It is isotropic mixture of oil, surfactant, co-surfactant, drug and water.

1. Nanoemulsion: A Versatile
Mode of Drug Delivery
System
Mr. Sagar Kishor Savale
(M. Pharm Student)
Department of Pharmaceutics and Quality Assurance
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur,
425405, Dist. Dhule, MS, India
Presented By:

2. 2
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Nanoemulsion
Difference between Microemulsion and
Nanoemulsion
Components of
Nanoemulsion
Formulation Aspects and
Method of Preparation
Evaluation Parameters of
Nanoemulsion
Conclusion
Reference

3. 3
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Nanoemulsion
Surfactant
Co-Surfactant
Water
Oil
Size range 50-100 nm.
Types: oil in water (o/w), water in oil (w/o) and Bicontinuous Nanoemulsion.

4. 4
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Difference between Microemulsion and Nanoemulsion
Parameter Microemulsion Nanoemulsion
Appearance Turbid Transparent
Droplet Size 200-500 nm 50- 100 nm
Formation Require vigorous shaking Spontaneous Formation
Energy High Low
Stability Thermo
dynamically unstable
Thermo
dynamically stable
Rate of Absorption Slow Fast
Bioavailability Minimum Maximum

5. 5
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Oil Surfactant Co-surfactant
Components of Nanoemulsion

6. 6
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Mechanism of Nanoemulsion
The entropy change
Dispersion is greater
Energy required to
increase the surface area
of the dispersion
Free energy of the
conventional emulsion is
a direct function
Energy required to
create a new surface
between the oil and
water phases

7. 7
Formulation Aspects and Method of Preparation
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India

8. 8
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
High pressure
homogenization
(HPH)
Ultrasonication
Micro-
fluidization

9. 9
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Phase inversion
Spontaneous
emulsification

10. 10
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Evaluation Parameters of Nanoemulsion

11. 11
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Droplet size Zeta Potential Drug content
ViscositypHRefractive index
Conductivity Test Dilution test In vitro study
Histopathological
study
In vitro
cytotoxicity assay
In vivo
pharmacokinetic
study

12. 12
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
 Nanoemulsion was widely used in pharmaceutical system. Nanoemulsion was offers
several advantaged for the delivery of drugs, biological and diagnostic agents.
 This novel technology was overcome the problem of less aqueous soluble drug and it
is a vehicle for aqueous insoluble drugs.
 nanoemulsion was used in targeted drug delivery of various anticancer drugs,
photosensitizers or therapeutic agents.
Conclusion

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R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425-405, MS, India
Reference
Jaiswal, M., Dudhe, R. and Sharma, P.K., 2015. Nanoemulsion: an advanced mode of drug
delivery system. 3 Biotech, 5(2), pp.123-127.
Mahajan, H. S., Savale, S. K., 2016. Nanoemulsions: A versatile Mode of Drug Delivery System.
Indian Journal of Novel Drug Delivery, 8(3), pp.123-132.
Mangale, M.R., Pathak, S.S., Mene, H.R., More, B. A., 2015. Nanoemulsion: As Pharmaceutical
Overview. International Journal of Pharmaceutical Science Review Research., 33(1),
pp.244-252.
Mishra, R.M., Soni, G.C., Mishra, R., 2014. Nanoemulsion: A Novel Drug Delivery Tool.
International Journal of Pharma Research & Review, 3(7), pp.32-43.
Savale, S.K., 2015. A Review - Self Nanoemulsifying Drug Delivery System (SNEDDS).
International Journal of Research in Pharmaceutical and Nano Sciences, 4(6), pp.385-397.

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Contact
Email: savalesagar484@gmail.com
Mobile no.: +919960885333