Pulmonary embolism (PE) is a sudden blockage of the pulmonary artery caused by a thrombus, fat, air, or tumor tissue. Key clinical features include shortness of breath, chest pain, and irregular heartbeat, with diagnostic measures like CT scans and D-dimer tests used for confirmation. Management involves initial treatment with oxygen, medications including anticoagulants and thrombolytics, and nursing care focused on monitoring and preventing complications.