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Chapter 6. Assessment of the
Patient
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Shelly F. Greenfield, M.D., M.P.H.Grace Hennessy, M.D.
A number of factors influence the accurate identification,
assessment, and
diagnosis of substance-related disorders among patients
presenting for
treatment. These include the clinical setting, the style of
interviewing, the attitude
of the clinician, and patient characteristics such as the presence
of co-occurring
medical and psychiatric disorders and the stage of use or abuse
of the substance.
The goals of assessing patients with substance-related disorders
are to 1) identify
the presence of a substance-related disorder, as well as signs of
harmful or
hazardous use so that prevention and early intervention may
take place; 2) make
an accurate diagnosis and relating this to any other co-occurring
medical or
psychiatric disorders; 3) identify barriers to treatment as well as
strengths and
supports; 4) assess and enhance the patient’s motivation to
change; and 5)
formulate and help to initiate appropriate evidence-based
interventions and
treatments. In this chapter, we review principles of eliciting a
substance use,
psychiatric, and medical history, as well as formulating an
accurate diagnosis.
Eliciting the Substance Abuse History
Interviewing Style
The clinician’s attitude and style of history taking can facilitate
a thorough and accurate
assessment. Patients with substance-related disorders often
report that they do not discuss their
substance use openly with physicians because of their feelings
of shame, discomfort, fear,
distrust, and hopelessness (Center for Substance Abuse
Treatment 2004; Weiss et al. 2000a).
Obstacles to obtaining an accurate history include the patient’s
defenses, such as denial,
minimization, rationalization, projection, and externalization
(Schottenfeld and Pantalon 1999).
Asking open-ended questions such as “What brought you here to
see me today?” may
circumvent these obstacles. Open-ended questions help the
clinician understand how the patient
defines the problem, and this can set the direction for the rest of
the interview.
Asking questions in an honest, respectful, and matter-of-fact
manner is likely to be most
effective (Center for Substance Abuse Treatment 2004).
Maintaining a nonjudgmental stance is
helpful to patients who may have feelings of shame or denial.
For example, a clinician may ask,
“How were you feeling before you drank?” rather than “Why
did you drink alcohol then?”
Another approach to reducing shame can be phrasing questions
in such a manner as “Some
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people who have alcohol problems experience blackouts. I
wonder if you have ever had that
experience.” This technique can help reduce shame by
conveying to the patient that there is a
range of experiences that others with similar problems have
had. It also demonstrates the
clinician’s knowledge about these experiences and ability to
hear the patient’s perspective.
Clinicians can also avoid using labels; instead, they can ask
patients to describe their pattern of
use without labeling it. For example, if the patient says, “I’m
not an addict. I just snort coke
sometimes,” the clinician can explain, “It would be helpful for
me to understand the pattern of
your cocaine use, so let’s look at this past week [or other period
of time].” Clinician attributes
that are effective in establishing a therapeutic alliance with
patients presenting with addiction
problems include a respectful, genuine, empathic, and
supportive style, as well as reflective
listening and a patient-centered approach (Center for Substance
Abuse Treatment 2004; Miller
and Rollnick 2012).
Patient Characteristics
The interview can also be influenced by a number of patient
characteristics that can affect the
clinical presentation of the substance-related disorder. These
characteristics include 1) age,
gender, partner or marital status, legal and employment status,
culture, and ethnicity; 2) level of
insight into as well as personal explanation for the nature of the
problem; 3) psychiatric or
medical comorbidity; 4) stage in the course of illness (e.g., first
treatment, recovery, recent
relapse); 5) current phase of use (e.g., intoxicated, withdrawing,
interepisode); and 6) stage of
readiness for change.
For example, an interview with an adolescent who is dependent
on marijuana may require a
different style of interviewing than an interview with an elderly
widow who developed a
drinking problem in the years after her husband’s death. Women
may be more likely than men to
explain their presenting problem as mood or anxiety related and
may see their drinking or
substance use as a result of these difficulties and not as the
primary problem (Greenfield et al.
2007). Cultural norms may differ regarding the quantity or
frequency of substance use and may
affect the social acceptability and the patient’s description of
his or her use (Westermeyer 2009).
A patient’s marital or partner status and employment status may
also influence his or her
presentation; individuals may present for evaluation because of
the urging or demands of
significant others or because of work or legal complications
resulting from substance use. The
clinical presentation may also vary depending on whether the
patient presents for treatment early
in the course of illness or at a more advanced phase of illness.
The current phase of drug use will also influence the clinical
presentation and interview. Patients
may present in a state of intoxication, withdrawal, remission,
slip, relapse, or maintenance. The
clinician is unlikely to elicit a valid history from an acutely
intoxicated patient (Babor et al.
1987). If possible, an interview during intoxication may be
confined to the ascertainment of
acute medical conditions in need of intervention. The complete
history is best deferred to a time
when the patient is no longer intoxicated.
Clinicians may interview substance-using patients when they
are requesting detoxification or
exhibiting signs and symptoms of acute withdrawal (American
Psychiatric Association 2006). In
this circumstance, determining the medical need for
detoxification and preventing withdrawal
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complications are the most important goals of the assessment.
The clinician must first assess for
signs and symptoms of withdrawal because untreated
withdrawal from alcohol or sedatives,
hypnotics, or anxiolytics (e.g., benzodiazepines, barbiturates)
can result in seizures, delirium
tremens, and death. Although opioid withdrawal is not
associated with severe medical
complications, inpatient detoxification may be necessary to
ameliorate withdrawal symptoms
that, if left untreated, could result in ongoing opioid use.
Withdrawal syndromes associated with
the use of marijuana and stimulants such as cocaine and
amphetamines do not require inpatient
detoxification (American Psychiatric Association 2006).
Nicotine withdrawal is also managed on
an outpatient basis (American Psychiatric Association 2006).
A patient may also present in full remission from a substance-
related disorder but may report
symptoms of another medical or psychiatric illness or a new
onset of urges and craving. It will be
important to find out the supports the patient has used to
maintain abstinence and recovery, to
examine how any other chronic or new-onset illnesses may be
affecting the patient’s recovery,
and to ascertain what types of treatments or interventions may
help support the patient’s ongoing
recovery. Similarly, a patient who presents with a recent slip or
relapse to substance use may be
directed toward understanding the triggers to the recent drug
use, as well as attempting to
identify strategies that will limit the relapse and help the patient
get back on the recovery track.
The patient’s current stage of motivation for change can affect
the interview (Prochaska et al.
1992). The interview with a patient who is precontemplative
will usually require more probing to
elicit the history. Interview strategies that focus on establishing
a pattern of use and that then
elicit advantages and disadvantages of such use may be helpful.
The clinician might use a
calendar method to determine days of use in the past week,
month, 3 months, 6 months, and year
(Sobell et al. 1992). For more recent time periods, the clinician
can ask for patterns of use (type
of substance, quantity, frequency, time of day, etc.) for each
day of the past week or month. For
more distant time periods, the questions may focus on seasonal
events, such as winter holidays,
or important life events, such as birthdays. Alternatively, the
clinician might ask the patient to
compare the past month’s substance use to previous 6-month
time intervals to determine if
substance use has lessened or increased over time.
A similar interviewing style can be used to obtain the lifetime
substance use history, with the
clinician asking for patterns of use during successive
developmental periods, such as childhood,
adolescence, young adulthood, and so on. Anchoring questions
to educational achievements and
other important life events (e.g., marriage, employment,
military service) can also help the
clinician understand the course of substance use throughout the
lifespan. After these use patterns
are identified, the patient might be encouraged to identify ways
in which he or she perceives that
substance use has caused negative consequences for him or her.
This interview will likely differ
from interviews with patients who have had a brief relapse after
a sustained period of recovery.
Eliciting the patient’s earlier history is likely to be more
straightforward and to require less
probing. These interviews are more likely to focus on the nature
of the relapse, the particular
triggers to substance use, the consequences of the relapse, and
the plans to help the patient return
to abstinence and recovery.
It is important to reserve time at the end of the interview to
summarize what the clinician has
heard about the patient’s history, the way in which the clinician
formulates this information, any
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diagnostic implications that the clinician is considering, and
any possible treatment options and
recommendations. The clinician may begin this part of the
interview by informing the patient
that feedback about the patient’s history will be provided but
then asking the patient if he or she
wants to add any information that has not been discussed or
asked. After the patient has had a
chance to add any further information, the clinician can present
what he or she has heard. It is
often useful to first let the patient know of any particular risk
factors or vulnerabilities that he or
she may have. For example, the clinician might say, “It sounds
to me as if you have a number of
risk factors. You reported that both parents had alcohol
problems, and we know that this is likely
to have made you more vulnerable to the substance. Second, you
reported that you have
struggled with a mood disorder, and we know that often patients
with other psychiatric disorders
such as mood disorders are more vulnerable to developing drug
and alcohol problems.” Then the
clinician might summarize the history the patient has given and
relate the key elements of the
history to specific diagnostic criteria. This should then lead to a
formulation of the diagnosis and
the treatment implications.
When the clinician is in the process of eliciting key elements of
the history that will allow him or
her to formulate the diagnosis and to relate these elements back
to the patient in a straightforward
manner, it is important to have in mind the diagnostic criteria
and to use the interview to elicit
history that will help establish a differential diagnosis and
exclude or include the likely diagnosis
for the particular patient.
Diagnosing Substance-Related Disorders
Substance-Related Disorders
In DSM-5 (American Psychiatric Association 2013), the DSM-
IV-TR (American Psychiatric
Association 2000) diagnoses of substance abuse and substance
dependence have been replaced
with one diagnosis, substance use disorder. Although each
substance has its own substance use
disorder criteria, criteria for substance use disorders are similar
across the different substances
(see Box 6–1). In general, a substance use disorder is described
as a problematic pattern of
substance use leading to clinically significant impairment or
distress, as manifested by at least
two symptoms occurring in a 12-month period. Current severity
for substance use disorders is
described as mild if two to three symptoms are present,
moderate if four to five symptoms are
present, or severe if six or more symptoms are present. The
criteria for substance-related
disorders are listed in the appendix to this textbook.
DSM-5 Diagnostic Criteria for Substance Use Disorder
A. A problematic pattern of use leading to clinically significant
impairment or distress, as
manifested by at least two of the following, occurring within a
12-month period:
1.
1. The substance is often taken in larger amounts or over a
longer period than
was intended.
2. There is a persistent desire or unsuccessful efforts to cut
down or control
use.
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3. A great deal of time is spent in activities necessary to obtain
the substance,
use the substance, or recover from its effects.
4. Craving, or a strong desire or urge to use the substance.
5. Recurrent substance use resulting in a failure to fulfill major
role
obligations at work, school, or home.
6. Continued substance use despite having persistent or
recurrent social or
interpersonal problems caused or exacerbated by the effects of
the
substance.
7. Important social, occupational, or recreational activities are
given up or
reduced because of substance use.
8. Recurrent substance use in situations in which it is physically
hazardous.
9. Substance use is continued despite knowledge of having a
persistent or
recurrent physical or psychological problem that is likely to
have been
caused or exacerbated by the substance.
10. Tolerance, as defined by either of the following:
a. A need for markedly increased amounts of the substance to
achieve
intoxication or desired effect.
b. A markedly diminished effect with continued use of the same
amount of the substance.
11. Withdrawal, as manifested by either of the following:
a. The characteristic withdrawal syndrome for the substance
(refer to
Criteria A and B of the specific criteria sets in the appendix to
this
textbook for withdrawal from the specific substances.
b. The substance (or a closely related substance) is taken to
relieve or
avoid withdrawal symptoms.
phencyclidines, hallucinogens, and inhalants, and so this
criterion
does not apply for those substances.
Specify if:
Specify if:
use disorder only)
Specify current severity:
: Presence of 2–3 symptoms.
–5 symptoms.
DSM-5 also provides for a number of course specifiers. In early
remission is specified if none of
the substance-related disorder criteria have been met for at least
3 months but for less than 12
months. In sustained remission is specified when none of the
criteria have been present for 12
months or longer. It should be noted that for these remission
specifiers, the criterion “craving, or
a strong desire or urge to use” the substance, may be met. For
opioid use disorder, the additional
specifier on maintenance therapy is used if the individual is
taking a prescribed agonist, partial
agonist, or agonist/antagonist medication and no criteria for the
opioid-related disorder have
been met for that class of medication (except tolerance to, or
withdrawal from, the agonist
medication). This specifier is also used for tobacco-related
disorder when long-term maintenance
medications, such as nicotine replacement therapies, are
prescribed. The specifier in a controlled
environment is similarly used when the individual is in an
environment where there is restricted
access to substances. Such an environment could be a locked
hospital unit, a supervised
residential setting, or a substance-free prison.
Substance Intoxication and Substance Withdrawal
Substance intoxication occurs after the recent use of a substance
and causes clinically significant
problematic behavioral or psychological changes that developed
during or shortly after substance
use. Substance withdrawal occurs when there is a reduction in
or cessation of substance use that
has been heavy or prolonged and symptoms characteristic of
withdrawal from a particular
substance are experienced. Although all categories of
substances except tobacco produce an
intoxication syndrome, the symptoms, signs, and durations of
the syndromes vary by substance
category. On the other hand, according to DSM-5,
phencyclidine and other hallucinogens, and
inhalants, do not produce a withdrawal syndrome. Knowledge of
the syndromes characteristic of
each category of substances is important in eliciting an accurate
history and clinical status.
Content of the Interview
Understanding the major categories of addictive substances
provides the interviewer with
knowledge about their characteristic intoxication and
withdrawal syndromes. This knowledge
helps the interviewer assess the patient and make appropriate
treatment recommendations. It is
important to ask patients about all categories of substances and
not only the primary substance.
The major categories of addictive substances are listed in Table
6–1.
History of the Substance-Related Disorder Major categories of
substances of
abuse
Enlarge table
A systematic and organized way of collecting information about
the patient’s history of
substance use is to address the following areas: 1) age at first
substance use, 2) frequency of
substance use, 3) amount of substance taken during an episode
of use, 4) route of administration
for the substance, 5) consequences associated with substance
use, 6) treatment history, 7) periods
of abstinence, and 8) relapses.
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The information obtained by asking about the age at first
substance use serves as the framework
for the history and guides the interviewer’s subsequent
questions. In addition, the age when the
patient began using substances has diagnostic and prognostic
implications. Early onset (before
age 15 years) of substance use is associated with the subsequent
development of substance-
related disorders (Chen et al. 2005; Hingson et al. 2006).
Inquiries about the frequency of substance use as well as the
amount of the substance used and
the route of administration (oral, inhaled, insufflated or snorted,
intravenous, subcutaneous) help
the interviewer understand the progression of substance use
over time. For example, a patient
who says she started snorting (route of administration) one bag
(amount) of heroin once a week
for 1 year (frequency) and then began injecting three bags of
heroin per day is reporting her
progression of heroin use in all three areas. In addition, the
frequency, amount, and route of
administration of use may be related to the development of
medical disorders associated with a
particular substance.
General questions about the consequences of substance use
focus on changes in academic
performance, occupational functioning, and interpersonal
relationships, as well as medical and
legal problems associated with substance use. The history of
addiction treatment includes
questions about hospital admissions for detoxification, as well
as admissions to other controlled
living situations (e.g., residential programs, halfway houses,
sober houses, therapeutic
communities) to support ongoing abstinence. Outpatient
programs such as partial hospital
programs, as well as group, individual, and pharmacological
therapies (e.g., disulfiram,
naltrexone, buprenorphine-naloxone, methadone, nicotine
replacement therapies), may also be a
part of the patient’s prior treatment. Understanding which
earlier treatments did or did not help
the patient achieve and maintain abstinence can serve as a guide
for treatment recommendations.
The interviewer should also ask about involvement in self-help
groups (e.g., Alcoholics
Anonymous, Narcotics Anonymous, Self-Management and
Recovery Training, Rational
Recovery, Women for Sobriety). Some patients may express
positive or negative feelings about a
particular type of self-help group. The interviewer should not
support or discredit the patient’s
feelings about self-help groups but instead should seek to
understand the patient’s experiences,
both to educate the patient about the effectiveness of self-help
groups and to formulate a realistic
treatment plan that will benefit the patient.
Information about a patient’s periods of abstinence as well as
relapses indicates the progression
or remission of substance use, the severity of the disorder, and
external factors—such as
interpersonal, psychiatric, occupational, legal or medical
problems, and treatment termination—
that may have influenced the return to substance use. The
interviewer should also review current
use of all substances even if no history of past use has been
provided from which to ascertain
current use patterns.
Psychiatric History
There is an increased prevalence of substance-related disorders
among patients diagnosed with
other psychiatric disorders (Compton et al. 2007; Kessler et al.
1997; Regier et al. 1990).
Conversely, patients diagnosed with substance-related disorders
are more likely to have a co-
occurring psychiatric disorder (Brady et al. 1991; Currie et al.
2005; Mueser et al. 2000). Studies
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have shown that the co-occurring substance-related and
psychiatric disorders can each worsen
the prognosis for the other disorder (Greenfield et al. 1998;
Hides et al. 2006; Nunes and Levin
2004). When coexisting substance-related and psychiatric
disorders are diagnosed, patients can
be referred to integrated treatment for both disorders. Because
evidence suggests that integrated
treatment improves and enhances outcomes for both disorders
(Bennett et al. 2001; Najavits et al.
1998, 2005; Weiss et al. 2000b), it is important to assess
substance-related disorders in patients
presenting for treatment of other psychiatric disorders and
equally important to assess psychiatric
disorders among patients presenting for treatment of substance-
related disorders.
If the patient reports symptoms consistent with a psychiatric
disorder, the interviewer should
inquire about the relationship between substance use and the
emergence, exacerbation, or
regression of psychiatric symptoms. A diagnosis of a substance-
induced mental disorder is made
when the development of the full criteria for a mental disorder
occurs during or within 1 month
of an intoxication with or withdrawal from a substance that is
capable of causing the mental
disorder (American Psychiatric Association 2013). A mental
disorder would be considered
independent of a substance if the disorder preceded the onset of
severe intoxication or
withdrawal, or if the mental disorder persisted for a substantial
period of time (e.g., at least 1
month) after substance intoxication or substance withdrawal
ended. Additionally, the disorder
cannot occur exclusively during the course of a delirium and the
disorder must cause clinically
significant distress or impairment in important areas of
functioning. DSM-5 criteria for other
psychiatric disorders include the specifiers with onset during
intoxication and with onset during
discontinuation/withdrawal. Reviewing the patient’s history of
psychiatric symptoms before the
onset of substance use, during episodes of intoxication with or
withdrawal from substances, and
after cessation of substance use can help the interviewer
distinguish between substance-induced
mental disorders and co-occurring psychiatric and substance-
related disorders.
A complete medical history—including current and past medical
problems, surgical procedures,
and medication allergies—is necessary for patients presenting
for assessment of a substance-
related disorder. Medical problems require treatment regardless
of their relationship to substance
use, and the interviewing clinician should make treatment
recommendations or referrals for
further evaluation for any conditions. In addition, patients with
substance-related disorders have
often neglected their health and routine medical care and are at
risk for a number of co-occurring
medical disorders. The clinician should ask about the dates of
the last complete physical
examination and follow-ups for any medical problems, past or
current. For each medical
condition, the interviewer should try to determine whether the
symptoms are related to or
independent of substance use. Questions about a reported
medical problem should include
inquiries about the temporal relationship between the
development of the medical condition and
substance use. It is also important to ask about current and past
medical problems that are
specific to use of a particular substance. A description of all the
medical problems associated
with each category of substances is beyond the scope of this
chapter; the major medical problems
and disorders associated with the more commonly abused
substances are listed in Table 6–2.
Medical History Medical problems associated with substance-
related
disorders
Enlarge table
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Obtaining a reproductive health history is important in the
evaluation of women with substance-
related disorders. Relevant history among women of
childbearing age includes a menstrual
history and determining whether the patient is or may be
pregnant. Women who know they are
pregnant may want additional information on risk of substance
use. A pregnancy test can be
offered if a pregnancy is in question. Pregnancy can serve as a
powerful motivator for cessation
of substance use, and pregnant women may wish to seek
substance abuse treatment that has
specialized services (Brady and Ashley 2005). During different
phases of the menstrual cycle,
women can experience changes in craving and substance use, as
well as differences in likelihood
of stopping their substance use (Greenfield et al. 2011).
Changes in sleep or symptoms such as
hot flashes may be relevant factors in the use of substances for
perimenopausal and
postmenopausal women.
Lastly, understanding the relationship between the development
and exacerbation of the patient’s
medical disorders and the patient’s substance use provides the
interviewer with information that
may motivate the patient to change addictive behavior. The
medical history will also provide the
information necessary to refer the patient to appropriate medical
care regardless of the origin of
the medical disorder.
Family History
The family history of substance-related disorders may reveal a
genetic vulnerability to the
patient’s own development of these disorders (Agrawal and
Lynskey 2008). The environment
created by families with substance-related disorders may also
have an impact on the
development of substance-related disorders in their children.
Interviewers can educate patients
about genetic vulnerability and family environmental factors
associated with substance-related
disorders. This information may provide patients with an
understanding of their current problems
with substances as well as compelling reasons why they should
refrain from substance use.
Social and Developmental History
Important psychosocial factors to explore include the patient’s
relationships with others, the
influence of these relationships on both initiation and continued
use of substances, and the
existence of any supportive relationships that help the patient
abstain from substances or stop
using substances after starting. Childhood physical or sexual
abuse (Nelson et al. 2006) is a risk
factor for the development of substance-related disorders as
well as for poorer drinking outcomes
(Greenfield et al. 2002) and psychiatric outcomes (Pirard et al.
2005). Developing meaningful
interpersonal relationships, however, can help patients build a
social network that supports
recovery (Havassy et al. 1991). The presence or absence of a
spouse or partner can have an
important influence on the development and perpetuation of a
substance-related disorder (Hser et
al. 1987) and may also have positive or negative effects on
treatment outcomes (Walitzer and
Dearing 2006). Educational attainment and employment can be
affected by substance use.
Substance use may lead to school absenteeism, poor school
performance, and dropout (Lynskey
and Hall 2000; Lynskey et al. 2003); lower educational status
(Crum et al. 1998); and lower
income (Mullahy and Sindelar 1989).
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Physical and mental status examinations of patients presenting
for an assessment of a substance-
related disorder are critical parts of the evaluation because both
medical and psychiatric
disorders are commonly found in this population. Although a
mental status examination can and
must be performed regardless of the treatment setting, the
interviewer may be unable to perform
a physical examination due to lack of appropriate space,
equipment, and training. Patient factors
such as refusal to undergo an examination or inability to
cooperate with the examination due to
substance intoxication or withdrawal may also be reasons to
defer the physical examination.
Under such circumstances, the interviewer should refer the
patient to the appropriate person
(e.g., primary care physician) or facility (e.g., emergency room)
for a complete physical
examination.
Specific signs of substance use that may present during the
physical or mental status examination
will depend on the type of substance used and the presence of
intoxication with or withdrawal
from substances (Washburn 2002). The signs and symptoms of
substance intoxication and
withdrawal, according to DSM-5, are listed in Tables 6–3 and
6–4, respectively.
Physical and Mental Status Examinations DSM-5 signs and
symptoms of
substance intoxication
Enlarge table
Physical and Mental Status Examinations DSM-5 signs and
symptoms of
substance withdrawal
Enlarge table
Although many physical signs of substance use are easily
observed when the interviewer
performs the mental status examination, other signs of
substance use are best detected by
performing a thorough physical examination. For example, a
patient with hepatic damage as a
result of chronic alcohol use or hepatitis infection resulting
from intravenous drug use may
present with a slightly enlarged liver or, in more advanced cases
of hepatic damage, jaundice,
abdominal distention secondary to ascites, gynecomastia, spider
angiomas, palmar erythema, and
caput medusa. A complete description of all the physical
findings associated with substance use
is beyond the scope of this chapter; this example is presented to
illustrate the importance of a
thorough physical examination to detect other signs of
substance-related medical disorders that
require immediate treatment.
The physical and mental status examinations of a patient
presenting for an evaluation of a
substance-related disorder can be dramatically affected by states
of intoxication or withdrawal.
Alterations in mood, affect, psychiatric symptoms, thought
processes, thought content, speech,
memory, orientation, cognition, insight, and judgment are
commonly seen when patients are
intoxicated with or are withdrawing from a particular substance.
Similarly, substance
intoxication or withdrawal can lead to significant changes in the
patient’s physiological state,
including abnormalities in blood pressure, body temperature,
and level of consciousness, as well
as disruption in the stability and functioning of major organ
systems such as the neurological and
gastrointestinal systems. In addition, the mental status
examination provides important
information for the diagnosis of other psychiatric disorders and
for the evaluation of the current
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remission, recurrence, or stability of any other concurrent
psychiatric disorder. A comparison of
the patient’s physical and mental status examinations during
different stages of substance abuse
treatment is one way to evaluate changes in substance use and
in any concurrent medical and
psychiatric disorders.
Obtaining Additional Information
A patient’s significant others can often serve as collateral
informants who can
corroborate and provide additional information about the
patient’s reported
substance use history (Carroll 1995). Speaking with the
patient’s significant
others also allows for their early involvement in treatment
planning and may help
in establishing social networks that can potentially support the
patient’s recovery
and help maintain abstinence (Havassy et al. 1991). Contact
with collateral
informants should occur only with written permission from the
patient.
Biological markers can help in detecting the degree and
regularity of the patient’s
substance use (Kolodziej et al. 2002) and may be useful in spite
of the limitations
of each specific test. These tests include breath alcohol testing,
quantitative urine
or serum drug screens, and serum tests for blood markers of
hepatic dysfunction
or hematological problems. Finally, a number of standardized
instruments exist
for screening, diagnostic assessment, and evaluation of severity
and may be
helpful in the overall assessment of the patient (Knight et al.
2003).
Conclusion
In this chapter we have discussed the importance of assessing
substance use in all
patients seen in the clinical setting. We have outlined the
content areas of inquiry
of the interview as well as the adjunctive use of the physical
examination and
mental status examination. A careful and accurate assessment of
the patient will
provide the necessary information for intervention and
treatment planning and
will increase motivation by beginning to engage the patient in
the process of
change.
Key Points
1. Successful treatment of substance-related disorders depends
on a careful,
accurate assessment and diagnosis.
2. Accurate assessment is facilitated by interview settings that
provide privacy
and patient confidentiality and that permit adequate time to ask
key
questions, to follow up on positive patient responses, and to
give feedback
to the patient.
3. A substance use history should be obtained from all patients
presenting for
treatment.
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4. Patient assessment can be influenced by a number of patient
characteristics, including the patient’s age, gender, ethnicity,
and legal,
marital, and employment status; degree of insight into the
nature of the
problem; medical or psychiatric comorbidity; stage in the
course of illness
(e.g., recovery, recent relapse, first treatment); current phase of
use (e.g.,
intoxication, withdrawal, interepisode); and stage of readiness
for change
and motivation.
5. A complete substance use assessment requires eliciting the
history of use
for all the major categories of substances, with a focus on age at
first use,
frequency and amount of use, consequences of use, substance
abuse
treatment history, and complete psychiatric, medical and social,
and
developmental histories.
6. Collateral informant interviews, standardized questionnaires,
and
biological testing may also provide additional helpful
information for some
patients.
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  • 1. Chapter 6. Assessment of the Patient https://doi- org.ezp.waldenulibrary.org/10.1176/appi.books.9781615370030. mg06 Shelly F. Greenfield, M.D., M.P.H.Grace Hennessy, M.D. A number of factors influence the accurate identification, assessment, and diagnosis of substance-related disorders among patients presenting for treatment. These include the clinical setting, the style of interviewing, the attitude of the clinician, and patient characteristics such as the presence of co-occurring medical and psychiatric disorders and the stage of use or abuse of the substance. The goals of assessing patients with substance-related disorders are to 1) identify the presence of a substance-related disorder, as well as signs of harmful or hazardous use so that prevention and early intervention may take place; 2) make an accurate diagnosis and relating this to any other co-occurring medical or psychiatric disorders; 3) identify barriers to treatment as well as strengths and supports; 4) assess and enhance the patient’s motivation to change; and 5) formulate and help to initiate appropriate evidence-based
  • 2. interventions and treatments. In this chapter, we review principles of eliciting a substance use, psychiatric, and medical history, as well as formulating an accurate diagnosis. Eliciting the Substance Abuse History Interviewing Style The clinician’s attitude and style of history taking can facilitate a thorough and accurate assessment. Patients with substance-related disorders often report that they do not discuss their substance use openly with physicians because of their feelings of shame, discomfort, fear, distrust, and hopelessness (Center for Substance Abuse Treatment 2004; Weiss et al. 2000a). Obstacles to obtaining an accurate history include the patient’s defenses, such as denial, minimization, rationalization, projection, and externalization (Schottenfeld and Pantalon 1999). Asking open-ended questions such as “What brought you here to see me today?” may circumvent these obstacles. Open-ended questions help the clinician understand how the patient defines the problem, and this can set the direction for the rest of the interview.
  • 3. Asking questions in an honest, respectful, and matter-of-fact manner is likely to be most effective (Center for Substance Abuse Treatment 2004). Maintaining a nonjudgmental stance is helpful to patients who may have feelings of shame or denial. For example, a clinician may ask, “How were you feeling before you drank?” rather than “Why did you drink alcohol then?” Another approach to reducing shame can be phrasing questions in such a manner as “Some https://doi- org.ezp.waldenulibrary.org/10.1176/appi.books.9781615370030. mg06 https://doi- org.ezp.waldenulibrary.org/10.1176/appi.books.9781615370030. mg06 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e670 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1873 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1781 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e670
  • 4. people who have alcohol problems experience blackouts. I wonder if you have ever had that experience.” This technique can help reduce shame by conveying to the patient that there is a range of experiences that others with similar problems have had. It also demonstrates the clinician’s knowledge about these experiences and ability to hear the patient’s perspective. Clinicians can also avoid using labels; instead, they can ask patients to describe their pattern of use without labeling it. For example, if the patient says, “I’m not an addict. I just snort coke sometimes,” the clinician can explain, “It would be helpful for me to understand the pattern of your cocaine use, so let’s look at this past week [or other period of time].” Clinician attributes that are effective in establishing a therapeutic alliance with patients presenting with addiction problems include a respectful, genuine, empathic, and supportive style, as well as reflective listening and a patient-centered approach (Center for Substance Abuse Treatment 2004; Miller and Rollnick 2012). Patient Characteristics
  • 5. The interview can also be influenced by a number of patient characteristics that can affect the clinical presentation of the substance-related disorder. These characteristics include 1) age, gender, partner or marital status, legal and employment status, culture, and ethnicity; 2) level of insight into as well as personal explanation for the nature of the problem; 3) psychiatric or medical comorbidity; 4) stage in the course of illness (e.g., first treatment, recovery, recent relapse); 5) current phase of use (e.g., intoxicated, withdrawing, interepisode); and 6) stage of readiness for change. For example, an interview with an adolescent who is dependent on marijuana may require a different style of interviewing than an interview with an elderly widow who developed a drinking problem in the years after her husband’s death. Women may be more likely than men to explain their presenting problem as mood or anxiety related and may see their drinking or substance use as a result of these difficulties and not as the primary problem (Greenfield et al.
  • 6. 2007). Cultural norms may differ regarding the quantity or frequency of substance use and may affect the social acceptability and the patient’s description of his or her use (Westermeyer 2009). A patient’s marital or partner status and employment status may also influence his or her presentation; individuals may present for evaluation because of the urging or demands of significant others or because of work or legal complications resulting from substance use. The clinical presentation may also vary depending on whether the patient presents for treatment early in the course of illness or at a more advanced phase of illness. The current phase of drug use will also influence the clinical presentation and interview. Patients may present in a state of intoxication, withdrawal, remission, slip, relapse, or maintenance. The clinician is unlikely to elicit a valid history from an acutely intoxicated patient (Babor et al. 1987). If possible, an interview during intoxication may be confined to the ascertainment of acute medical conditions in need of intervention. The complete history is best deferred to a time when the patient is no longer intoxicated.
  • 7. Clinicians may interview substance-using patients when they are requesting detoxification or exhibiting signs and symptoms of acute withdrawal (American Psychiatric Association 2006). In this circumstance, determining the medical need for detoxification and preventing withdrawal https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e670 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1381 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1381 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e941 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e941 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1966 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e496 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e496 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161
  • 8. 5370030.mg06#u2014-04-03T12581333-0400d1e483 complications are the most important goals of the assessment. The clinician must first assess for signs and symptoms of withdrawal because untreated withdrawal from alcohol or sedatives, hypnotics, or anxiolytics (e.g., benzodiazepines, barbiturates) can result in seizures, delirium tremens, and death. Although opioid withdrawal is not associated with severe medical complications, inpatient detoxification may be necessary to ameliorate withdrawal symptoms that, if left untreated, could result in ongoing opioid use. Withdrawal syndromes associated with the use of marijuana and stimulants such as cocaine and amphetamines do not require inpatient detoxification (American Psychiatric Association 2006). Nicotine withdrawal is also managed on an outpatient basis (American Psychiatric Association 2006). A patient may also present in full remission from a substance- related disorder but may report symptoms of another medical or psychiatric illness or a new onset of urges and craving. It will be important to find out the supports the patient has used to
  • 9. maintain abstinence and recovery, to examine how any other chronic or new-onset illnesses may be affecting the patient’s recovery, and to ascertain what types of treatments or interventions may help support the patient’s ongoing recovery. Similarly, a patient who presents with a recent slip or relapse to substance use may be directed toward understanding the triggers to the recent drug use, as well as attempting to identify strategies that will limit the relapse and help the patient get back on the recovery track. The patient’s current stage of motivation for change can affect the interview (Prochaska et al. 1992). The interview with a patient who is precontemplative will usually require more probing to elicit the history. Interview strategies that focus on establishing a pattern of use and that then elicit advantages and disadvantages of such use may be helpful. The clinician might use a calendar method to determine days of use in the past week, month, 3 months, 6 months, and year (Sobell et al. 1992). For more recent time periods, the clinician can ask for patterns of use (type of substance, quantity, frequency, time of day, etc.) for each
  • 10. day of the past week or month. For more distant time periods, the questions may focus on seasonal events, such as winter holidays, or important life events, such as birthdays. Alternatively, the clinician might ask the patient to compare the past month’s substance use to previous 6-month time intervals to determine if substance use has lessened or increased over time. A similar interviewing style can be used to obtain the lifetime substance use history, with the clinician asking for patterns of use during successive developmental periods, such as childhood, adolescence, young adulthood, and so on. Anchoring questions to educational achievements and other important life events (e.g., marriage, employment, military service) can also help the clinician understand the course of substance use throughout the lifespan. After these use patterns are identified, the patient might be encouraged to identify ways in which he or she perceives that substance use has caused negative consequences for him or her. This interview will likely differ from interviews with patients who have had a brief relapse after a sustained period of recovery.
  • 11. Eliciting the patient’s earlier history is likely to be more straightforward and to require less probing. These interviews are more likely to focus on the nature of the relapse, the particular triggers to substance use, the consequences of the relapse, and the plans to help the patient return to abstinence and recovery. It is important to reserve time at the end of the interview to summarize what the clinician has heard about the patient’s history, the way in which the clinician formulates this information, any https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e483 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e483 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1693 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1693 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1799 diagnostic implications that the clinician is considering, and
  • 12. any possible treatment options and recommendations. The clinician may begin this part of the interview by informing the patient that feedback about the patient’s history will be provided but then asking the patient if he or she wants to add any information that has not been discussed or asked. After the patient has had a chance to add any further information, the clinician can present what he or she has heard. It is often useful to first let the patient know of any particular risk factors or vulnerabilities that he or she may have. For example, the clinician might say, “It sounds to me as if you have a number of risk factors. You reported that both parents had alcohol problems, and we know that this is likely to have made you more vulnerable to the substance. Second, you reported that you have struggled with a mood disorder, and we know that often patients with other psychiatric disorders such as mood disorders are more vulnerable to developing drug and alcohol problems.” Then the clinician might summarize the history the patient has given and relate the key elements of the history to specific diagnostic criteria. This should then lead to a
  • 13. formulation of the diagnosis and the treatment implications. When the clinician is in the process of eliciting key elements of the history that will allow him or her to formulate the diagnosis and to relate these elements back to the patient in a straightforward manner, it is important to have in mind the diagnostic criteria and to use the interview to elicit history that will help establish a differential diagnosis and exclude or include the likely diagnosis for the particular patient. Diagnosing Substance-Related Disorders Substance-Related Disorders In DSM-5 (American Psychiatric Association 2013), the DSM- IV-TR (American Psychiatric Association 2000) diagnoses of substance abuse and substance dependence have been replaced with one diagnosis, substance use disorder. Although each substance has its own substance use disorder criteria, criteria for substance use disorders are similar across the different substances (see Box 6–1). In general, a substance use disorder is described as a problematic pattern of
  • 14. substance use leading to clinically significant impairment or distress, as manifested by at least two symptoms occurring in a 12-month period. Current severity for substance use disorders is described as mild if two to three symptoms are present, moderate if four to five symptoms are present, or severe if six or more symptoms are present. The criteria for substance-related disorders are listed in the appendix to this textbook. DSM-5 Diagnostic Criteria for Substance Use Disorder A. A problematic pattern of use leading to clinically significant impairment or distress, as manifested by at least two of the following, occurring within a 12-month period: 1. 1. The substance is often taken in larger amounts or over a longer period than was intended. 2. There is a persistent desire or unsuccessful efforts to cut down or control use. https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e490 https://psychiatryonline-
  • 15. org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e477 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e477 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#BABJHGAJ 3. A great deal of time is spent in activities necessary to obtain the substance, use the substance, or recover from its effects. 4. Craving, or a strong desire or urge to use the substance. 5. Recurrent substance use resulting in a failure to fulfill major role obligations at work, school, or home. 6. Continued substance use despite having persistent or recurrent social or interpersonal problems caused or exacerbated by the effects of the substance. 7. Important social, occupational, or recreational activities are given up or reduced because of substance use. 8. Recurrent substance use in situations in which it is physically hazardous. 9. Substance use is continued despite knowledge of having a persistent or
  • 16. recurrent physical or psychological problem that is likely to have been caused or exacerbated by the substance. 10. Tolerance, as defined by either of the following: a. A need for markedly increased amounts of the substance to achieve intoxication or desired effect. b. A markedly diminished effect with continued use of the same amount of the substance. 11. Withdrawal, as manifested by either of the following: a. The characteristic withdrawal syndrome for the substance (refer to Criteria A and B of the specific criteria sets in the appendix to this textbook for withdrawal from the specific substances. b. The substance (or a closely related substance) is taken to relieve or avoid withdrawal symptoms. phencyclidines, hallucinogens, and inhalants, and so this criterion does not apply for those substances. Specify if:
  • 17. Specify if: use disorder only) Specify current severity: : Presence of 2–3 symptoms. –5 symptoms. DSM-5 also provides for a number of course specifiers. In early remission is specified if none of the substance-related disorder criteria have been met for at least 3 months but for less than 12 months. In sustained remission is specified when none of the criteria have been present for 12 months or longer. It should be noted that for these remission specifiers, the criterion “craving, or a strong desire or urge to use” the substance, may be met. For opioid use disorder, the additional
  • 18. specifier on maintenance therapy is used if the individual is taking a prescribed agonist, partial agonist, or agonist/antagonist medication and no criteria for the opioid-related disorder have been met for that class of medication (except tolerance to, or withdrawal from, the agonist medication). This specifier is also used for tobacco-related disorder when long-term maintenance medications, such as nicotine replacement therapies, are prescribed. The specifier in a controlled environment is similarly used when the individual is in an environment where there is restricted access to substances. Such an environment could be a locked hospital unit, a supervised residential setting, or a substance-free prison. Substance Intoxication and Substance Withdrawal Substance intoxication occurs after the recent use of a substance and causes clinically significant problematic behavioral or psychological changes that developed during or shortly after substance use. Substance withdrawal occurs when there is a reduction in or cessation of substance use that has been heavy or prolonged and symptoms characteristic of withdrawal from a particular
  • 19. substance are experienced. Although all categories of substances except tobacco produce an intoxication syndrome, the symptoms, signs, and durations of the syndromes vary by substance category. On the other hand, according to DSM-5, phencyclidine and other hallucinogens, and inhalants, do not produce a withdrawal syndrome. Knowledge of the syndromes characteristic of each category of substances is important in eliciting an accurate history and clinical status. Content of the Interview Understanding the major categories of addictive substances provides the interviewer with knowledge about their characteristic intoxication and withdrawal syndromes. This knowledge helps the interviewer assess the patient and make appropriate treatment recommendations. It is important to ask patients about all categories of substances and not only the primary substance. The major categories of addictive substances are listed in Table 6–1. History of the Substance-Related Disorder Major categories of substances of abuse
  • 20. Enlarge table A systematic and organized way of collecting information about the patient’s history of substance use is to address the following areas: 1) age at first substance use, 2) frequency of substance use, 3) amount of substance taken during an episode of use, 4) route of administration for the substance, 5) consequences associated with substance use, 6) treatment history, 7) periods of abstinence, and 8) relapses. https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#BABBHAFG https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06 The information obtained by asking about the age at first substance use serves as the framework for the history and guides the interviewer’s subsequent questions. In addition, the age when the patient began using substances has diagnostic and prognostic implications. Early onset (before age 15 years) of substance use is associated with the subsequent development of substance-
  • 21. related disorders (Chen et al. 2005; Hingson et al. 2006). Inquiries about the frequency of substance use as well as the amount of the substance used and the route of administration (oral, inhaled, insufflated or snorted, intravenous, subcutaneous) help the interviewer understand the progression of substance use over time. For example, a patient who says she started snorting (route of administration) one bag (amount) of heroin once a week for 1 year (frequency) and then began injecting three bags of heroin per day is reporting her progression of heroin use in all three areas. In addition, the frequency, amount, and route of administration of use may be related to the development of medical disorders associated with a particular substance. General questions about the consequences of substance use focus on changes in academic performance, occupational functioning, and interpersonal relationships, as well as medical and legal problems associated with substance use. The history of addiction treatment includes questions about hospital admissions for detoxification, as well
  • 22. as admissions to other controlled living situations (e.g., residential programs, halfway houses, sober houses, therapeutic communities) to support ongoing abstinence. Outpatient programs such as partial hospital programs, as well as group, individual, and pharmacological therapies (e.g., disulfiram, naltrexone, buprenorphine-naloxone, methadone, nicotine replacement therapies), may also be a part of the patient’s prior treatment. Understanding which earlier treatments did or did not help the patient achieve and maintain abstinence can serve as a guide for treatment recommendations. The interviewer should also ask about involvement in self-help groups (e.g., Alcoholics Anonymous, Narcotics Anonymous, Self-Management and Recovery Training, Rational Recovery, Women for Sobriety). Some patients may express positive or negative feelings about a particular type of self-help group. The interviewer should not support or discredit the patient’s feelings about self-help groups but instead should seek to understand the patient’s experiences, both to educate the patient about the effectiveness of self-help
  • 23. groups and to formulate a realistic treatment plan that will benefit the patient. Information about a patient’s periods of abstinence as well as relapses indicates the progression or remission of substance use, the severity of the disorder, and external factors—such as interpersonal, psychiatric, occupational, legal or medical problems, and treatment termination— that may have influenced the return to substance use. The interviewer should also review current use of all substances even if no history of past use has been provided from which to ascertain current use patterns. Psychiatric History There is an increased prevalence of substance-related disorders among patients diagnosed with other psychiatric disorders (Compton et al. 2007; Kessler et al. 1997; Regier et al. 1990). Conversely, patients diagnosed with substance-related disorders are more likely to have a co- occurring psychiatric disorder (Brady et al. 1991; Currie et al. 2005; Mueser et al. 2000). Studies https://psychiatryonline-
  • 24. org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e677 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1098 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e721 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1187 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1737 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e584 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e809 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1398 have shown that the co-occurring substance-related and psychiatric disorders can each worsen the prognosis for the other disorder (Greenfield et al. 1998; Hides et al. 2006; Nunes and Levin 2004). When coexisting substance-related and psychiatric disorders are diagnosed, patients can be referred to integrated treatment for both disorders. Because evidence suggests that integrated
  • 25. treatment improves and enhances outcomes for both disorders (Bennett et al. 2001; Najavits et al. 1998, 2005; Weiss et al. 2000b), it is important to assess substance-related disorders in patients presenting for treatment of other psychiatric disorders and equally important to assess psychiatric disorders among patients presenting for treatment of substance- related disorders. If the patient reports symptoms consistent with a psychiatric disorder, the interviewer should inquire about the relationship between substance use and the emergence, exacerbation, or regression of psychiatric symptoms. A diagnosis of a substance- induced mental disorder is made when the development of the full criteria for a mental disorder occurs during or within 1 month of an intoxication with or withdrawal from a substance that is capable of causing the mental disorder (American Psychiatric Association 2013). A mental disorder would be considered independent of a substance if the disorder preceded the onset of severe intoxication or withdrawal, or if the mental disorder persisted for a substantial period of time (e.g., at least 1
  • 26. month) after substance intoxication or substance withdrawal ended. Additionally, the disorder cannot occur exclusively during the course of a delirium and the disorder must cause clinically significant distress or impairment in important areas of functioning. DSM-5 criteria for other psychiatric disorders include the specifiers with onset during intoxication and with onset during discontinuation/withdrawal. Reviewing the patient’s history of psychiatric symptoms before the onset of substance use, during episodes of intoxication with or withdrawal from substances, and after cessation of substance use can help the interviewer distinguish between substance-induced mental disorders and co-occurring psychiatric and substance- related disorders. A complete medical history—including current and past medical problems, surgical procedures, and medication allergies—is necessary for patients presenting for assessment of a substance- related disorder. Medical problems require treatment regardless of their relationship to substance use, and the interviewing clinician should make treatment recommendations or referrals for
  • 27. further evaluation for any conditions. In addition, patients with substance-related disorders have often neglected their health and routine medical care and are at risk for a number of co-occurring medical disorders. The clinician should ask about the dates of the last complete physical examination and follow-ups for any medical problems, past or current. For each medical condition, the interviewer should try to determine whether the symptoms are related to or independent of substance use. Questions about a reported medical problem should include inquiries about the temporal relationship between the development of the medical condition and substance use. It is also important to ask about current and past medical problems that are specific to use of a particular substance. A description of all the medical problems associated with each category of substances is beyond the scope of this chapter; the major medical problems and disorders associated with the more commonly abused substances are listed in Table 6–2. Medical History Medical problems associated with substance- related
  • 28. disorders Enlarge table https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e853 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1054 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1612 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1612 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e540 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1479 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1479 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1523 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1919 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e490 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161
  • 29. 5370030.mg06#BABBGJCD https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06 Obtaining a reproductive health history is important in the evaluation of women with substance- related disorders. Relevant history among women of childbearing age includes a menstrual history and determining whether the patient is or may be pregnant. Women who know they are pregnant may want additional information on risk of substance use. A pregnancy test can be offered if a pregnancy is in question. Pregnancy can serve as a powerful motivator for cessation of substance use, and pregnant women may wish to seek substance abuse treatment that has specialized services (Brady and Ashley 2005). During different phases of the menstrual cycle, women can experience changes in craving and substance use, as well as differences in likelihood of stopping their substance use (Greenfield et al. 2011). Changes in sleep or symptoms such as hot flashes may be relevant factors in the use of substances for perimenopausal and
  • 30. postmenopausal women. Lastly, understanding the relationship between the development and exacerbation of the patient’s medical disorders and the patient’s substance use provides the interviewer with information that may motivate the patient to change addictive behavior. The medical history will also provide the information necessary to refer the patient to appropriate medical care regardless of the origin of the medical disorder. Family History The family history of substance-related disorders may reveal a genetic vulnerability to the patient’s own development of these disorders (Agrawal and Lynskey 2008). The environment created by families with substance-related disorders may also have an impact on the development of substance-related disorders in their children. Interviewers can educate patients about genetic vulnerability and family environmental factors associated with substance-related disorders. This information may provide patients with an understanding of their current problems
  • 31. with substances as well as compelling reasons why they should refrain from substance use. Social and Developmental History Important psychosocial factors to explore include the patient’s relationships with others, the influence of these relationships on both initiation and continued use of substances, and the existence of any supportive relationships that help the patient abstain from substances or stop using substances after starting. Childhood physical or sexual abuse (Nelson et al. 2006) is a risk factor for the development of substance-related disorders as well as for poorer drinking outcomes (Greenfield et al. 2002) and psychiatric outcomes (Pirard et al. 2005). Developing meaningful interpersonal relationships, however, can help patients build a social network that supports recovery (Havassy et al. 1991). The presence or absence of a spouse or partner can have an important influence on the development and perpetuation of a substance-related disorder (Hser et al. 1987) and may also have positive or negative effects on treatment outcomes (Walitzer and Dearing 2006). Educational attainment and employment can be
  • 32. affected by substance use. Substance use may lead to school absenteeism, poor school performance, and dropout (Lynskey and Hall 2000; Lynskey et al. 2003); lower educational status (Crum et al. 1998); and lower income (Mullahy and Sindelar 1989). https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e628 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e985 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e440 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1568 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e897 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1649 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1010 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1143 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161
  • 33. 5370030.mg06#u2014-04-03T12581333-0400d1e1143 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1824 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1824 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1300 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1300 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1337 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e765 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1442 Physical and mental status examinations of patients presenting for an assessment of a substance- related disorder are critical parts of the evaluation because both medical and psychiatric disorders are commonly found in this population. Although a mental status examination can and must be performed regardless of the treatment setting, the interviewer may be unable to perform
  • 34. a physical examination due to lack of appropriate space, equipment, and training. Patient factors such as refusal to undergo an examination or inability to cooperate with the examination due to substance intoxication or withdrawal may also be reasons to defer the physical examination. Under such circumstances, the interviewer should refer the patient to the appropriate person (e.g., primary care physician) or facility (e.g., emergency room) for a complete physical examination. Specific signs of substance use that may present during the physical or mental status examination will depend on the type of substance used and the presence of intoxication with or withdrawal from substances (Washburn 2002). The signs and symptoms of substance intoxication and withdrawal, according to DSM-5, are listed in Tables 6–3 and 6–4, respectively. Physical and Mental Status Examinations DSM-5 signs and symptoms of substance intoxication Enlarge table Physical and Mental Status Examinations DSM-5 signs and
  • 35. symptoms of substance withdrawal Enlarge table Although many physical signs of substance use are easily observed when the interviewer performs the mental status examination, other signs of substance use are best detected by performing a thorough physical examination. For example, a patient with hepatic damage as a result of chronic alcohol use or hepatitis infection resulting from intravenous drug use may present with a slightly enlarged liver or, in more advanced cases of hepatic damage, jaundice, abdominal distention secondary to ascites, gynecomastia, spider angiomas, palmar erythema, and caput medusa. A complete description of all the physical findings associated with substance use is beyond the scope of this chapter; this example is presented to illustrate the importance of a thorough physical examination to detect other signs of substance-related medical disorders that require immediate treatment. The physical and mental status examinations of a patient presenting for an evaluation of a
  • 36. substance-related disorder can be dramatically affected by states of intoxication or withdrawal. Alterations in mood, affect, psychiatric symptoms, thought processes, thought content, speech, memory, orientation, cognition, insight, and judgment are commonly seen when patients are intoxicated with or are withdrawing from a particular substance. Similarly, substance intoxication or withdrawal can lead to significant changes in the patient’s physiological state, including abnormalities in blood pressure, body temperature, and level of consciousness, as well as disruption in the stability and functioning of major organ systems such as the neurological and gastrointestinal systems. In addition, the mental status examination provides important information for the diagnosis of other psychiatric disorders and for the evaluation of the current https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1860 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#BABEJCBG https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161
  • 37. 5370030.mg06#BABIFBJI https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06 remission, recurrence, or stability of any other concurrent psychiatric disorder. A comparison of the patient’s physical and mental status examinations during different stages of substance abuse treatment is one way to evaluate changes in substance use and in any concurrent medical and psychiatric disorders. Obtaining Additional Information A patient’s significant others can often serve as collateral informants who can corroborate and provide additional information about the patient’s reported substance use history (Carroll 1995). Speaking with the patient’s significant others also allows for their early involvement in treatment planning and may help in establishing social networks that can potentially support the patient’s recovery and help maintain abstinence (Havassy et al. 1991). Contact with collateral informants should occur only with written permission from the patient.
  • 38. Biological markers can help in detecting the degree and regularity of the patient’s substance use (Kolodziej et al. 2002) and may be useful in spite of the limitations of each specific test. These tests include breath alcohol testing, quantitative urine or serum drug screens, and serum tests for blood markers of hepatic dysfunction or hematological problems. Finally, a number of standardized instruments exist for screening, diagnostic assessment, and evaluation of severity and may be helpful in the overall assessment of the patient (Knight et al. 2003). Conclusion In this chapter we have discussed the importance of assessing substance use in all patients seen in the clinical setting. We have outlined the content areas of inquiry of the interview as well as the adjunctive use of the physical examination and mental status examination. A careful and accurate assessment of the patient will provide the necessary information for intervention and treatment planning and will increase motivation by beginning to engage the patient in the process of change. Key Points 1. Successful treatment of substance-related disorders depends on a careful,
  • 39. accurate assessment and diagnosis. 2. Accurate assessment is facilitated by interview settings that provide privacy and patient confidentiality and that permit adequate time to ask key questions, to follow up on positive patient responses, and to give feedback to the patient. 3. A substance use history should be obtained from all patients presenting for treatment. https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e645 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1010 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1275 https://psychiatryonline- org.ezp.waldenulibrary.org/doi/full/10.1176/appi.books.978161 5370030.mg06#u2014-04-03T12581333-0400d1e1231 4. Patient assessment can be influenced by a number of patient characteristics, including the patient’s age, gender, ethnicity, and legal, marital, and employment status; degree of insight into the nature of the problem; medical or psychiatric comorbidity; stage in the course of illness (e.g., recovery, recent relapse, first treatment); current phase of
  • 40. use (e.g., intoxication, withdrawal, interepisode); and stage of readiness for change and motivation. 5. A complete substance use assessment requires eliciting the history of use for all the major categories of substances, with a focus on age at first use, frequency and amount of use, consequences of use, substance abuse treatment history, and complete psychiatric, medical and social, and developmental histories. 6. Collateral informant interviews, standardized questionnaires, and biological testing may also provide additional helpful information for some patients. References addiction: evidence from family, adoption and twin studies.. Addiction 103:1069– 1081, 2008 Manual of Mental Disorders, 4th Edition, Text Revision. Washington, DC, American Psychiatric Association, 2000
  • 41. treatment of patients with substance use disorders, 2nd edition, in American Psychiatric Association Practice Guidelines for the Treatment of Psychiatric Disorders: Compendium. Washington, DC, American Psychiatric Association, 2006, pp 291–563 Manual of Mental Disorders, 5th Edition. Washington, DC, American Psychiatric Association, 2013 GA: Verbal report methods in clinical research on alcoholism: response bias and its minimization.. J Stud Alcohol 48:410–424, 1987 abuse in schizophrenia. An initial report.. J Subst Abuse Treat 20:163– 175, 2001 inpatient psychiatric sample.. Am J Drug Alcohol Abuse 17:389–397, 1991 Results From the Alcohol and Drug Services Study (ADSS). Rockville, MD, Substance Abuse and Mental Health Services Administration, 2005
  • 42. assessment of substance use.. Psychol Assess 3:349–358, 1995 t: Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. TIP Series #40 (DHHS Publ No SMA-04–3939). Rockville, MD, Substance Abuse and Mental Health Services Administration, 2004 becomes cannabis dependent soon after onset of use? Epidemiological evidence from the United States: 2000–2001.. Drug Alcohol Depend 79:11–22, 2005 correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions.. Arch Gen Psychiatry 64:566–576, 2007 educational achievement and school dropout with risk of alcoholism: a twenty-five- year prospective study of inner-city children.. J Stud Alcohol 59:318– 326, 1998
  • 43. major depression with substance use disorders.. Can J Psychiatry 50:660–666, 2005 depression on return to drinking: a prospective study.. Arch Gen Psychiatry 55:259– 265, 1998 abuse and drinking outcomes following inpatient alcohol treatment: a prospective study.. Drug Alcohol Depend 67:227–234, 2002 treatment entry, retention, and outcome in women: a review of the literature.. Drug Alcohol Depend 86:1–21, 2007 addiction, in Lowinson and Ruiz’s Substance Abuse: A Comprehensive Textbook, 5th Edition. Edited by Ruiz P, Strain EC, Philadelphia, PA, Lippincott Williams & Wilkins, 2011, pp 847–870 relapse: commonalities among alcoholics, opiate users, and cigarette smokers.. Addict Behav 16:235–246, 1991
  • 44. mptom and cannabis relapse in recent-onset psychosis. Prospective study.. Br J Psychiatry 189:137–143, 2006 - dependence onset: associations with severity of dependence and seeking treatment.. Pediatrics 118:e755–e763, 2006 addict careers. 1. Initiation of use.. Am J Drug Alcohol Abuse 13:33–57, 1987 - occurrence of DSM- III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey.. Arch Gen Psychiatry 54:313–321, 1997 alcohol screening tests among adolescents: a comparison of the AUDIT, POSIT, CAGE, and CRAFFT.. Alcohol Clin Exp Res 27:67–73, 2003 in substance use disorders, in Outcome Measurement in Psychiatry: A Critical Review. Edited by Burt T, Sederer L, IsHak W. Washington, DC, American Psychiatric Publishing, 2002,, pp 227–228
  • 45. on educational attainment: a review.. Addiction 95:1621–1630, 2000 study of the effects of adolescent cannabis use on high school completion.. Addiction 98:685–692, 2003 People for Change, 3rd Edition. New York, Guilford, 2012 SD, et al: Substance use disorder in hospitalized severely mentally ill psychiatric patients: prevalence, correlates, and subgroups.. Schizophr Bull 26:179–192, 2000 -cycle effects of alcoholism on education, earnings, and occupation.. Inquiry 26:272–282, 1989 outcome of a new cognitive-behavioral psychotherapy for women with posttraumatic stress disorder and substance dependence.. J Trauma Stress 11:437– 456, 1998 plus Exposure Therapy: an outcome study on dual diagnosis men.. J Psychoactive Drugs 37:425–435, 2005
  • 46. abuse and risks for licit and illicit drug-related outcomes: a twin study.. Psychol Med 36:1473–1483, 2006 with alcohol or other drug dependence: a meta-analysis.. JAMA 291:1887–1896, 2004 ng SK, et al: Prevalence of physical and sexual abuse among substance abuse patients and impact on treatment outcomes.. Drug Alcohol Depend 78:57–64, 2005 people change. Applications to addictive behaviors.. Am Psychol 47:1102– 1114, 1992 disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) study.. JAMA 264:2511–2518, 1990 feld R, Pantalon M: Assessment of the patient, in The American Psychiatric Press Textbook of Substance Abuse Treatment, 2nd Edition. Edited by Galanter M, Kleber HD. Washington, DC, American Psychiatric Press, 1999, pp 109–120
  • 47. Litten RZ, et al: Timeline follow- back: a technique for assessing self-reported alcohol consumption, in Measuring Alcohol Consumption: Psychosocial and Biochemical Methods. Totowa, NJ, Humana Press, 1992, pp 41–72 ferences in alcohol and substance use relapse.. Clin Psychol Rev 26:128–148, 2006 traditional history and physical, or screening? Occup Med 17(1):67–78, iv, 2002 allop R, et al: Predictors of self- help group attendance in cocaine dependent patients.. J Stud Alcohol 61:714– 719, 2000a for patients with bipolar disorder and substance dependence: results of a pilot study.. J Clin Psychiatry 61:361–367, 2000b Addiction Medicine, 4th Edition. Edited by Ries RK, Fiellin DA, Miller SC, Saitz R. Philadelphia, PA, Lippincott, Williams & Wilkins, 2009, pp 493–500
  • 48. Suggested Readings 1. Brady KT, Back SE, Greenfield SF (eds): Women and Addiction: A Comprehensive Handbook. New York, Guilford, 2009 2. Connors GJ, Donnovan DM, Diclemente CC: Substance Abuse Treatment and Stages of Change. New York, Guilford, 2001 3. Cummings NA, Cummings JL: The First Session With Substance Abusers: A Step-by-Step Guide. New York, Wiley, 2000 4. Miller WR, Rollnick S: Motivational Interviewing: Preparing People for Change, 3rd Edition. New York, Guilford, 2012 5. Stevens LH, Dennis ML: Clinical assessment, in Substance Abuse: A Comprehensive Assessment. Edited by Ruiz Pm, Strain E. Philadelphia, PA, Lippincott, Williams & Wilkins, 2011, pp 107–116