3. RECEPTOR: It is a specific binding site on the cell which exhibits
some functional groups which trigger the
pharmacological action
4. AFFINITY: Ability of agent to combine with receptor
INTRINSIC ACTIVITY: Ability of agent to activate the receptor
(efficacy)
AGONIST: maximum affinity and efficacy
ANTAGONIST: having affinity but no efficacy
INVERSE AGONIST: having affinity and negative efficacy
19. Examples of nuclear receptors:
Glucocorticoid receptors
Minero corticoid receptors
Oestrogen receptors
Progestero receptors
Androgen receptors
Vit A and vit B receptors
Thyroid hormone receptors
20. Other receptors:
Spare receptors: Maximum response is observed even though when all the
receptors of tissues are not occupied by drug moiety
Orphan receptors: Receptors with no endogenous ligand
Eg: PPAR-α receptors (peroxysomal proliferated activated receptors)
Silent receptors: Biologically silent even though stimulations of receptors
taking place no biological response
Normal receptors: Response observed when all the receptors of the
tissue occupied by drug moiety
21. REFERENCE:
Pharmacology by RANG and DALE
Integrated pharmacology by WALKER
pharmacology by LIPPINCOTT
pharmacology by BERTRUM
www.wikkipedia.org
www.winona.edu
www.pharmacologycorner.com
www.psychopharmacologyinstitute.com