How are obesity and NCDs linked? Inflammatory chemicals lead to chronic low-grade inflammation triggering metabolic changes that promote Type-2 Diabetes, CVD, and some cancers. Glucose from excessive carbohydrate intake stimulate chronic low-grade inflammation. Leaking fatty acids promote low-grade chronic inflammation. Adipose tissue secretes inflammatory chemicals. The more adipose tissue the more inflammatory chemicals secreted. Sugar is addicting and is therefore causing NCDs..