This document summarizes a study that used topological optimization and genetic algorithms to analyze and optimize the design of wheels for an unmanned aerial vehicle (UAV). The study used finite element analysis software to conduct topological optimization on a simplified 2D model of a wheel. The goal was to reduce the wheel's mass by 50% while maintaining structural integrity. Genetic algorithms from other optimization software were also utilized. The optimized wheel design reduced mass by 40% compared to previous designs. The study found that wheel width had the greatest influence on the aircraft's mechanical performance.