SlideShare a Scribd company logo
1 of 21
VACCINES & IMMUNIZATION
How to realize the full benefits of immunization
IMMUNIZATION SAVES LIVES AND KEEPS
PEOPLE HEALTHY
• Immunization saves up to 3 million lives
annually
• Vaccines are available to protect
against the following 26 infectious
diseases, with many more in
development
Cholera • Dengue • Diphtheria • Hepatitis A • Hepatitis B •
Hepatitis E • Haemophilus influenzae type b (Hib) • Human
papillomavirus • Influenza • Japanese encephalitis • Malaria •
Measles • Meningococcal meningitis • Mumps • Pertussis
(whooping cough) • Pneumococcal disease • Poliomyelitis •
Rabies • Rotavirus • Rubella • Tetanus • Tick-borne encephalitis •
Tuberculosis • Typhoid • Varicella (chickenpox) • Yellow Fever
VACCINES CAN ERADICATE
DISEASES, BUT DECLINING
COVERAGE PUTS PROGRESS AT
RISK
Immunization has
reduced wild
poliovirus by more
than
Immunization
eradicated Smallpox
Global vaccine
coverage has
stagnated at 86%
Large measles
outbreaks affected 1 in 4
European countries in
2017
99%
86%
HOW VACCINES WORK
The body is exposed to
a weakened or dead
pathogen
The body’s
immune cells
make antibodies
to attack the
pathogen
If the body is
exposed to the
pathogen again,
the body will be
prepared with
antibodies
VACCINES PROTECT THE
COMMUNITY
COMMUNITY IMMUNITY
When a sufficient proportion of a population
is immune to an infectious disease to make
its spread from person to person unlikely.
COVERAGE THRESHOLD
The minimum percentage of individuals
immune to a disease needed to prevent an
outbreak.
countries in the EU/EEA achieved the 95% coverage threshold
needed to prevent measles outbreaks in 2017
Only
6
VACCINES
PROTECT THE
COMMUNITY
Disease
spreads
through the
population
Disease
spreads
through some
of the
population
Spread of the
disease is
constrained
WHEN SOME OF THE
POPULATION IS IMMUNIZED
WHEN NO ONE IS
IMMUNIZED
WHEN MOST OF THE
POPULATION IS IMMUNIZED Not immunized but still healthy
Immunized & healthy
Not immunized, sick &
contagious
TYPES OF VACCINES
Live attenuated: contain weakened pathogen; require 1-2
doses. Ex. MMR, rotavirus, varicella
Subunit: contain killed, antigenic component of pathogen;
require several doses (booster shots). Ex. Hib, HPV,
pneumococcal
Inactivated: contain killed pathogen; require several doses
(booster shots). Ex. Hepatitis A, rabies, inactivated
poliovirus vaccine
Toxoid: contain toxin made by pathogen; may require
booster shots. Ex. Diphtheria, pertussis
VACCINE DOSING THROUGH THE
LIFESPAN
Some vaccines
provide life-long
immunity from a
single dose
New vaccines are
needed frequently
for pathogens that
mutate often (such
as influenza)
Others provide
greater
protection after
multiple doses
VACCINES AREN’T JUST FOR CHILDREN
– OLDER POPULATIONS NEED
TARGETED PROTECTION FROM
CERTAIN DISEASES
VACCINE COMPONENTS: SAFE
AND EFFECTIVE
• Provide immunity
• Antigens
• Adjuvants
• Keep vaccines safe and long lasting
• Preservatives
• Stabilizers
• Used during the production of vaccines
• Cell culture materials
• Inactivating ingredients
• Antibiotics
IMMUNIZATION SCHEDULES: BASED ON
SCIENTIFIC EVIDENCE
• Designed to best protect public health
• Formulated using robust scientific evidence
ENSURING VACCINES ARE SAFE AND
EFFECTIVE
20-100
HEALTHY
VOLUNTEERS
Is this vaccine safe?
Does this vaccine
seem to work?
Are there serious side
effects?
How is dose related to
side effects?
SEVERAL
HUNDRED
VOLUNTEERS
What are the most
common short-term
side effects?
How are the
volunteers’ immune
systems responding
to the vaccine?
HUNDREDS OF
THOUSANDS OF
VOLUNTEERS
How do people who
get the vaccine and
people who do not
compare?
Is the vaccine safe?
Is the vaccine
effective?
PHAS
E
1
PHAS
E
2
PHAS
E
3
CONTINUOUS SAFETY MONITORING
Collect & review data
Monitor side effects
Identify &
understand risks
Communicate &
manage risks
appropriately
A VACCINE’S SAFETY CONTINUES TO BE
MONITORED
CONTRAINDICATION
• A rare condition in a recipient that
increases the risk for a serious
adverse reaction
• The only contraindication
applicable to all vaccines is a
history of a severe allergic reaction
after a prior dose of vaccine or to a
vaccine constituent
PRECAUTION
• A condition in the recipient that may
increase the risk of a serious adverse
reaction, might cause diagnostic
confusion, or might compromise the
ability of the vaccine to produce
immunity
• Vaccine may be administered if the
benefit from the vaccine is judged to
outweigh the risk
CONTRAINDICATIONS & PRECAUTIONS
Contraindications and precautions are conditions under which vaccines
should not be administered. The majority of these conditions are temporary,
so immunizations often can be administered later when the conditions no
longer exists.
DANGEROUS EFFECTS OF LOW VACCINE
COVERAGE
EVEN SMALL POCKETS OF LOW COVERAGE CAN
TRIGGER DEADLY OUTBREAKS
Measles: Europe
sees record
number of cases
and 37 deaths so
far this year
(20 August 2018)
2,295 cases of
measles reported
in Italy in 2018.
(25 November
2018)
The number of
measles cases
reaches a record in
Europe
(23 August 2018)
U.S. officials say
measles cases hit
25-year record high
(29 April 2019)
As Measles Surges, ‘Decades of Progress’ Are in Jeopardy
(29 August 2018)
COMMON MYTHS
MYTH: VACCINES CAUSE
AUTISM
• Myth incited by flawed and fraudulent study
• Study retracted and lead author had his
medical license revoked
• Subsequent studies have found no connection
between vaccines and their ingredients and
autism
FACT:
NO LINK
EXISTS
BETWEEN
VACCINES
AND AUTISM
COMMON MYTHS
MYTH: IT IS BETTER TO SPACE
OUT CHILDHOOD VACCINES
USING AN ALTERNATIVE
SCHEDULE
• From birth, a baby’s immune system is well
equipped to respond to vaccines
• There is no evidence that spreading out the
schedule improves health outcomes
• Delaying vaccines increases the time children will
be susceptible to diseases
FACT:
SPREADING
OUT
VACCINES
LEAVES
CHILDREN
UNPROTECTE
D
COMMON MYTHS
MYTH: VACCINES CAUSE
THE DISEASES THEY ARE
DESIGNED TO PREVENT
• Inactivated vaccines cannot cause disease
• It is nearly unheard of for live attenuated
vaccines to cause disease
• Mild symptoms are rare, but can indicate
immune response (not infection)
FACT:
VACCINES
UNDERGO
EXTENSIVE
MONITORING
AND TESTING
BEFORE
APPROVAL
COMMON MYTHS
MYTH: MY CHILD IS AT
GREATER RISK OF HARM FROM
A VACCINE THAN FROM THE
DISEASE ITSELF
• The risks of natural infection are greater than the
risks of immunization for every recommended
vaccine
• Severe side effects from immunization are incredibly
rare
• Immunization is the best protection against deadly
diseases
• Immunization prevents individual illness and large-
scale outbreaks
FACT:
THE BENEFIT
OF
IMMUNIZATIO
N FAR
OUTWEIGHS
THE RISK
COMMUNICATING WITH PATIENTS TO
BOLSTER VACCINE CONFIDENCE
• Presume acceptance
• Listen
• Validate concerns
• Respond to concerns with positive messages
about vaccines, information debunking myths
• Communicate risks of delaying immunization
• Share experiences about immunization
• Have follow-up conversations
• Provide additional resources about vaccines
ADDITIONAL RESOURCES
U.S. National Institutes of Health, National Institute of Allergy
and Infectious Disease (https://www.niaid.nih.gov/)
• How do vaccines work? https://www.niaid.nih.gov/research/how-
vaccines-work
European Centre for Disease Prevention and Control
(www.ecdc.europa.eu)
• Let’s talk about hesitancy: Enhancing confidence in vaccination and
uptake
https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publica
tions/lets-talk-about-hesitancy-vaccination-guide.pdf
• Let’s talk about prevention: enhancing childhood vaccination uptake
https://ecdc.europa.eu/en/publications-data/lets-talk-about-protection-
enhancing-childhood-vaccination-uptake
ADDITIONAL RESOURCES
World Health Organization (https://www.who.int/)
• E-learning course on Vaccine Safety Basics http://vaccine-safety-training.org/
• Contraindications to common diseases
https://www.who.int/immunization/policy/contraindications.pdf
• Recommendations for routine immunization
https://www.who.int/immunization/policy/immunization_tables/en/
United Nations International Children’s Emergency Fund
(https://www.unicef.org/)
• Promoting and strengthening a life-saving investment (UNICEF)
https://www.unicef.org/eca/sites/unicef.org.eca/files/2018-07/In%20focus%20-
%20Immunization.pdf
U.S. Centers for Disease Control and Prevention (www.cdc.gov)
• Vaccines Do Not Cause Autism
https://www.cdc.gov/vaccinesafety/concerns/autism.htm

More Related Content

Similar to Sabin-Immunizatio.pptx

power point vaccination during pregnancy3faa.ppt
power point  vaccination during pregnancy3faa.pptpower point  vaccination during pregnancy3faa.ppt
power point vaccination during pregnancy3faa.pptIslamSaeed19
 
routine immunization in india( from gov.in) .ppt
routine immunization in india( from gov.in) .pptroutine immunization in india( from gov.in) .ppt
routine immunization in india( from gov.in) .pptSauravKumar927915
 
Whooping Cough and Measles: Vaccination on the Rise
Whooping Cough and Measles: Vaccination on the RiseWhooping Cough and Measles: Vaccination on the Rise
Whooping Cough and Measles: Vaccination on the RisebluetroyvictorVinay
 
Immunity and vaccine (community medicine )
Immunity and vaccine (community medicine )Immunity and vaccine (community medicine )
Immunity and vaccine (community medicine )Niko439610
 
Vaccines against infectious diseases
Vaccines against infectious diseasesVaccines against infectious diseases
Vaccines against infectious diseasesKanishkPatel6
 
vaccine resistance
vaccine resistancevaccine resistance
vaccine resistanceJaiShree34
 
Small pox and chicken pox
Small pox and chicken poxSmall pox and chicken pox
Small pox and chicken poxRizwan S A
 
Global Pandemic and Emerging Diseases ...
Global Pandemic and Emerging Diseases ...Global Pandemic and Emerging Diseases ...
Global Pandemic and Emerging Diseases ...ndagiremilly90
 
Vaccine ppt.pptx
Vaccine ppt.pptxVaccine ppt.pptx
Vaccine ppt.pptxSani42793
 
Share_smallpoxchickenpoxrizwan-160925004343.pdf
Share_smallpoxchickenpoxrizwan-160925004343.pdfShare_smallpoxchickenpoxrizwan-160925004343.pdf
Share_smallpoxchickenpoxrizwan-160925004343.pdfEkranthkumar
 
vaccines and anti-viral drugs
vaccines and anti-viral drugsvaccines and anti-viral drugs
vaccines and anti-viral drugsjawaria sultan
 
Homoeopathic prophylaxis VS Vaccination
Homoeopathic prophylaxis VS VaccinationHomoeopathic prophylaxis VS Vaccination
Homoeopathic prophylaxis VS VaccinationAnit Singh Vikram
 
Importance of vaccination & immunization presentation
Importance of vaccination & immunization presentationImportance of vaccination & immunization presentation
Importance of vaccination & immunization presentationExpressClinicsIndia
 
Specific prophylaxis and therapy of infectious diseases. Vaccines & toxoides
Specific prophylaxis and therapy of infectious diseases. Vaccines & toxoidesSpecific prophylaxis and therapy of infectious diseases. Vaccines & toxoides
Specific prophylaxis and therapy of infectious diseases. Vaccines & toxoidesEneutron
 
1-A-MPP-ToxGurukul-Safety Evaluation of Vaccines.ppt
1-A-MPP-ToxGurukul-Safety Evaluation of Vaccines.ppt1-A-MPP-ToxGurukul-Safety Evaluation of Vaccines.ppt
1-A-MPP-ToxGurukul-Safety Evaluation of Vaccines.pptMukulPore3
 

Similar to Sabin-Immunizatio.pptx (20)

power point vaccination during pregnancy3faa.ppt
power point  vaccination during pregnancy3faa.pptpower point  vaccination during pregnancy3faa.ppt
power point vaccination during pregnancy3faa.ppt
 
routine immunization in india( from gov.in) .ppt
routine immunization in india( from gov.in) .pptroutine immunization in india( from gov.in) .ppt
routine immunization in india( from gov.in) .ppt
 
Whooping Cough and Measles: Vaccination on the Rise
Whooping Cough and Measles: Vaccination on the RiseWhooping Cough and Measles: Vaccination on the Rise
Whooping Cough and Measles: Vaccination on the Rise
 
Immunity and vaccine (community medicine )
Immunity and vaccine (community medicine )Immunity and vaccine (community medicine )
Immunity and vaccine (community medicine )
 
Vaccines against infectious diseases
Vaccines against infectious diseasesVaccines against infectious diseases
Vaccines against infectious diseases
 
vaccine resistance
vaccine resistancevaccine resistance
vaccine resistance
 
Small pox and chicken pox
Small pox and chicken poxSmall pox and chicken pox
Small pox and chicken pox
 
Global Pandemic and Emerging Diseases ...
Global Pandemic and Emerging Diseases ...Global Pandemic and Emerging Diseases ...
Global Pandemic and Emerging Diseases ...
 
Vaccine ppt.pptx
Vaccine ppt.pptxVaccine ppt.pptx
Vaccine ppt.pptx
 
Share_smallpoxchickenpoxrizwan-160925004343.pdf
Share_smallpoxchickenpoxrizwan-160925004343.pdfShare_smallpoxchickenpoxrizwan-160925004343.pdf
Share_smallpoxchickenpoxrizwan-160925004343.pdf
 
Vaccination
VaccinationVaccination
Vaccination
 
vaccines and anti-viral drugs
vaccines and anti-viral drugsvaccines and anti-viral drugs
vaccines and anti-viral drugs
 
Immunization-Program.pdf
Immunization-Program.pdfImmunization-Program.pdf
Immunization-Program.pdf
 
Adult vaccination
Adult vaccinationAdult vaccination
Adult vaccination
 
Homoeopathic prophylaxis VS Vaccination
Homoeopathic prophylaxis VS VaccinationHomoeopathic prophylaxis VS Vaccination
Homoeopathic prophylaxis VS Vaccination
 
VACCINES
VACCINESVACCINES
VACCINES
 
vaccination
vaccinationvaccination
vaccination
 
Importance of vaccination & immunization presentation
Importance of vaccination & immunization presentationImportance of vaccination & immunization presentation
Importance of vaccination & immunization presentation
 
Specific prophylaxis and therapy of infectious diseases. Vaccines & toxoides
Specific prophylaxis and therapy of infectious diseases. Vaccines & toxoidesSpecific prophylaxis and therapy of infectious diseases. Vaccines & toxoides
Specific prophylaxis and therapy of infectious diseases. Vaccines & toxoides
 
1-A-MPP-ToxGurukul-Safety Evaluation of Vaccines.ppt
1-A-MPP-ToxGurukul-Safety Evaluation of Vaccines.ppt1-A-MPP-ToxGurukul-Safety Evaluation of Vaccines.ppt
1-A-MPP-ToxGurukul-Safety Evaluation of Vaccines.ppt
 

More from sergeipee

BP Lec for Vital Signs 2 lab.ppt
BP Lec for Vital Signs 2 lab.pptBP Lec for Vital Signs 2 lab.ppt
BP Lec for Vital Signs 2 lab.pptsergeipee
 
BP Lec for Vital Signs 2 lab.ppt
BP Lec for Vital Signs 2 lab.pptBP Lec for Vital Signs 2 lab.ppt
BP Lec for Vital Signs 2 lab.pptsergeipee
 
schistosoma presentation.pptx
schistosoma presentation.pptxschistosoma presentation.pptx
schistosoma presentation.pptxsergeipee
 
Bacterial Cell structure and Function (1).ppt
Bacterial Cell structure and Function (1).pptBacterial Cell structure and Function (1).ppt
Bacterial Cell structure and Function (1).pptsergeipee
 
Basics of HIV.ppt
Basics of HIV.pptBasics of HIV.ppt
Basics of HIV.pptsergeipee
 
Lesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxLesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxsergeipee
 
Lesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxLesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxsergeipee
 
13- malaria.ppt
13- malaria.ppt13- malaria.ppt
13- malaria.pptsergeipee
 
Shape-size-and-arrangment-of-bacteria.pptx
Shape-size-and-arrangment-of-bacteria.pptxShape-size-and-arrangment-of-bacteria.pptx
Shape-size-and-arrangment-of-bacteria.pptxsergeipee
 
sexuallytransmittedinfections-200729111142.pptx
sexuallytransmittedinfections-200729111142.pptxsexuallytransmittedinfections-200729111142.pptx
sexuallytransmittedinfections-200729111142.pptxsergeipee
 
sexuallytransmitteddiseasesverygoodwithnursingresponsibilty-160520145427.pptx
sexuallytransmitteddiseasesverygoodwithnursingresponsibilty-160520145427.pptxsexuallytransmitteddiseasesverygoodwithnursingresponsibilty-160520145427.pptx
sexuallytransmitteddiseasesverygoodwithnursingresponsibilty-160520145427.pptxsergeipee
 
Lesson 11 NOTES MC3.pptx
Lesson 11 NOTES MC3.pptxLesson 11 NOTES MC3.pptx
Lesson 11 NOTES MC3.pptxsergeipee
 
STI.STD.pptx
STI.STD.pptxSTI.STD.pptx
STI.STD.pptxsergeipee
 
HIV & AIDS.ppt
HIV & AIDS.pptHIV & AIDS.ppt
HIV & AIDS.pptsergeipee
 
inoculating a culture plate in bacteriology
inoculating a culture plate in bacteriologyinoculating a culture plate in bacteriology
inoculating a culture plate in bacteriologysergeipee
 
Shape-size-and-arrangement-of-bacteria
Shape-size-and-arrangement-of-bacteriaShape-size-and-arrangement-of-bacteria
Shape-size-and-arrangement-of-bacteriasergeipee
 
Std-2021.pptx
Std-2021.pptxStd-2021.pptx
Std-2021.pptxsergeipee
 
Parasitic Disease
Parasitic DiseaseParasitic Disease
Parasitic Diseasesergeipee
 
Introduction_to_Medical_Parasitology.ppt
Introduction_to_Medical_Parasitology.pptIntroduction_to_Medical_Parasitology.ppt
Introduction_to_Medical_Parasitology.pptsergeipee
 
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptx
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptxDiagnostic-Structures-Of-Enterobius-Vermicularis.pptx
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptxsergeipee
 

More from sergeipee (20)

BP Lec for Vital Signs 2 lab.ppt
BP Lec for Vital Signs 2 lab.pptBP Lec for Vital Signs 2 lab.ppt
BP Lec for Vital Signs 2 lab.ppt
 
BP Lec for Vital Signs 2 lab.ppt
BP Lec for Vital Signs 2 lab.pptBP Lec for Vital Signs 2 lab.ppt
BP Lec for Vital Signs 2 lab.ppt
 
schistosoma presentation.pptx
schistosoma presentation.pptxschistosoma presentation.pptx
schistosoma presentation.pptx
 
Bacterial Cell structure and Function (1).ppt
Bacterial Cell structure and Function (1).pptBacterial Cell structure and Function (1).ppt
Bacterial Cell structure and Function (1).ppt
 
Basics of HIV.ppt
Basics of HIV.pptBasics of HIV.ppt
Basics of HIV.ppt
 
Lesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxLesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptx
 
Lesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxLesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptx
 
13- malaria.ppt
13- malaria.ppt13- malaria.ppt
13- malaria.ppt
 
Shape-size-and-arrangment-of-bacteria.pptx
Shape-size-and-arrangment-of-bacteria.pptxShape-size-and-arrangment-of-bacteria.pptx
Shape-size-and-arrangment-of-bacteria.pptx
 
sexuallytransmittedinfections-200729111142.pptx
sexuallytransmittedinfections-200729111142.pptxsexuallytransmittedinfections-200729111142.pptx
sexuallytransmittedinfections-200729111142.pptx
 
sexuallytransmitteddiseasesverygoodwithnursingresponsibilty-160520145427.pptx
sexuallytransmitteddiseasesverygoodwithnursingresponsibilty-160520145427.pptxsexuallytransmitteddiseasesverygoodwithnursingresponsibilty-160520145427.pptx
sexuallytransmitteddiseasesverygoodwithnursingresponsibilty-160520145427.pptx
 
Lesson 11 NOTES MC3.pptx
Lesson 11 NOTES MC3.pptxLesson 11 NOTES MC3.pptx
Lesson 11 NOTES MC3.pptx
 
STI.STD.pptx
STI.STD.pptxSTI.STD.pptx
STI.STD.pptx
 
HIV & AIDS.ppt
HIV & AIDS.pptHIV & AIDS.ppt
HIV & AIDS.ppt
 
inoculating a culture plate in bacteriology
inoculating a culture plate in bacteriologyinoculating a culture plate in bacteriology
inoculating a culture plate in bacteriology
 
Shape-size-and-arrangement-of-bacteria
Shape-size-and-arrangement-of-bacteriaShape-size-and-arrangement-of-bacteria
Shape-size-and-arrangement-of-bacteria
 
Std-2021.pptx
Std-2021.pptxStd-2021.pptx
Std-2021.pptx
 
Parasitic Disease
Parasitic DiseaseParasitic Disease
Parasitic Disease
 
Introduction_to_Medical_Parasitology.ppt
Introduction_to_Medical_Parasitology.pptIntroduction_to_Medical_Parasitology.ppt
Introduction_to_Medical_Parasitology.ppt
 
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptx
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptxDiagnostic-Structures-Of-Enterobius-Vermicularis.pptx
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptx
 

Recently uploaded

Call Girls Varanasi Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Varanasi Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Varanasi Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Varanasi Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
Lucknow Call girls - 8800925952 - 24x7 service with hotel room
Lucknow Call girls - 8800925952 - 24x7 service with hotel roomLucknow Call girls - 8800925952 - 24x7 service with hotel room
Lucknow Call girls - 8800925952 - 24x7 service with hotel roomdiscovermytutordmt
 
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...jageshsingh5554
 
Top Rated Bangalore Call Girls Mg Road ⟟ 8250192130 ⟟ Call Me For Genuine Sex...
Top Rated Bangalore Call Girls Mg Road ⟟ 8250192130 ⟟ Call Me For Genuine Sex...Top Rated Bangalore Call Girls Mg Road ⟟ 8250192130 ⟟ Call Me For Genuine Sex...
Top Rated Bangalore Call Girls Mg Road ⟟ 8250192130 ⟟ Call Me For Genuine Sex...narwatsonia7
 
Call Girls Service Surat Samaira ❤️🍑 8250192130 👄 Independent Escort Service ...
Call Girls Service Surat Samaira ❤️🍑 8250192130 👄 Independent Escort Service ...Call Girls Service Surat Samaira ❤️🍑 8250192130 👄 Independent Escort Service ...
Call Girls Service Surat Samaira ❤️🍑 8250192130 👄 Independent Escort Service ...CALL GIRLS
 
Russian Escorts Girls Nehru Place ZINATHI 🔝9711199012 ☪ 24/7 Call Girls Delhi
Russian Escorts Girls  Nehru Place ZINATHI 🔝9711199012 ☪ 24/7 Call Girls DelhiRussian Escorts Girls  Nehru Place ZINATHI 🔝9711199012 ☪ 24/7 Call Girls Delhi
Russian Escorts Girls Nehru Place ZINATHI 🔝9711199012 ☪ 24/7 Call Girls DelhiAlinaDevecerski
 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...narwatsonia7
 
High Profile Call Girls Coimbatore Saanvi☎️ 8250192130 Independent Escort Se...
High Profile Call Girls Coimbatore Saanvi☎️  8250192130 Independent Escort Se...High Profile Call Girls Coimbatore Saanvi☎️  8250192130 Independent Escort Se...
High Profile Call Girls Coimbatore Saanvi☎️ 8250192130 Independent Escort Se...narwatsonia7
 
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...astropune
 
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore EscortsVIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escortsaditipandeya
 
Call Girls Bangalore Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Bangalore Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Bangalore Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Bangalore Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
Call Girls Ooty Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Ooty Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Ooty Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Ooty Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service KochiLow Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service KochiSuhani Kapoor
 
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...aartirawatdelhi
 
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls AvailableVip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls AvailableNehru place Escorts
 
Call Girls Jabalpur Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Jabalpur Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Jabalpur Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Jabalpur Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...Garima Khatri
 
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual NeedsBangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual NeedsGfnyt
 

Recently uploaded (20)

Call Girls Varanasi Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Varanasi Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Varanasi Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Varanasi Just Call 9907093804 Top Class Call Girl Service Available
 
Lucknow Call girls - 8800925952 - 24x7 service with hotel room
Lucknow Call girls - 8800925952 - 24x7 service with hotel roomLucknow Call girls - 8800925952 - 24x7 service with hotel room
Lucknow Call girls - 8800925952 - 24x7 service with hotel room
 
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
 
Top Rated Bangalore Call Girls Mg Road ⟟ 8250192130 ⟟ Call Me For Genuine Sex...
Top Rated Bangalore Call Girls Mg Road ⟟ 8250192130 ⟟ Call Me For Genuine Sex...Top Rated Bangalore Call Girls Mg Road ⟟ 8250192130 ⟟ Call Me For Genuine Sex...
Top Rated Bangalore Call Girls Mg Road ⟟ 8250192130 ⟟ Call Me For Genuine Sex...
 
Call Girls Service Surat Samaira ❤️🍑 8250192130 👄 Independent Escort Service ...
Call Girls Service Surat Samaira ❤️🍑 8250192130 👄 Independent Escort Service ...Call Girls Service Surat Samaira ❤️🍑 8250192130 👄 Independent Escort Service ...
Call Girls Service Surat Samaira ❤️🍑 8250192130 👄 Independent Escort Service ...
 
Russian Escorts Girls Nehru Place ZINATHI 🔝9711199012 ☪ 24/7 Call Girls Delhi
Russian Escorts Girls  Nehru Place ZINATHI 🔝9711199012 ☪ 24/7 Call Girls DelhiRussian Escorts Girls  Nehru Place ZINATHI 🔝9711199012 ☪ 24/7 Call Girls Delhi
Russian Escorts Girls Nehru Place ZINATHI 🔝9711199012 ☪ 24/7 Call Girls Delhi
 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
 
High Profile Call Girls Coimbatore Saanvi☎️ 8250192130 Independent Escort Se...
High Profile Call Girls Coimbatore Saanvi☎️  8250192130 Independent Escort Se...High Profile Call Girls Coimbatore Saanvi☎️  8250192130 Independent Escort Se...
High Profile Call Girls Coimbatore Saanvi☎️ 8250192130 Independent Escort Se...
 
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
 
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
 
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
 
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore EscortsVIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
 
Call Girls Bangalore Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Bangalore Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Bangalore Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Bangalore Just Call 9907093804 Top Class Call Girl Service Available
 
Call Girls Ooty Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Ooty Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Ooty Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Ooty Just Call 9907093804 Top Class Call Girl Service Available
 
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service KochiLow Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
 
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
 
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls AvailableVip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
 
Call Girls Jabalpur Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Jabalpur Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Jabalpur Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Jabalpur Just Call 9907093804 Top Class Call Girl Service Available
 
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
 
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual NeedsBangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
 

Sabin-Immunizatio.pptx

  • 1. VACCINES & IMMUNIZATION How to realize the full benefits of immunization
  • 2. IMMUNIZATION SAVES LIVES AND KEEPS PEOPLE HEALTHY • Immunization saves up to 3 million lives annually • Vaccines are available to protect against the following 26 infectious diseases, with many more in development Cholera • Dengue • Diphtheria • Hepatitis A • Hepatitis B • Hepatitis E • Haemophilus influenzae type b (Hib) • Human papillomavirus • Influenza • Japanese encephalitis • Malaria • Measles • Meningococcal meningitis • Mumps • Pertussis (whooping cough) • Pneumococcal disease • Poliomyelitis • Rabies • Rotavirus • Rubella • Tetanus • Tick-borne encephalitis • Tuberculosis • Typhoid • Varicella (chickenpox) • Yellow Fever
  • 3. VACCINES CAN ERADICATE DISEASES, BUT DECLINING COVERAGE PUTS PROGRESS AT RISK Immunization has reduced wild poliovirus by more than Immunization eradicated Smallpox Global vaccine coverage has stagnated at 86% Large measles outbreaks affected 1 in 4 European countries in 2017 99% 86%
  • 4. HOW VACCINES WORK The body is exposed to a weakened or dead pathogen The body’s immune cells make antibodies to attack the pathogen If the body is exposed to the pathogen again, the body will be prepared with antibodies
  • 5. VACCINES PROTECT THE COMMUNITY COMMUNITY IMMUNITY When a sufficient proportion of a population is immune to an infectious disease to make its spread from person to person unlikely. COVERAGE THRESHOLD The minimum percentage of individuals immune to a disease needed to prevent an outbreak. countries in the EU/EEA achieved the 95% coverage threshold needed to prevent measles outbreaks in 2017 Only 6
  • 6. VACCINES PROTECT THE COMMUNITY Disease spreads through the population Disease spreads through some of the population Spread of the disease is constrained WHEN SOME OF THE POPULATION IS IMMUNIZED WHEN NO ONE IS IMMUNIZED WHEN MOST OF THE POPULATION IS IMMUNIZED Not immunized but still healthy Immunized & healthy Not immunized, sick & contagious
  • 7. TYPES OF VACCINES Live attenuated: contain weakened pathogen; require 1-2 doses. Ex. MMR, rotavirus, varicella Subunit: contain killed, antigenic component of pathogen; require several doses (booster shots). Ex. Hib, HPV, pneumococcal Inactivated: contain killed pathogen; require several doses (booster shots). Ex. Hepatitis A, rabies, inactivated poliovirus vaccine Toxoid: contain toxin made by pathogen; may require booster shots. Ex. Diphtheria, pertussis
  • 8. VACCINE DOSING THROUGH THE LIFESPAN Some vaccines provide life-long immunity from a single dose New vaccines are needed frequently for pathogens that mutate often (such as influenza) Others provide greater protection after multiple doses VACCINES AREN’T JUST FOR CHILDREN – OLDER POPULATIONS NEED TARGETED PROTECTION FROM CERTAIN DISEASES
  • 9. VACCINE COMPONENTS: SAFE AND EFFECTIVE • Provide immunity • Antigens • Adjuvants • Keep vaccines safe and long lasting • Preservatives • Stabilizers • Used during the production of vaccines • Cell culture materials • Inactivating ingredients • Antibiotics
  • 10. IMMUNIZATION SCHEDULES: BASED ON SCIENTIFIC EVIDENCE • Designed to best protect public health • Formulated using robust scientific evidence
  • 11. ENSURING VACCINES ARE SAFE AND EFFECTIVE 20-100 HEALTHY VOLUNTEERS Is this vaccine safe? Does this vaccine seem to work? Are there serious side effects? How is dose related to side effects? SEVERAL HUNDRED VOLUNTEERS What are the most common short-term side effects? How are the volunteers’ immune systems responding to the vaccine? HUNDREDS OF THOUSANDS OF VOLUNTEERS How do people who get the vaccine and people who do not compare? Is the vaccine safe? Is the vaccine effective? PHAS E 1 PHAS E 2 PHAS E 3
  • 12. CONTINUOUS SAFETY MONITORING Collect & review data Monitor side effects Identify & understand risks Communicate & manage risks appropriately A VACCINE’S SAFETY CONTINUES TO BE MONITORED
  • 13. CONTRAINDICATION • A rare condition in a recipient that increases the risk for a serious adverse reaction • The only contraindication applicable to all vaccines is a history of a severe allergic reaction after a prior dose of vaccine or to a vaccine constituent PRECAUTION • A condition in the recipient that may increase the risk of a serious adverse reaction, might cause diagnostic confusion, or might compromise the ability of the vaccine to produce immunity • Vaccine may be administered if the benefit from the vaccine is judged to outweigh the risk CONTRAINDICATIONS & PRECAUTIONS Contraindications and precautions are conditions under which vaccines should not be administered. The majority of these conditions are temporary, so immunizations often can be administered later when the conditions no longer exists.
  • 14. DANGEROUS EFFECTS OF LOW VACCINE COVERAGE EVEN SMALL POCKETS OF LOW COVERAGE CAN TRIGGER DEADLY OUTBREAKS Measles: Europe sees record number of cases and 37 deaths so far this year (20 August 2018) 2,295 cases of measles reported in Italy in 2018. (25 November 2018) The number of measles cases reaches a record in Europe (23 August 2018) U.S. officials say measles cases hit 25-year record high (29 April 2019) As Measles Surges, ‘Decades of Progress’ Are in Jeopardy (29 August 2018)
  • 15. COMMON MYTHS MYTH: VACCINES CAUSE AUTISM • Myth incited by flawed and fraudulent study • Study retracted and lead author had his medical license revoked • Subsequent studies have found no connection between vaccines and their ingredients and autism FACT: NO LINK EXISTS BETWEEN VACCINES AND AUTISM
  • 16. COMMON MYTHS MYTH: IT IS BETTER TO SPACE OUT CHILDHOOD VACCINES USING AN ALTERNATIVE SCHEDULE • From birth, a baby’s immune system is well equipped to respond to vaccines • There is no evidence that spreading out the schedule improves health outcomes • Delaying vaccines increases the time children will be susceptible to diseases FACT: SPREADING OUT VACCINES LEAVES CHILDREN UNPROTECTE D
  • 17. COMMON MYTHS MYTH: VACCINES CAUSE THE DISEASES THEY ARE DESIGNED TO PREVENT • Inactivated vaccines cannot cause disease • It is nearly unheard of for live attenuated vaccines to cause disease • Mild symptoms are rare, but can indicate immune response (not infection) FACT: VACCINES UNDERGO EXTENSIVE MONITORING AND TESTING BEFORE APPROVAL
  • 18. COMMON MYTHS MYTH: MY CHILD IS AT GREATER RISK OF HARM FROM A VACCINE THAN FROM THE DISEASE ITSELF • The risks of natural infection are greater than the risks of immunization for every recommended vaccine • Severe side effects from immunization are incredibly rare • Immunization is the best protection against deadly diseases • Immunization prevents individual illness and large- scale outbreaks FACT: THE BENEFIT OF IMMUNIZATIO N FAR OUTWEIGHS THE RISK
  • 19. COMMUNICATING WITH PATIENTS TO BOLSTER VACCINE CONFIDENCE • Presume acceptance • Listen • Validate concerns • Respond to concerns with positive messages about vaccines, information debunking myths • Communicate risks of delaying immunization • Share experiences about immunization • Have follow-up conversations • Provide additional resources about vaccines
  • 20. ADDITIONAL RESOURCES U.S. National Institutes of Health, National Institute of Allergy and Infectious Disease (https://www.niaid.nih.gov/) • How do vaccines work? https://www.niaid.nih.gov/research/how- vaccines-work European Centre for Disease Prevention and Control (www.ecdc.europa.eu) • Let’s talk about hesitancy: Enhancing confidence in vaccination and uptake https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publica tions/lets-talk-about-hesitancy-vaccination-guide.pdf • Let’s talk about prevention: enhancing childhood vaccination uptake https://ecdc.europa.eu/en/publications-data/lets-talk-about-protection- enhancing-childhood-vaccination-uptake
  • 21. ADDITIONAL RESOURCES World Health Organization (https://www.who.int/) • E-learning course on Vaccine Safety Basics http://vaccine-safety-training.org/ • Contraindications to common diseases https://www.who.int/immunization/policy/contraindications.pdf • Recommendations for routine immunization https://www.who.int/immunization/policy/immunization_tables/en/ United Nations International Children’s Emergency Fund (https://www.unicef.org/) • Promoting and strengthening a life-saving investment (UNICEF) https://www.unicef.org/eca/sites/unicef.org.eca/files/2018-07/In%20focus%20- %20Immunization.pdf U.S. Centers for Disease Control and Prevention (www.cdc.gov) • Vaccines Do Not Cause Autism https://www.cdc.gov/vaccinesafety/concerns/autism.htm

Editor's Notes

  1. This presentation will cover the basics of vaccines and immunization. It is designed for health professionals. By the end of this presentation, you will be familiar with the impact of immunization, how vaccines work, vaccine safety, common myths about immunization, and best practices for communicating the importance of immunization with patients.
  2. Vaccines are one of the most effective public health interventions in history. Immunization prevents up to 3 million deaths from vaccine-preventable diseases every year (source: https://www.who.int/topics/immunization/en/). Thanks to widespread immunization efforts, rates of illness caused by vaccine-preventable diseases have declined significantly. Vaccine science is always evolving. Currently, vaccines are available to protect against 26 infectious diseases, with many more in development (source: https://www.who.int/immunization/diseases/en/).
  3. Vaccines play an important role in preventing illness and death in communities around the world. Immunization efforts led to the eradication of Smallpox, and the near-eradication of polio, with wild poliovirus cases declining by more than 99%, from 350,000 cases in 1988 to 33 cases in 2018 (source: http://polioeradication.org/polio-today/polio-now/). These are tremendous achievements that seemed impossible only a few decades ago, but there is still lots of work to be done before we reach the full potential of vaccines. Recent data show that global vaccine coverage has stagnated at 86 percent (source: https://www.who.int/news-room/fact-sheets/detail/immunization-coverage) In some areas, vaccine coverage rates have declined, leading to outbreaks. In 2017, measles outbreaks triggered by declining vaccine coverage affected 1 in 4 European countries, after a record low number of cases were reported in 2016 (source: http://www.euro.who.int/en/media-centre/sections/press-releases/2018/europe-observes-a-4-fold-increase-in-measles-cases-in-2017-compared-to-previous-year) Health professionals play an important role in making sure that people not only receive life-saving vaccines, but also understand the continued importance of immunization in today’s world.
  4. Vaccines are able to achieve these benefits by mimicking natural infection, but with lower risk of disease. When an individual is exposed to pathogens that cause infectious disease through natural infection, the body’s immune system responds by having its immune cells, like white blood cells, replicate and target these pathogens with antibodies, which are blood proteins that bind to pathogens and destroy them (source: https://www.cdc.gov/vaccines/terms/glossary.html). Once the pathogen has been destroyed, the immune cells disband and immune system activity returns to normal levels, but key cells known as memory cells remain. If the individual is exposed to the same pathogen in the future, these memory cells are able to identify the pathogen and respond incredibly quickly with the appropriate antibodies – often before an individual can even feel sick from an immune response – and prevent disease.
  5. Vaccines have the potential to protect more than just the individual. This is known as community immunity (or herd immunity). Community immunity occurs when enough people in a population are protected against an infectious disease to significantly interrupt the disease’s transmission (source: https://www.cdc.gov/vaccines/terms/glossary.html) A disease's threshold is the minimum percentage of immune individuals a community needs to prevent an outbreak. The thresholds necessary to achieve community immunity vary from disease to disease; the more contagious the pathogen, the higher the immunity threshold must be to protect a community. Community immunity is particularly important for protecting the health of the elderly, young children and individuals with compromised immune systems, who may not be able to receive vaccines. Source: countries in the EU/EEA achieved the 95% coverage threshold needed to prevent measles outbreaks in 2017 https://ecdc.europa.eu/en/publications-data/vaccination-coverage-second-dose-measles-containing-vaccine-eueea-2017
  6. Globally-recommended vaccines fall into four main categories (source: https://www.vaccines.gov/basics/types/index.html): Live attenuated vaccines – use a weakened (or attenuated) form of the pathogen that does not cause illness. These vaccines create a strong and lasting immune response; just one or two doses of most live vaccines can provide a lifetime of protection. Examples of live attenuated vaccines include the measles, mumps, rubella (MMR) vaccine, and the rotavirus and varicella vaccines. Inactivated vaccines – use a killed form of the pathogen. Inactivated vaccines typically don’t provide protection that is as strong as live attenuated vaccines, so several doses must be administered over time to elicit ongoing immunity. These additional doses are called booster shots. Examples of inactivated vaccines include the Hepatitis A, influenza and rabies vaccines. Subunit vaccines – like inactivated vaccines, subunit vaccines do not contain live pathogens, but they are distinct in that they contain only select antigenic parts of a pathogen – the parts that are necessary to elicit a protective immune response. They also require booster shots. Examples of subunit vaccines include Hib, HPV and pneumococcal vaccines. Toxoid vaccines – use a toxin (a harmful product) made by the pathogen that causes disease. This means the immune response is targeted to the toxin instead of the whole pathogen. They may require booster shots. Examples of toxoid vaccines are diphtheria and tetanus vaccines.
  7. The differing types of vaccines mean the timing and dosing of vaccines can vary (source: https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-safety/dosing-safety). Some vaccines are best able to protect the greatest number of people if they are given more than once. The chickenpox, or varicella, vaccine is one example of this: after 1 dose, 78 of 100 adults will be protected, but after a second dose, 99 of 100 adults will be protected. It’s recommended that everyone get a second dose, since it is safe to receive and extends protection to more people. Some vaccines provide a greater response and higher level of protection after a second dose. Haemophilus influenzae type b or Hib is an example of this. Some need several doses to produce the strongest immune response. DTaP vaccines are an example of this. Some vaccines protect against pathogens that mutate so often that older versions of vaccines would not offer protection. Influenza vaccines are an example of this, with new influenza vaccines recommended every year. It is important that health providers review dosing guidelines for each vaccine to ensure that patients comply with immunization recommendations throughout their entire lives, from birth through adulthood.
  8. Today’s vaccines use only the ingredients they need to be safe and effective. Each ingredient in a vaccine serves a specific purpose (source: https://www.vaccines.gov/basics/vaccine_ingredients/index.html). For example, vaccine ingredients may help provide immunity (protection) against a specific disease: Antigens are very small amounts of weak or dead pathogens that can cause diseases. They help the immune system learn how to fight off infections faster and more effectively. The influenza virus is an example of an antigen Adjuvants, which are in some vaccines, are substances that help the immune system respond more strongly to a vaccine. This increases the immunity against the disease. Aluminum is an example of an adjuvant (Aluminum is the world’s most abundant metal, found in plants, soil, water and air. The quantities of aluminum present in vaccines are low and highly regulated) Some ingredients help make sure a vaccine continues to work like it’s supposed to and that it stays free of outside pathogens. For example: Preservatives protect the vaccine from outside bacteria or fungus. Today, preservatives are usually only used in vials (containers) of vaccines that have more than 1 dose. Most vaccines are also available in single-dose vials and do not have preservatives in them Stabilizers, like sugar or gelatin, help the active ingredients in vaccines continue to work while the vaccine is made, stored and moved Sometimes, trace amounts of some ingredients that are needed to produce the vaccine remain in the final product. Examples of these non-harmful ingredients include: Cell culture (growth) material, like eggs, to help grow the vaccine antigens Inactivating (germ-killing) ingredients, like formaldehyde, to weaken or kill viruses, bacteria or toxins in the vaccine Antibiotics, like neomycin, to help keep outside germs and bacteria from growing in the vaccine
  9. With these varying vaccine types, dosing and ingredients in mind, key decision makers like national immunization managers and government officials develop schedules for vaccine administration to best protect public health. These schedules are formulated using robust scientific evidence. Routine immunization schedules vary country to country, but WHO has recommendations for routine immunization. These recommendations are based on conclusions from WHO position papers (source: https://www.who.int/immunization/policy/immunization_tables/en/). A link to WHO’s recommended immunization schedules is included at the end of this presentation.
  10. Much like how routine immunization schedules are formulated using robust scientific evidence, vaccine safety measures are thorough and rooted in rigorous scientific practices to inform vaccine testing, monitoring and surveillance. But like all medicines, vaccines can cause side effects. Testing, monitoring and surveillance occur before and after a vaccine’s introduction to minimize any potential side effects and ensure that all vaccines are both safe and effective (source: https://vaccine-safety-training.org/expectations-towards-safety-of-vaccines.html). WHO works closely with national regulatory authorities to ensure that global standards and guidelines are developed and made readily available to assess the quality, safety and immunogenicity of vaccines. The licensing process for vaccines varies from country to country, but the core components are largely the same. Before a vaccine’s introduction into an immunization program, a vaccine candidate must go through several phases of increasingly large clinical trials. If the vaccine is deemed safe and effective, and if the benefits outweigh the risks, then manufacturing facilities are prepared to ensure the vaccine safety and quality post-licensing. Once introduced, a vaccine is continuously monitored using extensive surveillance systems. National regulatory authorities continue to monitor and investigate adverse events following immunization to ensure the vaccine is safe. In addition to national surveillance, there is also global surveillance to detect, report and investigate any adverse reactions to immunization. Thanks in large part to this robust vaccine safety infrastructure before, during and after vaccine introduction, cases of vaccine-caused illness or injury are incredibly rare. We will go over common fears and misconceptions about vaccines and immunization later, but it is important to remember – and communicate with patients – that the benefits of immunization greatly outweigh the risks, thanks in large part to these measures.
  11. Much like how routine immunization schedules are formulated using robust scientific evidence, vaccine safety measures are thorough and rooted in rigorous scientific practices to inform vaccine testing, monitoring and surveillance. But like all medicines, vaccines can cause side effects. Testing, monitoring and surveillance occur before and after a vaccine’s introduction to minimize any potential side effects and ensure that all vaccines are both safe and effective (souce: https://vaccine-safety-training.org/expectations-towards-safety-of-vaccines.html). WHO works closely with national regulatory authorities to ensure that global standards and guidelines are developed and made readily available to assess the quality, safety and immunogenicity of vaccines. The licensing process for vaccines varies from country to country, but the core components are largely the same. Before a vaccine’s introduction into an immunization program, a vaccine candidate must go through several phases of increasingly large clinical trials. If the vaccine is deemed safe and effective, and if the benefits outweigh the risks, then manufacturing facilities are prepared to ensure the vaccine safety and quality post-licensing. Once introduced, a vaccine is continuously monitored using extensive surveillance systems. National regulatory authorities continue to monitor and investigate adverse events following immunization to ensure the vaccine is safe. In addition to national surveillance, there is also global surveillance to detect, report and investigate any adverse reactions to immunization. Thanks in large part to this robust vaccine safety infrastructure before, during and after vaccine introduction, cases of vaccine-caused illness or injury are incredibly rare. We will go over common fears and misconceptions about vaccines and immunization later, but it is important to remember – and communicate with patients – that the benefits of immunization greatly outweigh the risks, thanks in large part to these measures.
  12. There are some circumstances under which vaccines should not be administered, however. It is important that health providers screen patients for contraindications and precautions before giving each dose of vaccine. A contraindication to immunization is a rare condition in a recipient that increases the risk for a serious adverse reaction. If there is a contraindication, a vaccine should not be administered. Ignoring contraindications can lead to avoidable and adverse reactions that harm an individual’s health (source: https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/contraindications.htmlhttps://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/contraindications.html). The only contraindication applicable to all vaccines is a history of a severe allergic reaction after a prior dose of vaccine or to a vaccine constituent (the estimated rate of severe allergic reactions to immunization is 1 in 1,000,000 (source: https://www.cdc.gov/vaccines/vac-gen/side-effects.htm)). Health workers administering vaccines should know the signs of allergic reactions and be prepared to take immediate action. A precaution is a condition in a recipient that might increase the risk for a serious adverse reaction, might cause diagnostic confusion or might compromise the ability of the vaccine to produce immunity (source: https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/contraindications.html). A precaution is usually a reason to defer vaccine administration, although a health provider may decide the benefit of immunization outweighs the risk of an adverse reaction. Most contraindications and precautions are temporary, and the vaccine can be administered later. Health professionals should only diverge from recommended immunization schedules if a patient displays a known contraindication or precaution. Misperceptions about certain conditions or circumstances, or misidentifying contraindications or precautions, can result in missed opportunities to administer recommended vaccines, leaving individuals at greater risk of disease. A thorough list of contraindications and precautions for each vaccine is included for reference among additional resources at the end of the presentation.
  13. Promoting routine immunization schedules is an important component of ensuring that high percentages of a population are protected by vaccines, which in turn yields many benefits to communities. But it is important to remember that a high vaccine coverage rate across a large population doesn’t necessarily mean that everyone is protected. Amid broad areas of high coverage rates can be pockets of low coverage that have the potential to drive outbreaks. Measles is often the first infectious disease to capitalize on these pockets of low vaccine coverage, because it is one of the most contagious diseases. If a community’s measles vaccine coverage drops below 96 percent, measles can begin to spread. When this occurs, one case of measles can quickly turn into an outbreak. This tragic, avoidable scenario has played out numerous times in recent years around the world, including in the Romania, Moldova, Serbia, United States, France, Italy, Greece, Brazil, the Philippines, and many other countries. With a safe and effective measles vaccine available, these outbreaks – and the suffering they have caused – are completely avoidable.
  14. In some areas, low vaccine coverage is caused by weak health systems, or the lack of necessary infrastructure or implementation to ensure that vaccines meet the populations that need them most. But increasingly, low coverage is a result of common misconceptions about vaccines and immunization. One common myth is that vaccines cause autism. This myth is fueled largely by a 1998 study that raised concerns of a possible link between the MMR vaccine and autism. After publication, this study was found to be flawed and fraudulent. It was retracted, and the lead author had his medical license revoked. Many subsequent studies show no evidence of a link between the MMR vaccine and autism, or any other vaccines and autism. Additional information on this topic from the U.S. Centers for Disease Control and Prevention is included in the resources at the end of this presentation.
  15. Another common myth is that the routine immunization schedule exposes children to too many pathogens. This myth can lead parents to delay the administration of some vaccines. From the moment babies are born, they are exposed to trillions of bacteria and viruses, to which their immune systems respond and make antibodies. Not only are children’s immune systems more than capable of responding to vaccines, but delaying vaccines increases the amount of time that children are left vulnerable to diseases. There is no evidence that spreading out the schedule decreases the risk of adverse reactions, but there is evidence that the recommended immunization schedule is the most effective way to protect children from vaccine-preventable diseases. Most importantly, administering several vaccines at once, as recommended by routine immunizations schedules, is safe and effective. But following the recommended immunization schedule also comes with logistical benefits: administering several vaccines in one visit frees up time and resources for both health providers and caregivers, without sacrificing safety or health.
  16. Another common myth is that vaccines cause the disease they are designed to prevent. This can make parents hesitant to get their children vaccinated, because they might fear immunization could make their children sick. Vaccines use weakened or killed forms of pathogens that are not capable of causing illness. Inactivated vaccines cannot cause disease, and it is incredibly rare of for live attenuated vaccines to cause disease. In rare circumstances, immunization can prompt mild symptoms that are similar to the disease the vaccine is protecting against. These symptoms are not infection, but rather evidence of the body’s immune response to the vaccine.
  17. Another common myth is that vaccines are unsafe and more dangerous than the disease they are preventing. This stems from a low perceived risk of infectious disease. The benefits of immunization far outweigh the risks, for every recommended vaccine. Adverse events from immunization are incredibly rare (odds of a severe allergic reactions are 1 in 1 million) Immunization is the best protection against life-threatening diseases, which can spread and reemerge quickly if vaccine coverage is low. Benefits of immunization include preventing individual illness, large-scale outbreaks.
  18. Health professionals are among patients’ most trusted sources for medical information, and therefore play a crucial role in communicating accurate information and council about how vaccines can keep them and their loved ones healthy. When having a conversation with patients about vaccines, it is important that health professionals effectively address concerns and convey the benefits of immunization. There are several strategies for doing so (source: https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/lets-talk-about-hesitancy-vaccination-guide.pdf): First, presume that a patient will accept the vaccine. Research shows that communications from providers that presume patients will get vaccinated, rather than asking a patient how they feel about immunization, are more effective (source: https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/lets-talk-about-protection-vaccination-guide.pdf). If the patient is hesitant or resistant, listen to their concerns. Gain insights into their reasons for vaccine hesitancy (vaccine hesitancy is the delay in acceptance or refusal of immunization despite availability of immunization services (source: https://www.ncbi.nlm.nih.gov/pubmed/25896383). Patients or parents may be hesitant to get themselves or their children vaccinated for a variety of reasons. Some of the most common concerns are rooted in vaccine safety, conspiracy theories or myths, or lack of information. Once you have heard their concerns, address them by acknowledging legitimate fears, providing positive messages about vaccines and debunking myths. Like any medication, vaccines can cause side effects. Be truthful with patients about the risks, but emphasize that delaying or skipping vaccines is riskier than getting vaccinated. Lastly, it can be effective to provide your own story about how you have concluded that vaccines are safe and effective. Share any personal stories about getting vaccinated yourself, or having your own children vaccinated. This can instill a greater sense of connection and trust between patient and provider (source: http://pediatrics.aappublications.org/content/138/3/e20162146). Even if a patient does not accept a vaccine during one visit, they may in the future. Continue the conversation at a future visit. Ultimately, the benefits of vaccines can only be realized through immunization. Effectively communicating the benefits is one of the most important things health professionals can do to ensure communities are protected from disease.
  19. Thank you for taking the time to learn more about vaccines and immunization. From this presentation, we hope you feel more confident in your knowledge about the impact of immunization, how vaccines work, vaccine safety, common myths about immunization, and best practices for communicating the importance of immunization with patients. As a health professional, we hope you will apply what you learned today in your work and share this knowledge with your peers. We hope you will use this presentation as a resource, including the additional materials linked on these slides.
  20. Thank you for taking the time to learn more about vaccines and immunization. From this presentation, we hope you feel more confident in your knowledge about the impact of immunization, how vaccines work, vaccine safety, common myths about immunization, and best practices for communicating the importance of immunization with patients. As a health professional, we hope you will apply what you learned today in your work and share this knowledge with your peers. We hope you will use this presentation as a resource, including the additional materials linked on this slide.