ALIMENTAZIONE PRETERMINE DOPO DIMISSIONE

1. Alimentazione dopo la dimissione Luca Maggio TIN – UCSC – Roma

2. E dopo ?

3. Lucas A . Nutrition, Growth and Development of Postdischarge Preterm Infants. In: Post-hospital Nutrition of the Preterm Infant. Report of the 106th Ross Conference on Pediatric Research, Colorado Springs, Colorado, August 18–20, 1995. Columbus, OH: Ross Products Div, Abbott Labs; 1996 :81-89 Stop Supplementazione LM Formula per Neonati AT Divezzamento Standard 18 mesi > 30 % Peso < 10° pc 7-8 anni > 20 % Peso < 10° pc VLBW Dimissione > 50 % Peso < 10°pc

4. ZScore Peso 1a 3a 2a D -0,45 +0,12 +0,27

5. ZScore CC 1a 3a 2a D -0,49 -0,15 +0,14

6. B.Latal-Hajnal , K.Von Siebenthal, H.Kovari, H.U. Bucher, R.H Largo. Postnatal growth in VLBW infants: significant association with neudevelopmental outcome. J Pediatr 2003 143:163-70

7. Lucas A , King F, Bishop NB. Postdischarge formula consumption in infants born preterm. Arch Dis Child 1992 ;67:691-2 ml/kg/d

8. Lucas A , King F, Bishop NB. Postdischarge formula consumption in infants born preterm. Arch Dis Child 1992 ;67:691-2

10. Wheeler RE , Hall RT. Feeding of premature infant formula after hospi-tal discharge of infants weighing less than 1800 g at birth. J Perinatol. 1996 ;16:111–116 Cooke RJ , Griffin IJ, McCormick K, et al. Feeding preterm infants after hospital discharge: effect of dietary manipulation on nutrient intake and growth. Pediatr Res. 1998 ;43:355–360 Cooke RJ , McCormick K, Griffin IJ, et al. Feeding preterm infants after hospital discharge: effect of diet on body composition. Pediatr Res. 1999 ;46:461– 464 Cooke RJ, Embleton ND, Griffin IJ, Wells JC and McCormick KP. Feeding Preterm Infants after Hospital Discharge: Growth and Development at 18 Months of Age Pediatr Res 2001; 49: 719–722 Latte per Prematuri

11. RJ Cooke, Embleton ND, IJ Griffin, JCK Wells, K.McKormick. Feeding preterm infants after hospital discharge: growth and development at 18 months of age. Pediatr Res 2001 ;49:719-22 M F

12. RJ Cooke, Embleton ND, IJ Griffin, JCK Wells, K.McKormick. Feeding preterm infants after hospital discharge: growth and development at 18 months of age. Pediatr Res 2001 ;49:719-22

13. Lucas A , Bishop NJ, King FJ, Cole TJ. Randomised trial of nutrition for preterm infants after discharge. Arch Dis Child. 1992 ;67:1413–1414 Atkinson SA , Randall-Simpson J, Chang M, Bosco P. Randomized trial of feeding nutrient-enriched vs standard formula to premature infants during the first year of life. Pediatr Res. 1999 ;45:276A Jane D. Carver , Paul Y. K. Wu, Robert T. Hall, Ekhard E. Ziegler, Roberto Sosa, Joan Jacobs, Geraldine Baggs, Nancy Auesta and Beate Lloyd. Growth of Preterm Infants Fed Nutrient-Enriched or Term Formula After Hospital Discharge Pediatrics 2001 ;107:683– 689 Chan GM . Growth and bone mineral status of discharged very low birth weight infants fed different formulas or human milk. J Pediatr. 1993 ;123: 439–443 Brunton JA , Atkinson SA, Saigal S. Growth and body composition in infants with bronchopulmonary dysplasia up to 3 months corrected age: A randomized trial of high-energy nutrient-enriched formula fed after hospital discharge. J Pediatr 1998 ;133:340 –345 Lucas A , Fewtrell MS, Morley R, Singhal A, Abbott RA, Isaacs E, StephensonT, MacFadyenUM and Clements H. Randomized Trial of Nutrient-Enriched Formula Versus Standard Formula for Postdischarge Preterm Infants Pediatrics 2001 ;108:703–711 PDF

14. Caratteristiche PDF  Tutto Kal/Proteine 1

15. Composition of infant formulas (per dl)

16. Brunton J, Saigal S, Atkinson SA . Growth and body composition in infants with bronchopulmonary dysplasia up to 3 months corrected age:A randomized trial of a high-energy nutrient-enriched formula fed after hospital discharge. J Pediatr 1998 ;133:340-5

17. Proteine + 27 % Calorie + 6 % Calcio + 79 % Fosforo + 23 % Sodio + 29 % Potassio + 37 % Zinco + 76 % Rame + 36 % Mn + 47 % Carnitina + Vit B1 + 56 % Vit B2 + 82 % Vit B6 + 128 % Vit B12 + 43 % Folati + 635 % Vit C + 117 % Vit D + 30 % Vit E + 212 % Vit K + 122 % Ac Pan. + 74 % Lucas A , Fewtrell MS, Morley R, Singhal A, Abbot RA, Isaacs E, Stephenson T, MacFadyen UM, Clements H. Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants. Pediatrics 2001; 108:703-11

19. JD Carver, PYK Wu, RT Hall, EE Ziegler, R Sosa, J Jacobs, G Baggs, N Auestad, B Lloyd. Growth of preterm infants fed nutrient-enriched or term formula after hospital discharge . Pediatrics 2001 ;107:683-89 < 1250 g

20. Brunton J, Saigal S, Atkinson SA . Growth and body composition in infants with bronchopulmonary dysplasia up to 3 months corrected age:A randomized trial of a high-energy nutrient-enriched formula fed after hospital discharge. J Pediatr 1998 ;133:340-5

21. Lucas A , Fewtrell MS, Morley R, Singhal A, Abbot RA, Isaacs E, Stephenson T, MacFadyen UM, Clements H. Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants. Pediatrics 2001; 108:703-11

22. Lucas A , Fewtrell MS, Morley R, Singhal A, Abbot RA, Isaacs E, Stephenson T, MacFadyen UM, Clements H. Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants. Pediatrics 2001; 108:703-11

23. Dubbi Composizione Consumo (cc vs Kal) Target Durata Significatività Clinica Sviluppo NM Latte Materno 3

24. Type of milk Infants Authors Nutritional follow-up studies in preterm infants Lucas et al Wheeler et al Chan et al Cooke et al Brunton et al Carver et al Lucas A et al Rigo et al SF, PDF HM, SF, PTF HM, SF, PDF, PTF SF, PTF SF, PTF SF, PDF SF, PDF SF, PDF Preterm <1850g Preterm <1850g Preterm <1650g Preterm <1750g, <34 w. VLBW <1500g + BDP < 37 w.; <1800g < 37 w.; <1750g < 34 w.; <1800g

25. Duration N. infants Follow-up studies in premature infants: standard (SF) versus enriched formula (EF) Lucas et al (1992) Wheleer RE et al (1996) Chan GM et al (1993) Brunton JA et al (1997) Cooke R et al (1998) Carver JD et al (2001) Lucas A et al (2001) Rigo J et al (2001) 9 months 6 months 8 weeks 3 months 6 months 12 months 18 months 2 months 31 54 59 60 96 125 229 33

26. Lucas A , Fewtrell MS, Morley R, Singhal A, Abbot RA, Isaacs E, Stephenson T, MacFadyen UM, Clements H. Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants. Pediatrics 2001; 108:703-11