1. Fall Semester 2012-13
Rubric for Assessing Seminar Reflections
Roll Book.# 6 Name Juan Enrique Maldonado Weng
Date: October 12, 20012
Annotated Bibliography 1:
Adamaszek M, Heinrich A. 2010. Anti-Borna Disease virus antibody responses in psychiatric patients:
Long-term follow up. Psychiatry and Clinical Neurosciences [Internet]; [Cited 2012 October 12].
DOI:10.1111/j.1440-1819.2010.02073.x:64:255–261 Available at:
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1819.2010.02073.x/pdf
This longitudinal study explores the role of the Borna Disease Virus in psychiatric patients. The
investigators used a method called Indirect Immunofluorescence assay (IFA) to prove the presence of
BDV in an organism's system. Through this methodology, they measured the amount of antibodies
that fought against the virus. From 1985 to 2006, antibody analysis was done on the patients
participating in this study. For the experiment, 46 patients were chosen from the major group because
they were found to be seropositive for traces of BDV. From this group, the patients with advanced
stages of schizophrenia had more traces of antibodies than those in earlier stages. As a result, this
can help the scientific community understand that the BDV may be a cause or supporting factor in the
formation of schizophrenia. This idea is lead by the fact there has been a presence of the virus in the
system. The investigation supports the idea that BDV has a role in the pathogenesis of conditions,
and as a result, BDV may contribute to the development of schizophrenic conditions. This group of
investigators did an excellent job for collecting data from a large period of time. It also seemed to lack
more varied testing of BDV presence, only to have inclined on solely on type of test.
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