Prepared by: Shahid Nawaz
King Saud University
To provide high quality clinical laboratory services for
the researchers and scientists of KSU Hospital and
beyond; and to undertake research that is clinically
focused, ethically appropriate and fiscally responsible.
Table of Content
3. o expertise
6. Consultant and Technical Staff
7. Section and Function of Laboratory
8. FINANCIAL ASPECTS
9. Future Training Programmed
10. Clinical Research Laboratory Flow chart
11. Request Form
Clinical Research laboratory testing is an essential part of quality
health care. It provides Researcher with objective data needed
to achieve their goal. Our fully equipped clinical laboratory
allows researcher to prepare, evaluate and store samples from
various studies. The Clinical Research laboratory Users are
mainly medical doctors, research fellows, research associates,
scientific officers, research assistants, post graduate students
(Ph.D. and M.Phil.) and post doctoral research workers. This
multi-disciplinary research unit is such a set up to encourage
exchange of ideas and experiences from different clinical
experts. Moreover, this arrangement enables sharing of
expensive equipment; research facilities and supportive
Our laboratory is under the management of a Ph.D. Qualified
researchers. This clinical laboratory provides specialized
assays for research purposes that generally are not available
from routine clinical laboratories.
Current research testing provided by the “clinical labs” is
i. Research testing can interfere with clinical
ii. Clinical labs do not offer customized services or
most "esoteric" research tests.
iii. No capability to perform special handling/storage or
iv. Clinical lab charges are too high for many research
v. Consultation with laboratory faculty not routinely
available for research.
vi. Some physicians have mistakenly sent research testing to
the clinical labs without clearly designating that they
are research specimens, which can create considerable
compliance problems with respect to billing of research
services to clinical sources.
vii. Services/tests provided only for research purposes
(i.e. for the purpose of qualifying a study subject or
research only end point) will not be billed to any Patient.
Viii. Services/tests paid for by the study sponsor cannot be
billed to any insurer or to the participant.
ix. Research Laboratory is billed only for clinical trial
Costs permitted under the University Management.
OUR EXPERTISE O:
The scientists and technologists of the Clinical Laboratory for
Research have many years experience in the area of blood
collection, specimen caring, instruments handling data
processing, record keeping.
The OBJECTIVES of the Research Laboratory is to serve
the Researcher/scientists from inside, or outside of the
Organization to the best standards attainable (i.e. Quality
• Provision of Consultation and Support to the
Researcher in order to achieve their goal.
• Provision of Genetic and General Health counseling and
Contact with different institute Researchers inside and outside the
CONSULTANTS / SPECIALISTS /
TECHNICAL AND SUPPORT STAFF
The Laboratory Department consists of consultant
or senior specialist.
1. Dr.Assim alfadda
2. DR. Waheed
3. Dr. Amr Mustafa
Mobile No :
4. Shahid Nawaz
Mobile No :
Medical Laboratory Specialist and Medical Technologist with
B.Sc and M.Sc in general or specialized laboratory discipline.
Equipment & Reagent's Officer
FUNCTIONS OF THE LABORATORY
The Laboratory Department provides state-of-the-art laboratory
testing in support of Researchers/Scientists in side and out side
the Research center.
1- Clinical Chemistry SECTION
LIST OF Tests:
- Acid Phosphatase - Lipase
- Albumin - Lithium
- Alkaline Phosphatase - Magnesium
- Amylase - Phosphorus
- ALT / SGPT - Potassium
- AST / SGOT - Sodium
- Bicarbonate - TIBC
- Calcium - Total Bilirubin
- Cholesterol - Total Protein
- Cholinesterase - Triglyceride
- CK / CPK - Urea
- CK-MB - Uric Acid
- Creatinine - Direct Bilirubin
- Glucose - HDL-C
- Lactate / Lactic Acid
- LDH (Lactate Dehydrogenase)
- LDL-C (Low Density Lipoprotein-Cholesterol)
- GGT (Gamma-Glutamyl / Transterase)
Interpretation of Blood Tests:
A few test interpretations is below
Increased in late pregnancy, the neophrotic syndrome, hypothyroidism,
and most hyperlipoproteinaemias especially in familiar
hypercholesteolaemia , diabetes mellitus, primary biliary cirrhosis and
Decreased in hyperthyroidism, severe infection, severe anemia, protein-
calorie malnutrition, long-standing steatorrhea, subacute hepatic necrosis,
terminal portal cirrhosis, hypo-β-lipoproteinaemia and abeta-lipoproteinaemia.
• Hyperglycemia occurs in strenuous exercise, emotion, shock, infections,
presence of circulating insulin antibodies, phaechromocytoma,
postgastrectomy dumping syndrome, liver disease, and acute pancreatitis,
some cases of pancreatic cancer, diabetes mellitus, acromegaly,
Cushing's syndrome, thyrotoxicosis and severe burns.
• Blood glucose below 2.2 mmol/L may occur in underweight infants,
premature infants of diabetic mothers, healthy infants, prolonged
exercise, normal pregnancy, protein-calorie malnutrition, leucine
sensitivity, galactosaemia, hereditary fructose intolerance, glycogen
storage diseases, insulin over dosage, β-islet cell tumor, dumping
syndrome, liver disease, hypopituitarism, adrenocortical insufficiency,
ackee nut poisoning, amantia phalloides poisoning, acute alcoholism
and poisoning with Salicylate, Paracetamol, antihistamines, etc..
Increased in normal pregnancy, obesity, von Gierke's disease,
diabetes mellitus, alcoholism, the nephrotic syndrome, uremia,
maintenance dialysis, hypothroidism, cholestasis, biliary cirrhosis,
paraproteinaemias, most hyperlipoproteinnaemias (especially
hyperchylomicronaemia). Transient increase in serum triglycerides
occurs in alcoholic fatty liver, cirrhosis, acute pancreatitis and
Creatinine Kinase (CK / CPK)
• Increased in hypoxia, hypothermia, after severe exercise, multiple
injections, cardiac massage, in malignant hyperpyrexia, myxoedema,
cerebrovascular accidents, cerebral ischaemia, motor neuron disease,
• Decreased in thyrotoxicosis.
• Increase prostatic acid phosphatase occurs in prostatic cancer,
prostatic infarction, and occasionally in benign prostatic hypertrophy.
Rectal examination increased the level of prostatic cancer and benign
• Increased non-prostatic acid phosphatase occurs in primary
hyperparathyroidism, myeloma, Paget's disease of bone, primary bone
tumors, metastases in bone and Gaucher's disease.
Alanine Aminotransferase (ALT, SGPT)
• Increased in liver disease, myocardial infarction (moderate increases)
and skeletal muscle disease.
• Increased in haemoconcentration.
• Decreased in haemodilution, analbuminaemia, inadequate intake or
protein, malabsorption, severe liver disease, the nephrotic syndrome,
protein-losing enteropathies, severe haemorrhage, severe burns, after
severe injury, chronic infections and in malignancy.
• Increased in diseases of cardiac muscle, skeletal muscle and liver.
• Increased in cholestasis, rickets, osteromalacia, hyperparathyroidism,
Paget's disease of the bone, osteagenic sarcoma and bone
metastases. A transient, very marked increase (up to about 30 times
the upper limit of normal for adults) sometimes occurs in less than 3
years-old infants who have no biochemical or radiological evidence of
bone or liver disease.
• Decreased in severe anaemia, kwashiorkor, scurvy, cretinism,
achondroplasia and hypophosphatasaemia.
• Increased in haemoconcentration and the hyper gammaglobulinaemias.
• Decreased in haemodilution, low protein intake, severe liver
disease, the nephrotic syndrome and protein-losing enteropathies.
Specific Proteins & Serologies
Note: So many other research related test can be performed by this
26 Available Parameters
WBC RBC Plt
NE# Hgb MPV
NE% Hct Pct*
LY# MCV PDW*
1-INSTRUMENTS AND EQUIPMENT REQUIRMENT
A list of all items, we required to start new clinical Research
laboratory is as follow.
S.NO Equipment Manufacturer Distributor Quantity
1 Clinical Chemistry Analyzer 1
2 Nephlometer 1
3 Hematology Analyzer 1
4 Dis/Deionizer Water Sys. 1
5 Autoclave 1
6 Oven 1
7 - 33-80 C Freezer 4
8 34 -20 C Freezer 4
9 35.4 C Refrigerator 8
36.4 C Refrigerator with
10 Balance 0.1 mg 1
11 Flammable liquid cabinet 2
12 Balance 1
13 Balance 1
14 pH meters 4
15 Refrigerated centrifuge 3
16 Clinical Centrifuge 2
17 High Speed Centrifuge 1
18 Micro Centrifuge 4
19 Hot plate and stirrer 4
20 Thermomixer 2
21 Heating Block 4
22 Water Bath 2
23 Shaking water Bath 2
24 Orbital shaker 2
25 Vortex mixer 6
26 Automatic pipette(set of 4) 8
27 Multichannel pipette 4
28 Body Fat analyzer 1
29 Shaking incubator for
30 Glass ware washing system
31 Pipette filler 06
S.NO Description Charges/Per
1 Building Rent
3- WORKING CAPITAL:
S.NO Description Quantity Salary/Mo Total
COST OF TEST
CELL DYNE EMERALD
FUTURE TRAINING PROGRAMME
DESCRITPTION UNIT ENOUGH FOR PRICE Test Run on
LYSE 960 mL 2050 TESTS 3000
DILUENT 10 L 650 TESTS 800
CLEANER 960 mL 300 TESTS 600
CALIBRATOR 2X2.5 mL 6 Month 800
CONTROL 6X2.5 mL 6 Month 800
------ -------- -------- 600 Tests
----- ------- -------- ------- 10 SR/Test
TOTAL CAST 6000 SR
We have planned in future to start laboratory training for our Medical
students and Medical Technicians in our Laboratory
• To start a carrier with a passion for both medicine and research.
• Opportunity for an integrative career as a clinician and a scientist
-Direct patient care
-Basic research with an understanding of human disease.
CLINICAL RESEARCH LABORATORY
Specimens to lab:
Custom Clinical Requisition
MRN or Unique Study –ID From Lab.
(study IDs Coded by CRL)
Meet with laboratory to initiate
study: Support for method
-Selection of safety relevant
tests and EMR transmission
Requisitions Form: Custom
King Saud University
Obesity Research Center
Ordering the samples
Lab Support services
Fund Number: Telephone No:
Provider: Patient Identification area: MRN,
Full Name; Gender, DOB
Date of Birth:
Date collected: Time Collected:
Specimen Type: Blood Serum Plasma Urine Culture Medium
Buffy Coat Fluid Other _______________
Number of Specimens in bag _____________ sampling sheet
Visit : Subject ID: