2. Peripheral areterial occlusive disease
(PAOD/PAD/PVD) refers to the obstruction or
detoriation of ateries other than those supplying
the heart and within the brain
3. Impairment of circulation
Incidence increases with age
0.3%/yr (40 to 55yrs) to 1%/yr (after 75yrs)
Quality of life/cost of treatment
Non whites> whites
Male gender
Obesity
4. Black (hispanic)
Increasing age
Smoking
Hypertension
Dyslipidemia
Hypercoaguble states
Renal insufficiency
DM
Younger>aged
5. Family history of vascular disease or stroke/
heart attack
In study
C-reactive protein
Homocysteine
6.
7. Intima
Internal elastic membrane
Media
Composed of smooth m/s, collagen, elastin and
preteoglycans
Blood suply:
Internal half: Direct diffusion
External half: vasa vasorum
External elastic membrane
Adventitia
• Fibroblasts and collagen
8.
9. Acute
Sudden occlusion of an artery
No time for collateral openings
Poikilothermia, Pain, Pulseless, Pallor, Parasthesia
and Paralysis
Chronic
No sudden obstruction
Gradual narrowing of lumen
Enough time for collaterals to develop
More tolerant to prolonged ischemia
12. Atherosclerosis =
Athero + sclerois
Plaque composed of
smooth m/s, lipids,
connective tissue and
macrophages
13. Brief pathophysiology
Lipid deposition calcification erosive
areas and ulceration prothrombotic cell
activity plaque lipid core becomes necrotic
covered by FIBROUS CAP rupture,
perceived as injury laying down of platelets
and formation of a clot.
14.
15. Ischemia may be due to
Narrowing of the lumen
Rupture leading to fibrous cap
Embolization
16. More shearing stress/
increased turbulence
Infra renal aorta
Iliac bifurcation
Carotid bifircation
Superficaial femoral
arteries
Ostia or renal, coronary
and mesenteric arteries.
17. Inflammatory reaction of the arterial wall with
involvement of neighboring vein and nerves
2nd to 4th decade of life; male>females
Specifically linked to smoking
Low socio-economic groups
Recently, familial disposition and autoimmune
mechanism has also been postulated
20. Involves medium and small sized vessels;
those distal to the popliteal artery
Very rare upper limb involvement
Acute Lesion:
Arteritis, periarteritis, acute phlebitis (migratory in
30%) and periphlebitis.
Invasion of wall by polymorphs and giant cells.
Thrombus, with microabscesses
21. Chronic Lesion
Arteries and veins bound together by fibrosis
Nerve involvement
Fibroblastic activity and endothelial proliferation in
the thrombus
Thrombus organized as fibrous tissue
22. Pain (Intermittent claudication)
“Claudio”= I limp
Cramp like pain
Brought on by exercise
Not present on walking the first step
Relieved by standing still
Slight variation each day
Due to accumulation of substance P
Site of Claudication:
Group of muscles distal to the site of obstruction
23. Pain (Intermittent claudication)
Clinical Classification
a) Boyd’s Classification
Grade Pain
I Pain relieved on continued walking
II Walks in pain
III Compelled to take rest
IV Pain at rest
27. Pain (Intermittent claudication)
Occlusion and site of claudication
Site of Occlusion Claudication site/ other symptoms
Aorto-iliac
obstruction
• Claudication in in both buttocks, thighs and calf
• Absent femoral, popliteal and DP pulses
• Impotence (Leriche’s syndrome)
Iliac obstruction • Unilateral claudication in thigh and calf
• Unilateral absence of femoral and distal pulses
Femoropopliteal
obstruction
• Unilateral claudication in the calf
• Absent distal pulses
Distal obstruction • Ankle pulses absent
• Claudication in calf and foot
28. Pain (Intermittent claudication)
Rest pain
Grade IV Boyd’s classification
Felt in the foot (most distal parts)
Due to ischemia of the somatic nerves (cry of the dying nerves)
Exacerbate on lying down or elevation of foot
Worse at night; patient sits in “hen-holding” position
Pressure of even bed clothes worsens the pain
Lessened by hanging the foot down or sleeping on a chair
Patient may commit suicide
30. Pain (Intermittent claudication)
Critical limb ischemia
Persistently recurring ischemic rest pain requiring
regular, adequate analgesia for more than 2 weeks or
ulceration or gangrene of foot or toes with ankle
pressure <50mmHg or toe pressure <30mmHg
31. Pain (Intermittent claudication)
Differential Diagnosis
1. Nerve root compression (eg: herniated disc)
Sharp lacinating pain
Sudden onset on walking
History of back problems
2. Spinal stenosis
History of back problems
Motor weakness more prominent
Onset by standing also
Relived by change in position
32. Pain (Intermittent claudication)
Differential Diagnosis
3. Arthritic/ inflammatory
Aching pain
Variable pain
Not relieved as quickly
4. Baker’s cyst
Swelling, tenderness
Rest pain
Subsides slowly
Not intermittent
33. Pain (Intermittent claudication)
Differential Diagnosis
5. Venous claudication
Bursting type of pain
Relief speeded by elevation
h/o DVT
Signs of venous congestion
6. Chronic compartment syndrome
Bursting pain
Heavily muscled legs
Relief speeded by elevation
34. Other symptoms
Ulceration
Gangrene
Loss of senstion
Loss of movements
35. History
Can identify the location and severity of the disease
Pain:
Location
Precipitating and aggravating factors
Frequency, duration and evolution
Rule out other causes of pain in the lower limbs
Patients with co- morbid conditions who cannot walk present
late with gangrene and rest pain
Drug/Medical history
Surgical history
Family history : first degree with abdominal aortic aneurysm
36. History
Vascular review of symptoms
TIA
Difficulty in speech or swallowing
Dizziness/ drop attacks
Blurry vision
Arm fatigue
Pain in abdomen after eating
Renal insufficiency (poorly controlled hypertension)
Impotence
Claudication
Rest pain or tissue loss
37. Physical examination
Inspection
Change in colour
Signs of ischemia
Bueger’s test
Capillary filling test
Venous refilling
Pregangrenous/ gangrenous part examination
39. Physical examination
Dry vs Wet Gangrene
Dry gangrene Wet gangrene
Dry, shriveled, mummified Odematous, putrified and
discoloured
Occurs due to slow and gradual loss
of blood supply
Occurs due to sudden loss of blood
supply
Clear line of demarcation is present Vague/ No line of demarcation
No proximal extention Proximal extension
Limited amputation High amputation
42. ABPI
Physiological testing
SBP of PT/PT/PA (higher)
--------------------------------- = ABPI
Higher of the two brachial SBPs
Normal value =>1
Claudication <0.9
Rest pain <0.5
Imminent necrosis <0.3
Note:
Normal value doesn’t rule out ischemia
Retest after exercise, ABPI may fall
Wrong high readings in calcified arteries, e.g. seen in diabetics &ESRD
43. ABPI
Note:
Normal value doesn’t rule out ischemia
Retest after exercise, ABPI may fall
Post exercise ABPI considered POSITIVE when
ABPI fall => 0.2 and/or
Failure to return to baseline in 3 minutes
Wrong high readings in calcified arteries, e.g. seen in diabetics
&ESRD
45. Photo-Plethysmography
Investigation for segmental flow
Infra-red light emitting source + a photosensor
Light decreases when flow increases
Generates a pressure and waveform of different arteries
A difference of 20-30 mmHg is significant.
46. Doppler Ultrasound
(DU)
Continous wave DU with
segmental waveforms
Doppler shift converted to
audio signal
Normal Triphasic Signal
Sharp systolic upstroke
Reversal of flow in early
diastole
Low amplitude forward
flow throughout
diastole.
47. Doppler Ultrasound (DU)
Obstructive disease
Initial Loss of reversal flow in early diastole (Bi-phasic)
Severe blunting of arterial waveform with decreased amplitude
Worsening only diastolic flow (Mono-phasic )
In case of a proximal obstruction/ stenosis
Assessment downstream is less accurate
Shows moving blood but it may/ may not be
sufficient
49. Duplex Ultrasound
Provides with B mode settings (gray settings)
Pulsed Doppler spectral waveforms
Can even detect very low flow states
Color flow data and waveforms for analysis by a computer.
Shows blood flow and turbulence
Peak systolic velocities (PSV) and End diastolic velocities are
recorded.
50. Duplex Ultrasound
Change in waveforms
Triphasic biphasic Monophasic
Ratio of PSV proximal and distal to occlusion
>2.0 indicates a stenosis of 50% or more
Difficult in aoto-illiac segments, especially in obese
individuals
(patient should fast overnight)
51. Angiography
Invasive techique of visualising the arterial tree
Hypaque 45 (Sodium Diatrazoate) is used as a dye (75 to 100
ml)
Course of arteries, constrictions, and distal “Run off”
To plan interventions
1. Transfemoral
2. Trans-lumbar (established bi-lateral obstruction)
Seldinger technique is used
52. Angiography
Done in 4 stages
i. Dye released at the level of diaphragm in the aorta
Abdominal aorta
Celiac artery
Sup mesenteric artery
Inferior mesenteric artery
ii. Dye released at aortic bifurcation
B/L common iliac arteries
Hypogastric arteries
External iiliac arteries
Common femoral arteries
Sup Femoral arteries
Profunda femoris
55. Angiography
Cork-screw pattern of
vessels in TAO
Block at multiple sites
in small and medium
sized arteries
56. Angiography
Risk / Complications:
a) Groin hematoma
b) Retroperitoneal bleeding
c) Pseudo-anuerysm
d) Arterial dissection
e) Contrast nephropathy
f) Contrast allergy
57. CT angiography
IV contrast followed by Ct imaging
Thin slices of 0.625mm
Allows 3-D reconstruction
Improved speed
Lesser contrast material
Appreciation of thrombus, calcification, etc. better
Disadvantages similar to angiography
58. Digital subtraction angiography (DSA)
Angiographic images being digitilised by a computer
With substraction of extrenous background (bone, soft
tissues)
59. MR angiography
Uses Godalinium as contrast
Better sensitivity and specificity
Disadvantages:
longer study duration
Costlier
Metallic implants contra-indication
Nephrotoxic contrast
Fibrosed nodules of skin, eyes and joints (rare complication)
60. Carbon Dioxide angiography
CO2 as contrast agent
In cases of renal insuffieciency
CO2 temporarily displaces blood but dissolves in 3-5
minutes
Poor detail
Significant patient discomfort
Gas trapping mesenteric ischemia
61. General Investigations
ECG
ECHO
Lipid profile
COPD
Blood tests to exclude
Anemia
DM
Deranged RFT
High blood viscosity (polycythemia and thrombocythemia)
62. Intravascular
ultrasound (IVUS)
Catheter based
intravascular
ultrasound
Provides transverse and
360 degree image of the
lumen of the vessel
Qualitative data about
the wall anatomy
63. Brown’s vasomotor index
For Buerger’s disease
Test of vasospasm
Block the nerves with Local anesthesia to predict
efficacy of Sympathectomy
Rise in skin temperature is recorded
Index = Rise in skin temperature – Rise of mouth temperature
Rise of mouth temperature
Index =>3.5 is positive for sympethectomy
64. Conservative management
Indications:
Ankle pressure >60mmHg
Femoral pulse +
No rest pain
No tissue loss
Controlled infection (eg diabetic patient)
Unfit for surgery
ABPI >0.5 (Relative indication)
65. Conservative management
Stop smoking
Keep walking
Reduce weight (obese individuals)
Exercise
Diabestes and hypertension
Care of feet
Buerger’s position
Buerger’s exercise
67. Conservative management
Drugs
To Control
Diabetes
Hypertension
Dyslipidemia
Atherosclerosis
Infection
Note: Risk of limb Loss to be explained to the patient
(Failure in 25% of patients)
Opening up of collaterals or change of gait with less usage
of the affected muscle
69. Indirect surgeries
Sympathectomy
Chemical
Produces cutaneous vasodilatation
Injection in front of the lumbar fascia which contains
sympathetic trunk; Under C-Arm
5ml phenol in water is inected in front of 2nd, 3rd and 4th
lumbar vertebra
70. Indirect surgeries
Sympathectomy
Surgical (pre-ganglionic sympathectomy)
Abdomen opened with oblique incision under genral
anasthesia
Dissection through flat abdominal muscles, and peritoneum
The sympathic chain is situated medial to the medial margin
of psoas muscle
Rt side overlapped by IVC
Lt side overlapped by aorta
Sympathetic chain identified by the presence of ganglia
First lumbar ganglia is as high as crus of the diaphragm
71. Indirect surgeries
Sympathectomy
Surgical
Sympathectomy from 1 to 4th lumbar ganglion
Closed the site in layers
Note: in case of bilateral surgery; preserve L1 of atleast one
side causes retrograde ejaculation.
74. Surgical Revascularization Procedures
Open vs endo-vascular
Trans-Atlantic Inter Society Documentation Management
of Peripheral Arterial Disease (TASC) 2000
TASC –II in 2007
“Endovascular therapy is the treatment of choice for
Type A lesions and surgery is the treatment of choice
for Type D lesions. Endovascular treatment is the
preferred treatment for Type B lesions and surgery is
the preferred treatment for good risk patients with
Type C lesions”
83. Open Surgical Management (Aorto-iliac disease)
Aorto-bifemoral bypass with a prosthetic graft via
transabdominal or retroperitoneal approach.
End to end or end to side proximal anastomosis
Nervi erigentes should be taken care of (damage will
lead to retrograde ejaculation) in the area of CIA
Mortality 5%
84. Open Surgical Management
Choice of Graft (Conduits)
Great Sephanous vein
Preferred for lower limbs with better patency rates (90% First
yr and 60% five yrs)
Should preferentially be used in all below knee by-passes
Can be used in situ
Better size match
Removal of valves with valvulotome
Reversed
No need of disruption of valves
May be harvested endoscopically
No added advantage of one over the other
85. Open Surgical Management
Choice of Graft (Conduits)
PTFE (Polytetrafluoroethylene)
Can be used as a replacement of LSV
Poorer results compared to LSV (50% in five yrs)
New: with heparin coating
Dacron is a brand name of PTFE
86. Open Surgical Management
Choice of Graft (Conduits)
Small sephanous vein
Basillic vein
Cephalic vein
All these three veins have very thin walls, hence no good
results
veins when joined to increase the length gives poor results
Cryo-preserved arteries
Cadevaeric arteries preserved in cold
Bovine pericardial patches
87. Open Surgical Management (Aorto-iliac disease)
Aorto-bifemoral bypass
Midline or transverse abdominal incision
CFA and branches exposed through groin incision
Small bowel retracted to right
Posterior peritoneum is open
Retroperitoneal tunnels are made to groin.
Heparin 5000U given iv bolus and vessels clamped
88. Open Surgical Management (Aorto-iliac disease)
Aorto-bifemoral bypass
Vertical incision on anterior aspect of Aorta
Dacron sutured end to side (taking all the layers)
The Limbs fed to the groin sutured end to side to CFA
Posterior peritoneum closed over peritoneum
90. Open Surgical Management (femoro-popliteal)
Open groin surgery
CFA endarectomy + profundoplasty/ iliofemoral bypass
In case of added proximal (iliac) occlusion
CFA endarectomy + profundoplasty / iliofemoral bypass
+ iliac stenting
In case of added distal (SFA)occlusion
CFA endarectomy + profundoplasty +SFA stenting/
femoropopliteal bypass
91. Open Surgical Management
Endarterectomy
Open:
When it involves short segment of big arteries
Also called “dis-obliteration/ reboring”
Heparin 5000U given pre-opeartively
Artery is exposed after placing clamps
Distal clamp applied first
Longitudinal incision taken oven the occlusion till the plaque
is reached
92. Open Surgical
Management
Endarterectomy
Open:
Plane created between
plaque and media
The plaque is removed
with the diseased intima
In case of thrombus, it is
removed
Closed with non
absorbable fine sutures
directly or a vein graft
Post op anticoagulant
therapy with warfarin
93. Open Surgical Management
Endarterectomy
Closed
Artery exposed and clamped
Proximal and distal transverse incisions taken
Plane created between plaque and tunica media
Wire loop passed from distal to lower arteriotomy insion,
stripping the plaque
Can be used in relatively longer occlusions
94. Open Surgical Management
Endarterectomy
Balloon
Artery is exposed after clamping
Proximal arteriotomy is made
Fogarty ballon catheter is passed
95. Open Surgical
Management
Endarterectomy
Passed beyond the
obstruction
Ballon is inflated
Pulling the catheter
removes the atheroma
More commonly used
for emboli (as they are
comparetively loosely
adherant)
96. Open Surgical Management
Profundoplasty
Repairing of profunda femoris
Arises posterior to CFA
The vessel is dissected out and clamps are applied
Arteriotomy extending from CFA to distal to occlusion
Atherectomy is then performed
97. Open Surgical
Management
Profundoplasty
Defect is them closed by
a vein patch
On table angiography is
then performed to check
for patency
May be done in adjunct
to bypass surgeries
98. Open Surgical Management
Femoro-popliteal bypass
In patients with SFA and popliteal artery occlusion with a distal
segment of patent popliteal artery.
In continuity with any crural artery
Longitudinal groin incision to access the CFA
Popliteal artery is exposed medially from thigh or the leg
In above knee bypass, incision proximal to the knee to access
popliteal artery
In below knee bypass, popliteal fossa is opened
99. Femoro-popliteal
bypass
Polpileat vein is held in
Silastic loops
Graft is tunnelled and
placed at the
anastomotic site
Sephanous vein graft
can be used
In situ (requires
desruption of valves)
Reversed, can be
accessed by a parallel
skin incision
100. Open Surgical Management
Infrapopliteal bypass
Disease involving popliteal artery and proximal tibial arteries.
the target artery must have luminal continuity with the foot
Stenosis upto 50% is accepted as patent for surgery
Calcification also not considered a contra-indiaction.
SFA or Popliteal artery is used for “inflow”
101. Open Surgical Management
Infrapopliteal bypass
Access to PTA with dissection and separation of Soleal muscle
attachment from tibea access to PTA and PA
Access to ATA with anterolateral incision on legseparation of
ant tibial muscle and external longus muscle ATA.
Separation of interosseus membrane for tunneling of the graft.
Small veins can be used for anastomosis
Or PTFE graft can be used
102. Open Surgical Management
Other bypasses
A. Axillofemoral graft
Tunnelled subcutaneously between the axillary artery
proximally, to reachone or both CFA
Low patency rates
B. Femoro-femoral crossover bypass
Crossover graft by tunnelling a prosthetic graft
subcutaneously above the pubis between the groins
103.
104. Endovascular management
Basically involves gaining access into transmural space
via percutaneous femoral artery puncture
Balloon angioplasty
Subintimal angioplasty
Stenting
Stent graft
Variations of balloon angioplasty
105. Endovascular management
Balloon angioplasty
Guide wire is negotiated through the stenosis or occlusion
Then a balloon is inflated to open the occlusion
It is kept inflated for approx 1 minutes with high pressure
then deflated
May be combined with stenting
106. Endovascular management
Balloon angioplasty
Very good results for dilating the iliac and
femporopopliteal segments
Below knee procedures are less successful
98% success in CLI (extremely good results)
Limb salvage rate of 91% over 5 fyrs
Failure in TASC D patients
107. Endovascular management
Subintimal angioplasty
Creating an arterial dissection purposely begenning at the
proximal end of the oclusion
The guide wire is made to re-enter the lumen at the
diastal end of occlusion
Use of balloon angioplasty to increase the diameter of the
false lumen
Poor results
3 yrs patency rates being only 30%
But good for critical limb ischemia
109. Endovascular management
Stenting
If the vessel fail to remain dilated use stents
Stainless steel stents
May be introduced on a balloon catheter and placed in
position
Self expanding stents (nitinol), which expand on
withdrawing the sheath
Angioplasty (balloon) + stenting > primary stenting
But primary stenting > only angioplasty
Poor results in TASC D patients
112. Endovascular management
Stent garft
Expanded PTFE (ePTFE) with external nitinol stent
Inner surface bonded with heparin
Extremely flexible
Can close conform to the shape of artery (esp: SFA)
Self expanding stents
Easier with better patency rates than atherectomy.
It is easier, with more better technical succes comapred t o
PTA
Few studies show similar results comapred to bypass
113. Endovascular
management
Cutting balloon
Originally designed for
coronary arteries
The balloon has three or
four atherotomes or
micro-surgical blades
These are mounted
longitudinally on the
balloon
The blades score the
lesion and dilate the
lesions
114. Endovascular management
Cryoplasty
Apoptosis by cooling
Designed by Polar Cath Peripheral Dilatation System
(Boston Scientific)
Balloon filled with nitrous oxide gas
To cool to -10 degrees C
Supposed to prevent restenosis
115. Endovascular management
Endovascular atherectomy
Excision atherectomy catheters remove and collect the atheroma
Ablative atherectomy device fragment it
Rotational cutters turn at the speed of 8000rpm to shave the plaque
and collect in a storage chamber
Laser atherectomy has a cold tipped laser that delivers burst of
ultraviolet Xenon energy in short pulse durations
Results same as balloon angioplasty
Resulting into ischemiaMay be due to co-morbid conditions and poverty
DESCRIBE EACHIntima, single layer of cells, longitudinal axis, in contact with bloodMedia: strengthProteoglycans: disachharide bound to proteins, act as cement
I- limbs are viable and not immediately threatenedIIa – limbs are viable but salvagable if treatedIIb – limbs are salvagable if treated ungentlyIII- not salvagable
Infective eg: syphilis
Cap composed of smooth musclesandconnective tissuesIn this way an insignificant narrowing can result in major obstruction
Occlusion one level above the site of claudication
BP cuff and continous wave doppler<0.9 …6 folds of cardiovascular morbity
BP cuff and continous wave doppler<0.9 …6 folds of cardiovascular morbity
A continous wave ultrasound is transmitted by the probe which is reflected by moving RBCsand picked up by the receiver within the probe and converted to audio signalsChange in frequency of the reflected beam gives Doppler shift
A continous wave ultrasound is transmitted by the probe which is reflected by moving RBCsand picked up by the receiver within the probe and converted to audio signalsChange in frequency of the reflected beam gives Doppler shift
Previously under LA , now under USG guidance
Nephropathy:Increase hydration
DSA with PA view
High blood viscosity (polycythemia and thrombocythemia) smoking, malignancy, renal dysfunction,
From erecter spinae to medial border of rectus
From erecter spinae to medial border of rectus
From erecter spinae to medial border of rectus
End to end : better flow dynamicsEnd to side : the blood supply to pelvis is intact
Bypass can be performed even if one or more tibial arteries are occluded in the leg
PTA : percuatneous transluminal angioplasty
Emotional decision for the patientCause of depressionMore hospital stayMortality of 5-10% (BKA) and 15%(AKA)