3D printing presents many opportunities across hardware, software, services, and applications. It is reaching a point of "breakout" with unlimited potential. While material science and hardware development require large capital and long-term focus, services and applications are areas ripe for startups to capture value now by delivering customized solutions. Israel in particular has opportunities to transition from a "Startup Nation" to a "Self Manufacturing Nation" through further development of hardware, software intelligence, and utilizing 3D printing in strategic industries.