The document provides detailed chemical information about 2-amino-5-bromopyridine, including its molecular structure, physical properties, safety information, and applications in organic synthesis and pharmaceutical development. Production methods are described involving specific reactants and conditions, resulting in various chemical compounds. Safety precautions and handling instructions are also outlined, highlighting its irritant classification.

1. Description
Light yellow Cryst
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Basic Attributes
CAS No：1072-97-5
Molecular Formula ：C5H5BrN2
Molecular Mass ：173.01
Exact Mass ：171.963608
PSA ：38.9 A^2
LogP ：1.2
EINECS ：214-019-9
InChIKeys ：WGOLHUGPTDEKCF-UHFFFAOYSA-N
H-bond Acceptor ：2
H-bond Donor ：1
SP3 ：0.00
RBN ：0
Characteristics
Appearance ：White to beige Crystalline Powder
Density ：1.6065 (rough estimate)
Melting Point ：133-138 °C(lit.)
Bolling Point ：230.9±20.0 °C(Predicted)
Flash Point ：93.4±21.8 °C
Refractive Index ：1.5182 (estimate)
Solubility ：Soluble in methanol, chloroform, ethyl acetate. Slightly soluble in water.

2. Storage Condition ：Store below +30°C.
BRN ：108737
Safety Information
Hazard Class ：IRRITANT
HS Code ：29333999
UN No. ：UN 2811 6.1/PG 3
WGK_Germany ：2
Risk Code ：22-36/37/38
Safety Instructions ：26-36
Dangerous Mark ：Xn,Xi
P Code ：P261-P301 + P310-P305 + P351 + P338
Hazard Statements ：H301-H315-H319-H335
Hazard Note ：Irritant
Product Usage
2-Amino-5-bromopyridine is an organic synthesis intermediate and pharmaceutical intermediate.

3. It can be used in the laboratory research and development process and the chemical medicine
research and development process. It can be used as a raw material for the preparation of drugs
and fine chemicals.
Production Methods
General procedure: Nitrobenzene (0.6mmol), 5wtpercent Pd/C (0.5mmol percent, 0.003mmol),
H2O (10 equiv, 6.0mmol), B2(OH)4 (3.3 equiv, 2.0mmol), and CH3CN (1.0mL) were added in a
10mL tube. The reaction mixture was stirred at 50°C for 24h. When the reaction was complete
monitored by TLC, the mixture was cooled to room temperature. Water (5mL) was added, and
extracted with EtOAc (3×5mL). The combined organic phase was dried over anhydrous Na2SO4,
filtered, and concentrated under reduced pressure. The residue was purified by silica gel column
chromatography to give aniline 2a (55mg, 99percent).To the mixture of pyridin-2-ylamine (10.0 g,
106 mmol) in acetone (200 mL), was added NBS (22.6 g, 127 mmol) portionwise at 0°C. The
mixture was warmed to room temperature and stirred overnight. Solvent was evaporated in
vacuum. The residue was purified by silica gel column (DCM/MeOH, 20/1) to afford 18 g (yield:
98percent) of 5-bromo-pyridin-2- ylamine as yellow solid. [00589] 1H NMR (DMSO-d6): δ =
7.94 (IH, d), 7.61 (IH, dd), 6.43 (IH, d), 6.10 (2H, brs).4.5.4 14.8 g (89.4 mmol) of potassium
bromate was dissolved in the succinimide aqueous solution recovered in the previous step.In the
condition of 25 ° C, stirring, 17.5 mL of 50percent sulfuric acid aqueous solution was added
dropwise.
Material and Products
Products ：
2-Hydroxy-3-amino-5-bromopyridine, 1,1'-Biphenyl, 2-AMINO-3-CHLORO-5-BROMOPYRIDINE,
2-Fluoro-5-bromopyridine, 2-AMINO-5-BROMO-3-IODOPYRIDINE,
2-Amino-5-bromo-3-nitropyridine, 6-BROMO-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE,
2-Fluoropyridine-5-carboxaldehyde, 2-Amino-3,5-dibromopyridine,
5-Bromo-2-chloro-3-nitropyridine, 2-AMINO-5-PHENYLPYRIDINE, 5-P-TOLYLPYRIDIN-2-YLAMINE,
5-Bromo-3-nitro-2-pyridinol, 2-Amino-5-cyanopyridine, 2-Hydroxy-5-bromopyridine,
6-BROMO-2-METHYLIMIDAZO[1,2-A]PYRIDINE, 3-AMINO-5-BROMO-PYRIDIN-2-OL