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Funders and RRIDs

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RRIDs were created jointly by NIH, Journal Editors, UCSD and other researchers; RRIDs function in support of NIH guidelines for Rigor and Transparency

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Funders and RRIDs

  1. 1. Funders and RRIDs RRIDs were created jointly by NIH, Journal Editors, UCSD and other researchers; RRIDs function in support of NIH guidelines for Rigor and Transparency RRIDs are funded and maintained jointly by the following: U24-DA039832 to The Neuroscience Information Framework, U24-DK097771 to dkNet, (COI declaration) R43-OD024432 to SciCrunch Inc, and Leona M. and Harry B. Helmsley Charitable Trust
  2. 2. NIH Rigor and Transparency Guidelines describe changes to grant review guidelines, including an explicit call to improve use of: Antibodies, Cell Lines, Organisms, and Chemicals
  3. 3. Freeman et al, 2017. Reproducibility2020: Progress and priorities; F1000Research *
  4. 4. Why these reagents and not all reagents?
  5. 5. How do you authenticate an antibody? Nature Methods, 2016: A proposal for validation of antibodies Mathias Uhlen1, Anita Bandrowski2, Steven Carr3, Aled Edwards4, Jan Ellenberg5, Emma Lundberg1, David L Rimm6, Henry Rodriguez7, Tara Hiltke7, Michael Snyder8 & Tadashi Yamamoto9 These pillars rest on proper identification
  6. 6. Who authenticates every antibody? There are 5,700 journals indexed in PubMed
  7. 7. 34 journals say they require cell line authentication, others enforce identification
  8. 8. At the simplest level every study is like a recipe, resources (ingredients) and a protocol
  9. 9. • •
  10. 10. The State of The Art in Publishing
  11. 11. Can you find this mouse at the stock center?
  12. 12. Papers are still poor at identifying the simplest part of the paper, the materials used, but when asked the authors know what they used so this is culture not malice! Vasilevsky 2013
  13. 13. • • • • • • • • •
  14. 14. RRID system is designed to be easily extensible to other resources
  15. 15. Anatomy of the RRID syntax DSHB Cat# GAD-6, Lot #12, RRID:AB_528264 Company or Provider Local Identifier Version or Lot used Global Unique Persistent Identifier
  16. 16. http://scicrunch.org/resources
  17. 17. SciBot reads a paper and creates a W3C- annotation, display is in Hypothes.is https://blog.box.com/blog/int roducing-developer-tokens/
  18. 18. RRIDs in the wild
  19. 19. But why should NIH care?
  20. 20. 1. RRIDs enable an early warning system for bad resources
  21. 21. 2. RRIDs enable tracking of non-traditional intellectual output
  22. 22. PubMed ID / DOI I published this paper RRID I made this antibody I am a researcher
  23. 23. RRIDs make it easier to track NIH investments
  24. 24. 3. RRIDs help researchers demonstrate they comply with NIH guidelines
  25. 25. http://doi.org/10.6075/J0RB72JC
  26. 26. Tools for Authors/Reviewers Hypothetical workflow for paper (or grant) submission enabled by RRIDs AUTOMATED REVIEW Areas of concern: RRID:AB_2341130: This antibody is being used for immunohistochemistry by authors, approved uses from manufacturer include western blot RRID:CVCL_2346: This is a known contaminated cell line REVIEWER REPORT Submit Paper R43-OD024432
  27. 27. To recommend that researchers use RRIDs: ● before they start their experiments ● when they report on their experimental findings

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