ICRISAT Global Planning Meeting 2019: Modernising Crop Improvement II (AVISA...ICRISAT
Most public breeding programs in the developing world are 20-30 years behind state-of-art private sector programs due to: Lack of engineering support for mechanization and automation; Primitive data collection, management, and decision support systems; Obsolete and expensive genotyping capacity unsuited to forward breeding; Inadequate selection pressure for yield in multi-location trials; Breeders are not trained, incentivized, or supported to optimize pipelines; Reliance on visual selection; Lengthy breeding cycles, excessive backcrossing, No selection of parents for high breeding value; Obsolete dissemination models designed for the Green Revolution
Delivering a sustainable rice seed system in a complex institutional settingHillary Hanson
Scientific and Technical Partnerships in Africa: Technologies, Platforms, and Partnerships in support of the African agricultural science agenda, Abidjan, Cote d'Ivoire, April 4&5, 2017
ICRISAT Global Planning Meeting 2019: Modernising Crop Improvement II (AVISA...ICRISAT
Most public breeding programs in the developing world are 20-30 years behind state-of-art private sector programs due to: Lack of engineering support for mechanization and automation; Primitive data collection, management, and decision support systems; Obsolete and expensive genotyping capacity unsuited to forward breeding; Inadequate selection pressure for yield in multi-location trials; Breeders are not trained, incentivized, or supported to optimize pipelines; Reliance on visual selection; Lengthy breeding cycles, excessive backcrossing, No selection of parents for high breeding value; Obsolete dissemination models designed for the Green Revolution
Delivering a sustainable rice seed system in a complex institutional settingHillary Hanson
Scientific and Technical Partnerships in Africa: Technologies, Platforms, and Partnerships in support of the African agricultural science agenda, Abidjan, Cote d'Ivoire, April 4&5, 2017
Research Program Genetic Gains (RPGG) - Review Meeting 2021: Overview By Dr R...ICRISAT
Harnessing the full potential of modern genomics, molecular biology, and advanced breeding approaches. Generating trait knowledge, tools/technologies and platforms for integrating with crop improvement programs towards increasing crop productivity, profitability, and improving nutrition. Empowering national programs for adopting modern technologies in their crop improvement programs.
Research Program Genetic Gains (RPGG) Review Meeting 2021: Delivering Acceler...ICRISAT
Strengthening the Science of Delivery by increasing total seed production and availability, increasing access to high-quality seed of improved varieties, creating demand for quality seed (e.g. through value-chain support, demonstration trials, postharvest handling including seed, business training and market linkages), reaching farmers through formal and informal seed systems, lowering costs of seed.......
Seed security and resilience: Gender perspectivesCGIAR
This presentation was given by Shawn McGuire (Food and Agriculture Organization / FAO) on 21 November 2019, as part of the webinar ‘Gender dynamics in formal seed systems in Sub-Saharan Africa and worldwide lessons'. The webinar was co-organized by the CGIAR Collaborative Platform for Gender Research and CGIAR Research Program on Maize.
Read more about this webinar at: https://gender.cgiar.org/webinar-seed-system-ssa/
Find out about other webinars hosted by the CGIAR Collaborative Platform for Gender Research: http://gender.cgiar.org/gender_events/webinars/
Lead Authors:
Carlo Fadda
James Legg
Margaret McEwan
Beatrice Aighewi
Jorge Andrade
Zewdie Bishaw
Sammy Carsan
Steven Michael Cole
Alan Duncan
Alessandra Galie
Karen Garrett
Jonathan Hellin James Lillesø
Chris Stephen Jones
Christopher Kettle
Jan Kreuze
Kumar, Lava
Jens-Peter Barnekow Lillesø
Alice Muchugi
Bonaventure Aman Omondi
Michael Peters
Kelvin Mashisia Shikuku
David Spielman
Ronnie Vernooy
General constraints of the Tree crops sector in Cameroon,Potential Areas of intervention for the cooperatives in Participatory research and agricultural transformation,Key actors for the agricultural transformation
Presented at the American Association for the Advancement of Science (AAAS) in Boston, February 19, 2017. This presentation highlights the need for a new global food system that is knowledge based and one that will address complex issues. The need for smart agriculture has to be firmly based on excellence in science but also firmly situated by design in the social context in which it operates. The presentation discusses genetically engineered crops as an example of convergence and provides a few broad ideas about the characteristics a new innovation system in agriculture needs to pursue.
Research Program Genetic Gains (RPGG) - Review Meeting 2021: Overview By Dr R...ICRISAT
Harnessing the full potential of modern genomics, molecular biology, and advanced breeding approaches. Generating trait knowledge, tools/technologies and platforms for integrating with crop improvement programs towards increasing crop productivity, profitability, and improving nutrition. Empowering national programs for adopting modern technologies in their crop improvement programs.
Research Program Genetic Gains (RPGG) Review Meeting 2021: Delivering Acceler...ICRISAT
Strengthening the Science of Delivery by increasing total seed production and availability, increasing access to high-quality seed of improved varieties, creating demand for quality seed (e.g. through value-chain support, demonstration trials, postharvest handling including seed, business training and market linkages), reaching farmers through formal and informal seed systems, lowering costs of seed.......
Seed security and resilience: Gender perspectivesCGIAR
This presentation was given by Shawn McGuire (Food and Agriculture Organization / FAO) on 21 November 2019, as part of the webinar ‘Gender dynamics in formal seed systems in Sub-Saharan Africa and worldwide lessons'. The webinar was co-organized by the CGIAR Collaborative Platform for Gender Research and CGIAR Research Program on Maize.
Read more about this webinar at: https://gender.cgiar.org/webinar-seed-system-ssa/
Find out about other webinars hosted by the CGIAR Collaborative Platform for Gender Research: http://gender.cgiar.org/gender_events/webinars/
Lead Authors:
Carlo Fadda
James Legg
Margaret McEwan
Beatrice Aighewi
Jorge Andrade
Zewdie Bishaw
Sammy Carsan
Steven Michael Cole
Alan Duncan
Alessandra Galie
Karen Garrett
Jonathan Hellin James Lillesø
Chris Stephen Jones
Christopher Kettle
Jan Kreuze
Kumar, Lava
Jens-Peter Barnekow Lillesø
Alice Muchugi
Bonaventure Aman Omondi
Michael Peters
Kelvin Mashisia Shikuku
David Spielman
Ronnie Vernooy
General constraints of the Tree crops sector in Cameroon,Potential Areas of intervention for the cooperatives in Participatory research and agricultural transformation,Key actors for the agricultural transformation
Presented at the American Association for the Advancement of Science (AAAS) in Boston, February 19, 2017. This presentation highlights the need for a new global food system that is knowledge based and one that will address complex issues. The need for smart agriculture has to be firmly based on excellence in science but also firmly situated by design in the social context in which it operates. The presentation discusses genetically engineered crops as an example of convergence and provides a few broad ideas about the characteristics a new innovation system in agriculture needs to pursue.
The International Food Policy Research Institute – South Asia Regional Office (IFPRI-SAR) has extensively worked in Nepal on a wide range of policy issues in collaboration with the Ministry of Agriculture and Livestock Development, Government of Nepal. The key outputs from this engagement have been published in a book, Agricultural Transformation in Nepal: Trends, Prospects and Policy Options. The book addresses some of the key strategic agricultural policy questions on major contemporary developments and emerging challenges in Nepal. The book also covers on issues leading to the changing role of agriculture with economic growth, structural transformation and poverty reduction, improvement in nutritional outcomes, as well as challenges of tackling climate change.
IFPRI South Asia researchers Devesh Roy, Ruchira Boss, Mamata Pradhan and Manmeet Ajmani presented ‘Understanding the landscape of pulse policy in India and implications for trade’ to the Global Pulse Federation. The paper examines Indian policy around production, consumption and trade. The need for pulse trade policy in India to be supportive of Domestic priorities focused on serving interest of both India’s farmers and consumers.
Green Revolution in Eastern India: Constraints, Opportunities and Way Forward” on Oct 09-10, 2017 at NASC, Pusa, New Delhi, India. The conference was jointly organized by the Indian Council of Agricultural Research (ICAR), International Food Policy Research Institute (IFPRI) and Tata Cornell Institute for Agriculture and Nutrition (TCI). The conference is expected to develop a “road map” with clear prioritization and strategies for accelerated and sustainable agricultural growth in eastern India
Presented in ACIAR-IFPRI two days Regional Dialogue on Machine Reforms’ for Sustainable Intensification of Agriculture in South Asia on July 21-22, 2017 in New Delhi, India
Presented in ACIAR-IFPRI two days Regional Dialogue on Machine Reforms’ for Sustainable Intensification of Agriculture in South Asia on July 21-22, 2017 in New Delhi, India
Presented in ACIAR-IFPRI two days Regional Dialogue on Machine Reforms’ for Sustainable Intensification of Agriculture in South Asia on July 21-22, 2017 in New Delhi, India
More from International Food Policy Research Institute- South Asia Office (20)
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
1. NATIONAL SEMINAR
Regulations &
Governance Issues in
Indian Seed Sector
Harmonization of Regulations
for Better Governance of the
Indian Seed Sector
Dr Swati Nayak
South Asia Lead- Seed Systems & Product
Management, IRRI
September 26, 2023
ICAR Lecture Hall,
Second Floor, NASC Complex,
Pusa, New Delhi
2. Current Challenges which impede sustainability in the seed
➢ Climate Change and lack in terms of access to localized resilient varieties
➢ Negligible stake for primary seed producers and also institutions led by them
➢ Fragmented Seed Sector and seed chain
➢ Lack of optimized seed rolling plans and timeliness
➢ Obsolete Varieties in cereal crops Seed Chain
➢ Poor breeder seed multiplication programs- poor diffusion of new genotypes from public sectors
➢ Seed Production through public channels is almost non-functional
➢ Poor SRR% and VRR% especially in resource-poor demographies
➢ Lack of technological interventions like seed traceability
➢ Sub-optimal Seed and Field Standards- weak seed certification programs result in seeds failing to meet
International Standards
3. Impact of poor seed regulation at different levels of the production chain
Farmers level
• Poor access
• SRR
• Varietal
turnover/adoption
Public Inst
• Poor SC facility /
staffing
• Quality testing
limited to agronomic
traits
• Lack of processing
infra
• Malpractice-old
+new stock
Pvt Inst
• Hybrid vs inbred
cost
• Traceability/branding
• Often chemistry is
bundled
• TL Seed/ credibility
4. Small &medium enterprises
SAU, DOA
Farmers Collectives
Individual
Large Companies
CBO
Corporations
WSHG
Seed Village
PUBLIC
INFORMAL/SE
MI FORMAL FORMAL
PRIVATE
Quality Issues, Capacity deficit, Scaling constraints
Seed Scaling Ecosystem in India
Small Cooperatives
Sustainabilit
y/ viability
issues?
Strong
delivery,
market
intelligence,
TL/Credibility
, traceability,
hybrid vs
inbred
Weak
forward
linkages,
poor market
intelligence,
inventory or
demand
planning
5. Reform Agenda for informal seed sector
Needs access to product choice, regulatory ease and market supports
Landscaping
Product Infrastructure
Who are the producers:
Farmers collectives—SHG,
FPOs, APC etc, Individual
growers
Huge investment for
processing unit—a major
bottleneck. Grant can be
helpful
Widened choice of new crops
and cultivars-EGS
decentralization, hedging
SEED EXTENSION
1
2
4
5
Certification Market
Informal seed production is
often by many farmers,
making certification costly
and tedious. Collective
certification
Support for markets—
Buyback, DBT for seeds sold
by informal sector
3 6
Ease of licensing to allow
production and sales of
seeds—currently lengthy
Licensing
Rigorous Capacity building and skill based trainings
6. Capacity development of the informal seed sector
➢ Establishing liaison and support systems for Farmer groups like FPO, FPCs, and NGOs.
➢ Special attention towards Women’s rural entrepreneurship
➢ Sourcing linkage of foundation seeds of high quality.
➢ Providing educational training related to optimum seed production, storage, handling, and
marketing.
➢ Extending technological supports related to farm mechanization, storage facilities, and Seed
processing (graders, cleaners, etc.).
➢ Pipeline development with new and improved lines, which have special traits and competitive.
➢ Training related to maintaining seed genetic purity, vigor, and viability and seed health
➢ Development of alternative marketing channels
7. Key Policy Thrusts
➢ Develop a National Seed Register and data base for varietal fitment and targeted varietal positioning and
seed planning
➢ Harmonize licensing, rules, and guidelines between the states and to overcome existing discrepancies
and complications responsible for slow adoptions.
➢ Digitizing indenting processes for transparent and efficient demand aggregation for better market
intelligence and inventory planning
➢ Decentralizing breeder seed production and provisioning
➢ Robust compensation policies for farmers for poor quality seed supply
➢ Incentivization support for alternative farmer led seed institutions – in terms quality control measures
and certification, marketing channels, buy back, DBT etc
➢ Digital seed traceability
➢ Making seed health an essential thrust area in quality certification
➢ Seed morphological factors along with agronomic parameters (image analysis )
8. Opportunities to strengthen the seed sector in India
Strengthened
Seed Sector
Decentralised
EGS
Digitization
Seed Export
Market driven
breeding/
product
placement Alternative seed
systems and
capacity,
Alternative
Marketing
mechanism
QC in small &
medium scale
initiatives