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Breast metastase
1.
2. Metastatic breast cancer
• stage IV
• Cancer cells can break away
from the original tumor in
the breast and travel to other
parts of the body
• Most of the time, metastatic
breast cancer affects the
bones, lungs, brain, or liver.
3. A metastatic tumor in a different
part of the body is made up of
cells from the breast cancer. So if
breast cancer spreads to the
bone, the metastatic tumor in the
bone is made up of breast cancer
cells, not bone cells!
4. Which cells exactly?
• Parenchymal cells of the breast
• Tumor arises from the lining of the
lactiferous ducts
• That’s why it is called - invasive
ductal carcinoma
5. How do the cells invade?
• Lymph nodes
• Most lymph (>75%) especially from
the lateral breast quadrants drain
to the axillary lymph nodes,
initially to the anterior (pectoral)
nodes for the most part.
• Most of the remaining lymph, from
the medial breast quadrants drain
to the parasternal lymph nodes or
to the opposite breast.
6. Bone metastasis
Most common
Mostly in ribs, spine, pelvis, and
long bones in the arms and legs.
Symptoms:
• Sudden severe pain
In the bones or joints
In the back or neck
• Fragile bones
• Numbness and weakness
• trouble urinating
• Constipation
• Nausea
• Lack of appetite
Vertebral
fracture
7. Lung metastasis
often doesn’t cause symptoms
If there are symptoms:
• pain or discomfort in the lung
• shortness of breath
• wheezing
• persistent cough
• coughing up blood and mucus
8. Brain Metastasis
About 10-15% of women with
stage IV breast cancer develop
brain metastases
High risk in most aggressive
subtypes (HER2-positive or triple-
negative breast cancer)
Symptoms:
• headache
• changes in senses
• memory problems
• mood or personality changes
• seizures
• stroke or “brain attack,” in which blood
supply to the brain is cut off
9. LIVER METASTASIS
often doesn’t cause symptoms
If there are symptoms:
• pain or discomfort in the mid-section
• fatigue and weakness
• weight loss/poor appetite
• fever
• swelling in the legs
• Jaundice
• Rashes on the skin
Metastatic breast cancer (also called stage IV) is breast cancer that has spread to another part of the body, most commonly the liver, brain, bones, or lungs.
Cancer cells can break away from the original tumor in the breast and travel to other parts of the body through the bloodstream or the lymphatic system, which is a large network of nodes and vessels that works to remove bacteria, viruses, and cellular waste products
A metastatic tumor in a different part of the body is made up of cells from the breast cancer. So if breast cancer spreads to the bone, the metastatic tumor in the bone is made up of breast cancer cells, not bone cells
49 years old male, called I.B, entered with the chief complaint: “Low backache and pain in the leg”
