This document discusses how a librarian's perceptions and biases can affect reference interviews. It explores how a librarian's worldview and that of the patron can impact the interaction. Research shows librarians may exhibit biases related to linguistic differences, closed stacks policies, and virtual reference services. The document also examines predictable gender differences in how men and women meet their information needs and cultural shifts that have occurred in library communities with high Mexican immigrant populations, such as adjustments to collections, programming, staffing, and communication.