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Question 1. What term is used to describe a hernial protrusion of a saclike cyst that contains meninges, spinal fluid, and a portion of the spinal cord through a defect in a posterior arch of a vertebra?
Question 2. What provides the best estimate of the
1. NR 507 Final Exam (100% Correct)
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Exam
Question 1. What term is used to describe a hernial protrusion of a
saclike cyst that contains meninges, spinal fluid, and a portion of the
spinal cord through a defect in a posterior arch of a vertebra?
Question 2. What provides the best estimate of the
functioning of renal tissue?
Question 3. Where are Langerhans cells found?
Question 4. Where in the lung does gas exchange occur?
Question 5. The tonic neck reflex observed in a newborn
should no longer be obtainable by:
Question 6. When renin is released, it is capable of which
action?
Question 7. The portion of the antigen that is configured
for recognition and binding is referred to as what type of determinant?
Question 8. Which sexually transmitted infection
frequently coexists with gonorrhea?
Question 9. How is the effectiveness of vitamin B12
therapy measured?
Question 10. Carcinoma refers to abnormal cell proliferation
originating from which tissue origin?
Question 11. Which type of microorganism reproduces on
the skin?
Question 12. An infant has a crescendo-decrescendo systolic
ejection murmur located between the second and third intercostal
2. spaces along the left sternal border. A wide fixed splitting of the
second heart sound is also found. These clinical findings are
consistent with which congenital heart defect?
Question 13. An infant diagnosed with a small patent ductus
arteriosus (PDA) would likely exhibit which symptom?
Question 14. What is the function of erythrocytes?
Question 15. Which terms represent the correct
nomenclature for benign and malignant tumors of adipose tissue,
respectively?
Question 16. What is the chance with each pregnancy that a
child born to two parents with the sickle trait will have sickle cell
disease (SCD)?
Question 17. What pulmonary defense mechanism propels a
mucous blanket that entraps particles moving toward the oropharynx?
Question 18. The concentration of the final urine is
determined by antidiuretic hormone (ADH), which is secreted by
which gland?
Question 19. Why is the herpes virus inaccessible to
antibodies after the initial infection?
Question 20. Which renal change is found in older adults?
Question 21. Which immunoglobulin is present in blood,
saliva, breast milk, and respiratory secretions?
Question 22. Which hormone prompts increased anxiety,
vigilance, and arousal during a stress response?
Question 23. Which statement is true regarding maternal
antibodies provided to the neonate?
Question 24. The function of the tumor cell marker is to:
Question 25. Which statement is true concerning a fungal
infection?
Question 26. Which change is a result of puberty and
defends the vagina from infection?
Question 27. The number of persons living with a specific
disease at a specific point in time is referred to by which term?
Question 28. Which risk factor for hypertension is
influenced by genetic factors and lifestyle?
Question 29. Having ejected a mature ovum, the ovarian
follicle develops into a(n):
3. Question 30. The failure of bones to ossify, resulting in soft
bones and skeletal deformity, characterizes which disorder?
Question 31. What is the term that denotes the duration of
time or the intensity of pain that a person will endure before
outwardly responding?
Question 32. Aldosterone directly increases the reabsorption
of:
Question 33. Atrial fibrillation, rheumatic heart disease, and
valvular prosthetics are risk factors for which type of stroke?
Question 34. Which clinical manifestations are associated
with fibromyalgia?
Question 35. Prolonged high environmental temperatures
that produce dehydration, decreased plasma volumes, hypotension,
decreased cardiac output, and tachycardia cause which disorder of
temperature regulation?
Question 36. What is the leading cause of infertility in
women?
Question 37. Which substance is a water-soluble protein
hormone?
Question 38. What is the target tissue for prolactin-releasing
factor?
Question 39. What is the cause of familial
hypercholesterolemia (FH)?
Question 40. Regarding type 2 diabetes, obesity is
considered to be what type of risk?
Question 41. Which four-step process correctly describes
muscle contraction?
Question 42. Adoption studies have shown that the offspring
of an alcoholic parent when raised by nonalcoholic parents have what
amount of an increased risk of developing alcoholism?
Question 43. Which hormone stimulates gonads to produce
both male and female hormones?
Question 44. A person with 47, XXY karyotype has the
genetic disorder resulting in which syndrome?
Question 45. Which would be considered a positive
symptom of schizophrenia?
4. Question 46. What term describes the loss of the
comprehension or production of language?
Question 47. Consanguinity refers to the mating of persons:
Question 48. The major sleep center is located in which
section of the brain?
Question 49. Which type of ion directly controls the
contraction of muscles?
Question 50. Bacteria gain access to the female urinary tract
by which means?
Question 51. A criterion for a diagnosis of generalized
anxiety disorder (GAD) is a period of excessive worrying that lasts
for at least how many months?
Question 52. What is the first indication of nephrotic
syndrome in children?
Question 53. An amniocentesis indicates a neural tube defect
when an increase in which protein is evident?
Question 54. What is the risk for the recurrence of
autosomal dominant diseases?
Question 55. Which term is used to identify the temporary
displacement of two bones causing the bone surfaces to partially lose
contact?
Question 56. The tear in a ligament is referred to as a:
Question 57. Why is prolonged diarrhea more severe in
children than it is in adults?
Question 58. The BRCA1 and BRCA2 mutations increase
the risk of which cancer in women?
Question 59. Insulin transports which electrolyte in the cell?
Question 60. What term is used to identify an interlacing
bundle of dense, white fibrous tissue that is richly supplied with
nerves, blood vessels, and lymphatic vessels?
Question 61. Which of the following is a lipid-soluble
hormone?
Question 62. The mucosal secretions of the cervix secrete
which immunoglobulin?
Question 63. The sudden apparent arousal in which a child
expresses intense fear or another strong emotion while still in a sleep
state characterizes which sleep disorder?
5. Question 64. What is the basic structural unit in compact
bone?
Question 65. Parkinson disease is a degenerative disorder of
the brain’s:
Question 66. Which pain theory proposes that a balance of
impulses conducted from the spinal cord to the higher centers in the
central nervous system (CNS) modulates the transmission of pain?
Question 67. Saliva contains which immunoglobulin (Ig)?
Question 68. What type of fracture occurs at a site of a
preexisting bone abnormality and is a result of a force that would not
normally cause a fracture?
Question 69. An infant suddenly develops abdominal pain,
becomes irritable (colicky), and draws up the knees. Vomiting occurs
soon afterward. The mother reports that the infant passed a normal
stool, followed by one that looked like currant jelly. Based on these
data, which disorder does the nurse suspect?
Question 70. In 95% of children of delayed puberty, the
problem is caused by:
Question 71. Which characteristic is true of type II (white
fast-motor) muscle fibers?
Question 72. Neurofibrillary tangles characterize which
neurologic disorder?
Question 73. Which hormone triggers uterine contractions?
Question 74. How does the release (increase) of epinephrine
raise body temperature?
Question 75. Which hormone is linked to an increase in
appetite during puberty?
*******************************************************
NR 507 Week 1 Discussions Altered Immune
System and Altered Inflammatory Response
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Week 1: Altered Immune System and Altered Inflammatory Response
Part One
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
Discussion Part One (graded)
7. John is a 19-year-old college football player who presents with
sneezing, itchy eyes, and nasal congestion that worsens at night. He
states that he has a history of asthma, eczema and allergies to pollen.
There is also one other person on the football team that has similar
symptoms. His vitals are BP 110/70, P 84, R 18, T 100 F. Write a
differential of at least five (5) possible items from the most likely to
less likely. For each disease include information about the
epidemiology, pathophysiology and briefly argue why this disease fits
the presentation and why it might not fit the presentation Week 1:
Altered Immune System and Altered Inflammatory Response
Discussion Part Two
A patient has been admitted into the emergency room that was in the
passenger side of a car that collided with another car head on. The
patient is pale, barely conscious and has a weak and thread pulse. An
IV is started. The vitals are BP 80/50, P 140, T 96.0 and R 26. As the
team fights to keep the patient alive they have to remove the spleen.
Blood is given but it has been mistyped. A transfusion reaction
occurs. Describe the type of hypersensitivity reaction that has
occurred and discuss the molecular pathophysiology of the specific
type of hypersensitive reaction you have chosen.
In the event that this patient survived the car accident and the
transfusion reaction which organs are most likely to be damaged and
why?
Discussion Part Three
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
8. 2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1,
4 Distinguish risk factors associated with selected disease states.(PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
Discussion
A 44-year-old patient presents with lump in the chest of
approximately 2 cm in diameter. There is a slight dimple over the
location of the lump and when the lump is manipulated it seems to be
attached to the surrounding tissue. A lumpectomy is performed and
the mass is sent to pathology. The pathology report comes back and
the mass is confirmed to be an estrogen receptor negative, a
progesterone receptor negative and a her2/neu receptor positive breast
cancer.
What are some of the risk factors for breast cancer? What tumor
suppressor genes are associated with breast cancer?
What tumor oncogenes are associated with breast cancer?
Compare and contrast tumor suppressor genes from oncogenes?
9. *******************************************************
NR 507 Week 2 Discussions Respiratory
Disorders and Alterations in Acid/Base
Balance,Fluid and Electrolytes
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Week 2: Respiratory Disorders and Alterations in Acid/Base
Balance,
Fluid and Electrolytes – Discussion Part One
This week’s graded topics relate to the following Course
Outcomes (COs).
Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
Examine the way in which homeostatic, adaptive, and
compensatory physiological mechanisms can be supported and/or
altered through specific therapeutic interventions. (PO 1, 7)
10. Distinguish risk factors associated with selected disease states.
(PO1)
Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
Distinguish risk factors associated with selected disease states.
(PO1)
Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
Discussion Part One (graded)
A five-month-old Caucasian female is brought into the clinic as
the parent complain that she has been having ongoing foul-
smelling , greasy diarrhea. She seems to be small for her age and
a bit sickly but, her parent’s state that she has a huge appetite.
Upon examination you find that the patient is wheezing and you
observe her coughing.
Write a differential diagnosis of at least five (5) disorders and
explain why each might be a possibility and any potential
weaknesses of each differential.
Why is it that the later in age this disease manifest itself, the less
severe the disease is?
What tests would you run to clarify your differential and
potentially come to a definitive diagnosis? If the same child was
African in ancestry would this change your initial differential?
Why or why not?
Week 2: Respiratory Disorders and Alterations in Acid/Base
Balance, Fluid and Electrolytes
Discussion Part Two
11. This week’s graded topics relate to the following Course
Outcomes (COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and
compensatory physiological mechanisms can be supported and/or
altered through specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states.
(PO 1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states.
(PO 1)
7 Explore age-specific and developmental alterations in
physiologic and disease states. (PO 1, 4)
Tammy is a 33-year-old who presents for evaluation of a cough.
She reports that about 3 weeks ago she developed a “really bad
cold” with rhinorrhea. The cold seemed to go away but then she
developed a profound, deep, mucus-producing cough. Now, there
is no rhinorrhea or rhinitis—the primary problem is the cough.
She develops these coughing fits that are prolonged, very deep,
and productive of a lot of green sputum. She hasn’t had any fever
but does have a scratchy throat. Tammy has tried over-the-
counter cough medicines but has not had much relief. The cough
12. keeps her awake at night and sometimes gets so bad that she gags
and dry heaves.
Write a differential of at least five (5) possible diagnosis’s and
explain how each may be a possible answer to the clinical
presentation above.
Remember, to list the differential in the order of most likely to
less likely.
Based upon what you have at the top of the differential how
would you treat this patient?
Suppose now, the patient has a fever of 100.4 and complains of
foul smelling mucous and breath. Indeed, she complains of
producing cups of mucous some days. She has some trouble
breathing on moderate exertion but this is only a minor complaint
to her. How does this change your differential and why?
Discussion Part Three
This week’s graded topics relate to the following Course
Outcomes (COs).
Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
Examine the way in which homeostatic, adaptive, and
compensatory physiological mechanisms can be supported and/or
altered through specific therapeutic interventions. (PO 1, 7)
Distinguish risk factors associated with selected disease states.
13. Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
Distinguish risk factors associated with selected disease states.
(PO
Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
A nursing student comes into your office because they are
struggling with the concept of pulmonary function. They know
you as an experienced FNP and so they are comfortable asking if
you could clarify the terms residual volume (RV), functional
reserve capacity (FRC), total lung capacity (TLC) inspiratory
reserve volume (IRV), and expiratory reserve volume (ERV).
Give her a definition of each?
List three (3) disorders that can alter the residual volume and
explain how they do so?
*******************************************************
NR 507 Week 3 Discussions Cardiovascular,
Cellular, and Hematologic Disorders
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Week 3: Cardiovascular, Cellular, and Hematologic Disorders
14. Discussion Part One
This week’s graded topics relate to the following Course
Outcomes (COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and
compensatory physiological mechanisms can be supported and/or
altered through specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states.
(PO 1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states.
(PO 1)
7 Explore age-specific and developmental alterations in
physiologic and disease states
A 17-year-old African American from the inner city complains of
severe chest and abdominal pain. Upon examination the attending
physician performs and EKG, chest x-ray, and an abdominal and
chest clinical examination and finds nothing. Assuming, she is
drug seeking he sends her home. She comes back to the ER 4
hours later and now you see the patient. She explains that she was
running track this past afternoon at school and that despite being
very hot (100 F) she pushed on. Afterwards, she starts feeling
extensive pain in her chest and abdomen. She has jaundiced eyes,
15. her blood pressure is 98/50, pulse is 112, T = 99.9 F, R = 28. The
pain seems out of proportion to the physical findings.
What is your list of differential diagnoses in this case and explain
how each of these fits with the case patient as described above. Be
sure to list at least four (4) pertinent differential diagnoses.
Indicate which of these you would select as the most likely
diagnosis and explain why.
Now, as she is in the ER she begins to exhibit stroke like features.
? Does this change your differential? How do you treat this
patient now? Are they any preventative actions that could have
been taken?
Discussion Part Two
This week’s graded topics relate to the following Course
Outcomes (COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and
compensatory physiological mechanisms can be supported and/or
altered through specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states.
(PO 1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
16. 6 Distinguish risk factors associated with selected disease states.
(PO 1)
7 Explore age-specific and developmental alterations in
physiologic and disease states. (PO 1, 4)
Jesse is a 57-year-old male who presents with gradual onset of
dyspnea on exertion and fatigue. He also complains of frequent
dyspepsia with nausea and occasional epigastric pain. He states
that at night he has trouble breathing especially while lying on his
back. This is relieved by him sitting up. His vitals are 180/110, P =
88, T = 98.0 C, R = 20.
Write a differential in this case and explain how each item in your
differential fits and how it might not fit.
What tests would you order? What immediate treatment would
you consider giving this patient and what treatment when he went
home? Assume your first differential is definitive.
Now, he comes back to your clinic 3 months later and both his
ankles are slightly swollen. What possible explanations are there
for this observation?
Discussion Part Three
This week’s graded topics relate to the following Course
Outcomes (COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
17. 3 Examine the way in which homeostatic, adaptive, and
compensatory physiological mechanisms can be supported and/or
altered through specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states.
(PO 1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states.
(PO 1)
7 Explore age-specific and developmental alterations in
physiologic and disease states. (PO 1, 4)
A new patient is brought into the office for their annual
evaluation. The child is a 6-year-old and appears a bit small for
their age but not so small that any alarm bells are set off. The
vitals are: P = 116, R = 22, T = 98.6 , BP = 110/50. (The normal
vitals in a 6-year-old are P = 75 – 120, R = 16 – 22, T = 98.6 , BP =
(85-115)/(48-64).
Examination of the lungs is normal, HEENT is normal, as is the
abdominal exam. The heart however, seems laterally displaced
and there appears to be only a continuous murmur which can be
described as crescendo/decrescendo systolic murmur that extends
into diastole. Because, you were trained at Chamberlain College
of Nursing you immediately know that this is probably a patent
ductus arteriosus.
Explain the murmur from a mechanistic view of the hearts
physiological functioning?
What is the epidemiology of a patent ductus arteriosus?
How is a patent ductus arteriosus treated?
18. *******************************************************
NR 507 Week 3 Quiz
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Quiz
Question 1.1. A 72-year-old woman with a recent onset of syncopal
episodes has been referred to a cardiology group by her family
physician. As part of the patient’s diagnostic workup, the nurse
practitioner conducting the intake assessment has ordered a Holter
monitor for 24 hours. Which of the following statements best captures
an aspect of Holter monitoring? (Points : 0.4)
A Holter monitor is preferable to standard ECG due to its increased
sensitivity to cardiac electrical activity.
The primary goal is to allow the cardiologist to accurately diagnose
cardiomyopathies.
Accurate interpretation of the results requires correlating the findings
with the activity that the woman was doing at the time of recording.
Holter monitors are normally set to record electrical activity of the
heart at least once per hour.
Question 2.2. As part of the diagnostic workup for a male patient with
a complex history of cardiovascular disease, the care team has
identified the need for a record of the electrical activity of his heart,
insight into the metabolism of his myocardium, and physical
measurements, and imaging of his heart. Which of the following
19. series of tests is most likely to provide the needed data for his
diagnosis and care? (Points : 0.4)
Echocardiogram, PET scan, ECG
Ambulatory ECG, cardiac MRI, echocardiogram
Serum creatinine levels, chest auscultation, myocardial perfusion
scintigraphy
Cardiac catheterization, cardiac CT, exercise stress testing
Question 3.3. An 81-year-old female patient of a long-term care
facility has a history of congestive heart failure. The nurse practitioner
caring for the patient has positioned her sitting up at an angle in bed
and is observing her jugular venous distention. Why is jugular venous
distention a useful indicator for the assessment of the patient’s
condition? (Points : 0.4)
Increased cardiac demand causes engorgement of systemic blood
vessels, of which the jugular vein is one of the largest.
Blood backs up into the jugular vein because there are no valves at the
point of entry into the heart.
Peripheral dilation is associated with decreased stroke volume and
ejection fraction.
Heart valves are not capable of preventing backflow in cases of atrial
congestion.
Question 4.4. A physical assessment of a 28-year-old female patient
indicates that her blood pressure in her legs is lower than that in her
arms and that her brachial pulse is weaker in her left arm than in her
right. In addition, her femoral pulses are weak bilaterally. Which of
the following possibilities would her care provider be most likely to
suspect? (Points : 0.4)
*******************************************************
NR 507 Week 4 Discussions Alterations in
Renal Function
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Week 4: Alterations in Renal Function
Discussion Part One
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1)
21. Mrs. Orndorf is a 28-year-old woman married for 3 years who has just
returned from an outdoor camping trip with her husband, with
symptoms of dysuria with a burning sensation, urgency to urinate, and
frequent urination. She said, “I have had similar symptoms three
times over the last 2 years. Pubic and low back discomfort awoke me
two nights ago and that is why I am here.” On physical examination,
her temperature was 98.6° F, blood pressure was 114/64 mm Hg,
pulse was 68 beats per minute, and the respiratory rate was 12 breaths
per minute. Other than a tender abdominal pelvic area, the
examination was unremarkable.
• What is your list of differential diagnoses in this case and explain
how each of these fits with the case patient as described above. Be
sure to list at least four (4) pertinent differential diagnoses. Indicate
which of these you would select as the most likely diagnosis and
explain why.
• According to the first item in your differential, what are the risk
factors for this disorder?
• What are some treatments for this disorder?
Discussion Part Two
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
22. 4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
A 56-year-old female comes into the clinic complaining of
intermittent severe pain that radiates from the flank to the groin and
sometimes to the inner thigh. Upon further questioning she tell you
that she has an urge to always go to the restroom and that she
sometime sweats and feels nauseous. A urinalysis provides traces of
blood, a few white blood cells and no bacteria.
• What is your differential diagnosis? Discuss in detail the
pathophysiology of each item in your differential and how it might fit
in describing this case.
• The x-ray comes back and there is nothing abnormal except a
slightly dilated ureter. Does this change your differential or narrow it?
• How would you treat the pain in this case?
Discussion Part Three
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
23. 2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
A 60-year-old patient comes into your office with a history of
hypertension and a myocardial infarction 13 years ago. You notice
that both of her ankles are swollen and that her skin seems shiny. She
first noticed her ankle swelling 9 months ago and it has gotten
progressively worse. She has a smell of ammonia on her. She also has
a 2 year history of diabetes.
• What are at least five systemic effects of chronic kidney disease?
• How would you modify the diet and what is the rationale to the
changes of the diet that you make?
*******************************************************
NR 507 Week 5 Discussions Alterations in
Endocrine Function
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Week 5: Alterations in Endocrine Function
Discussion Part One
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
25. 7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
Ms. Blake is an older adult with diabetes and has been too ill to get
out of bed for 2 days. She has had a severe cough and has been unable
to eat or drink during this time. She has a history of Type I diabetes.
On admission her laboratory values show:
Sodium (Na+) 156 mEq/L
Potassium (K+) 4.0 mEq/L
Chloride (Cl–) 115 mEq/L
Arterial blood gases (ABGs) pH- 7.30; Pco2-40; Po2-70; HCO3-20
Normal values Sodium (Na+) 136-146 mEq/L
Potassium (K+) 3.5-5.1 mEq/L
Chloride (Cl–) 98-106 mEq/L
Arterial blood gases (ABGs) pH- 7.35-7.45
Pco2- 35-45 mmHg
Po2-80-100 mmHg
HCO3–22-28 mEq/L
• List five (5) reasons on why she may have become bed ridden?
• Based on these reasons what tests would you order?
• Describe the molecular mechanism of the development of
ketoacidosis.
26. Discussion Part Two
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states
A three-month-old baby boy comes into your clinic with the main
complaint that he frequently vomits after eating. He often has a
swollen upper belly after feeding and acts fussy all the time. The
vomiting has become more frequent this past week and he is
beginning to lose weight.
• What is your differential diagnosis at this time?
• Is there any genetic component to the top of your differential?
27. • What tests would you order?
Discussion Part Three
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
Write a one (1) paragraph case study of your own for a patient with
Ulcerative Colitis?
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28. NR 507 Week 6 Discussions Dermatologic and
Musculoskeletal Disorders
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Week 6: Dermatologic and Musculoskeletal Disorders
Discussion Part One
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
29. 6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states
You are contacted by an attorney representing a client who has been
charged with child abuse and whom faces loss of her child and 15
years in prison. The record indicated that the child was 4 years old
and presented to the ER room with a broken arm and a broken leg
There also appeared to be multiple previous fractures. Now, you
examine the child and find blue sclera, a sunken chest wall, severe
scoliosis, and you observe a triangular face and prominent forehead.
You confirm that there have been multiple previous fractures by
evaluating the previous X-rays. This is a genetic disorder.
• What is the most likely genetic disease that this presents and why?
• What is the molecular basis of this disease?
• Before, calling the police what should the initial clinician have
done?
Discussion Part Two
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
30. 3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1)
Johnny is a 5-year-old Asian boy who is brought to a family practice
office with a “runny” nose that started about 1 week ago but has not
resolved. He has been blowing his nose quite frequently and “sores”
have developed around his nose. His mother states, “The sores started
as ‘big blisters’ that rupture; sometimes, a scab forms with a crust that
looks like “dried maple syrup” but continues to seep and drain.” She
is worried because the lesions are now also on his forearm. Johnny’s
past medical and family histories are normal. He has been febrile but
is otherwise asymptomatic. The physical examination was
unremarkable except for moderate, purulent rhinorrhea and 0.5- to 1-
cm diameter weeping lesions around the nose and mouth and on the
radial surface of the right forearm. There is no regional
lymphadenopathy.
• Write a differential of at least five (5) possible diagnosis’s and
explain how each may be a possible answer to the clinical
presentation above. Remember, to list the differential in the order of
most likely to less likely.
31. • Based upon what you have at the top of the differential how would
you treat this patient? Differential diagnosis for this clinical
presentation and justify it.
• When would you allow the student back to school? Elaborate on
your reasoning?
Discussion Part Three
Keisha, a 13-year-old female, has come into your urgent care center.
She has red conjunctiva, a cough and a fever of about 104 0C, She
also has a rash on her face a possibly the beginning of a rash on her
arms. About 10 days ago she was around another student who had
similar symptoms.
• What is the differential diagnosis?
• What are some of the complications of this disease, assume that the
top of your differential is the definitive?
• Assume that the second item you place on your differential is the
definitive diagnosis. What are some complications of that disease?
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NR 507 Week 7 Discussions Behavioral,
Neurologic, and Digestive Disorders
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32. Week 7: Behavioral, Neurologic, and Digestive Disorders
Discussion Part One
This week’s graded topics relate to the following Course Outcomes
(COs).
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
You are at the local mall and you see a patient who appears to be
homeless by his physical appearance and you witness the person
“walk 50 feet to a table sit down, and after 5 seconds he gets up and
walks to a tree and urinates on it” He repeats this action 5 times
apparently oblivious to his surroundings. When the police come he
ignores them as if they aren’t there. Later, you go to work and sitting
33. in exam room 3 is the same person! Now, he is your patient, when
you talk to him he has no recollection of his behavior by the mall.
• What is your differential diagnosis?
• What tests do you order?
• An MRI comes back and there seems to be a lesion in the temporal
lobe does this change your differential? The EEG also comes back
with unusual excitatory activity. What is your definitive diagnosis? In
retrospect did anything bias your first differential?
Discussion Part Two
Your patient is a 77-year-old woman who has been more socially
withdrawn lately and told her daughter she had not been feeling well.
Her daughter has noticed a stepwise decline. While shopping for
groceries with her daughter she became separated from daughter in
the aisles. She became confused and angry when store employees and
others tried to assist her. Her current medications are
Hydrochlorothiazide, Lisinopril and Atorvastatin.
• What is your differential diagnosis based on the information you
now have?
• What other questions would you like to ask her now? (Questions can
be asked of patient first, and then of reliable historian separately.)
• How would you treat this patient and discuss why you give each
medication or therapy you give.
Discussion Part Three
1 Analyze pathophysiologic mechanisms associated with selected
disease states. (PO 1)
34. 2 Differentiate the epidemiology, etiology, developmental
considerations, pathogenesis, and clinical and laboratory
manifestations of specific disease processes. (PO 1)
3 Examine the way in which homeostatic, adaptive, and compensatory
physiological mechanisms can be supported and/or altered through
specific therapeutic interventions. (PO 1, 7)
4 Distinguish risk factors associated with selected disease states. (PO
1)
5 Describe outcomes of disruptive or alterations in specific
physiologic processes. (PO 1)
6 Distinguish risk factors associated with selected disease states. (PO
1)
7 Explore age-specific and developmental alterations in physiologic
and disease states. (PO 1, 4)
A 19-year-old freshman in college has been brought to your office by
campus security. The patient had been standing on top of the school
chapel proclaiming that he was the prophet of God and that God was
speaking to him. In fact he claimed to actually hear God’s voice.
When he is in your office you notice that he is speaking very fast,
can’t seem to sit still and his sentences at times don’t seem to make
sense. He states, “I saw the professor sit on the ham sandwich and eat
the raw calculus in his mind”
• What is your differential diagnosis, how does it fit how might it not
fit?
• Based on the top of your differential what is the epidemiology of
that disorder?
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35. NR 507 Week 8 Discussions Genomes, Genetic
Alterations, and Reproductive Disorders
Reflection
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Week 8: Genomes, Genetic Alterations, and Reproductive Disorders
Reflection
Reflect on personal and professional growth toward achieving
competence as a family nurse practitioner. (PO 5, 10)
Reflect back over the past eight weeks and describe how the
achievement of the course outcomes in this course have prepared you
to meet the MSN program outcome #, MSN Essential VIII, and Nurse
Practitioner Core Competencies # 1 Scientific Foundation
Competencies
Program Outcome #4: Evaluate the design, implementation, and
outcomes of strategies developed to meet healthcare needs (MSN
Essentials III, IV, VIII). MSN Essential VIII: Clinical Prevention and
Population Health for Improving Health
•Recognizes that the master’s-prepared nurse applies and integrates
broad, organizational, client-centered, and culturally appropriate
concepts in the planning, delivery, management, and evaluation of
evidence-based clinical prevention and population care and services
to individuals, families, and aggregates/identified populations.
36. Nurse Practitioner Core Competencies # 1 Scientific Foundation
Competencies
1. Critically analyzes data and evidence for improving advanced
nursing practice.
2. Integrates knowledge from the humanities and sciences within the
context of nursing science.
3. Translates research and other forms of knowledge to improve
practice processes and outcomes.
4. Develops new practice approaches based on the integration of
research, theory, and practice knowledge.
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