1. implantable drug infusion pumps with remote physician control We talked to >60 physicians, patients, entrepreneurs, potential OEM partners, and many others

2. Ellis Meng Christian Gutierrez Tuan Hoang Carol Christopher (PI) (EL) (FE) (IM)

3. Our Innovation Fluid Synchrony Targeting 11M Chronic Pain Patients

4. Canvas Version 1 (10/10/11) Physician remote control Chronic pain patients Training Hospitals Unit sales Trade shows Neurosurgeon Oncologist Anesthesiologist Support Services Pain clinics Clinical data KOLs Formulary Acceptance FDA IP Advocacy Group Foundations OEMs Wireless Developers Manufacturing Costs Product Dev Costs Marketing Costs FS Team

6. What We Found: Value Propositions Fluid Synchrony Clinical Care -Easier surgery - 1 incision (vs. 3) - >25% time saving -  complications (30% now) Patient Care -Personalized relief -Dosing flexibility -Easier recovery Pharmacoeconomics -Reduce clinical visits/ Hospitalization -Outpatient/Home care Access multiple markets

7. Canvas Version 1 (10/10/11) Physician remote control Chronic pain patients Training Hospitals Unit sales Trade shows Neurosurgeon Oncologist Anesthesiologist Support Services Pain clinics Clinical data KOLs Formulary Acceptance FDA IP Advocacy Group Foundations OEMs Wireless Developers Manufacturing Costs Product Dev Costs Marketing Costs FS Team Feature, not VP Broaden Broaden

8. Implantable Pump Markets Implantable Pumps ~ 250k in use WW Spasticity 12 M pts WW 1 M pts US Liver Cancer 300K pts Experimental (PD, AD, neuromodulation) (Biologics/Biosimilars) Chronic Pain $12.6 B (11 M pts US) Only 2 major players Medtronic and J&J

9. What We Found: Opportunity to Expand Product Offering + + Pump Catheter + tools (OEM) External controller

10. Pump + Controller Support Services Bundled Kits Trail and error, multiple visits, can take months What We Found: Patient Care Flow Fluid Synchrony Hospitals (Anesthesiologists Neurosurgeons) Scheduled follow-up Patient Discharged Surgery/Rx/ reprogramming Trial period/ Home setting Partners/ OEMS

11. Pump + Controller Support Services Bundled Kits Electronic Records Actionable feedback to doctors/institutions E-prescription / closing loop - Process shortened to days - Improves outcomes What We Found: Patient Care Flow Fluid Synchrony Electronic Health Records Hospitals (Anesthesiologists Neurosurgeons) Scheduled follow-up Patient Discharged Surgery/Rx/ reprogramming Trial period/ Home setting Partners/ OEMS

12. Pay for coverage Hospital Reimbursement Product purchase Service provided CPT reimbursement Pump $13,305 Surgical Kit $2887 Refill Kit $200 What We Found: Value Chain Fluid Synchrony

13. Regulatory Pathways (Class III) US IDE EU CE US HDE US PMA US HUD EU CE  3 pathways available; balance cost & speed $2-3MM 1-2YR $3-5MM 30 patients 1-2YR $15-22MM 150 patients 2-3YR $2MM 1YR $2-3MM <20 patients 1YR $5-8MM <60 patients 1-2YR $2MM 1YR $2-3MM <20 patients 1YR $6-9MM <60 patients 1-2YR $20-30MM 4-7YR $10-14MM 3-4YR $9-13MM 3-4YR

16. implantable drug infusion pumps with remote physician control “ the right dose at the right time and place ”

17. EXTRA SLIDES

18. Canvas (10/10/11) Physician remote control Chronic pain patients Training Hospitals Unit sales Trade shows Neurosurgeon Oncologist Anesthesiologist Support Services Pain clinics Clinical data KOLs Formulary Acceptance FDA IP Advocacy Group Foundations OEMs Wireless Developers Manufacturing Costs Product Dev Costs Marketing Costs FS Team

19. Patients Training Hospitals Unit sales Trade shows Clinicians Institutions Support Services Pain clinics Clinical data KOLs Formulary Acceptance FDA IP Advocacy Group Foundations OEMs Wireless Developers Manufacturing Costs Product Dev Costs FDA/Clinical Trials Chronic Pain v2 FS Team Payors Marketing Costs Faster relief Efficient patient management Reduce length of hospital stays ? Canvas (10/12/11)

20. Patients Training Hospitals Unit sales Trade shows Clinicians Institutions Support Services Pain clinics Clinical data KOLs Formulary Acceptance FDA IP Advocacy Groups Foundations OEMs Wireless Developers Manufacturing Costs Product Dev Costs FDA/Clinical Trials Chronic Pain v3 FS Team Payors Marketing Costs Faster relief Efficient patient management and Dosing flexibility Access to high-value therapies and pharmacoeconomics Reduce length of hospital stays and pharmacoeconomics Support Proprietary knowledge Human Resources Canvas (10/18/11)

21. Patients Training Hospitals Unit sales Trade shows Clinicians Institutions Support Services Pain clinics Clinical data KOLs Formulary Acceptance FDA IP Advocacy Groups Foundations OEMs Wireless Developers Manufacturing Costs Product Dev Costs FDA/Clinical Trials Chronic Pain v4 FS Team Payors/ICA Marketing Costs Faster relief Efficient patient management and Dosing flexibility Access to high-value therapies and pharmacoeconomics pharmacoeconomics Support Proprietary knowledge Human Resources Electronic records Electronic health record providers Bundled kits CMS (Medicare) Canvas (10/25/11)

25. Pump + Controller Support Services Bundled Kits Electronic Records Sourcing for Expanded Product Offering Patients Fluid Synchrony Electronic Health Records OEMS Hospitals (Anesthesiologists Neurosurgeons) Pain Clinic (Anesthesiologists Neurosurgeons)

26. Sourcing for Expanded Product Offering Pump + Controller Support Services Bundled Kits Electronic Records Partner Partner Patients Fluid Synchrony Electronic Health Records OEMS Hospitals (Anesthesiologists Neurosurgeons) Pain Clinic (Anesthesiologists Neurosurgeons)