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Synthesis of hydralazine
1. Bangabandhu Sheikh Mujibur Rahman Science and Technology
University
A Presentation on Hydralazine
Presented By
Md. Shimul Bhuia
Department of Pharmacy
Course Title: Medicinal Chemistry-II
Course Code: PHR303
2. Chemistry of hydralazine
• Hydralazine belongs
to the
hydrazinophthalazine
class of drugs
• Chemical name: 1-
Hydrazinophthalazine
4. Mechanism action of hydralazine
• It is a direct-acting smooth
muscle relaxant and acts as
a vasodilator primarily
in resistance arteriole. By
relaxing vascular smooth muscle,
vasodilators act to
decrease peripheral resistance,
thereby lowering blood
pressure and decreasing afterload.
5. Therapeutic uses of hydralazine
• Used to treat severe essential hypertension
• often used to treat hypertension in pregnancy, with methyldopa
• To prevent heart attacks, stocks and kidney problems
• To treat heart failure (in combination with beta-blockers)
• Used to treat congestive heart failure (in combination with isosorbide
dinitrate)