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Why should my institution support RRIDs?

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Reproducibility woes touch all aspects of the research enterprise. RRIDs are a thoughtful and arguably necessary tool for combating the issue.

Published in: Science
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Why should my institution support RRIDs?

  1. 1. Why should my institution support RRIDs? RRIDs were created jointly by NIH, Journal Editors, UCSD and other researchers and function in support of NIH guidelines for Rigor and Transparency RRIDs are funded and maintained jointly by the following: U24-DA039832 to The Neuroscience Information Framework, U24-DK097771 to dkNet, R43-OD024432 to SciCrunch Inc, and Leona M. and Harry B. Helmsley Charitable Trust
  2. 2. Reproducibility woes touch all aspects of the research enterprise
  3. 3. New NIH Guidelines affect all grants (2016/2017) NIH Rigor and Transparency Guidelines describe changes to grant review guidelines, including an explicit call to improve use of: Antibodies, Cell Lines, Organisms, and Chemicals What is the annual budget from NIH?
  4. 4. Freeman et al, 2017. Reproducibility2020: Progress and priorities *
  5. 5. Why these reagents and not all reagents?
  6. 6. How do you authenticate an antibody? Nature Methods, 2016: A proposal for validation of antibodies Mathias Uhlen1, Anita Bandrowski2, Steven Carr3, Aled Edwards4, Jan Ellenberg5, Emma Lundberg1, David L Rimm6, Henry Rodriguez7, Tara Hiltke7, Michael Snyder8 & Tadashi Yamamoto9 These pillars rest on proper identification
  7. 7. Who authenticates every antibody? There are 5,700 journals indexed in PubMed
  8. 8. 34 journals say they require cell line authentication, others enforce identification
  9. 9. At the simplest level every study is like a recipe, resources (ingredients) and a protocol
  10. 10. • •
  11. 11. • • • •
  12. 12. The State of The Art in Publishing
  13. 13. Papers are still poor at identifying the simplest part of the paper, the materials used, but when asked the authors know what they used so this is culture not malice! Vasilevsky 2013
  14. 14. Anatomy of the RRID syntax NeuroMab Cat# 75-028 Lot#45, RRID:AB_2307331 Company or Provider Local Identifier Version or Lot used Global Identifier
  15. 15. http://rrid.site
  16. 16. PubMed ID / DOI I used this mouse RRID registered I made this antibody I am a UC researcher
  17. 17. • • • •
  18. 18. -eLife Blog
  19. 19. RRIDs in the wild
  20. 20. But why should my institution care?
  21. 21. 1. RRIDs help researchers demonstrate they comply with NIH guidelines
  22. 22. http://doi.org/10.6075/J0RB72JC
  23. 23. 2. RRIDs enable an early warning system for bad resources
  24. 24. 3. RRIDs enable UC to track resources as intellectual output of faculty/staff
  25. 25. To recommend that researchers use RRIDs
  26. 26. Useful links for RRIDs Resource authentication example document: https://library.ucsd.edu/research-and-collections/data-curation/_files/ExampleAuthenticationKeyBiologicalChemicalResources201609b.pdf Here are the people pushing RRIDs: Here are 2 FOAs that mention RRIDs https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-18-014.html https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-010.html Cell Press, eLife etc instructions to authors that we have found so far https://docs.google.com/spreadsheets/d/1cGtY2oIMfBzg6MKei_S2niCbu0Cici2n17dZNLgBdNw/edit#gid=1245999377 External Resolvers back RRIDs n2t.net/RRID:AB_90755 (California Digital Library) identifiers.org/RRID/RRID:AB_90755 (European Bioinformatics institute) Companies, vendors, random projects etc Cellosaurus: web.expasy.org/cellosaurus/CVCL_2260 MMRRC: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=32045 BioLegend: https://www.biolegend.com/en-us/products/purified-anti-akt1-antibody-12289 NeuroMab: http://neuromab.ucdavis.edu/catalog.cfm Hypothes.is https://web.hypothes.is/blog/introducing-developer-api-tokens/

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