Forms and Surveys !
  • 219. Laboratory Panels! Double-click panel name to see components !
  • 221. Clinical Panels! Find where a term has been used !
  • 222. LOINC Term Panel Usage!
  • 224. Proposing New LOINC Terms! LOINC grows because you ask.!
  • 225. Proposing a New Term! Are you sure?! Give us all you got! RELMA is best! Send them in groups!
  • 226. What We Need! •  Local test/observation name! •  Local order (panel) name! •  Description of the test ! •  Name of send out lab (if applicable)! •  Name of healthcare organization that stimulated the request for this term (if you are submitting on behalf of someone else)! •  Units of measure (for quantitative observations)! •  Answer lists (for qualitative observations)! •  Sample results, reports (if applicable)! •  Package inserts, test kit documentation (if applicable)! •  Vendor, instrument, and/or reagent kit used to perform this test (if applicable)! •  Description of the project or activity that stimulated the request for this term, or any other documentation you have!
  • 227. Propose new LOINC terms! Select Propose a LOINC !
  • 228. Your Info! Navigate through Create new term, proposed terms! save current term or Exit form! Suggested LOINC Name!
  • 229. Use Existing Terms as Template! Click the Propose Term button ! Select your closest match!
  • 230. Use Existing Terms as Template! All required components "lled in!
  • 231. Review Proposed Terms! Review your new terms!
  • 232. Review Proposed Terms! Choose whether to send or postpone! All proposed terms fully editable!
  • 233. Submitting New Terms! Still need to email us the "le! !submissions@loinc.org! ! More Information! !http://loinc.org/submissions! ! LOINC Submissions Policy! !http://loinc.org/submissions-policy! ! !!
  • 235. photo via milos milosevic!