1. Fall Semester 2012-13
Annotated Bibliography 4
Roll Book.# 6 Name Juan Enrique Maldonado Weng
Date: December 6, 2012
Annotated Bibliography 4:
S. Odebrechet, E. Nakagawa, M. Karine, E. Maria, H. Cristina, C. Eduardo, T. Matsuo, H. Odebrechet, and
M. Angelica. 2008. RNA From Borna Disease Virus in Patients With Schizophrenia, Schizoaffective Patients,
and in Their Biological Relatives. Journal of Clinical Laboratory Analysis, [Internet]; [Cited 2012 December 6].
DOI: 10.1002/jcla.20261: 22: 314–320 Available at:
http://onlinelibrary.wiley.com/doi/10.1002/jcla.20261/abstract
With the goal to establish the pathogenesis of schizophrenia through the Borna Disease Virus, Sandra
Odebrechet and her team investigated this perplexing problem. Their methodology consisted in running
various tests to find traces of the disease in the subjects, which some were mental patients. It is stated that
their procedures did not run through the risk of contamination because they followed the international safety
guidelines. This research project collected subjects' personal history information like smoking habits and
body mass index, which could play as an external factor. The groups of subjects were composed of 27
schizophrenic and schizoaffective patients, and 27 healthy volunteer controls. To obtain more data the
investigators introduced family members with and without mood disorders. As a result, the percentage of
BDV RNA was 44% of the schizophrenic subjects, 50% of relatives without mental disorders, and 37.5% for
relatives with mood disorders. This investigation covered many factors that other investigations did not, like
preventing contamination. This investigation provides more insight on geographical aspects because the lab
is located at Brazil. This benefits the review because there will be more variation in location for the statistics.
![Fall Semester 2012-13
Annotated Bibliography 4
Roll Book.# 6 Name Juan Enrique Maldonado Weng
Date: December 6, 2012
Annotated Bibliography 4:
S. Odebrechet, E. Nakagawa, M. Karine, E. Maria, H. Cristina, C. Eduardo, T. Matsuo, H. Odebrechet, and
M. Angelica. 2008. RNA From Borna Disease Virus in Patients With Schizophrenia, Schizoaffective Patients,
and in Their Biological Relatives. Journal of Clinical Laboratory Analysis, [Internet]; [Cited 2012 December 6].
DOI: 10.1002/jcla.20261: 22: 314–320 Available at:
http://onlinelibrary.wiley.com/doi/10.1002/jcla.20261/abstract
With the goal to establish the pathogenesis of schizophrenia through the Borna Disease Virus, Sandra
Odebrechet and her team investigated this perplexing problem. Their methodology consisted in running
various tests to find traces of the disease in the subjects, which some were mental patients. It is stated that
their procedures did not run through the risk of contamination because they followed the international safety
guidelines. This research project collected subjects' personal history information like smoking habits and
body mass index, which could play as an external factor. The groups of subjects were composed of 27
schizophrenic and schizoaffective patients, and 27 healthy volunteer controls. To obtain more data the
investigators introduced family members with and without mood disorders. As a result, the percentage of
BDV RNA was 44% of the schizophrenic subjects, 50% of relatives without mental disorders, and 37.5% for
relatives with mood disorders. This investigation covered many factors that other investigations did not, like
preventing contamination. This investigation provides more insight on geographical aspects because the lab
is located at Brazil. This benefits the review because there will be more variation in location for the statistics.](https://image.slidesharecdn.com/pub-annotatedbibliography4-121221175834-phpapp02/85/pub-annotated-bibliography-4-1-320.jpg)
