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Screening	
  When	
  where	
  why	
  
Dr.	
  Kawita	
  Bapat	
  
	
  	
  
 
	
  
Dr.	
  Kawita	
  Bapat	
  	
  
	
  •  MS FICOG
•  Director Of One Centre For Gynecological Excellence
•  Senior Practicing Obgyn At Indore
•  One Day Hysterectomy Specialist
•  FOGSI Affiliated Colposcopy Center
•  Vice President (Elect) FOGSI,2021
•  President Indore Menopause Society
•  Vice President AMPOG
•  President MP Chapter Of Vaginal Surgeons
•  Secretory MP IAGE
•  Executive Member ISAR
•  Executive Member IAGE
•  Chairperson Breast Committee FOGSI 16-18
•  Past President OBGYN Society INDORE
•  GOVRNING COUNCIL MEMBER ICOG
•  Past President LIONS Club INDORE
•  Award Winner Of Nayika Indore And Captain Of Industry
•  bapatkawita@gmail.Com
•  www.Onegynae.Com
•  Bapat Hospital Bapat Choraha Sukhlia Indore
+919826055666
•  Breast	
  cancer	
  is	
  an	
  increasing	
  health	
  problem	
  in	
  
India.	
  
	
  
•  The	
  trend	
  of	
  rising	
  incidence	
  rates	
  is	
  likely	
  to	
  
con9nue	
  due	
  to	
  further	
  changes	
  in	
  lifestyle	
  factors	
  
such	
  as:	
  
	
  -­‐	
  Childbearing	
  	
  
	
  -­‐	
  Dietary	
  habits	
  
	
  -­‐	
  Early	
  Menarche	
  
	
  -­‐	
  Late	
  Marriages	
  
	
  -­‐	
  Less	
  BreasBeeding	
  
	
  -­‐	
  Economic	
  evolu9on	
  of	
  country	
  
JNCI:	
  Journal	
  of	
  the	
  Na1onal	
  Cancer	
  Ins1tute,	
  Volume	
  100,	
  Issue	
  18,	
  17	
  September	
  2008,	
  Pages	
  1270–1271,	
  
hOps://doi.org/10.1093/jnci/djn303	
  
	
  	
  
	
  
•  The current age-standardized rate is 19.1 per 100 000
per annum, but, in contrast to what is observed in
developed countries, the incidence rate peaks below
age 50. Stage distribution at presentation is less
favorable than in developed countries, with 50%–70%
of cases presenting for treatment being locally
advanced , and the availability and level of facilities for
treatment are variable ..
JNCI:	
  Journal	
  of	
  the	
  Na1onal	
  Cancer	
  Ins1tute,	
  Volume	
  100,	
  Issue	
  18,	
  17	
  September	
  2008,	
  Pages	
  1270–1271,	
  
hOps://doi.org/10.1093/jnci/djn303	
  
	
  
	
  
•  Survival rates are consequently low , and
there is a clear need to improve the
availability and accessibility of facilities for
diagnosis and treatment, as well as education
and awareness .	
  
Screening	
  test	
  should	
  be	
  	
  
	
  
•  Easy	
  To	
  Use	
  	
  
•  Cost	
  Effec9ve	
  	
  
•  Available	
  	
  
•  Accessible	
  	
  
•  Reproducible	
  	
  
•  Can	
  Be	
  Applied	
  In	
  The	
  Field	
  Set	
  Up,	
  
•  Good	
  Sensi9vity	
  And	
  Specificity	
  
•  Branded	
  awareness	
  	
  
 	
  	
  	
  	
  	
  
	
  
8	
  
Clinical	
  and	
  self	
  breast	
  
examina?on	
  
Mammography	
  
Gene?c	
  screening	
  
Ultrasound	
  
Magne?c	
  resonance	
  
imaging	
  
Molecular	
  breast	
  
imaging	
  
USPSTF	
   ACS	
   ACOG	
  
Recommends	
  against	
  
clinicians	
  teaching	
  women	
  
how	
  to	
  perform	
  Breast	
  self-­‐
examina9on	
  
Recommends	
  against	
  
clinicians	
  teaching	
  women	
  
how	
  to	
  perform	
  Breast	
  self	
  
examina9on	
  
Consider	
  Breast	
  self	
  
examina?on	
  instruc?on	
  for	
  
high-­‐risk	
  pa9ents.	
  Breast	
  
self-­‐awareness	
  should	
  be	
  
encouraged	
  and	
  can	
  include	
  
Breast	
  self-­‐examina9on	
  	
  
	
  
	
  
	
  
Recommenda?ons	
  for	
  Breast	
  Cancer	
  Screening	
  
Benefits	
  &	
  Harms	
  of	
  BSE	
  
Gene9c	
  Screening	
  
	
  	
  	
  	
  	
  
•  One	
  or	
  more	
  rela9ves	
  with	
  breast	
  cancer	
  diagnosed	
  before	
  age	
  
50	
  	
  
•  Two	
  or	
  more	
  rela9ves	
  diagnosed	
  with	
  breast	
  cancer	
  at	
  any	
  age	
  	
  
•  One	
  or	
  more	
  rela9ves	
  with	
  ovarian	
  cancer	
  	
  
•  One	
  or	
  more	
  rela9ves	
  with	
  male	
  breast	
  cancer	
  
•  Two	
  or	
  more	
  rela9ves	
  with	
  prostate	
  cancer	
  or	
  pancrea9c	
  
cancertwo	
  or	
  more	
  rela9ves	
  with	
  brca-­‐associated	
  cancers	
  
•  A	
  history	
  of	
  breast	
  cancer	
  at	
  A	
  young	
  age	
  in	
  two	
  or	
  more	
  blood	
  
rela9ves,	
  such	
  as	
  your	
  parents,	
  siblings	
  or	
  children	
  
•  A	
  rela9ve	
  with	
  A	
  known	
  BRCA1	
  or	
  BRCA2	
  muta9on	
  
mammogram	
  
•  Biennial	
  screening	
  mammography	
  is	
  recommended	
  
for	
  women	
  in	
  the	
  50–74	
  years	
  age	
  group,	
  but	
  is	
  
available	
  to	
  all	
  women	
  aged	
  over	
  40	
  years.	
  
•  Imaging	
  plays	
  a	
  major	
  role	
  in	
  the	
  diagnosis,	
  
treatment,	
  and	
  follow-­‐up	
  of	
  breast	
  cancer.	
  	
  
•  Findings	
  that	
  require	
  further	
  assessment	
  will	
  be	
  
detected	
  both	
  at	
  screening	
  and	
  cura9ve	
  
mammography	
  
Digital	
  Mammogram	
  vs.	
  Tradi?onal	
  X-­‐Ray	
  
Mammogram	
  
Digital Mammogram Traditional X-Ray Mammogram
17
Digital Mammogram MRI
Digital	
  Mammogram	
  vs.	
  MRI	
  
USPTSF	
  
• Biennial	
  screening	
  mammography	
  beginning	
  at	
  age	
  50.(B	
  Recommend)	
  
• Evidence	
  is	
  insufficient	
  for	
  assessing	
  the	
  addi9onal	
  benefits	
  of	
  screening	
  
mammography	
  in	
  women	
  past	
  age	
  74	
  
• Annual	
  screening	
  mammography	
  beginning	
  at	
  age	
  45	
  with	
  an	
  op9on	
  to	
  
begin	
  at	
  age	
  40.	
  Transi9on	
  to	
  biennial	
  screening	
  at	
  age	
  55	
  with	
  op9on	
  to	
  
con9nue	
  annual	
  screening	
  
• Con9nue	
  biennial	
  screening	
  mammography	
  for	
  as	
  long	
  as	
  a	
  woman	
  is	
  in	
  
good	
  health	
  and	
  a	
  life	
  expectancy	
  of	
  has	
  at	
  least	
  10	
  years	
  
• Annual	
  Screening	
  Mammography	
  beginning	
  at	
  age	
  40	
  
• Women	
  aged	
  75	
  years	
  and	
  older	
  should	
  consult	
  with	
  their	
  physicians	
  to	
  
decide	
  whether	
  or	
  not	
  to	
  con9nue	
  screening	
  mammography	
  
Controversies	
  in	
  Mammography	
  
ACS	
  
ACOG	
  
•  Mammography	
  Screening	
  	
  	
  	
  	
  	
  	
  Increased	
  detec9on	
  of	
  
precancerous	
  lesions	
  /	
  In-­‐situ	
  
•  25%	
  of	
  newly	
  diagnosed	
  BC	
  cases	
  in	
  screening	
  is	
  DCIS.(FEA,	
  
ADH)	
  
•  Biological	
  Significance	
  and	
  prac9cal	
  M/M	
  	
  	
  	
  	
  	
  	
  	
  Big	
  challenge	
  
and	
  s9ll	
  unclear	
  
•  Trials/Individual	
  studies	
  	
  	
  	
  	
  	
  	
  	
  	
  No	
  	
  reduc9on	
  to	
  30-­‐45%	
  
modest	
  decrease	
  in	
  BC	
  when	
  screened	
  every	
  1-­‐2	
  years	
  
Controversies	
  in	
  Mammography	
  
Key	
  methods	
  	
  
•  Three-­‐dimensional	
  (3D)	
  Approaches	
  To	
  X‑ray	
  
Mammography	
  (Digital	
  Breast	
  Tomosynthesis),	
  	
  
•  Contrast-­‐enhanced	
  Mammography	
  
•  Quan9fiable	
  Ultrasound	
  Techniques	
  (E. G.,	
  Shear	
  Wave	
  
Elastography)	
  
•  	
  	
  
•  Func9onal	
  Magne9c	
  Resonance	
  Imaging	
  (Mri;	
  E. G.,	
  
Contrast-­‐enhanced	
  MRI,	
  Diffusion-­‐weighted	
  Imaging).	
  	
  
•  This	
  Review	
  Focuses	
  On	
  These	
  Techniques	
  And	
  Their	
  
Poten9al	
  Use	
  In	
  The	
  Breast	
  Clinic.	
  
Breast	
  imaging	
  workflow.	
  
	
  Boxes	
  represent	
  typical	
  steps	
  in	
  the	
  breast	
  imaging	
  workflow,	
  logical	
  steps	
  are	
  connected	
  by	
  arrows.	
  Circles	
  indicate	
  where	
  the	
  
new	
  imaging	
  tools	
  discussed	
  in	
  this	
  ar9cle	
  can	
  be	
  of	
  help.	
  ARFI	
  acous9c	
  radia9on	
  force	
  impulse,	
  DBT	
  digital	
  breast	
  
tomosynthesis,	
  DWI	
  diffusion-­‐weighted	
  imaging	
  
Conclusion	
  	
  
•  Benefits	
  of	
  Screening	
  
•  Screening	
  for	
  breast	
  cancer	
  means	
  looking	
  for	
  
signs	
  of	
  breast	
  cancer	
  in	
  all	
  women,	
  even	
  if	
  
they	
  have	
  no	
  symptoms.	
  	
  
•  The	
  goal	
  of	
  screening	
  is	
  to	
  catch	
  cancers	
  early.	
  
•  	
  Early-­‐stage	
  cancers	
  are	
  easier	
  to	
  treat	
  than	
  
later-­‐stage	
  cancers	
  	
  
•  chance	
  of	
  survival	
  is	
  higher.	
  	
  
•  Rou1ne	
  screening	
  for	
  breast	
  cancer	
  lowers	
  
one’s	
  risk	
  of	
  dying	
  of	
  breast	
  cancer.	
  
THANK	
  YOU	
  

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Screening when where why

  • 1. Screening  When  where  why   Dr.  Kawita  Bapat      
  • 2.     Dr.  Kawita  Bapat      •  MS FICOG •  Director Of One Centre For Gynecological Excellence •  Senior Practicing Obgyn At Indore •  One Day Hysterectomy Specialist •  FOGSI Affiliated Colposcopy Center •  Vice President (Elect) FOGSI,2021 •  President Indore Menopause Society •  Vice President AMPOG •  President MP Chapter Of Vaginal Surgeons •  Secretory MP IAGE •  Executive Member ISAR •  Executive Member IAGE •  Chairperson Breast Committee FOGSI 16-18 •  Past President OBGYN Society INDORE •  GOVRNING COUNCIL MEMBER ICOG •  Past President LIONS Club INDORE •  Award Winner Of Nayika Indore And Captain Of Industry •  bapatkawita@gmail.Com •  www.Onegynae.Com •  Bapat Hospital Bapat Choraha Sukhlia Indore +919826055666
  • 3.
  • 4. •  Breast  cancer  is  an  increasing  health  problem  in   India.     •  The  trend  of  rising  incidence  rates  is  likely  to   con9nue  due  to  further  changes  in  lifestyle  factors   such  as:    -­‐  Childbearing      -­‐  Dietary  habits    -­‐  Early  Menarche    -­‐  Late  Marriages    -­‐  Less  BreasBeeding    -­‐  Economic  evolu9on  of  country  
  • 5. JNCI:  Journal  of  the  Na1onal  Cancer  Ins1tute,  Volume  100,  Issue  18,  17  September  2008,  Pages  1270–1271,   hOps://doi.org/10.1093/jnci/djn303         •  The current age-standardized rate is 19.1 per 100 000 per annum, but, in contrast to what is observed in developed countries, the incidence rate peaks below age 50. Stage distribution at presentation is less favorable than in developed countries, with 50%–70% of cases presenting for treatment being locally advanced , and the availability and level of facilities for treatment are variable ..
  • 6. JNCI:  Journal  of  the  Na1onal  Cancer  Ins1tute,  Volume  100,  Issue  18,  17  September  2008,  Pages  1270–1271,   hOps://doi.org/10.1093/jnci/djn303       •  Survival rates are consequently low , and there is a clear need to improve the availability and accessibility of facilities for diagnosis and treatment, as well as education and awareness .  
  • 7. Screening  test  should  be       •  Easy  To  Use     •  Cost  Effec9ve     •  Available     •  Accessible     •  Reproducible     •  Can  Be  Applied  In  The  Field  Set  Up,   •  Good  Sensi9vity  And  Specificity   •  Branded  awareness    
  • 8.               8   Clinical  and  self  breast   examina?on   Mammography   Gene?c  screening   Ultrasound   Magne?c  resonance   imaging   Molecular  breast   imaging  
  • 9.
  • 10. USPSTF   ACS   ACOG   Recommends  against   clinicians  teaching  women   how  to  perform  Breast  self-­‐ examina9on   Recommends  against   clinicians  teaching  women   how  to  perform  Breast  self   examina9on   Consider  Breast  self   examina?on  instruc?on  for   high-­‐risk  pa9ents.  Breast   self-­‐awareness  should  be   encouraged  and  can  include   Breast  self-­‐examina9on           Recommenda?ons  for  Breast  Cancer  Screening  
  • 11. Benefits  &  Harms  of  BSE  
  • 12. Gene9c  Screening             •  One  or  more  rela9ves  with  breast  cancer  diagnosed  before  age   50     •  Two  or  more  rela9ves  diagnosed  with  breast  cancer  at  any  age     •  One  or  more  rela9ves  with  ovarian  cancer     •  One  or  more  rela9ves  with  male  breast  cancer   •  Two  or  more  rela9ves  with  prostate  cancer  or  pancrea9c   cancertwo  or  more  rela9ves  with  brca-­‐associated  cancers   •  A  history  of  breast  cancer  at  A  young  age  in  two  or  more  blood   rela9ves,  such  as  your  parents,  siblings  or  children   •  A  rela9ve  with  A  known  BRCA1  or  BRCA2  muta9on  
  • 13.
  • 14.
  • 15. mammogram   •  Biennial  screening  mammography  is  recommended   for  women  in  the  50–74  years  age  group,  but  is   available  to  all  women  aged  over  40  years.   •  Imaging  plays  a  major  role  in  the  diagnosis,   treatment,  and  follow-­‐up  of  breast  cancer.     •  Findings  that  require  further  assessment  will  be   detected  both  at  screening  and  cura9ve   mammography  
  • 16. Digital  Mammogram  vs.  Tradi?onal  X-­‐Ray   Mammogram   Digital Mammogram Traditional X-Ray Mammogram
  • 17. 17 Digital Mammogram MRI Digital  Mammogram  vs.  MRI  
  • 18. USPTSF   • Biennial  screening  mammography  beginning  at  age  50.(B  Recommend)   • Evidence  is  insufficient  for  assessing  the  addi9onal  benefits  of  screening   mammography  in  women  past  age  74   • Annual  screening  mammography  beginning  at  age  45  with  an  op9on  to   begin  at  age  40.  Transi9on  to  biennial  screening  at  age  55  with  op9on  to   con9nue  annual  screening   • Con9nue  biennial  screening  mammography  for  as  long  as  a  woman  is  in   good  health  and  a  life  expectancy  of  has  at  least  10  years   • Annual  Screening  Mammography  beginning  at  age  40   • Women  aged  75  years  and  older  should  consult  with  their  physicians  to   decide  whether  or  not  to  con9nue  screening  mammography   Controversies  in  Mammography   ACS   ACOG  
  • 19. •  Mammography  Screening              Increased  detec9on  of   precancerous  lesions  /  In-­‐situ   •  25%  of  newly  diagnosed  BC  cases  in  screening  is  DCIS.(FEA,   ADH)   •  Biological  Significance  and  prac9cal  M/M                Big  challenge   and  s9ll  unclear   •  Trials/Individual  studies                  No    reduc9on  to  30-­‐45%   modest  decrease  in  BC  when  screened  every  1-­‐2  years   Controversies  in  Mammography  
  • 20. Key  methods     •  Three-­‐dimensional  (3D)  Approaches  To  X‑ray   Mammography  (Digital  Breast  Tomosynthesis),     •  Contrast-­‐enhanced  Mammography   •  Quan9fiable  Ultrasound  Techniques  (E. G.,  Shear  Wave   Elastography)   •      •  Func9onal  Magne9c  Resonance  Imaging  (Mri;  E. G.,   Contrast-­‐enhanced  MRI,  Diffusion-­‐weighted  Imaging).     •  This  Review  Focuses  On  These  Techniques  And  Their   Poten9al  Use  In  The  Breast  Clinic.  
  • 21. Breast  imaging  workflow.    Boxes  represent  typical  steps  in  the  breast  imaging  workflow,  logical  steps  are  connected  by  arrows.  Circles  indicate  where  the   new  imaging  tools  discussed  in  this  ar9cle  can  be  of  help.  ARFI  acous9c  radia9on  force  impulse,  DBT  digital  breast   tomosynthesis,  DWI  diffusion-­‐weighted  imaging  
  • 22. Conclusion     •  Benefits  of  Screening   •  Screening  for  breast  cancer  means  looking  for   signs  of  breast  cancer  in  all  women,  even  if   they  have  no  symptoms.     •  The  goal  of  screening  is  to  catch  cancers  early.   •   Early-­‐stage  cancers  are  easier  to  treat  than   later-­‐stage  cancers     •  chance  of  survival  is  higher.     •  Rou1ne  screening  for  breast  cancer  lowers   one’s  risk  of  dying  of  breast  cancer.