about when GH deficiency occur

1. ABNORMALITIES OF GH
HORMONE

2. HYPERSECRETION OF GH
• Tumours of acidophilic cells of anterior pituitary
• Depending upon age of an individual , Excess of GH may cause
1. Gigantism
2. Acromegaly

3. GIGANTISM
• Hypersecretion of GH hormone in children before closure of it’s epiphyseal line
of long bones .
• Clinical features
1. Abnormal height
2. Long hands and legs
3. Coarse facial features
4. Bilateral gynaecomastia ( in males , enlarge ment of breast )
5. Loss of libido ( sexual desire )
6. Hyperglycaemia

4. FEATURES DUE TO TUMOUR MASS
1. Headache
2. Visual field defects
3. Cranial nerve palsies
4. Enlargement of pituitary fossa

5. ACROMEGALY
• Excess of GH hormone in adult in which epiphyseal closure of
long bones occur
• Growth in area in which cartilage Persistent.

6. CLINICAL FEATURES
1. Acromegalic face
2. Prognathism – protrusion of lower jaw due to elongation and
widening of mandible associated with increased spacing of teeth
3. Acral part abnormalities – large spade like hands , thick wide
fingers , large feet with an increase in size of shoes .
4. Kyphosis – due to improper vertebral growth .
5. Excessive growth of internal organs
6. Excessive sympathetic activity like excessive sweating and
hypertension.

7. HYPOSECRETION OF GH HORMONE
• Deficiency of GH in childhood. -. Leads to stunted growth or
dwarfism.
• Deficiency of GH in adulthood. -. Mild anaemia
1. Reduction muscle mass
2. Hypoglycemia
• Dwarfism
• Short stature

8. ENDOCRINAL CAUSES OF DWARFISM
1. Deficiency of GH
2. Panhypopituitarism
3. Hypothyroidism
4. Cushing’s syndrome

9. NON ENDOCRINAL CAUSES OF DWARFISM
1. Familial dwarfism
2. Achondroplasia – hereditary condition in which growth of long
bones by ossification of cartilage retarded .
3. Nutritional ( malnutrition or malabsorption )
4. Chromosomal abnormalities – turner’s syndrome
5. Psychological dwarfism – Hauser’s syndrome

10. GROWTH HORMONE RELATED DWARFISM
1. Pituitary dwarfism
• Deficiency of GH hormone
• Retardation of growth
• Shortness of stature
• Normal mental activity
• Plumpness ( fatness )
• Immature face
• Delecate extremities
• Sexual maturity doesn’t occur when gonadotropin deficiency

11. AFRICAN PYGMIES
• Lack of GH receptors
• Normal level of GH and somatomedin
• IGF-1 levels fail to increase time of puberty

12. LARON DWARFISM
GROWTH HORMONE INSENSITIVITY
SYNDROME
• Congenital abnormality of GH receptors
• Decrease GH binding protein
• IGF-1 not secreted sufficient.

13. • Reference from Indu khurana