plegable biología molecular

1. “DNA 'replication fork' reconstituted for the first time”
and “Sweet genes: New way found by which metabolism
is linked to the regulation of DNA”
Yineth Paola Rangel Rincón
medicine student
III Semester
Molecular Biology

4. INTRODUCTION
The investigation in this
fields help us in medicine,
to found solutions for
troubles in the health area.
All findings make part of a
tools datebase for the
humanity progress.

5. DNA ‘replication fork’ reconstituted for the first time
(July 9, 2014)
The DNA replication is
very important to keep
information on the
generation, so findings
in this part of the
central molecular
biology dogma is an
advance in the
genetic information

6. DNA ‘replication fork’ reconstituted for the first time
They explain that
the fork is the
important place
where the new two
daughter strands
are synthesized

7. DNA ‘replication fork’ reconstituted for the first time
To understand the mistery
about DNA replication,
researchers at Rockefeller
University built the first
model system of the
replication fork.
The experiment was from
yeast cells, an eukaryot cell
like the human cells.

8. DNA ‘replication fork’ reconstituted for the first time
For this model
they used the
sames enzymes
from yeast
cells.
Finally they can
reconstitute the
central components
that propel the
eukaryotic
replication fork.
So for the first time
they could study
the process and
its regulation by
the cell in fine
detail.

9. DNA ‘replication fork’ reconstituted for the first time
Student observation
I think these Works are very important
to give us the posibilities to make
more confortable the lifes in the
deseases patients, providing another
chance to live or improve a difficult
situation in the present or the future.

10. “Sweet genes: New way
found by which metabolism
is linked to the regulation of
DNA”
The most important part in the
cells is DNA, this control all
sintesized proteins. The discovered
helped to linked the metabolism
and it’s regulation with the DNA,
conducting to understand of
many commons diseases.

11. “Sweet genes: New way found by which metabolism
is linked to the regulation of DNA”
They found an mitocondrial
enzyme in the core. This finding
was accidentally, because they
were studing the mitocondria
and they had the core isolated at
the same time.

12. “Sweet genes: New way found by which metabolism
is linked to the regulation of DNA”
The histones need a
molecule called
acetyl-CoA, they
thought this was found
in the mitochondria,
but the research
change it all.

13. “Sweet genes: New way found by which metabolism
is linked to the regulation of DNA”
Finally , they found PDC
in the core when it`s
supossed to be
located in the
mitochondria

14. “Sweet genes: New way found by which metabolism
is linked to the regulation of DNA”
It’s amazing that unexpected things are
discovered, as the enzyme which was
found in the nucleus. This discover open
doors to found the solutions of many
commons diseases.

15. Medical utility
This science works help to
find ways to improve the
lifes of many people using
the genetic information
to prevent the hereditary
deseases

16. Medical utility
Findiing that a structure in the core is related
with a structure involved in a common
deseases suggest that can exist an therapy
that help in complicate diseases

17. Medical utility
Manangement of the
complex structure can
be the oportunity to do
better diagnosis in
certain diseseases

18. Medical utility
The creation of a model about
the DNA replication is
important to regulate the
diseases involved in processes
related with a incontrolated
cells grow.

19. references
• Martínez Sánchez, Lina María; Vargas
Grisales, Natalia; Toro Montoya, Andrés
Eduardo; Pamplona Sierra, Ana Paulina;
Quevedo Orrego, Esteban.2012.Biología
molecular. Séptima edición. Medellín,
Colombia. Editorial Universidad Pontificia
Bolivariana. Pp: 31-38;74-84
• Rockefeller University. “DNA ‘replication fork’
reconstituted for the first time”.Scince Daily.
www.sciencedaily.com/releases/2014/07/14070
9100106.htm ( accessed July 19,2014)
• University of Alberta, Faculty of medicine and
dentistry. “Sweet genes: New way found by
which metabolism is linked to the regulation of
DNA”. Scince Daily.
www.scincedaily.com/releases/2014/07/140703
151821.htm ( accessed July 22,2014)