Seventh Wave Bioanalytical Lab

[object Object],[object Object],Deqing Xiao, Annie Walker, Lucy Hestco, Roger Melton, Andrew Vick Pharmacokinetics, Dynamics & Metabolism, Seventh Wave Laboratories LLC, 743 Spirit 40 Park Drive, Suite 209,Chesterfield, MO 63005 The BIOANALYTICAL LABORATORY The Bioanalytical Laboratory (BA Lab) of Seven Wave was founded in 2006. It works closely with the In-Life and PK groups as a part of the Pharmacokinetics, Dynamics and Metabolism (PDM) Department. Located approximately 30 miles west of downtown St. Louis, Missouri, this new BA service lab is focused on the drug discovery needs of our clients with an emphasis on responsiveness, speed, integrity, and teamwork. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],SUPPORTED PHARMACOLOGY MODELS ACKNOWLEDGEMENT We thank E. Schmidt and J. DeBold for their kind contribution to this poster. CONTACTS For additional information please contact: Andrew Vick: [email_address] Roger Melton: [email_address] Deqing Xiao: 636-519-4873 (O), [email_address] Cardiovascular • ApoE -/- transgenic mice • LDL receptor deficient mice Hepatic • Hepatic injury and fibrosis (carbon tetrachloride-induced) Oncology • A/J mouse lung tumor studies • NNK-induced lung tumors Metabolic/Diabetes • db/db mice • ob/ob mice • ZDF rats • Chemically induced diabetes (STZ) Respiratory • Rhinitis • Bronchitis Additional models are under evaluation. BA LAB FACILITY The BA lab is equipped with state-of-the-art technology that is constantly updated to afford our clients the most modern research and analytical tools. Our LC-MS/MS/UV instrumentation is built around Sciex API 4000 QqQ and 4000 Q Trap MS/MS systems with Shimadzu HPLCs, and we are implementing a variety of other technologies and processes to increase data quality and speed and keep in accordance with industry standards. BA LAB TEAM The BA Lab has assembled an excellent team of scientists with 60+ combined years of pharmaceutical industry experience in bioanalytical, ADME, PK, In-Life, and pharmacology related fields. Recently, Andrew Vick, PhD was appointed Executive Vice President and Senior Director of PDM. His contributions will further enhance our efforts in pharmacokinetics and drug metabolism for early stage drug development, where the identification of robust drug candidates is a critical first step in the development process. He brings extensive experience working within the biotechnology and pharmaceutical industry in the fields of toxicology, pharmacology, and drug disposition (PK/PD). Seventh Wave President and Founder, Dr. John Sagartz (2 nd from left), accepts the 2009 Outstanding Entrepreneur Award Andrew Vick, PhD Executive Vice President, Senior Director of PDM ,[object Object],[object Object],[object Object],Column: Prevail C18_3u, 2.1x20, Lot No. 3506, PN: 43827 Filter: Javelin Column Filter MP-A: 0.1% FA in Water MP-B: 0.1% FA in Acetonitrile Wash-1: 1% FA in Acetonitrile: Water (15:85) Wash-2: Acetonitrile Flow Rate: 0.45mL/min Temperature: 35-40°C Loop size: 5uL Representative Bioanalytical Method Representative In Vitro Data for CYP3A4 Inhibition Assay Bioanalytical Lab of Seventh Wave 10 45 85 80 490.3 531.9 Ketoconazole 18 37 76 80 203 342.1 1-OH Midazolam 8 39 111 80 291.3 325.8 Midazolam 14 25 51 80 155.2 271.2 Tolbutamide CXP CE DP Dwell Time (ms) Daughter Ion (amu) Parent Ion (amu) Compound Name stop 3.30 5 3.00 5 2.85 95 2.80 95 2.50 5 0.30 % B Time (min)

Seventh Wave Bioanalytical Lab

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