Ribavirin has been shown to reduce mortality from Lassa fever by 5-10 fold when administered intravenously within 6 days of symptoms onset. It works through three main mechanisms: 1) immunomodulation, 2) inhibition of the enzyme inosine-monophosphate-dehydrogenase, and 3) inducing mutations in the viral genome. Specifically, ribavirin is phosphorylated and competes with guanine nucleotides to inhibit the viral RNA polymerase and prevent replication. By understanding ribavirin's multivalent mechanisms of action, it can continue to be an effective broad-spectrum antiviral and aid in developing new drugs for viral hemorrhagic fevers.